{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.jaundice","code":"thing-q133244","url":"https://ver.cy/models/thing/q133244/","name":"jaundice","alternateNames":["icteric eyes","icteric skin","hemolytic jaundice","hepatocellular jaundice","neonatal jaundice","obstructive jaundice","perinatal jaundice due to hepatocellular damage","Lucey–Driscoll syndrome","congenital nonhemolytic jaundice","kernicterus","kernicterus due to isoimmunization"],"kind":"thing","status":"published","version":"0.2.0-wave.3","language":"en","classifiers":{"family":"Thing Registry","category":"Information and virtual systems","entryKind":"thing","plane":"INF","domain":["INF.KNW"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A yellow discolouration of the skin, the whites of the eyes and mucous membranes caused by raised bilirubin in the blood, classified by cause as hemolytic or pre-hepatic from red cell breakdown, hepatocellular from liver disease, and obstructive or post-hepatic from blocked bile ducts, and occurring commonly and usually harmlessly as neonatal jaundice in newborns; jaundice is a sign rather than a disease, requires investigation of its cause, and in newborns needs monitoring to prevent bilirubin toxicity.","purpose":"Let an agent explain jaundice and its kinds in general terms from clinical sources, describe causes and investigation, identify urgent presentations in adults and newborns, and route personal questions to clinicians.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Bilirubin elevation","Yellow sclera","Three causal categories","Neonatal form common"],"structure":{"bundles":[{"id":"help","name":"Help","description":"Urgent situations first.","layers":[{"id":"urgent","name":"Urgent","description":"Urgent signs.","findings":[{"id":"urgent-finding","name":"Urgent","description":"Urgent.","questions":[{"text":"When does jaundice need urgent assessment, such as in newborns, with fever, confusion, pain or dark urine?","kind":"action"},{"text":"Is the user describing jaundice in a newborn or with warning signs, which needs urgent care now?","kind":"boundary"}]}]},{"id":"assessment","name":"Assessment","description":"Assessment.","findings":[{"id":"assessment-finding","name":"Assessment","description":"Assessment.","questions":[{"text":"How do clinicians investigate jaundice with blood tests and imaging, in general terms?","kind":"provenance"},{"text":"Is the user asking about their own jaundice, which needs a clinician?","kind":"boundary"}]}]}]},{"id":"understand","name":"Understand","description":"The sign.","layers":[{"id":"mechanism","name":"Mechanism","description":"Bilirubin and mechanism.","findings":[{"id":"mechanism-finding","name":"Mechanism","description":"Mechanism.","questions":[{"text":"How is bilirubin formed and cleared, and why does it accumulate?","kind":"definition"},{"text":"Is the question about jaundice or another cause of yellow skin?","kind":"boundary"}]}]},{"id":"kinds","name":"Kinds","description":"Kinds and causes.","findings":[{"id":"kinds-finding","name":"Kinds","description":"Kinds.","questions":[{"text":"What are hemolytic, hepatocellular and obstructive jaundice, and what causes each?","kind":"definition"},{"text":"Which entry fits the specific cause?","kind":"action"}]}]}]},{"id":"newborn","name":"Newborn","description":"Neonatal jaundice.","layers":[{"id":"neonatal","name":"Neonatal","description":"Neonatal jaundice.","findings":[{"id":"neonatal-finding","name":"Neonatal","description":"Neonatal.","questions":[{"text":"Why is neonatal jaundice common, and how is it monitored and treated with phototherapy, per guidelines?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"risks","name":"Risks","description":"Risks.","findings":[{"id":"risks-finding","name":"Risks","description":"Risks.","questions":[{"text":"What is kernicterus, and which newborns are at higher risk?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]}]},{"id":"context","name":"Context","description":"Treatment and history.","layers":[{"id":"treatment","name":"Treatment","description":"Treating causes.","findings":[{"id":"treatment-finding","name":"Treatment","description":"Treatment.","questions":[{"text":"How is jaundice managed by treating hepatitis, gallstones, cancer or hemolysis, in general terms?","kind":"provenance"},{"text":"Which entry fits the specific condition?","kind":"action"}]}]},{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How was jaundice understood historically, from humoral theory to bilirubin chemistry?","kind":"provenance"},{"text":"Which entry fits the history of hepatology?