{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.fumagillin","code":"thing-q120199","url":"https://ver.cy/models/thing/q120199/","name":"fumagillin","alternateNames":[],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Fumagillin is a fungal natural-product antibiotic originally isolated from Aspergillus fumigatus that inhibits methionine aminopeptidase 2 and exhibits antimicrosporidial and antiangiogenic activity.","purpose":"Enable an agent to recognise fumagillin, assess the identity and condition of a particular material, and determine which handling or use decisions its evidence supports.","scope":{"in":["Stereochemically resolved fumagillin identity and authoritative identifiers","Free-acid identity and relationships to salts, derivatives and formulated products","Lot composition, purity, provenance and analytical confirmation","Physical state, solubility and stability under recorded conditions","Evidence for biological activity, exposure hazards and applicable substance restrictions"],"out":["Manufacturing or fermentation processes as operational systems","Complete specifications for medicines, bee treatments or other formulated products","Diagnosis, prescribing and treatment protocols","Biology of producing fungi, target organisms or treated hosts","Independent models of fumagillol, fumagillin salts and semisynthetic analogues"],"boundaries":[]},"distinguishingFeatures":["Match the resolved structure and stereochemistry to fumagillin, using CAS 23110-15-8 and PubChem CID 6917655 as corroborating identifiers; its molecular formula is C26H34O7. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/fumagillin)","Confirm the fumagillol-derived ester of an all-E conjugated tetraenedioic acid, rather than identifying fumagillol alone as fumagillin. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/fumagillin)","Check whether the material contains a counterion: bicyclohexylammonium fumagillin has a separate compound record and must not inherit the free acid's mass basis automatically. [PubChem salt record](https://pubchem.ncbi.nlm.nih.gov/compound/Bicyclohexylammonium-Fumagillin)","Require structural or analytical evidence beyond a product name or biological effect; methionine aminopeptidase II inhibition is a documented activity, not a unique identity test. [MEROPS](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=m24)"],"structure":{"bundles":[{"id":"molecular-identity-and-boundaries","name":"Molecular identity and boundaries","description":"Establishes which chemical entity the fumagillin registry entry denotes.","layers":[{"id":"structure-and-identifiers","name":"Structure and identifiers","description":"Connects registry identity to a resolved chemical structure.","findings":[{"id":"stereochemical-identity","name":"Stereochemical identity","description":"Record the structure, stereochemistry and identifier evidence used to recognise fumagillin.","questions":[{"text":"Which authoritative record establishes the structure and stereochemistry intended by vr.tr.fumagillin?","id":"stereochemical-identity-q01","kind":"definition"},{"text":"Do the sample's analytical results distinguish that structure from related compounds or unresolved isomers?","id":"stereochemical-identity-q02","kind":"measurement"}]}]},{"id":"salt-and-product-boundaries","name":"Salt and product boundaries","description":"Separates fumagillin identity from counterions, analogues and formulation ingredients.","findings":[{"id":"free-acid-equivalence","name":"Free-acid equivalence","description":"Make material form and reporting basis explicit before transferring properties or quantities.","questions":[{"text":"Does this record describe fumagillin free acid, an identified salt or a product containing it?","id":"free-acid-equivalence-q01","kind":"boundary"},{"text":"What counterion stoichiometry, water content and assay basis support conversion to fumagillin-equivalent mass?","id":"free-acid-equivalence-q02","kind":"measurement"}]}]}]},{"id":"lot-quality-and-authentication","name":"Lot quality and authentication","description":"Establishes what a particular fumagillin material contains and how that is known.","layers":[{"id":"origin-and-reference-material","name":"Origin and reference material","description":"Links material history to the evidence used for authentication.","findings":[{"id":"traceable-authentication","name":"Traceable authentication","description":"Record lot origin and the reference material or independent analytical evidence supporting identity.","questions":[{"text":"Which producer, lot and certificate identify this material, and what origin is actually documented?","id":"traceable-authentication-q01","kind":"provenance"},{"text":"Which reference standard and analytical methods support the fumagillin assignment?","id":"traceable-authentication-q02","kind":"provenance"}]}]},{"id":"content-and-impurity-profile","name":"Content and impurity profile","description":"Separates fumagillin quantity from accompanying substances.","findings":[{"id":"assay-basis-and-related-substances","name":"Assay basis and related substances","description":"Require an interpretable content assay and impurity profile rather than an unexplained purity percentage.","questions":[{"text":"Is the stated purity a mass assay, chromatographic area percentage or biological potency measurement?","id":"assay-basis-and-related-substances-q01","kind":"measurement"},{"text":"Which related substances, residual solvents and counterion contributions were measured, and which remain