{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.carbadox","code":"thing-q1810456","url":"https://ver.cy/models/thing/q1810456/","name":"carbadox","alternateNames":[],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Carbadox is a synthetic quinoxaline di-N-oxide antibacterial compound used in veterinary medicine, particularly in medicated feed for pigs.","purpose":"Enable an agent to identify carbadox, assess a particular material or analytical result, and determine which handling or veterinary-use decisions require further evidence.","scope":{"in":["Chemical identity and differentiation from related quinoxaline compounds","Purity, impurities, physical state and stability of carbadox material","Analytical identification and quantification in specified matrices","Relationships between carbadox, its metabolites and residue measurements","Hazard evidence and applicable handling controls","Dated links to veterinary authorizations and residue requirements"],"out":["Complete formulations and manufacturing specifications of branded medicated feeds","Veterinary diagnosis, prescribing and animal treatment plans","Full models of desoxycarbadox and quinoxaline-2-carboxylic acid as separate substances","Industrial synthesis processes and production equipment","Farm management, slaughter scheduling and food-product release workflows"],"boundaries":[]},"distinguishingFeatures":["Match the molecular structure as well as the name: PubChem identifies carbadox with formula C11H10N4O4; formula alone cannot establish identity. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Carbadox)","Require analytical discrimination between parent carbadox and desoxycarbadox rather than treating both as one analyte.","Distinguish carbadox from quinoxaline-2-carboxylic acid (QCA), a residue marker whose measurement does not directly measure parent carbadox. [FDA](https://www.fda.gov/animal-veterinary/product-safety-information/questions-and-answers-regarding-carbadox)","Distinguish the active chemical from a medicated-feed product by reporting the carrier composition and carbadox concentration.","Require structure-specific identification against related quinoxaline antibacterials; shared class membership or a residue-marker signal is insufficient."],"structure":{"bundles":[{"id":"carbadox-identity","name":"Carbadox identity","description":"Establish which chemical entity the registry entry denotes and how candidate materials are matched to it.","layers":[{"id":"molecular-identity","name":"Molecular identity","description":"Connect the registered name to a verified molecular representation.","findings":[{"id":"structure-and-identifiers","name":"Structure and identifiers","description":"Use the carbadox structure as the identity anchor; PubChem reports C11H10N4O4. Reconcile database identifiers against that structure. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Carbadox)","questions":[{"text":"Which structural representation and stereochemical specification define carbadox for this entry?","id":"structure-and-identifiers-q01","kind":"definition"},{"text":"Which authoritative records establish the CAS number, PubChem CID and any EC identifier for that representation?","id":"structure-and-identifiers-q02","kind":"provenance"}]}]},{"id":"substance-boundaries","name":"Substance boundaries","description":"Separate the parent chemical from related substances and mixtures.","findings":[{"id":"parent-versus-related-material","name":"Parent versus related material","description":"Treat desoxycarbadox, QCA and carbadox-containing feed as related entities rather than interchangeable names for carbadox.","questions":[{"text":"What evidence distinguishes this sample from desoxycarbadox, QCA and other quinoxaline compounds?","id":"parent-versus-related-material-q01","kind":"measurement"},{"text":"Does the record describe carbadox material, a reference solution or a formulated feed product?","id":"parent-versus-related-material-q02","kind":"boundary"}]}]}]},{"id":"carbadox-material-quality","name":"Carbadox material quality","description":"Represent the condition and composition of an actual carbadox lot.","layers":[{"id":"assay-and-related-substances","name":"Assay and related substances","description":"Describe carbadox content and separately measured non-parent components.","findings":[{"id":"lot-composition","name":"Lot composition","description":"Record assay basis, water or solvent content and identified impurities without assuming that all non-parent material is equivalent.","questions":[{"text":"What is the measured carbadox mass fraction, on what basis and with what uncertainty?","id":"lot-composition-q01","kind":"measurement"},{"text":"Which related substances were tested, and what specification governs their acceptance?","id":"lot-composition-q02","kind":"provenance"}]}]},{"id":"physical-state-and-stability","name":"Physical state and stability","description":"Connect observed material condition to experimentally supported storage and preparation conditions.","findings":[{"id":"condition-dependent-properties","name":"Condition-dependent properties","description":"Require measured thermal, solubility and stability evidence with conditions; leave unsupported constants unresolved.","questions":[{"text":"What phase, solid form and thermal events are established, and was decomposition distinguished from melting?","id":"condition-dependent-properties-q01","kind":"measurement"},{"text":"Which temperature, light, moisture, solvent and pH conditions have validated stability evidence?","id":"condition-dependent-properties-q02","kind":"provenance"},{"text":"What excursion or analytical change requires quarantine, retesting or rejection of the lot?","id":"condition-dependent-properties-q03","kind":"action"}]}]}]},{"id":"carbadox-analytical-evidence","name":"Carbadox analytical evidence","description":"Determine what an analytical result actually identifies and quantifies.","layers":[{"id":"analyte-and-matrix","name":"Analyte