{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.ribonucleic-acid","code":"thing-q11053","url":"https://ver.cy/models/thing/q11053/","name":"ribonucleic acid","alternateNames":[],"kind":"thing","status":"published","version":"0.2.0-wave.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Ribonucleic acid, a nucleic acid polymer of ribonucleotides that carries genetic information from DNA to protein synthesis (mRNA), forms ribosomes (rRNA), transfers amino acids (tRNA) and regulates genes; some viruses use RNA genomes.","purpose":"Let an agent handle RNA by type, sequence, function and applications, including mRNA vaccines, with accurate and non-sensational information.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Single-stranded nucleic acid with ribose and uracil","Many types and functions","Less stable than DNA","Some viruses have RNA genomes"],"structure":{"bundles":[{"id":"type","name":"Type","description":"Which RNA.","layers":[{"id":"kind","name":"Kind","description":"mRNA, tRNA, rRNA.","findings":[{"id":"kind-finding","name":"Kind","description":"RNA type.","questions":[{"text":"Which type of RNA is it?","kind":"definition"},{"text":"What does it do?","kind":"definition"}]}]},{"id":"sequence","name":"Sequence","description":"Identity.","findings":[{"id":"sequence-finding","name":"Sequence","description":"Sequence and accession.","questions":[{"text":"What is its sequence or accession?","kind":"provenance"},{"text":"Which gene or organism?","kind":"definition"}]}]}]},{"id":"function","name":"Function","description":"Role in cells.","layers":[{"id":"expression","name":"Expression","description":"Gene expression.","findings":[{"id":"expression-finding","name":"Expression","description":"Role in expression.","questions":[{"text":"How does it contribute to gene expression?","kind":"definition"},{"text":"How is it regulated?","kind":"definition"}]}]},{"id":"viruses","name":"Viruses","description":"RNA genomes.","findings":[{"id":"viruses-finding","name":"Viruses","description":"Viral RNA.","questions":[{"text":"Is it part of a viral genome?","kind":"definition"},{"text":"How is it detected in tests?","kind":"definition"}]}]}]},{"id":"applications","name":"Applications","description":"Medicine and research.","layers":[{"id":"vaccines","name":"Vaccines","description":"mRNA vaccines.","findings":[{"id":"vaccines-finding","name":"Vaccines","description":"mRNA vaccine facts.","questions":[{"text":"How do mRNA vaccines work, according to health authorities?","kind":"provenance"},{"text":"Which claims are misinformation?","kind":"boundary"}]}]},{"id":"therapies","name":"Therapies","description":"RNA drugs.","findings":[{"id":"therapies-finding","name":"Therapies","description":"RNA therapies.","questions":[{"text":"Which RNA therapies are approved?","kind":"provenance"},{"text":"For what conditions?","kind":"definition"}]}]}]},{"id":"laboratory","name":"Laboratory","description":"Handling and testing.","layers":[{"id":"handling","name":"Handling","description":"Degradation.","findings":[{"id":"handling-finding","name":"Handling","description":"Handling needs.","questions":[{"text":"How should RNA samples be handled to avoid degradation?","kind":"action"},{"text":"At what temperature are they stored?","kind":"measurement"}]}]},{"id":"testing","name":"Testing","description":"Diagnostics.","findings":[{"id":"testing-finding","name":"Testing","description":"Test interpretation.","questions":[{"text":"How should an RNA test result be interpreted?","kind":"boundary"},{"text":"When should a clinician be consulted?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Explain RNA's structure and roles from scientific sources.","Analyse RNA sequence data the agent is authorized to use."],"mustNot":["Help design pathogens or enhance their harm.","Present unproven RNA-based treatments as cures.","Disclose genetic data of identifiable people without consent.","Spread misinformation about mRNA vaccines."],"requiresHuman":["Work with RNA data from identifiable people."]},"ethics":{"considerations":["RNA science underpins vaccines and treatments.","Misinformation about it costs lives."],"affectedParties":["Patients","Research participants","The public"]},"owners":{"steward":"Nobody owns the molecule; researchers and biobanks hold data and samples.","roles":[],"masterSystems":["Sequence databases"]},"relations":[{"target":"Q123619","type":"parent","note":"registry parent class"},{"target":"Q422649","type":"parent","note":"registry parent class"},{"target":"Q424689","type":"parent","note":"registry parent class"},{"target":"Q85210139","type":"parent","note":"registry parent class"},{"target":"DNA","type":"related","note":"nucleic acids"},{"target":"protein","type":"related","note":"gene expression"},{"target":"vaccine","type":"related","note":"mRNA vaccines"},{"target":"cell","type":"related","note":"location"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.ribonucleic-acid","Wikidata: Q11053 (https://www.wikidata.org/wiki/Q11053)","RNAcentral id: URS plus hex non-coding RNA","RefSeq accession: NM_ or NR_ plus digits transcripts"]},"properties":{"applicability":"required","items":["Molecular length:  nucleotides - Determine the number of nucleotide residues from the sequence or estimate it using calibrated electrophoresis.","Molar mass:  g/mol - Calculate molar mass from the nucleotide sequence while accounting for terminal groups and chemical modifications.","Hydrodynamic radius:  nm - Determine the effective radius in solution from diffusion measurements under specified temperature and buffer conditions."]},"recognition":{"applicability":"required","items":["Sequences with uracil (U) instead of thymine","Types such as mRNA, tRNA, rRNA","PCR tests detect viral RNA","Invisible; shown as sequences, structures and gel bands."]},"capabilities":{"applicability":"required","items":["sequence and quantify it","study its functions","use it in therapies and vaccines","detect viral RNA in diagnostics"]},"hazards":{"applicability":"required","items":["Misinformation about mRNA vaccines","Sample degradation in diagnostics","Over-interpreting test cycle thresholds"]},"interfaces":{"applicability":"required","items":["Medicines regulation for RNA therapies","Biosafety rules for RNA work","Diagnostic test regulation"]},"context":{"applicability":"required","items":["RNA is central to how cells make proteins; it is also used in medicine and research.","messenger RNA","ribosomal RNA","transfer RNA","regulatory RNAs such as microRNA","viral RNA genomes"]}},"sources":[{"title":"Wikidata item Q11053: ribonucleic acid","url":"https://www.wikidata.org/wiki/Q11053","note":"identity and sense of the item"},{"title":"Wikipedia: RNA","url":"https://en.wikipedia.org/wiki/RNA","note":"general description of the item"}],"openQuestions":["Should RNA types be separate entries?","How should transcripts be linked to genes?","How should agents address vaccine misinformation calmly?"],"resources":{"spec":"/models/things/publications/thing-q11053/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q11053/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-11T06:07:00Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:25+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}