{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.thrombophilia","code":"thing-q1570013","url":"https://ver.cy/models/thing/q1570013/","name":"thrombophilia","alternateNames":["hypercoagulability in pregnancy","protein S deficiency","hereditary thrombophilia","thrombophilia due to thrombomodulin defect","thrombophilia due to thrombin defect","protein C deficiency","activated protein C resistance","hypoprothrombinemia","thrombophilia, X-linked, due to factor 9 defect","heparin cofactor 2 deficiency","hyperprothrombinemia","hereditary thrombophilia due to congenital protein S deficiency"],"kind":"thing","status":"published","version":"0.2.0-wave.4","language":"en","classifiers":{"family":"Thing Registry","category":"Information and virtual systems","entryKind":"thing","plane":"INF","domain":["INF.KNW"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"An increased tendency to form blood clots, inherited or acquired, including hereditary thrombophilias such as factor V Leiden, prothrombin gene mutation, and deficiencies of antithrombin, protein C and protein S, rare defects of thrombomodulin or thrombin, and acquired states such as antiphospholipid syndrome and hypercoagulability in pregnancy and after childbirth; thrombophilia raises risk of deep vein thrombosis and pulmonary embolism, especially with other factors such as oestrogen-containing contraception, surgery or immobility, and testing and management are individualised by clinicians. Leg swelling and pain, sudden breathlessness or chest pain need urgent medical care.","purpose":"Let an agent explain thrombophilia in general terms, relay types, risks, testing debates and prevention from haematology sources with positions attributed, route clot symptoms to urgent care, describe the named forms, and distinguish thrombophilia from bleeding disorders, clots themselves, atherosclerosis and anticoagulant medication effects, without diagnosing individuals.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Clot predisposition","Inherited and acquired","Interacts with other risks","Testing debated"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What thrombophilia is.","layers":[{"id":"definition","name":"Definition","description":"Definition.","findings":[{"id":"definition-finding","name":"Definition","description":"Definition.","questions":[{"text":"Is there a painful swollen leg, sudden breathlessness or chest pain, in which case seek urgent medical care?","kind":"boundary"},{"text":"What is thrombophilia, and how does it differ from bleeding disorders, clots, atherosclerosis and anticoagulant effects?","kind":"definition"}]}]},{"id":"forms","name":"Forms","description":"Named forms.","findings":[{"id":"forms-finding","name":"Forms","description":"Forms.","questions":[{"text":"What are protein C and S deficiency, thrombomodulin and thrombin defects, hereditary thrombophilia and pregnancy hypercoagulability?","kind":"definition"},{"text":"Which entry fits the specific form?","kind":"action"}]}]}]},{"id":"biology","name":"Biology","description":"Mechanisms.","layers":[{"id":"coagulation","name":"Coagulation","description":"Coagulation balance.","findings":[{"id":"coagulation-finding","name":"Coagulation","description":"Coagulation.","questions":[{"text":"How do natural anticoagulants balance clotting?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"leiden","name":"Factor V Leiden","description":"Factor V Leiden.","findings":[{"id":"leiden-finding","name":"Factor V Leiden","description":"Factor V Leiden.","questions":[{"text":"How does factor V Leiden resist activated protein C?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]}]},{"id":"care","name":"Care","description":"Testing and prevention.","layers":[{"id":"testing","name":"Testing","description":"Testing debates.","findings":[{"id":"testing-finding","name":"Testing","description":"Testing.","questions":[{"text":"When do guidelines recommend or discourage testing, with positions attributed?","kind":"provenance"},{"text":"Which entry fits thrombophilia screening?","kind":"action"}]}]},{"id":"contraception","name":"Contraception","description":"Contraception and pregnancy.","findings":[{"id":"contraception-finding","name":"Contraception","description":"Contraception.","questions":[{"text":"How do guidelines address oestrogen contraception and pregnancy for people with thrombophilia, in general