{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.fshb","code":"thing-q17930727","url":"https://ver.cy/models/thing/q17930727/","name":"FSHB","alternateNames":[],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.OBJ"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"FSHB is the gene encoding the beta subunit of follicle-stimulating hormone, which associates with a common alpha subunit to form a pituitary glycoprotein hormone involved in ovarian follicle development and spermatogenesis.","purpose":"Enable an agent to identify the human FSHB gene, distinguish it from its transcripts, encoded beta subunit and assembled follicle-stimulating hormone, and judge which genetic or functional claims the evidence supports.","scope":{"in":["Human FSHB gene identity includes its symbol, curated identifiers and genomic reference.","Genomic location and regulatory DNA are described against an identified reference assembly.","Genetic variants retain their sequence context and supporting evidence.","Transcripts and the encoded beta subunit are linked to the gene without being treated as the gene itself.","Expression and functional evidence retain their biological and experimental context."],"out":["The isolated FSH beta subunit is a separate protein entity.","Complete follicle-stimulating hormone is separate from its encoding genes.","The common glycoprotein hormone alpha subunit and other hormone beta subunits are separate entities.","FSH receptor identity and downstream signalling networks are outside this gene's scope.","Clinical diagnosis, fertility treatment and dosing decisions are outside this gene's scope.","Commercial follitropin medicines, manufacturing systems and delivery devices are separate entities."],"boundaries":[]},"distinguishingFeatures":["A human FSHB identification requires a gene identifier or genomic reference establishing Homo sapiens as the species.","The symbol FSHB alone does not distinguish the gene from its transcript or protein product.","Genomic coordinates and variant descriptions require an identified reference assembly or reference sequence.","The FSHB gene encodes the beta subunit rather than the complete alpha-beta hormone complex.","A medicine named follitropin beta is not the FSHB gene and cannot establish gene identity."],"structure":{"bundles":[{"id":"fshb-referent-and-identity","name":"FSHB referent and identity","description":"Establish what the registry label denotes and how a molecular record qualifies as FSH beta.","layers":[{"id":"registry-referent","name":"Registry referent","description":"Resolve the protein interpretation before accepting molecular attributes.","findings":[{"id":"gene-product-boundary","name":"Gene-product boundary","description":"Record the protein interpretation as provisional until the originating registry record establishes the intended entity.","questions":[{"text":"Does the originating registry or Wikidata identifier denote the FSHB gene, its protein product, or a combined gene/product concept?","id":"gene-product-boundary-q01","kind":"boundary"},{"text":"Which original record and description support the selected interpretation of vr.tr.fshb?","id":"gene-product-boundary-q02","kind":"provenance"}]}]},{"id":"sequence-and-taxon","name":"Sequence and taxon","description":"Anchor protein identity to a versioned sequence and organism.","findings":[{"id":"fsh-beta-identification","name":"FSH beta identification","description":"Require evidence distinguishing the specified FSH beta sequence from other hormone subunits and species orthologues.","questions":[{"text":"Which species and versioned protein accession define the FSH beta sequence under consideration?","id":"fsh-beta-identification-q01","kind":"definition"},{"text":"Which sequence coverage or discriminating assay evidence supports FSH beta identity rather than a related subunit?","id":"fsh-beta-identification-q02","kind":"measurement"}]}]}]},{"id":"fshb-molecular-forms","name":"FSHB molecular forms","description":"Describe the chain and modifications actually present in the referenced material.","layers":[{"id":"chain-processing","name":"Chain processing","description":"Distinguish reference precursor annotations from the observed protein chain.","findings":[{"id":"processed-chain-boundaries","name":"Processed chain boundaries","description":"Attach residue boundaries and processing evidence to each claimed chain form.","questions":[{"text":"Does this record describe the precursor or a processed chain, and what are its reference residue boundaries?","id":"processed-chain-boundaries-q01","kind":"definition"},{"text":"Are the reported termini experimentally observed or transferred from a reference