{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.dysmelia","code":"thing-q1269288","url":"https://ver.cy/models/thing/q1269288/","name":"dysmelia","alternateNames":["mesomelic dysplasia, Camera type","mesomelia","split hand-foot malformation","acromelia","acromicria","congenital lower extremity deformity","Hypodactylia","reduction defects of upper limb","meromelia","Rhizomelia","Reinhardt-Pfeiffer mesomelic dysplasia","Mesomelic dysplasia, Savarirayan type"],"kind":"thing","status":"published","version":"0.2.0-wave.3","language":"en","classifiers":{"family":"Thing Registry","category":"Cross-cutting context","entryKind":"thing","plane":"XCT","domain":["XCT.STA"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A group of congenital limb malformations in which limbs or parts of limbs are missing, shortened or malformed, including amelia with absent limbs, meromelia with partial absence, phocomelia with shortened proximal segments, mesomelia and mesomelic dysplasias affecting the middle segments, acromelia and acromicria affecting the hands and feet, and split hand-foot malformation, arising from genetic causes, teratogens such as thalidomide or vascular disruption during development; management involves multidisciplinary care, prosthetics and surgery.","purpose":"Let an agent explain dysmelia and its types in neutral clinical terms, relay causes, diagnosis and management from medical and genetic sources, describe support and adaptive approaches respectfully, and route families and individuals to specialist clinicians and support organisations.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Congenital origin","Classified by segment","Genetic, teratogenic or vascular causes","Multidisciplinary care"],"structure":{"bundles":[{"id":"help","name":"Help","description":"Care and support first.","layers":[{"id":"diagnosis","name":"Diagnosis","description":"Diagnosis and care.","findings":[{"id":"diagnosis-finding","name":"Diagnosis","description":"Diagnosis.","questions":[{"text":"Why do prenatal findings or a limb difference at birth need assessment by specialist teams in genetics, orthopaedics and rehabilitation?","kind":"action"},{"text":"Is the user asking about a specific pregnancy, child or themselves, which needs clinicians?","kind":"boundary"}]}]},{"id":"support","name":"Support","description":"Support.","findings":[{"id":"support-finding","name":"Support","description":"Support.","questions":[{"text":"What support organisations and peer networks exist for people with limb differences?","kind":"provenance"},{"text":"Is the presentation respectful and person-first?","kind":"boundary"}]}]}]},{"id":"understand","name":"Understand","description":"The conditions.","layers":[{"id":"types","name":"Types","description":"Types.","findings":[{"id":"types-finding","name":"Types","description":"Types.","questions":[{"text":"What are amelia, meromelia, phocomelia, mesomelia, acromelia and split hand-foot malformation?","kind":"definition"},{"text":"Is the question about a congenital limb difference or an acquired amputation?","kind":"boundary"}]}]},{"id":"causes","name":"Causes","description":"Causes.","findings":[{"id":"causes-finding","name":"Causes","description":"Causes.","questions":[{"text":"What genetic, teratogenic and vascular causes lead to dysmelia, in general terms?","kind":"definition"},{"text":"Which entry fits the specific cause?","kind":"action"}]}]}]},{"id":"care","name":"Care","description":"Management.","layers":[{"id":"management","name":"Management","description":"Management.","findings":[{"id":"management-finding","name":"Management","description":"Management.","questions":[{"text":"How are limb differences managed with prosthetics, surgery, therapy and adaptive approaches, in general terms?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"living","name":"Living","description":"Living with limb difference.","findings":[{"id":"living-finding","name":"Living","description":"Living.","questions":[{"text":"How do people with limb differences describe their lives and needs, in their own words?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]}]},{"id":"context","name":"Context","description":"History and research.","layers":[{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"What was the thalidomide tragedy, and how did it change drug regulation, as historians describe?","kind":"provenance"},{"text":"Which entry fits thalidomide?","kind":"action"}]}]},{"id":"research","name":"Research","description":"Research.","findings":[{"id":"research-finding","name":"Research","description":"Research.","questions":[{"text":"What research explores limb development genes and new prosthetics?","kind":"provenance"},{"text":"Which entry fits limb development?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Explain the types and known causes of congenital limb malformations, citing medical sources.","Point people to support organizations and specialist services."],"mustNot":["Use stigmatizing language about people with limb differences.","Diagnose a person or unborn child from images or descriptions.","Publish images or details of identifiable people with limb differences without consent."],"requiresHuman":["Any advice that bears on prenatal or treatment decisions for a particular person."]},"ethics":{"considerations":["People with limb differences face stigma and barriers more than limits from the condition itself.","Some causes, such as drug exposure in pregnancy, involved serious failures of medicine regulation."],"affectedParties":["People with limb differences","Parents and families"]},"owners":{"steward":"Nobody owns the condition; each person's care is with their clinicians.","roles":[],"masterSystems":["Congenital anomaly registers"]},"relations":[{"target":"Q2852249","type":"parent","note":"registry parent class"},{"target":"Q5160441","type":"parent","note":"registry parent class"},{"target":"congenital limb deformity","type":"related","note":"in registry terms"},{"target":"congenital abnormality","type":"related","note":"in registry terms"},{"target":"thalidomide","type":"related","note":"as a teratogen"},{"target":"prosthesis","type":"related","note":"and surgery when appropriate"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.dysmelia","Wikidata: Q1269288 (https://www.wikidata.org/wiki/Q1269288)","ICD-11: LB98 reduction defects of limbs, related codes","MeSH: D017880 limb deformities, congenital"]},"properties":{"applicability":"not-applicable","items":["limb reduction defects: about 1 in 2000 births - estimates","thalidomide affected children: about 10000 count - late 1950s and early 1960s"]},"recognition":{"applicability":"optional","items":["Congenital limb absence or malformation","Amelia, meromelia, phocomelia, mesomelia, acromelia, acromicria, split hand-foot malformation, lower extremity deformities","Acquired amputation is not congenital; skeletal dysplasias may affect the whole skeleton","Not a visible object as a category; limb differences of many forms."]},"capabilities":{"applicability":"required","items":["explain types and causes","relay diagnosis and management","describe support","route to specialists"]},"hazards":{"applicability":"required","items":["Agents giving personal medical advice","Stigmatising language","Missing associated syndromes"]},"interfaces":{"applicability":"required","items":["Congenital anomaly surveillance registries","Teratogen regulation including thalidomide controls","Disability rights and prosthetic provision rules"]},"context":{"applicability":"required","items":["Not applicable; a group of conditions.","amelia and meromelia","phocomelia","mesomelia and mesomelic dysplasias such as the Camera type","acromelia and acromicria","split hand-foot malformation","congenital lower extremity deformities such as fibular hemimelia"]}},"sources":[{"title":"Wikidata item Q1269288: dysmelia","url":"https://www.wikidata.org/wiki/Q1269288","note":"identity and sense of the item"},{"title":"Wikipedia: Dysmelia","url":"https://en.wikipedia.org/wiki/Dysmelia","note":"general description of the item"}],"openQuestions":["Should phocomelia and split hand-foot malformation be separate primary entries?","How should medical and genetic sources be linked?","The registry entry has merged aliases naming distinct conditions; should they be split off?"],"resources":{"spec":"/models/things/publications/thing-q1269288/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q1269288/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-13T05:29:43Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:51:54+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane XCT: no invented physical properties."},"score":1.0}}