{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.pyrrolidine-alkaloid","code":"thing-q17325781","url":"https://ver.cy/models/thing/q17325781/","name":"pyrrolidine alkaloid","alternateNames":["(3S,5R)-3-methyl-5-[3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-8-yl]pyrrolidin-2-one","tetramic acid","1-pyrroline-5-carboxylate","Davallioside A","2-{[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-8-(5-hydroxy-3,4-dihydro-2H-pyrrol-2-yl)-3,4-dihydro-2H-1-benzopyran-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol","Celogentin H","celogentin J","Celogentin E","Maltacine C1b","Celogentin G","Maltacine D1b","celogentin F"],"kind":"thing","status":"published","version":"0.2.0-wave.2","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A class of alkaloids containing a pyrrolidine ring, a five-membered saturated nitrogen heterocycle, including simple pyrrolidines such as hygrine, nicotine-related and tropane-related compounds, tetramic acid derivatives, plant metabolites such as Davallioside A and Celogentin H, and flavonoid-linked pyrrolidinones; pyrrolidine alkaloids occur in plants, fungi and marine organisms, show diverse biological activities studied in pharmacology, and are analysed in natural products chemistry.","purpose":"Let an agent explain pyrrolidine alkaloids as a chemical class, describe their sources and biosynthesis, summarise documented biological activities with attribution, and route medicinal questions to professionals.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Five-membered nitrogen ring","Diverse structures","Biological activity","Natural product class"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"The chemical class.","layers":[{"id":"structure","name":"Structure","description":"Structure and members.","findings":[{"id":"structure-finding","name":"Structure","description":"Structure.","questions":[{"text":"What defines pyrrolidine alkaloids, and how do simple pyrrolidines, tetramic acids and pyrrolidinone derivatives differ?","kind":"definition"},{"text":"Is the pyrrolidine or the pyrrolizidine class meant?","kind":"boundary"}]}]},{"id":"sources","name":"Sources","description":"Sources and biosynthesis.","findings":[{"id":"sources-finding","name":"Sources","description":"Sources.","questions":[{"text":"Which organisms produce pyrrolidine alkaloids, and how are they biosynthesised from ornithine and proline?","kind":"provenance"},{"text":"Which entry fits a specific organism?","kind":"action"}]}]}]},{"id":"activity","name":"Activity","description":"Biological activity.","layers":[{"id":"pharmacology","name":"Pharmacology","description":"Documented activities.","findings":[{"id":"pharmacology-finding","name":"Pharmacology","description":"Pharmacology.","questions":[{"text":"What biological activities are documented for pyrrolidine alkaloids in research, and how strong is the evidence?","kind":"provenance"},{"text":"Which findings are preliminary?","kind":"boundary"}]}]},{"id":"safety","name":"Safety","description":"Toxicity.","findings":[{"id":"safety-finding","name":"Safety","description":"Safety.","questions":[{"text":"Which members are toxic, and what safety data exist?","kind":"provenance"},{"text":"Is the user asking about their own use of a product, which needs a professional?","kind":"boundary"}]}]}]},{"id":"analyse","name":"Analyse","description":"Analysis and research.","layers":[{"id":"methods","name":"Methods","description":"Analytical methods.","findings":[{"id":"methods-finding","name":"Methods","description":"Methods.","questions":[{"text":"How are pyrrolidine alkaloids isolated, identified and quantified?","kind":"provenance"},{"text":"Which databases document them?","kind":"provenance"}]}]},{"id":"synthesis","name":"Synthesis","description":"Research synthesis.","findings":[{"id":"synthesis-finding","name":"Synthesis","description":"Synthesis.","questions":[{"text":"How are pyrrolidine alkaloids studied in synthetic and medicinal chemistry research at a general level?","kind":"provenance"},{"text":"Which entry fits natural product synthesis?","kind":"action"}]}]}]},{"id":"learn","name":"Learn","description":"History and teaching.","layers":[{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How were pyrrolidine alkaloids discovered and classified?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"teach","name":"Teach","description":"Teaching.","findings":[{"id":"teach-finding","name":"Teach","description":"Teaching.","questions":[{"text":"How can alkaloid classes be taught with pyrrolidine examples?","kind":"action"},{"text":"Which misconceptions arise?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Describe the pyrrolidine alkaloid class and its natural sources at a reference level.","Point to poison centres when someone may have been exposed to an alkaloid-containing plant.","Identify members of the class from published chemical data."],"mustNot":["Provide extraction, synthesis or dosing information for any alkaloid in this class.","Advise anyone on using these alkaloids to poison or harm people or animals.","Present toxic plants as safe remedies.","Help evade controls on regulated alkaloids."],"requiresHuman":["Advising a person who may have been exposed or poisoned."]},"ethics":{"considerations":["Some of these alkaloids are addictive or toxic, including nicotine.","Plants containing them are a poisoning risk for children and livestock."],"affectedParties":["Children","Livestock","People with addiction"]},"owners":{"steward":"Nobody owns the class; chemical regulators control specific substances.","roles":[],"masterSystems":[]},"relations":[{"target":"Q2875193","type":"parent","note":"registry parent class"},{"target":"Q70702","type":"parent","note":"registry parent class"},{"target":"alkaloid","type":"related","note":"category"},{"target":"pyrrolidine","type":"related","note":"category"},{"target":"aporphine alkaloids","type":"related","note":"another alkaloid class entry"},{"target":"morphinan alkaloid","type":"related","note":"another alkaloid class entry"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.pyrrolidine-alkaloid","Wikidata: Q17325781 (https://www.wikidata.org/wiki/Q17325781)"]},"properties":{"applicability":"required","items":["Molar mass:  g/mol - Calculate this from the molecular formula of the identified compound, including any specified salt or solvate.","Melting temperature:  degrees Celsius - Measure a crystalline sample by capillary melting analysis or differential scanning calorimetry and distinguish melting from decomposition.","Solubility:  g/L - Determine the equilibrium dissolved concentration in a specified solvent at a recorded temperature and pH."]},"recognition":{"applicability":"required","items":["Pyrrolidine ring","Plant, fungal and marine sources","Pyrrolizidine alkaloids have a fused bicyclic ring and distinct toxicity","Not physical as a class; compounds in the laboratory."]},"capabilities":{"applicability":"required","items":["explain the class","describe sources and biosynthesis","summarise activities","route medicinal questions"]},"hazards":{"applicability":"required","items":["Confusing pyrrolidine with pyrrolizidine alkaloids","Unproven medicinal claims","Toxicity of some compounds"]},"interfaces":{"applicability":"required","items":["Chemical nomenclature conventions","Safety data for toxic members","Herbal medicine regulation"]},"context":{"applicability":"required","items":["Alkaloids with a pyrrolidine ring.","simple pyrrolidine alkaloids such as hygrine","tetramic acid derivatives","pyrrolidinone and flavonoid-linked alkaloids","proline-derived intermediates","marine and fungal pyrrolidine alkaloids"]}},"sources":[{"title":"Wikidata item Q17325781: pyrrolidine alkaloid","url":"https://www.wikidata.org/wiki/Q17325781","note":"identity and sense of the item"},{"title":"Wikipedia: Pyrrolidine alkaloids","url":"https://en.wikipedia.org/wiki/Pyrrolidine_alkaloids","note":"general description of the item"}],"openQuestions":["Should each compound be a separate entry?","How should natural product databases be linked?","How should safety data be linked?"],"resources":{"spec":"/models/things/publications/thing-q17325781/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q17325781/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T01:35:44Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:26+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}