annotation?","id":"processed-chain-boundaries-q02","kind":"provenance"}]}]},{"id":"modifications-and-constructs","name":"Modifications and constructs","description":"Capture departures from the reference sequence and measured chemical modifications.","findings":[{"id":"specified-molecular-form","name":"Specified molecular form","description":"Describe sequence alterations and glycosylation at the resolution supported by evidence.","questions":[{"text":"Which substitutions, truncations, tags or fusion partners distinguish this material from the reference FSH beta chain?","id":"specified-molecular-form-q01","kind":"boundary"},{"text":"Which glycosylation sites and occupancies were measured, and which remain unresolved?","id":"specified-molecular-form-q02","kind":"measurement"}]}]}]},{"id":"fshb-assembly-and-function","name":"FSHB assembly and function","description":"Connect the beta subunit to hormone assembly without transferring whole-hormone findings indiscriminately.","layers":[{"id":"alpha-beta-association","name":"Alpha-beta association","description":"Identify the partner and assembly state of the beta-containing material.","findings":[{"id":"beta-containing-species","name":"Beta-containing molecular species","description":"Distinguish free beta chain, alpha-associated beta and mixtures through explicit composition evidence.","questions":[{"text":"What evidence establishes whether the beta subunit is free or associated with an alpha subunit?","id":"beta-containing-species-q01","kind":"measurement"},{"text":"Which alpha-subunit identity and preparation are linked to the observed complex?","id":"beta-containing-species-q02","kind":"provenance"}]}]},{"id":"functional-attribution","name":"Functional attribution","description":"Keep assembly and receptor-response results attached to the tested molecular form.","findings":[{"id":"subunit-versus-hormone-effects","name":"Subunit versus hormone effects","description":"Require experimental context before attributing a measured response specifically to FSH beta.","questions":[{"text":"Was the reported response measured using isolated beta subunit, reconstituted FSH or a preparation of unresolved composition?","id":"subunit-versus-hormone-effects-q01","kind":"boundary"},{"text":"Which controls permit an agent to attribute a changed response to the beta-subunit form rather than assembly efficiency or preparation differences?","id":"subunit-versus-hormone-effects-q02","kind":"action"}]}]}]},{"id":"fshb-detection-and-comparison","name":"FSHB detection and comparison","description":"Specify what a measurement detects and when observations can be compared.","layers":[{"id":"assay-target","name":"Assay target","description":"Resolve the analyte behind an FSHB-labelled result.","findings":[{"id":"beta-subunit-specificity","name":"Beta-subunit specificity","description":"Record whether the method detects nucleic acid, free beta, assembled FSH or multiple forms.","questions":[{"text":"Does this assay measure FSHB RNA, FSH beta protein, intact FSH or an unresolved combination?","id":"beta-subunit-specificity-q01","kind":"boundary"},{"text":"What validation establishes recognition of the claimed molecular form and excludes relevant cross-reactivity?","id":"beta-subunit-specificity-q02","kind":"provenance"}]}]},{"id":"measurement-comparability","name":"Measurement comparability","description":"Constrain interpretation using sample context, calibration and analytical limits.","findings":[{"id":"comparable-beta-measurements","name":"Comparable beta measurements","description":"Compare results only after resolving differences in analyte definition, units and reference material.","questions":[{"text":"What sample matrix, units, calibration material and detection limits qualify the reported beta-subunit abundance?","id":"comparable-beta-measurements-q01","kind":"measurement"},{"text":"Can these results be compared directly, or must an agent retain them separately because they measure different FSH-containing forms?","id":"comparable-beta-measurements-q02","kind":"action"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of FSHB this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of FSHB this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of FSHB this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of FSHB this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of FSHB this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Describe FSHB and its role in follicle-stimulating hormone from curated gene and protein databases.","Report the evidence behind a claim about the gene, such as a sequence record or published assay."],"mustNot":["Interpret a person's FSHB variant as a fertility diagnosis without a qualified clinician.","Share or link a person's genetic data about FSHB without their consent.","Overstate how far a single gene explains infertility or delayed puberty.","Present hormone or fertility treatment advice as settled from gene data alone."],"requiresHuman":["Returning a genetic finding about fertility to a patient or family.","Using genetic data in a reproductive decision."]