{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.piperidine-alkaloids","code":"thing-q17325708","url":"https://ver.cy/models/thing/q17325708/","name":"piperidine alkaloids","alternateNames":["N-Demethylbuchenavianine","Buchenavianine","O-demethylbuchenavianine","2-Ethoxy-4-[2-[[3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-oxoethyl]benzoic acid","Capitavine","[(3S,4R)-4-(5,7-dihydroxy-2-methyl-4-oxochromen-8-yl)-1-methylpiperidin-3-yl] 2-methylbut-2-enoate","chrotacumine B","[4-(5,7-Dihydroxy-2-methyl-4-oxochromen-8-yl)-1-methylpiperidin-3-yl] 3,4,5-trimethoxybenzoate","[(3S,4S)-4-(5,7-dihydroxy-2-methyl-4-oxochromen-8-yl)-1-methylpiperidin-3-yl] acetate","rohitukine","[4-(5,7-Dihydroxy-2-methyl-4-oxochromen-8-yl)-1-methylpiperidin-3-yl] 3,4-dimethoxybenzoate","Rohitukine N-oxide"],"kind":"thing","status":"published","version":"0.2.0-wave.2","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A class of alkaloids containing a piperidine ring, a saturated six-membered nitrogen heterocycle, found in plants and animals and including piperine from black pepper, coniine from hemlock, lobeline and various rare plant alkaloids; piperidine alkaloids range from flavour compounds to potent toxins and pharmaceutical leads.","purpose":"Let an agent explain piperidine alkaloids, their sources, structures and biological activities, and address toxicity and pharmaceutical relevance with safety first.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Piperidine ring","Natural products","Wide activity range","Some highly toxic"],"structure":{"bundles":[{"id":"safety","name":"Safety","description":"Poisoning risk.","layers":[{"id":"exposure","name":"Exposure","description":"Suspected poisoning.","findings":[{"id":"exposure-finding","name":"Exposure","description":"Poisoning.","questions":[{"text":"Has someone ingested a plant such as hemlock that contains toxic piperidine alkaloids?","kind":"boundary"},{"text":"Should poison control or emergency services be contacted now?","kind":"action"}]}]},{"id":"limits","name":"Limits","description":"Misuse.","findings":[{"id":"limits-finding","name":"Limits","description":"Limits.","questions":[{"text":"Does the request seek to extract or use toxic alkaloids to harm?","kind":"boundary"},{"text":"How should the agent decline?","kind":"action"}]}]}]},{"id":"chemistry","name":"Chemistry","description":"Structures and sources.","layers":[{"id":"structure","name":"Structure","description":"Structure and biosynthesis.","findings":[{"id":"structure-finding","name":"Structure","description":"Structure.","questions":[{"text":"What is the structure of this piperidine alkaloid, and how is it biosynthesised?","kind":"provenance"},{"text":"Which organisms produce it?","kind":"provenance"}]}]},{"id":"identify","name":"Identify","description":"Identification.","findings":[{"id":"identify-finding","name":"Identify","description":"Identification.","questions":[{"text":"How are piperidine alkaloids identified and quantified analytically?","kind":"provenance"},{"text":"Which databases record them?","kind":"provenance"}]}]}]},{"id":"activity","name":"Activity","description":"Biological effects.","layers":[{"id":"effects","name":"Effects","description":"Activities.","findings":[{"id":"effects-finding","name":"Effects","description":"Activities.","questions":[{"text":"What biological activity does this alkaloid have, such as pungency, toxicity or pharmacological effects?","kind":"provenance"},{"text":"What is its mechanism?","kind":"definition"}]}]},{"id":"pharma","name":"Pharma","description":"Drug relevance.","findings":[{"id":"pharma-finding","name":"Pharma","description":"Pharmaceuticals.","questions":[{"text":"Which piperidine alkaloids or derivatives are used or studied as medicines, in general terms?","kind":"provenance"},{"text":"Is the user asking about personal use?","kind":"boundary"}]}]}]},{"id":"learn","name":"Learn","description":"Study.","layers":[{"id":"plants","name":"Plants","description":"Poisonous plants.","findings":[{"id":"plants-finding","name":"Plants","description":"Poisonous plants.","questions":[{"text":"Which plants containing these alkaloids should be recognised for safety, such as hemlock?","kind":"provenance"},{"text":"How can they be distinguished from edible look-alikes?","kind":"provenance"}]}]},{"id":"teach","name":"Teach","description":"Teaching.","findings":[{"id":"teach-finding","name":"Teach","description":"Teaching.","questions":[{"text":"How can alkaloid chemistry be taught with these examples?","kind":"action"},{"text":"Which historical cases, such as the death of Socrates, are attributed to them?