unresolved?","id":"assay-basis-and-related-substances-q02","kind":"measurement"}]}]}]},{"id":"physical-state-and-stability","name":"Physical state and stability","description":"Determines whether fumagillin remains characterised and usable under actual conditions.","layers":[{"id":"phase-and-solution-behaviour","name":"Phase and solution behaviour","description":"Records thermal observations and dissolved-state measurements for the specified form.","findings":[{"id":"conditioned-physical-properties","name":"Conditioned physical properties","description":"Treat phase, thermal events and solubility as measurements with conditions and methods.","questions":[{"text":"What phase and melting or decomposition behaviour were measured for this fumagillin form?","id":"conditioned-physical-properties-q01","kind":"measurement"},{"text":"At the intended solvent composition, pH and temperature, how much intact fumagillin is demonstrably dissolved?","id":"conditioned-physical-properties-q02","kind":"measurement"}]}]},{"id":"storage-and-degradation","name":"Storage and degradation","description":"Relates exposure history to intact fumagillin content.","findings":[{"id":"remaining-intact-material","name":"Remaining intact material","description":"Use stability-indicating evidence to evaluate stored solids and prepared solutions.","questions":[{"text":"How do documented light, temperature, solvent and pH conditions affect intact fumagillin over the relevant interval?","id":"remaining-intact-material-q01","kind":"measurement"},{"text":"What measured change or evidence gap requires reassay, quarantine or disposal?","id":"remaining-intact-material-q02","kind":"action"}]}]}]},{"id":"biological-activity-and-evidence","name":"Biological activity and evidence","description":"Connects fumagillin to measured target effects and application-specific evidence.","layers":[{"id":"target-level-activity","name":"Target-level activity","description":"Qualifies enzyme inhibition by target identity and experimental conditions.","findings":[{"id":"methionine-aminopeptidase-inhibition","name":"Methionine aminopeptidase inhibition","description":"Fumagillin inhibits type II methionyl aminopeptidase; record the tested enzyme and evidence behind any more specific mechanism claim. [MEROPS](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=m24)","questions":[{"text":"Which species, enzyme form and assay establish the reported inhibition?","id":"methionine-aminopeptidase-inhibition-q01","kind":"provenance"},{"text":"What concentration, incubation time and endpoint define the activity measurement?","id":"methionine-aminopeptidase-inhibition-q02","kind":"measurement"}]}]},{"id":"organism-and-host-context","name":"Organism and host context","description":"Keeps biological outcomes attached to their tested setting.","findings":[{"id":"limits-of-activity-transfer","name":"Limits of activity transfer","description":"Record organism-level effects separately from enzyme inhibition and host tolerability.","questions":[{"text":"Which organism, life stage, host and endpoint support each claimed biological effect?","id":"limits-of-activity-transfer-q01","kind":"provenance"},{"text":"What evidence supports extending that result to the proposed application, and what remains untested?","id":"limits-of-activity-transfer-q02","kind":"boundary"}]}]}]},{"id":"exposure-residues-and-use-constraints","name":"Exposure, residues and use constraints","description":"Supports handling and use decisions through form-specific hazard and regulatory evidence.","layers":[{"id":"hazard-and-exposure-evidence","name":"Hazard and exposure evidence","description":"Associates safety information with the actual fumagillin material.","findings":[{"id":"form-specific-hazard-assessment","name":"Form-specific hazard assessment","description":"Separate evidence about fumagillin from hazards attributable to counterions or formulation ingredients.","questions":[{"text":"Which current safety data and toxicological sources apply to this chemical form and exposure route?","id":"form-specific-hazard-assessment-q01","kind":"provenance"},{"text":"What handling controls follow from those sources for the proposed quantity and operation?","id":"form-specific-hazard-assessment-q02","kind":"action"}]}]},{"id":"use-status-and-residue-identity","name":"Use status and residue identity","description":"Relates the intended application to dated jurisdictional decisions and defined residue analytes.","findings":[{"id":"applicable-permission-and-residue-basis","name":"Applicable permission and residue basis","description":"Record applicable authority decisions without inferring permission from historical use or commercial availability.","questions":[{"text":"Which jurisdiction, date, product and intended use determine the applicable authorization or restriction?","id":"applicable-permission-and-residue-basis-q01","kind":"action"},{"text":"Where residue assessment applies, does the governing definition measure parent fumagillin, specified transformation products or another stated analyte set?","id":"applicable-permission-and-residue-basis-q02","kind":"definition"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of fumagillin this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of fumagillin this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of fumagillin this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of fumagillin this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of fumagillin this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-regional-variation","name":"Regional