{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.smallpox","code":"thing-q12214","url":"https://ver.cy/models/thing/q12214/","name":"smallpox","alternateNames":["hemorrhagic smallpox","variola major","alastrim"],"kind":"thing","status":"research-draft","version":"0.2.0-wave.3","language":"en","classifiers":{"family":"Thing Registry","category":"Cross-cutting context","entryKind":"thing","plane":"XCT","domain":["XCT.QLT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"An acute contagious disease caused by the variola virus, marked by fever and a characteristic pustular rash, with the severe variola major form killing about a third of those infected and the milder alastrim form far fewer, and rare haemorrhagic presentations; smallpox killed hundreds of millions over history, was the first disease prevented by vaccination, and was declared eradicated by the World Health Organization in 1980 after a global campaign, with the virus retained only in two authorised laboratories.","purpose":"Let an agent explain smallpox as a historical and eradicated disease, relay its history, the vaccination and eradication story and current biosecurity arrangements from WHO and historical sources, and keep to public information without laboratory or agent handling detail.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["First eradicated human disease","First vaccine","Two virus repositories","Historical mass mortality"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What smallpox was.","layers":[{"id":"definition","name":"Definition","description":"Definition and forms.","findings":[{"id":"definition-finding","name":"Definition","description":"Definition.","questions":[{"text":"What was smallpox, and how did variola major and minor differ?","kind":"definition"},{"text":"Is the question about historical smallpox or a current poxvirus disease such as mpox?","kind":"boundary"}]}]},{"id":"transmission","name":"Transmission","description":"Transmission and course.","findings":[{"id":"transmission-finding","name":"Transmission","description":"Transmission.","questions":[{"text":"How did smallpox spread and progress, in general terms?","kind":"definition"},{"text":"Which entry fits variola virus?","kind":"action"}]}]}]},{"id":"history","name":"History","description":"History and eradication.","layers":[{"id":"history","name":"History","description":"Historical impact.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How did smallpox affect populations across history, including its role in colonisation, as historians describe?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"eradication","name":"Eradication","description":"Vaccination and eradication.","findings":[{"id":"eradication-finding","name":"Eradication","description":"Eradication.","questions":[{"text":"How did vaccination from Jenner and the WHO campaign eradicate smallpox?","kind":"provenance"},{"text":"Which entry fits the smallpox eradication programme?","kind":"action"}]}]}]},{"id":"today","name":"Today","description":"Biosecurity today.","layers":[{"id":"retention","name":"Retention","description":"Virus retention and oversight.","findings":[{"id":"retention-finding","name":"Retention","description":"Retention.","questions":[{"text":"Where is variola virus retained, and how is research overseen by WHO, in public terms?","kind":"provenance"},{"text":"Is the presentation free of laboratory or agent handling detail?","kind":"boundary"}]}]},{"id":"preparedness","name":"Preparedness","description":"Preparedness.","findings":[{"id":"preparedness-finding","name":"Preparedness","description":"Preparedness.","questions":[{"text":"What preparedness measures and vaccine stockpiles exist, per public health sources?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]}]},{"id":"legacy","name":"Legacy","description":"Legacy and lessons.","layers":[{"id":"lessons","name":"Lessons","description":"Lessons for public health.","findings":[{"id":"lessons-finding","name":"Lessons","description":"Lessons.","questions":[{"text":"What lessons has eradication offered for other disease programmes, with positions attributed?","kind":"provenance"},{"text":"Is the presentation neutral?","kind":"boundary"}]}]},{"id":"related","name":"Related","description":"Related diseases.","findings":[{"id":"related-finding","name":"Related","description":"Related.","questions":[{"text":"How do mpox and other orthopoxvirus diseases relate to smallpox and its vaccine?","kind":"provenance"},{"text":"Which entry fits mpox?","kind":"action"}]}]}]}]},"agentConduct":{"may":["explain the disease and its forms","relay the history of vaccination and eradication","relay current biosecurity arrangements in general terms","distinguish from related poxvirus diseases"],"mustNot":[],"requiresHuman":["First eradicated human disease"]},"ethics":{"considerations":["Variola major and minor forms","variola minor or alastrim"],"affectedParties":[]},"owners":{"steward":"","roles":[],"masterSystems":[]},"relations":[{"target":"Q12353899","type":"parent","note":"registry parent class"},{"target":"Q89415750","type":"parent","note":"registry parent class"},{"target":"Q949302","type":"parent","note":"registry parent class"},{"target":"Poxviridae infectious disease","type":"related","note":"in registry terms"},{"target":"eradicated disease","type":"related","note":"in registry terms"},{"target":"variola virus","type":"related","note":"the pathogen"},{"target":"smallpox vaccine","type":"related","note":"from 1796"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.smallpox","Wikidata: Q12214 (https://www.wikidata.org/wiki/Q12214)","ICD-10: B03 smallpox","ICD-11: 1E70"]},"properties":{"applicability":"not-applicable","items":["eradication declared: 1980 year - WHO","last natural case: 1977 year - Somalia","variola major case fatality: about 30 percent - historical"]},"recognition":{"applicability":"optional","items":["Variola virus disease, eradicated","Variola major and minor forms","Mpox, chickenpox and cowpox are different diseases","Not a visible object; historically a fever followed by a rash of pustules over the body."]},"capabilities":{"applicability":"required","items":["explain the disease and its forms","relay the history of vaccination and eradication","relay current biosecurity arrangements in general terms","distinguish from related poxvirus diseases"]},"hazards":{"applicability":"required","items":["Re-emergence risk from laboratory or deliberate release, addressed by international oversight","Agents providing laboratory or agent handling detail","Confusing smallpox with mpox or chickenpox"]},"interfaces":{"applicability":"required","items":["WHO resolutions on variola virus retention and research oversight","International Health Regulations on notification","Biosecurity and select agent rules for the virus"]},"context":{"applicability":"required","items":["Not applicable; an eradicated disease.","variola major","variola minor or alastrim","haemorrhagic and flat presentations","historical epidemics by period and region"]}},"sources":[{"title":"Wikidata item Q12214: smallpox","url":"https://www.wikidata.org/wiki/Q12214","note":"identity and sense of the item"},{"title":"Wikipedia: Smallpox","url":"https://en.wikipedia.org/wiki/Smallpox","note":"general description of the item"}],"openQuestions":["Should smallpox vaccine and eradication programme be separate primary entries?","How should WHO sources be linked?","The registry entry has merged aliases naming forms; should they be split off?","Which entry fits variola virus?","Which entry fits the smallpox eradication programme?","Which entry fits mpox?"],"resources":{"spec":"/models/things/publications/thing-q12214/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q12214/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T23:55:52Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"derived","ethics":"derived","owners":"missing","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"agentConduct":"Affordances listed as what may be done; prohibitions collected from the text.","interaction.properties":"Plane XCT: no invented physical properties."},"score":0.875}}