{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.acridone-alkaloid","code":"thing-q109173474","url":"https://ver.cy/models/thing/q109173474/","name":"acridone alkaloid","alternateNames":["Glycocitrine-Iv","1,2,3,5-tetramethoxy-10-methylacridin-9-one","1,5-dihydroxy-2,3,4-trimethoxy-10H-acridin-9-one","Toddaliopsin C","1-hydroxy-3-methoxy-10-methylacridin-9-one","6,11-dihydroxy-3,3-dimethyl-5-phenyl-12H-pyrano[2,3-c]acridin-7-one","Bis(5-hydroxynoracronycine)","1,3,5-trihydroxy-4-methoxy-10-methylacridin-9-one","1,5-dihydroxy-3,4-dimethoxy-10H-acridin-9-one","1,3,5-trihydroxy-4-methoxy-2,8-bis(3-methylbut-2-enyl)-10H-acridin-9-one","1,3,5-trihydroxy-4-methoxy-10H-acridin-9-one","6,11-Dihydroxy-3,3,12-trimethyl-5-phenylpyrano[2,3-c]acridin-7-one"],"kind":"thing","status":"published","version":"0.2.0-wave.3","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A class of alkaloids based on the acridone ring system, a tricyclic aromatic ketone containing nitrogen, produced mainly by plants of the citrus family Rutaceae such as Glycosmis, Toddalia and Citrus species, including compounds such as glycocitrine, toddaliopsin and various methoxylated and pyrano-fused acridones; acridone alkaloids show antimicrobial, antiviral and cytotoxic activities in laboratory studies and are investigated in pharmacology and chemotaxonomy.","purpose":"Let an agent explain acridone alkaloids and their structure, relay sources, biosynthesis and reported activities from natural product chemistry references, describe research directions, and distinguish acridone alkaloids from acridine dyes and drugs and from other alkaloid classes.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Acridone core","Rutaceae origin","Anthranilate biosynthesis","Bioactivity in research"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What acridone alkaloids are.","layers":[{"id":"definition","name":"Definition","description":"Definition and structure.","findings":[{"id":"definition-finding","name":"Definition","description":"Definition.","questions":[{"text":"What are acridone alkaloids, and how does the acridone core differ from acridine and related dyes?","kind":"definition"},{"text":"Is the question about the class, a specific compound or a synthetic acridine?","kind":"boundary"}]}]},{"id":"members","name":"Members","description":"Members.","findings":[{"id":"members-finding","name":"Members","description":"Members.","questions":[{"text":"What are glycocitrine, toddaliopsins and the methoxylated and pyrano-fused acridones named in the registry?","kind":"definition"},{"text":"Which entry fits the specific compound?","kind":"action"}]}]}]},{"id":"biology","name":"Biology","description":"Sources and biosynthesis.","layers":[{"id":"sources","name":"Sources","description":"Plant sources.","findings":[{"id":"sources-finding","name":"Sources","description":"Sources.","questions":[{"text":"Which Rutaceae plants produce acridone alkaloids, and what roles do they play in the plant?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"biosynthesis","name":"Biosynthesis","description":"Biosynthesis.","findings":[{"id":"biosynthesis-finding","name":"Biosynthesis","description":"Biosynthesis.","questions":[{"text":"How are acridone alkaloids made from anthranilate by acridone synthase and later modified?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]}]},{"id":"research","name":"Research","description":"Research.","layers":[{"id":"activity","name":"Activity","description":"Reported activities.","findings":[{"id":"activity-finding","name":"Activity","description":"Activity.","questions":[{"text":"What antimicrobial, antiviral and cytotoxic activities have been reported, and at what stage of evidence, with findings attributed?","kind":"provenance"},{"text":"Is the presentation careful not to overstate clinical relevance?","kind":"boundary"}]}]},{"id":"methods","name":"Methods","description":"Methods.","findings":[{"id":"methods-finding","name":"Methods","description":"Methods.","questions":[{"text":"How are acridone alkaloids isolated, identified and synthesised in research?","kind":"provenance"},{"text":"Which entry fits natural product chemistry?","kind":"action"}]}]}]},{"id":"context","name":"Context","description":"Chemotaxonomy and history.","layers":[{"id":"chemotaxonomy","name":"Chemotaxonomy","description":"Chemotaxonomy.","findings":[{"id":"chemotaxonomy-finding","name":"Chemotaxonomy","description":"Chemotaxonomy.","questions":[{"text":"How are acridone alkaloids used as markers in Rutaceae classification?","kind":"provenance"},{"text":"Which entry fits chemotaxonomy?","kind":"action"}]}]},{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How were acridone alkaloids discovered and studied?","kind":"provenance"},{"text":"Which entry fits the history of natural products?