{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.ctsg","code":"thing-q14906548","url":"https://ver.cy/models/thing/q14906548/","name":"CTSG","alternateNames":[],"kind":"thing","status":"published","version":"0.2.0-wave.56","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.LIV"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"CTSG is the human protein-coding gene for cathepsin G, a serine protease stored in the azurophilic granules of neutrophils that is released at sites of inflammation and helps kill engulfed microbes and remodel tissue; the gene lies in a cluster of related protease genes on chromosome 14.","purpose":"Let an agent explain the CTSG gene and its product cathepsin G, relay function, location and disease associations from curated genomic sources, and keep the gene apart from its protein, from the cysteine cathepsins and from other neutrophil proteases.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["A serine protease, unlike most cathepsins, which are cysteine proteases","The gene is not the protein: CTSG names the gene, cathepsin G the enzyme","Distinct from neutrophil elastase (ELANE) and proteinase 3 (PRTN3), other granule serine proteases","Human gene, distinct from its orthologues in other species"],"structure":{"bundles":[{"id":"gene-identity","name":"Gene identity","description":"Symbol, name and location.","layers":[{"id":"nomenclature","name":"Nomenclature","description":"Symbol and aliases.","findings":[{"id":"nomenclature-finding","name":"Nomenclature","description":"Symbol and aliases.","questions":[{"text":"What is the official symbol and name, and which aliases are in use?","kind":"definition"},{"text":"Which database holds the authoritative record?","kind":"provenance"}]}]},{"id":"locus","name":"Locus","description":"Chromosomal location.","findings":[{"id":"locus-finding","name":"Locus","description":"Chromosomal location.","questions":[{"text":"Where on chromosome 14 does CTSG lie, and which genes neighbour it?","kind":"provenance"},{"text":"Which genome assembly is the location given against?","kind":"measurement"}]}]}]},{"id":"protein","name":"Protein","description":"Cathepsin G.","layers":[{"id":"enzyme-class","name":"Enzyme class","description":"Serine protease.","findings":[{"id":"enzyme-class-finding","name":"Enzyme class","description":"Serine protease.","questions":[{"text":"What class of enzyme is cathepsin G, and how does it differ from cysteine cathepsins?","kind":"boundary"},{"text":"Which substrates does it act on?","kind":"provenance"}]}]},{"id":"expression","name":"Expression","description":"Where it is made and stored.","findings":[{"id":"expression-finding","name":"Expression","description":"Where it is made and stored.","questions":[{"text":"In which cells is it expressed, and where is it stored?","kind":"provenance"},{"text":"When is it released?","kind":"definition"}]}]}]},{"id":"function","name":"Function","description":"Role in immunity and inflammation.","layers":[{"id":"host-defence","name":"Host defence","description":"Killing microbes.","findings":[{"id":"host-defence-finding","name":"Host defence","description":"Killing microbes.","questions":[{"text":"How does cathepsin G contribute to killing engulfed microbes?","kind":"provenance"},{"text":"Which evidence supports this role?","kind":"provenance"}]}]},{"id":"inflammation","name":"Inflammation","description":"Tissue effects.","findings":[{"id":"inflammation-finding","name":"Inflammation","description":"Tissue effects.","questions":[{"text":"How does it affect tissue and signalling at sites of inflammation?","kind":"provenance"},{"text":"Which effects are shown in humans and which in models?","kind":"boundary"}]}]}]},{"id":"associations","name":"Associations","description":"Disease and research links.","layers":[{"id":"disease-links","name":"Disease links","description":"Reported associations.","findings":[{"id":"disease-links-finding","name":"Disease links","description":"Reported associations.","questions":[{"text":"Which diseases have been linked to CTSG or cathepsin G, and how strong is the evidence?","kind":"provenance"},{"text":"Is the link to the gene, the protein level or autoantibodies?","kind":"boundary"}]}]},{"id":"variants","name":"Variants","description":"Genetic variation.","findings":[{"id":"variants-finding","name":"Variants","description":"Genetic variation.","questions":[{"text":"Are any CTSG variants classified in curated clinical databases?","kind":"provenance"},{"text":"Who may interpret a variant found in a patient?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Relay the gene's function and associations from curated databases and cite them.","Explain the difference between the gene, its protein and a variant."],"mustNot":["Interpret a person's genetic test result as a diagnosis.","Disclose or infer a named person's genetic data without consent.","State a variant is disease-causing without a curated classification."],"requiresHuman":["Clinical interpretation of a variant found in a patient.","Any genetic counselling decision."]},"ethics":{"considerations":["Genetic data is sensitive and identifying.","Overstated associations can mislead patients and research."],"affectedParties":["People who have their genes tested","Their relatives","Researchers"]},"owners":{"steward":"Nobody owns the gene; the gene nomenclature authority maintains its official name and symbol.","roles":[],"masterSystems":["HGNC","NCBI Gene","Ensembl","UniProt"]},"relations":[{"target":"Q20747295","type":"parent","note":"registry parent class"},{"target":"protein-coding gene","type":"related"},{"target":"cysteine cathepsins","type":"related","note":"share the cathepsin name but differ in mechanism"},{"target":"ELANE","type":"related","note":"another neutrophil serine protease gene"},{"target":"cathepsin G (protein)","type":"related","note":"the product, not the gene"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.ctsg","Wikidata: Q14906548 (https://www.wikidata.org/wiki/Q14906548)","Wikidata: Q14906548 registry item","HGNC symbol: CTSG official human gene symbol","HGNC ID: HGNC: followed by digits look up in the HGNC database","NCBI Gene ID: digits only look up in NCBI Gene"]},"properties":{"applicability":"required","items":["kind: protein-coding gene note","organism: Homo sapiens note","product: cathepsin G, a serine protease note"]},"recognition":{"applicability":"required","items":["Official HGNC symbol CTSG in human gene records","Protein named cathepsin G","Located on chromosome 14 near the granzyme gene cluster"]},"capabilities":{"applicability":"required","items":["identify the gene and its official symbol","relay the function of the encoded protein","relate it to neighbouring protease genes","relay curated disease and research associations","point to authoritative gene records"]},"hazards":{"applicability":"required","items":["Confusing the gene with the protein or with cysteine cathepsins","Overstating disease associations from single studies","Misusing personal genetic data"]},"interfaces":{"applicability":"required","items":["HGNC gene nomenclature rules","Genetic data protection under health and privacy law"]},"context":{"applicability":"required","items":["Encoding cathepsin G, which takes part in the immune defence and inflammatory functions of neutrophils.","chymotrypsin-like serine protease family","neutrophil granule serine proteases","orthologues in other mammals"]}},"sources":[{"title":"Wikidata item Q14906548: CTSG","url":"https://www.wikidata.org/wiki/Q14906548","note":"identity and sense of the item"},{"title":"Wikipedia: Cathepsin G","url":"https://en.wikipedia.org/wiki/Cathepsin_G","note":"general description of the item"}],"openQuestions":["How strong are the reported disease associations?","Should the protein have its own linked entry?","How should orthologues in other species be linked?"],"resources":{"spec":"/models/things/publications/thing-q14906548/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q14906548/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-10-06T10:46:19Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-09T07:29:59+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}