},"ethics":{"considerations":["Fertility findings are intimate and can affect relationships and family planning.","Genetic data identifies a person and their relatives."],"affectedParties":["Patients undergoing fertility testing","Their relatives","Research participants"]},"owners":{"steward":"Nobody owns the gene; curated gene databases keep its reference record.","roles":[],"masterSystems":["HGNC gene symbol registry","Reference sequence databases"]},"relations":[{"target":"Q20747295","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.fshb","Wikidata: Q17930727 (https://www.wikidata.org/wiki/Q17930727)"]},"properties":{"applicability":"required","items":["Molecular referent: protein precursor | processed beta chain | beta chain within FSH | unresolved","Species attribution: Taxon identifier linked to a sequence-supported attribution","Reference sequence: Versioned protein accession with residue boundaries","Chain length: amino-acid residues, specifying precursor or processed chain","Sequence differences: Reference-matching | substitutions | insertion/deletion | engineered fusion | unresolved; with residue-level descriptions","Glycosylation evidence: Site-specific occupancy and glycan annotation | detected but unresolved | not detected | not measured","Alpha-subunit association: Free beta subunit | alpha-associated | mixed population | unresolved","Measured abundance: mol/L or mass/volume, with molecular target, sample matrix, method and calibration","Functional evidence: Linked assembly or receptor-response experiment identifying the tested preparation and controls"]},"recognition":{"applicability":"not-applicable","items":[]},"capabilities":{"applicability":"required","items":["Resolve an FSHB label against a species-specific protein reference.","Compare precursor, processed and engineered sequences while preserving their distinctions.","Annotate experimentally supported molecular modifications and assembly states.","Assess whether an assay identifies beta subunit, intact FSH or an unresolved mixture.","Compare abundance measurements only when molecular targets and calibration are compatible.","Route gene-level, hormone-level and clinical claims to neighbouring models."]},"hazards":{"applicability":"required","items":["Loss-of-function variants are linked to hypogonadism and infertility.","Misread variant reports can lead to wrong reproductive advice."]},"interfaces":{"applicability":"required","items":["HGNC guidelines for human gene nomenclature, HUGO Gene Nomenclature Committee."]},"context":{"applicability":"required","items":["FSHB is encountered in human genetics and reproductive endocrinology as the gene encoding the beta subunit of follicle-stimulating hormone.","Its sequence, expression and variants are studied to understand hormone production and reproductive function."]}},"sources":[{"title":"Wikidata item Q17930727: FSHB","url":"https://www.wikidata.org/wiki/Q17930727","note":"identity and sense of the item"},{"title":"Wikipedia: FSHB","url":"https://en.wikipedia.org/wiki/FSHB","note":"general description of the item"}],"openQuestions":["Does the originating record for vr.tr.fshb identify the gene, the protein or a combined concept, requiring revision of this provisional protein scope?","Is the registered thing specifically human FSHB or a species-independent protein kind?","Does an existing Vercy world model already cover this exact referent and therefore require a registry link instead of a separate model?","Which authoritative protein reference and experimentally supported processing and modification annotations should anchor the completed model?","Which evidence supports distinguishing free beta-subunit measurements from intact FSH and attributing functional effects to particular beta-subunit forms?"],"resources":{"spec":"/models/things/publications/thing-q17930727/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q17930727/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T09:53:49Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"not-applicable","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T12:16:29+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.recognition":"FSHB has no distinctive visible appearance because identifying this gene requires molecular sequence evidence rather than visual cues."},"score":1.0}}