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Explain jaundice, its main kinds of cause and warning signs in general terms.","Urge parents of a yellow newborn or a yellow adult to seek prompt medical care."],"mustNot":["Diagnose the cause of jaundice for a specific person.","Recommend home treatment such as sunlight for a jaundiced newborn instead of medical care.","Promote unproven liver cleanses or remedies.","Disclose a named person's liver condition without consent."],"requiresHuman":["Any clinical decision on testing or treatment for jaundice."]},"ethics":{"considerations":["Severe newborn jaundice can cause brain damage if not treated in time.","Liver disease carries stigma that can deter people from seeking care."],"affectedParties":["Newborns and parents","Patients"]},"owners":{"steward":"The person themselves; the treating clinician answers for diagnosis and care.","roles":[],"masterSystems":[]},"relations":[{"target":"Q100751718","type":"parent","note":"registry parent class"},{"target":"Q1441305","type":"parent","note":"registry parent class"},{"target":"Q47085690","type":"parent","note":"registry parent class"},{"target":"clinical sign","type":"related","note":"in registry terms"},{"target":"abnormal skin coloration","type":"related","note":"in registry terms"},{"target":"skin and integumentary tissue symptom","type":"related","note":"in registry terms"},{"target":"hyperbilirubinemia","type":"related","note":"from various sources"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.jaundice","Wikidata: Q133244 (https://www.wikidata.org/wiki/Q133244)","ICD-11: ME10.0 jaundice, not elsewhere classified","MeSH: D007565 jaundice"]},"properties":{"applicability":"not-applicable","items":["visible jaundice threshold: about 2-3 mg/dL bilirubin - adults","neonatal jaundice incidence: about 60 percent - of term newborns"]},"recognition":{"applicability":"optional","items":["Yellowing from raised bilirubin","Hemolytic, hepatocellular, obstructive and neonatal jaundice; icteric eyes and skin","Carotenemia yellows skin but not eyes; anaemia causes pallor","Yellow skin and yellow whites of the eyes."]},"capabilities":{"applicability":"required","items":["explain kinds and mechanism","relay causes and investigation","identify urgent presentations","route personal questions"]},"hazards":{"applicability":"required","items":["Kernicterus from untreated neonatal jaundice","Missed liver disease or biliary obstruction","Agents giving personal medical advice","Confusing jaundice with carotenemia"]},"interfaces":{"applicability":"required","items":["Clinical guidelines on neonatal jaundice such as NICE and AAP","Guidelines on investigation of adult jaundice"]},"context":{"applicability":"required","items":["Not applicable; a clinical sign.","hemolytic or pre-hepatic jaundice","hepatocellular jaundice","obstructive or post-hepatic jaundice","neonatal jaundice including physiological and pathological forms","inherited hyperbilirubinaemias such as Gilbert syndrome","icteric skin and icteric eyes as signs"]}},"sources":[{"title":"Wikidata item Q133244: jaundice","url":"https://www.wikidata.org/wiki/Q133244","note":"identity and sense of the item"},{"title":"Wikipedia: Jaundice","url":"https://en.wikipedia.org/wiki/Jaundice","note":"general description of the item"}],"openQuestions":["Should neonatal jaundice and obstructive jaundice be separate primary entries?","How should clinical guidelines be linked?","The registry entry has merged aliases naming signs and causal categories; should they be split off?"],"resources":{"spec":"/models/things/publications/thing-q133244/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q133244/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-13T03:25:34Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:51:54+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane INF: no invented physical properties."},"score":1.0}}