{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.renal-cell-carcinoma","code":"thing-q1164529","url":"https://ver.cy/models/thing/q1164529/","name":"renal cell carcinoma","alternateNames":["renal clear cell carcinoma","childhood kidney cell carcinoma","metastatic renal cell carcinoma","multilocular cystic clear cell renal cell carcinoma","hereditary conventional renal cell carcinoma","sporadic conventional renal cell carcinoma","Clear cell papillary renal cell carcinoma","hereditary renal cell carcinoma","Renal medullary carcinoma","granular renal cell carcinoma","Tubulocystic renal cell carcinoma","Thyroid-like follicular renal cell carcinoma"],"kind":"thing","status":"research-draft","version":"0.2.0-wave.4","language":"en","classifiers":{"family":"Thing Registry","category":"Cross-cutting context","entryKind":"thing","plane":"XCT","domain":["XCT.STA"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"The most common kidney cancer in adults, arising from the lining of the renal tubules, with clear cell carcinoma the main subtype alongside papillary, chromophobe and rarer forms such as multilocular cystic clear cell carcinoma, occurring sporadically or in hereditary syndromes such as von Hippel-Lindau disease, rarely in children, and staged from localised to metastatic; treatment ranges from surveillance and surgery to targeted and immune therapies, and anyone with blood in the urine, flank pain or a mass needs medical assessment.","purpose":"Let an agent explain renal cell carcinoma and its subtypes, relay risk factors, diagnosis, staging and treatment from oncology guidelines in general terms, route people with symptoms or a diagnosis to clinicians, and distinguish renal cell carcinoma from urothelial carcinoma of the renal pelvis, Wilms tumour and benign kidney masses.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Tubular epithelial origin","Clear cell dominance","VHL pathway","Immunotherapy responsive"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What renal cell carcinoma is.","layers":[{"id":"definition","name":"Definition","description":"Definition and subtypes.","findings":[{"id":"definition-finding","name":"Definition","description":"Definition.","questions":[{"text":"What is renal cell carcinoma, and how do clear cell, papillary, chromophobe and rare subtypes differ?","kind":"definition"},{"text":"Is the user asking about their own symptoms or diagnosis, which need a clinician?","kind":"boundary"}]}]},{"id":"causes","name":"Causes","description":"Risk factors and genetics.","findings":[{"id":"causes-finding","name":"Causes","description":"Causes.","questions":[{"text":"What are the risk factors and hereditary syndromes, in general terms?","kind":"provenance"},{"text":"Which entry fits von Hippel-Lindau disease?","kind":"action"}]}]}]},{"id":"care","name":"Care","description":"Diagnosis and treatment.","layers":[{"id":"diagnosis","name":"Diagnosis","description":"Diagnosis and staging.","findings":[{"id":"diagnosis-finding","name":"Diagnosis","description":"Diagnosis.","questions":[{"text":"How is renal cell carcinoma detected, imaged, biopsied and staged, as guidelines describe?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"treatment","name":"Treatment","description":"Treatment.","findings":[{"id":"treatment-finding","name":"Treatment","description":"Treatment.","questions":[{"text":"What treatments do guidelines recommend for localised and metastatic disease, in general terms?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]}]},{"id":"support","name":"Support","description":"Living with the disease.","layers":[{"id":"followup","name":"Follow-up","description":"Follow-up and survivorship.","findings":[{"id":"followup-finding","name":"Follow-up","description":"Follow-up.","questions":[{"text":"What does follow-up after treatment involve, as guidelines state?","kind":"provenance"},{"text":"Which entry fits cancer survivorship?","kind":"action"}]}]},{"id":"organisations","name":"Organisations","description":"Support organisations.","findings":[{"id":"organisations-finding","name":"Organisations","description":"Organisations.","questions":[{"text":"Where can patients find kidney cancer organisations and trials?","kind":"action"},{"text":"Which entry fits cancer support organisations?","kind":"action"}]}]}]},{"id":"context","name":"Context","description":"Research