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Describe acridone alkaloids, their structure and plant sources from the literature.","Report laboratory findings as laboratory findings, with citations."],"mustNot":["Present laboratory or animal activity as a proven treatment in people.","Give personal medical advice on using plants or extracts containing them.","Confuse acridone alkaloids with acridine dyes.","Encourage harvesting protected plants for extraction."],"requiresHuman":["Any decision to use such compounds in people or animals."]},"ethics":{"considerations":["Hype about natural compounds can lead people to abandon proven care.","Traditional knowledge about source plants deserves credit."],"affectedParties":["Patients seeking remedies","Researchers","Communities holding plant knowledge"]},"owners":{"steward":"Nobody owns the compound class; researchers answer for the claims they publish.","roles":[],"masterSystems":["Chemical substance databases"]},"relations":[{"target":"Q70702","type":"parent","note":"registry parent class"},{"target":"Q76608011","type":"parent","note":"registry parent class"},{"target":"alkaloid","type":"related","note":"in registry terms"},{"target":"acridones","type":"related","note":"in registry terms"},{"target":"Rutaceae","type":"related","note":"plants"},{"target":"acridone synthase","type":"related","note":"from anthranilate"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.acridone-alkaloid","Wikidata: Q109173474 (https://www.wikidata.org/wiki/Q109173474)"]},"properties":{"applicability":"required","items":["core: acridin-9(10H)-one structure","main plant family: Rutaceae family","biosynthetic precursor: anthranilic acid note - via acridone synthase"]},"recognition":{"applicability":"required","items":["Alkaloids with an acridone core","Glycocitrine, toddaliopsin, methoxylated 10-methylacridin-9-ones, pyranoacridones","Acridines lack the ketone; acridine orange is a synthetic dye; furoquinolines are related Rutaceae alkaloids","Not a visible object; yellow crystalline compounds in plants."]},"capabilities":{"applicability":"required","items":["explain structure and sources","relay biosynthesis and activities","describe research","distinguish related compounds"]},"hazards":{"applicability":"required","items":["Confusing acridone alkaloids with acridine dyes","Overstating laboratory activities as clinical effects","Agents giving medical advice on unproven compounds"]},"interfaces":{"applicability":"required","items":["No regulation as a class; research chemical handling rules"]},"context":{"applicability":"required","items":["Not applicable; a chemical class.","simple acridone alkaloids such as glycocitrine","methoxylated and hydroxylated acridones","pyranoacridones and furoacridones","acridone dimers","acridone alkaloids from Toddalia such as toddaliopsins","acridones from Citrus and Glycosmis species"]}},"sources":[{"title":"Wikidata item Q109173474: acridone alkaloid","url":"https://www.wikidata.org/wiki/Q109173474","note":"identity and sense of the item"},{"title":"Wikipedia: Acridone alkaloids","url":"https://en.wikipedia.org/wiki/Acridone_alkaloids","note":"general description of the item"}],"openQuestions":["Should acridone synthase and specific compounds be separate entries?","How should natural product references be linked?","The registry entry has merged aliases naming specific compounds by systematic names; should they be split off?"],"resources":{"spec":"/models/things/publications/thing-q109173474/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q109173474/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-13T05:51:18Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:51:53+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}