{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.inflammation","code":"thing-inflammation","url":"https://ver.cy/models/thing/inflammation/","name":"inflammation","alternateNames":["housemaid's knee","water on the knee","dermatomyositis","polymyositis","inclusion body myositis","ankylosing spondylitis","Marie-Strumpell disease","rheumatoid spondylitis","adenitis","alveolitis","dry socket","angiitis"],"kind":"thing","status":"published","version":"0.2.0-wave.3","language":"en","classifiers":{"family":"Thing Registry","category":"Cross-cutting context","entryKind":"noun.state","plane":"XCT","domain":["XCT.STA"],"industry":[],"navPath":"","tags":[],"facets":{"substance":"abstract","origin":"conceptual","agency":"inert","mobility":"not-applicable","scale":"not-applicable","affordances":["observable"]}},"whatItIs":"A response of body tissues to injury, infection or irritation, marked by redness, heat, swelling, pain and loss of function, in which blood flow increases and immune cells and mediators move into the tissue to remove the cause and begin repair; inflammation may be acute and protective or chronic and harmful, and it underlies many named conditions such as arthritis, bursitis and inflammatory myopathies.","purpose":"Let an agent explain inflammation as a biological process, distinguish acute from chronic inflammation, relay its role in disease and treatment principles from clinical sources, and route personal symptoms to clinicians.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Cardinal signs","Vascular and cellular phases","Protective or harmful","Basis of many diseases"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What inflammation is.","layers":[{"id":"process","name":"Process","description":"Process and signs.","findings":[{"id":"process-finding","name":"Process","description":"Process.","questions":[{"text":"What happens in inflammation, and what are its cardinal signs?","kind":"definition"},{"text":"Is the user describing their own symptoms, which need a clinician?","kind":"boundary"}]}]},{"id":"kinds","name":"Kinds","description":"Acute and chronic.","findings":[{"id":"kinds-finding","name":"Kinds","description":"Kinds.","questions":[{"text":"How do acute and chronic inflammation differ in cause, course and effect?","kind":"definition"},{"text":"Which entry fits the specific condition?","kind":"action"}]}]}]},{"id":"biology","name":"Biology","description":"Mechanisms.","layers":[{"id":"mediators","name":"Mediators","description":"Cells and mediators.","findings":[{"id":"mediators-finding","name":"Mediators","description":"Mediators.","questions":[{"text":"Which cells and mediators drive inflammation, and how is it resolved?","kind":"provenance"},{"text":"Which entry fits innate immunity?","kind":"action"}]}]},{"id":"disease","name":"Disease","description":"Role in disease.","findings":[{"id":"disease-finding","name":"Disease","description":"Disease.","questions":[{"text":"How does inflammation contribute to autoimmune, cardiovascular and other diseases, with findings attributed?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]}]},{"id":"clinical","name":"Clinical","description":"Assessment and treatment.","layers":[{"id":"markers","name":"Markers","description":"Markers.","findings":[{"id":"markers-finding","name":"Markers","description":"Markers.","questions":[{"text":"How is inflammation measured clinically, such as by CRP and ESR?","kind":"provenance"},{"text":"Is the presentation free of personal medical advice?","kind":"boundary"}]}]},{"id":"treatment","name":"Treatment","description":"Treatment principles.","findings":[{"id":"treatment-finding","name":"Treatment","description":"Treatment.","questions":[{"text":"What treatment principles apply, from NSAIDs to biologics, in general terms?","kind":"provenance"},{"text":"Which entry fits anti-inflammatory drugs?","kind":"action"}]}]}]},{"id":"context","name":"Context","description":"History and public understanding.","layers":[{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How was inflammation understood from Celsus to modern immunology?","kind":"provenance"},{"text":"Which entry fits the history of medicine?","kind":"action"}]}]},{"id":"public","name":"Public","description":"Public understanding.","findings":[{"id":"public-finding","name":"Public","description":"Public.","questions":[{"text":"How is inflammation discussed in diet and wellness marketing, and what does evidence say?","kind":"provenance"},{"text":"Is the presentation attributed?","kind":"boundary"}]}]}]}]},"agentConduct":{"may":["Give general information on inflammation and its signs from medical sources.","Point people with severe or spreading symptoms to medical care."],"mustNot":["Diagnose an inflammatory condition or prescribe treatment.","Promote unproven anti-inflammatory diets or products as cures.","Recommend long-term anti-inflammatory medicines without a clinician."],"requiresHuman":["Treatment decisions for inflammatory conditions."]},"ethics":{"considerations":["Inflammation is part of healing but can signal serious illness.","Health claims about inflammation are widely exploited in marketing."],"affectedParties":["Patients","Consumers of health products"]},"owners":{"steward":"Nobody: a body process; each person with their clinician manages their own condition.","roles":[],"masterSystems":[]},"relations":[{"target":"oewn-14323139-n","type":"parent","note":"registry parent class"},{"target":"immune response","type":"related","note":"the innate response"},{"target":"tissue injury","type":"related","note":"and infection"},{"target":"inflammatory disease","type":"related","note":"many named conditions"},{"target":"anti-inflammatory drug","type":"related","note":"among other measures"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.inflammation","Open English WordNet: oewn-14359944-n","MeSH: D007249 inflammation"]},"properties":{"applicability":"not-applicable","items":[]},"recognition":{"applicability":"optional","items":["Redness, heat, swelling, pain, loss of function","Acute or chronic","Infection is a cause; inflammation is the response","Red, warm, swollen and painful tissue in acute cases; chronic inflammation may be invisible."]},"capabilities":{"applicability":"required","items":["explain the process and its signs","distinguish acute from chronic inflammation","relay its role in named conditions","route personal symptoms to clinicians"]},"hazards":{"applicability":"required","items":["Chronic inflammation damaging tissue","Masking of infection by anti-inflammatory treatment","Agents giving personal medical advice","Misuse of the term in marketing"]},"interfaces":{"applicability":"required","items":["Clinical guidelines for inflammatory conditions","Drug regulation for anti-inflammatory medicines"]},"context":{"applicability":"required","items":["Defending and repairing tissue.","acute inflammation","chronic inflammation","inflammation by site: arthritis, bursitis such as prepatellar bursitis, dermatitis","autoimmune inflammatory conditions such as ankylosing spondylitis and inflammatory myopathies","systemic inflammation and sepsis"]}},"sources":[{"title":"Open English WordNet 2024, synset oewn-14359944-n","url":"https://en-word.net/id/oewn-14359944-n","note":"sense and gloss of the concept"},{"title":"Wiktionary: inflammation","url":"https://en.wiktionary.org/wiki/inflammation","note":"word senses and usage"}],"openQuestions":["Should named inflammatory conditions be separate entries?","How should guidelines be linked?","The registry entry has merged aliases naming specific conditions; should they be split off?"],"resources":{"spec":"/models/things/publications/thing-inflammation/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-inflammation/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T22:09:37Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T12:16:27+00:00: completeness 1.00; sense: WordNet gloss; 2 live sources; review by codex: pass","interaction.properties":"Plane XCT: no invented physical properties."},"score":1.0}}