{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.liver-cirrhosis","code":"thing-q147778","url":"https://ver.cy/models/thing/q147778/","name":"liver cirrhosis","alternateNames":["primary biliary cholangitis","Silvestrini-Corda syndrome","secondary biliary cirrhosis","Familial cirrhosis","alcoholic liver cirrhosis","cirrhosis, familial, with antigenemia"],"kind":"thing","status":"published","version":"0.2.0-wave.2","language":"en","classifiers":{"family":"Thing Registry","category":"Activities and processes","entryKind":"thing","plane":"ACT","domain":["ACT.PRC"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Advanced scarring of the liver in which normal tissue is replaced by fibrous tissue and regenerative nodules, impairing liver function, caused by chronic alcohol use, viral hepatitis, fatty liver disease, autoimmune and biliary conditions such as primary biliary cholangitis, and rare familial forms; cirrhosis can lead to complications such as bleeding, fluid accumulation, confusion and liver cancer, and is managed by treating causes and complications, with transplantation for advanced disease.","purpose":"Let an agent explain cirrhosis in general terms, route symptoms and complications to care, describe causes, prevention and management with attribution, and support people living with cirrhosis without individual medical advice.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Advanced fibrosis","Regenerative nodules","Loss of function","Serious complications"],"structure":{"bundles":[{"id":"urgent","name":"Urgent","description":"Complications.","layers":[{"id":"redflags","name":"Red flags","description":"Emergency signs.","findings":[{"id":"redflags-finding","name":"Red flags","description":"Red flags.","questions":[{"text":"Are there signs such as vomiting blood, black stools, confusion, severe abdominal swelling or fever that need urgent care?","kind":"boundary"},{"text":"Should emergency services be called now?","kind":"action"}]}]},{"id":"monitor","name":"Monitor","description":"Ongoing monitoring.","findings":[{"id":"monitor-finding","name":"Monitor","description":"Monitoring.","questions":[{"text":"How is cirrhosis monitored, including surveillance for liver cancer, according to guidelines?","kind":"provenance"},{"text":"Is the user asking for individual medical advice?","kind":"boundary"}]}]}]},{"id":"understand","name":"Understand","description":"Causes and course.","layers":[{"id":"causes","name":"Causes","description":"Causes.","findings":[{"id":"causes-finding","name":"Causes","description":"Causes.","questions":[{"text":"What causes cirrhosis, from alcohol and viral hepatitis to fatty liver and biliary diseases, according to clinical sources?","kind":"provenance"},{"text":"Which entry fits a specific cause?","kind":"action"}]}]},{"id":"course","name":"Course","description":"Stages and complications.","findings":[{"id":"course-finding","name":"Course","description":"Course.","questions":[{"text":"How does cirrhosis progress from compensated to decompensated disease, and what complications arise?","kind":"definition"},{"text":"How is severity scored?","kind":"provenance"}]}]}]},{"id":"manage","name":"Manage","description":"Management and living.","layers":[{"id":"treatment","name":"Treatment","description":"Management approaches.","findings":[{"id":"treatment-finding","name":"Treatment","description":"Treatment.","questions":[{"text":"Which management approaches do guidelines describe, including treating the cause, managing complications and transplantation, in general terms?","kind":"provenance"},{"text":"How does alcohol abstinence affect outcomes, according to evidence?","kind":"provenance"}]}]},{"id":"living","name":"Living","description":"Living with cirrhosis.","findings":[{"id":"living-finding","name":"Living","description":"Living.","questions":[{"text":"Which diet, medication and lifestyle guidance do health bodies give, in general terms, and which support organisations exist?","kind":"provenance"},{"text":"How is stigma addressed?","kind":"provenance"}]}]}]},{"id":"learn","name":"Learn","description":"Prevention and research.","layers":[{"id":"prevent","name":"Prevent","description":"Prevention.","findings":[{"id":"prevent-finding","name":"Prevent","description":"Prevention.","questions":[{"text":"How can cirrhosis be prevented at individual and population levels, according to public health guidance?","kind":"provenance"},{"text":"Which screening exists for hepatitis and fatty liver?","kind":"provenance"}]}]},{"id":"research","name":"Research","description":"Research.","findings":[{"id":"research-finding","name":"Research","description":"Research.","questions":[{"text":"What are current research directions in cirrhosis?","kind":"provenance"},{"text":"How can people participate in research?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain cirrhosis, its causes and complications from medical sources.","Point people to alcohol support, hepatitis testing and liver services."],"mustNot":["Blame or shame patients for their condition.","Recommend medicines or herbal products that can harm the liver.","Interpret liver tests for a patient.","Share a person's diagnosis or alcohol history without consent."],"requiresHuman":["Decisions on transplant listing or end-of-life care."]},"ethics":{"considerations":["Stigma about alcohol keeps people from seeking care.","Access to transplants raises hard questions of fairness."],"affectedParties":["Patients","Families","Transplant candidates"]},"owners":{"steward":"The person affected; clinicians and transplant authorities hold records.","roles":[],"masterSystems":["Transplant waiting list registers"]},"relations":[{"target":"Q12569389","type":"parent","note":"registry parent class"},{"target":"Q929737","type":"parent","note":"registry parent class"},{"target":"liver disease","type":"related","note":"category"},{"target":"cirrosis","type":"related","note":"category"},{"target":"fibrosis","type":"related","note":"the underlying process"},{"target":"abstinence","type":"related","note":"alcohol abstinence in management"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.liver-cirrhosis","Wikidata: Q147778 (https://www.wikidata.org/wiki/Q147778)"]},"properties":{"applicability":"not-applicable","items":[]},"recognition":{"applicability":"optional","items":["Fibrosis with nodules in the liver","Impaired liver function","Fibrosis without nodules is an earlier stage","Not visible in early stages; later jaundice, swelling and other signs."]},"capabilities":{"applicability":"required","items":["explain causes and course","route complications to care","describe management in general terms","support patients and carers"]},"hazards":{"applicability":"required","items":["Life-threatening complications such as variceal bleeding","Agents diagnosing or advising on treatment","Stigma toward patients"]},"interfaces":{"applicability":"required","items":["Hepatology clinical guidelines","Alcohol policy and public health guidance","Transplant allocation rules"]},"context":{"applicability":"required","items":["End-stage liver scarring.","alcohol-related cirrhosis","viral hepatitis cirrhosis","fatty liver disease cirrhosis","biliary cirrhosis including primary biliary cholangitis","familial and rare cirrhosis"]}},"sources":[{"title":"Wikidata item Q147778: liver cirrhosis","url":"https://www.wikidata.org/wiki/Q147778","note":"identity and sense of the item"},{"title":"Wikipedia: Cirrhosis","url":"https://en.wikipedia.org/wiki/Cirrhosis","note":"general description of the item"}],"openQuestions":["Should each cause be a separate entry?","How should guidelines be linked?","How should support organisations be localised?"],"resources":{"spec":"/models/things/publications/thing-q147778/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q147778/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-11T22:19:13Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:51:54+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane ACT: no invented physical properties."},"score":1.0}}