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Describe piperidine alkaloids and their sources from pharmacology references.","Warn that some, such as coniine from hemlock, are highly poisonous."],"mustNot":["Assist in extracting or using these alkaloids to harm anyone.","Advise eating or using hemlock or other toxic plants.","Recommend alkaloid-containing supplements without evidence.","Confuse toxic plants with edible lookalikes."],"requiresHuman":["Responding to a suspected poisoning beyond directing to emergency services."]},"ethics":{"considerations":["Accidental poisoning from mistaken plants is a real risk to foragers and children.","Toxic alkaloids have a history of use as poisons."],"affectedParties":["Foragers","Children","Livestock"]},"owners":{"steward":"Nobody owns the class; poison control and plant authorities document hazards.","roles":[],"masterSystems":["Poison centre databases"]},"relations":[{"target":"Q70702","type":"parent","note":"registry parent class"},{"target":"alkaloid","type":"related","note":"category"},{"target":"heterocyclic compound","type":"related","note":"chemistry"},{"target":"toxin","type":"related","note":"toxic alkaloids"},{"target":"drug","type":"related","note":"pharmaceutical relevance"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.piperidine-alkaloids","Wikidata: Q17325708 (https://www.wikidata.org/wiki/Q17325708)"]},"properties":{"applicability":"required","items":["Molar mass:  g/mol - Calculate this for an identified compound from its molecular formula, distinguishing the free compound from salts and solvates.","Melting temperature:  degrees Celsius - Measure a crystalline compound by capillary melting analysis or differential scanning calorimetry and record any decomposition.","Solubility:  g/L - Measure the equilibrium dissolved concentration for an identified compound at a stated solvent composition, temperature and pH."]},"recognition":{"applicability":"required","items":["Piperidine ring in the structure","Plant and animal sources","Pyridine alkaloids have an aromatic ring","Not visible; compounds in plants and animals."]},"capabilities":{"applicability":"required","items":["identify piperidine alkaloids and their sources","explain structures and biosynthesis","describe biological activities and toxicity","describe pharmaceutical relevance"]},"hazards":{"applicability":"required","items":["Poisoning from hemlock and related plants","Misidentification of plants","Misuse of toxic alkaloids"]},"interfaces":{"applicability":"required","items":["Chemical and food safety regulations","Poisonous plant guidance","Medicines regulation for derived drugs"]},"context":{"applicability":"required","items":["Natural products chemistry, pharmacology and toxicology.","piperine and pepper alkaloids","coniine and hemlock alkaloids","lobelia alkaloids","rare plant piperidine alkaloids","piperidine alkaloids from animals"]}},"sources":[{"title":"Wikidata item Q17325708: piperidine alkaloids","url":"https://www.wikidata.org/wiki/Q17325708","note":"identity and sense of the item"},{"title":"Wikipedia: Piperidine alkaloids","url":"https://en.wikipedia.org/wiki/Piperidine_alkaloids","note":"general description of the item"}],"openQuestions":["Should major alkaloids be separate entries?","How should natural product databases be linked?","How should poison control contacts be localised?"],"resources":{"spec":"/models/things/publications/thing-q17325708/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q17325708/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-11T20:31:50Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:26+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}