terms?","kind":"provenance"},{"text":"Is the presentation neutral and attributed?","kind":"boundary"}]}]}]},{"id":"context","name":"Context","description":"Prevention.","layers":[{"id":"travel","name":"Travel","description":"Travel and immobility.","findings":[{"id":"travel-finding","name":"Travel","description":"Travel.","questions":[{"text":"What general advice exists about clot prevention on long journeys?","kind":"provenance"},{"text":"Which entry fits travel-related thrombosis?","kind":"action"}]}]},{"id":"aps","name":"Antiphospholipid","description":"Antiphospholipid syndrome.","findings":[{"id":"aps-finding","name":"Antiphospholipid","description":"Antiphospholipid.","questions":[{"text":"What is antiphospholipid syndrome?","kind":"provenance"},{"text":"Which entry fits antiphospholipid syndrome?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Explain thrombophilia, its inherited and acquired forms and their general risks with sources.","Encourage people with clot history or family history to discuss testing with a clinician."],"mustNot":["Diagnose thrombophilia or interpret a person's test results.","Advise starting, stopping or changing anticoagulants or hormonal contraception.","Disclose genetic test results to relatives, employers or insurers without consent."],"requiresHuman":["Decisions about testing relatives or about anticoagulation in pregnancy or surgery."]},"ethics":{"considerations":["Genetic results affect whole families and can lead to discrimination.","Wrong advice on anticoagulants can cause dangerous clots or bleeding."],"affectedParties":["Patients and their relatives","Pregnant people"]},"owners":{"steward":"The patient's treating clinician answers for care; health services keep the medical record.","roles":[],"masterSystems":[]},"relations":[{"target":"Q890200","type":"parent","note":"registry parent class"},{"target":"blood coagulation disease","type":"related","note":"in registry terms"},{"target":"deep vein thrombosis","type":"related"},{"target":"factor V Leiden","type":"related"},{"target":"haemophilia","type":"related"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.thrombophilia","Wikidata: Q1570013 (https://www.wikidata.org/wiki/Q1570013)"]},"properties":{"applicability":"not-applicable","items":["factor V Leiden prevalence: about 3-8 percent in European-ancestry populations note - heterozygous","factor V Leiden described: 1994 year - Leiden","postpartum clot risk period: up to about 6 weeks or more note - elevated"]},"recognition":{"applicability":"optional","items":["Increased clotting tendency","Hypercoagulability in pregnancy, protein S deficiency, hereditary thrombophilia, thrombomodulin defect, thrombin defect, protein C deficiency","Bleeding disorders reduce clotting; clots are events; atherosclerosis is arterial plaque; anticoagulants reduce clotting","Not visible; identified by blood tests or clot history."]},"capabilities":{"applicability":"required","items":["explain types and risks","relay testing and prevention in general terms","describe named forms","route clot symptoms"]},"hazards":{"applicability":"required","items":["Missing DVT or PE symptoms","Overtesting and misinterpretation","Diagnosing individuals"]},"interfaces":{"applicability":"required","items":["ASH and NICE thrombophilia testing guidelines","Contraception safety criteria such as UKMEC and WHO MEC"]},"context":{"applicability":"required","items":["Not applicable; a clotting tendency.","factor V Leiden","prothrombin mutation","natural anticoagulant deficiencies","antiphospholipid syndrome","pregnancy-related hypercoagulability"]}},"sources":[{"title":"Wikidata item Q1570013: thrombophilia","url":"https://www.wikidata.org/wiki/Q1570013","note":"identity and sense of the item"},{"title":"Wikipedia: Thrombophilia","url":"https://en.wikipedia.org/wiki/Thrombophilia","note":"general description of the item"}],"openQuestions":["Should factor V Leiden be linked separately?","How should testing guidelines be linked?","How should debates on testing be presented?"],"resources":{"spec":"/models/things/publications/thing-q1570013/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q1570013/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-14T00:01:21Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:51:54+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane INF: no invented physical properties."},"score":1.0}}