and epidemiology.","layers":[{"id":"research","name":"Research","description":"Research.","findings":[{"id":"research-finding","name":"Research","description":"Research.","questions":[{"text":"What research directions exist in kidney cancer, with findings attributed?","kind":"provenance"},{"text":"Which entry fits cancer immunotherapy?","kind":"action"}]}]},{"id":"epidemiology","name":"Epidemiology","description":"Epidemiology.","findings":[{"id":"epidemiology-finding","name":"Epidemiology","description":"Epidemiology.","questions":[{"text":"How common is renal cell carcinoma, and how do rates vary?","kind":"provenance"},{"text":"Which entry fits the epidemiology of cancer?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Describe renal cell carcinoma and its subtypes in general terms.","Point people to clinicians, cancer services and patient organisations."],"mustNot":["Diagnose or stage a person's kidney cancer.","Recommend or discourage a specific treatment for a person.","Present outdated treatment information as current.","Disclose a person's diagnosis or genetic syndrome without consent."],"requiresHuman":["Any decision about testing, surgery or drug treatment."]},"ethics":{"considerations":["Cancer patients are vulnerable to false hope and unproven treatments.","Hereditary syndromes affect relatives who have not been tested."],"affectedParties":["Patients","Families with hereditary syndromes","Clinicians"]},"owners":{"steward":"The patient; clinicians and cancer registries hold the records.","roles":[],"masterSystems":["Cancer registries"]},"relations":[{"target":"Q18556333","type":"parent","note":"registry parent class"},{"target":"renal carcinoma","type":"related","note":"in registry terms"},{"target":"von Hippel-Lindau disease","type":"related","note":"in hereditary cases"},{"target":"Wilms tumour","type":"related","note":"a childhood kidney cancer"},{"target":"immunotherapy","type":"related","note":"among other approaches"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.renal-cell-carcinoma","Wikidata: Q1164529 (https://www.wikidata.org/wiki/Q1164529)","ICD-10: C64 malignant neoplasm of kidney","MeSH: D002292 Carcinoma, Renal Cell"]},"properties":{"applicability":"not-applicable","items":["share of kidney cancers in adults: about 90 percent","clear cell share: about 75 percent","new cases worldwide: about 430000 per year - kidney cancer, estimates"]},"recognition":{"applicability":"optional","items":["Cancer of the renal tubular epithelium","Clear cell, papillary, chromophobe, multilocular cystic, hereditary and sporadic, metastatic, childhood forms","Urothelial carcinoma arises in the collecting system; Wilms tumour is a childhood embryonal tumour; oncocytoma is benign","Not a visible object; a kidney mass on imaging."]},"capabilities":{"applicability":"required","items":["explain subtypes","relay diagnosis and treatment","route to clinicians","distinguish related tumours"]},"hazards":{"applicability":"required","items":["Agents giving personal medical advice","Confusing subtypes and other kidney tumours","Stale treatment information"]},"interfaces":{"applicability":"required","items":["ESMO, NCCN and EAU guidelines for kidney cancer","Drug approvals for targeted and immune therapies","Cancer registration rules"]},"context":{"applicability":"required","items":["Not applicable; a disease.","clear cell renal cell carcinoma","papillary renal cell carcinoma","chromophobe renal cell carcinoma","multilocular cystic and other rare subtypes","hereditary forms in VHL and other syndromes","sporadic forms","childhood renal cell carcinoma","metastatic renal cell carcinoma"]}},"sources":[],"openQuestions":["Should clear cell carcinoma and hereditary forms be separate primary entries?","How should oncology guidelines be linked?","The registry entry has merged aliases naming subtypes and settings; should they be split off?"],"resources":{"spec":"/models/things/publications/thing-q1164529/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q1164529/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-13T12:55:08Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"missing"},"notes":{"interaction.properties":"Plane XCT: no invented physical properties.","sources":"Written from model knowledge without web access; claims are unverified."},"score":0.938}}