variation","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these regional variation hold for the sense of fumagillin this model covers, and on what evidence?","id":"evidence-regional-variation-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of fumagillin this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Identify fumagillin and describe its documented uses, such as in research and in some veterinary contexts, citing sources.","Report where its use in animals is restricted or not authorized."],"mustNot":["Recommend using it in beehives or animals where it is not authorized.","Recommend it as a treatment for a person.","Supply or describe ways to obtain it outside lawful channels.","Discharge it or treated material where it can enter food, honey or water."],"requiresHuman":["Any treatment of animals with it.","Disposing of stock or treated material."]},"ethics":{"considerations":["Residues in honey and food can reach consumers who never agreed to exposure.","Unauthorized use undermines rules that protect food safety."],"affectedParties":["Consumers of honey and animal products","Beekeepers and farmers","Laboratory workers"]},"owners":{"steward":"The laboratory, veterinarian or authorized user holding it; regulators decide where it may be used.","roles":[],"masterSystems":[]},"relations":[{"target":"Q47006373","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.fumagillin","Wikidata: Q120199 (https://www.wikidata.org/wiki/Q120199)"]},"properties":{"applicability":"required","items":["Resolved molecular identity: Stereochemical structure, InChIKey, CAS and PubChem identifiers","Material form: Free acid; identified salt; mixture containing fumagillin; unresolved","Fumagillin content: Mass fraction %, mg/g or mol/L, with assay method and free-acid-equivalent basis","Related substances and residual impurities: Named analytes in %, mg/kg or below a stated detection limit","Physical and thermal state: Observed phase and appearance at °C; melting or decomposition event with method","Solubility: mg/mL or mol/L with solvent, pH, temperature and equilibration method","Stability under storage or preparation: Intact fumagillin remaining %, elapsed time, temperature, light exposure, pH and solvent","Biological activity: IC50 or other defined endpoint, concentration unit, target species and assay conditions","Lot provenance: Supplier, producer, lot, certificate, reference standard and analytical records","Hazard and permitted-use status: Dated, jurisdiction-specific classifications, restrictions and unresolved determinations"]},"recognition":{"applicability":"required","items":["A pale yellow crystalline solid as a substance, not identifiable by sight.","Products are labelled with the active substance; analysis settles identity."]},"capabilities":{"applicability":"required","items":["Reconcile a labelled sample with the stereochemically defined fumagillin identity.","Calculate fumagillin-equivalent content when salt composition and assay basis are established.","Compare lots or reference materials using comparable analytical methods.","Assess whether storage history and current measurements support continued use.","Associate activity evidence with the tested target, concentration and experimental context.","Flag a proposed use for rejection or further review when quality, exposure or regulatory evidence is insufficient."]},"hazards":{"applicability":"required","items":["Residues in food products where it is used without authorization.","Toxic effects in exposed people and animals.","Degradation by light, giving ineffective material."]},"interfaces":{"applicability":"required","items":["Globally Harmonized System of Classification and Labelling of Chemicals (GHS), United Nations."]},"context":{"applicability":"required","items":["Fumagillin is encountered in natural-product chemistry and research on microsporidia, methionine aminopeptidase 2 and blood vessel formation.","It also appears in literature on microsporidial infections in humans and honey bees, where the host, formulation and intended application determine the relevant evidence."]}},"sources":[{"title":"Wikidata item Q120199: fumagillin","url":"https://www.wikidata.org/wiki/Q120199","note":"identity and sense of the item"},{"title":"Wikipedia: Fumagillin","url":"https://en.wikipedia.org/wiki/Fumagillin","note":"general description of the item"}],"openQuestions":["Which authoritative EC identifier, hazard classifications and occupational exposure limits, if any, apply specifically to fumagillin free acid rather than a salt or product?","Which reliable measurements establish form-specific solubility and thermal behaviour, including whether decomposition prevents a meaningful boiling-point determination?","What stability-indicating studies establish storage and solution-use intervals under relevant light, temperature, solvent and pH conditions?","Which impurities or transformation products materially affect identity, potency or hazard, and what analytical acceptance criteria are justified?","For each proposed application, what current jurisdictional authorization, residue definition and efficacy evidence apply to the exact material and target context?"],"resources":{"spec":"/models/things/publications/thing-q120199/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q120199/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T09:54:29Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:25+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}