and matrix","description":"Specify the chemical target and material tested before interpreting a result.","findings":[{"id":"method-selectivity","name":"Method selectivity","description":"Require demonstrated discrimination of carbadox from related compounds in the stated matrix.","questions":[{"text":"Does the method measure parent carbadox, a named metabolite or a chemically converted residue fraction?","id":"method-selectivity-q01","kind":"definition"},{"text":"How were selectivity, extraction recovery and matrix effects established for this sample type?","id":"method-selectivity-q02","kind":"measurement"}]}]},{"id":"result-interpretation","name":"Result interpretation","description":"Preserve detection limits and the boundaries of each measurement.","findings":[{"id":"qualified-results","name":"Qualified results","description":"Attach analyte, matrix, units, detection capability and uncertainty to every quantitative or nondetection statement.","questions":[{"text":"What are the result, LOD, LOQ and uncertainty for the reported analyte?","id":"qualified-results-q01","kind":"measurement"},{"text":"Which conclusions remain unsupported when the result is below the detection or quantification limit?","id":"qualified-results-q02","kind":"boundary"}]}]}]},{"id":"carbadox-transformation-and-residues","name":"Carbadox transformation and residues","description":"Connect parent carbadox to metabolites and food-residue evidence without collapsing their identities.","layers":[{"id":"transformation-evidence","name":"Transformation evidence","description":"Represent supported links among parent drug, metabolites and residue fractions.","findings":[{"id":"identified-transformation-products","name":"Identified transformation products","description":"Record desoxycarbadox and QCA relationships with the biological or experimental context that supports each link.","questions":[{"text":"Which studies establish the relationship of each identified residue to administered carbadox?","id":"identified-transformation-products-q01","kind":"provenance"},{"text":"Which species, tissue, sampling time and extraction conditions delimit that evidence?","id":"identified-transformation-products-q02","kind":"boundary"}]}]},{"id":"marker-validity","name":"Marker validity","description":"Evaluate whether a residue marker supports the proposed safety or compliance inference.","findings":[{"id":"qca-inference-limits","name":"QCA inference limits","description":"FDA explains that its 1998-approved QCA method did not establish the necessary relationship to residues of carcinogenic concern. Preserve this method-specific limitation. [FDA](https://www.fda.gov/animal-veterinary/product-safety-information/questions-and-answers-regarding-carbadox)","questions":[{"text":"What evidence links the measured QCA concentration to residues of concern for this method and tissue?","id":"qca-inference-limits-q01","kind":"provenance"},{"text":"Does the proposed conclusion require a relationship that has not been established?","id":"qca-inference-limits-q02","kind":"boundary"},{"text":"What additional measurement or authoritative determination is needed before accepting that conclusion?","id":"qca-inference-limits-q03","kind":"action"}]}]}]},{"id":"carbadox-hazards-and-handling","name":"Carbadox hazards and handling","description":"Translate endpoint-specific hazard evidence into controls for the actual material and exposure route.","layers":[{"id":"toxicological-evidence","name":"Toxicological evidence","description":"Preserve the basis and limits of hazard claims.","findings":[{"id":"carcinogenic-concern","name":"Carcinogenic concern","description":"FDA identifies carcinogenic concern for carbadox residues; record supporting endpoints and avoid converting that concern into an unsupported numerical exposure limit. [FDA](https://www.fda.gov/animal-veterinary/product-safety-information/questions-and-answers-regarding-carbadox)","questions":[{"text":"Which studies establish carcinogenicity and genotoxicity endpoints for parent carbadox and relevant residues?","id":"carcinogenic-concern-q01","kind":"provenance"},{"text":"Which conclusions apply to the parent substance, particular metabolites or the total residue mixture?","id":"carcinogenic-concern-q02","kind":"boundary"}]}]},{"id":"exposure-controls","name":"Exposure controls","description":"Connect material form and task to documented handling requirements.","findings":[{"id":"task-specific-handling","name":"Task-specific handling","description":"Resolve controls for powder handling, solution preparation and contaminated waste using applicable evidence and current documentation.","questions":[{"text":"Which SDS revision and jurisdiction-specific hazard classification apply to this carbadox material?","id":"task-specific-handling-q01","kind":"provenance"},{"text":"What containment, protective equipment and waste route are required for the proposed operation?","id":"task-specific-handling-q02","kind":"action"},{"text":"Is an applicable exposure limit established, or must its absence be explicitly recorded?","id":"task-specific-handling-q03","kind":"definition"}]}]}]},{"id":"carbadox-use-and-regulatory-status","name":"Carbadox use and regulatory status","description":"Maintain dated evidence governing a proposed use or residue decision.","layers":[{"id":"veterinary-use-context","name":"Veterinary use context","description":"Connect the substance to authorized products and uses without owning the treatment plan.","findings":[{"id":"product-linked-permission","name":"Product-linked permission","description":"FDA describes carbadox use in swine feed; establish present permission from the applicable product and jurisdiction rather than historical use alone. [FDA](https://www.fda.gov/animal-veterinary/product-safety-information/questions-and-answers-regarding-carbadox)","questions":[{"text":"Which current authorization covers the exact product, species and proposed purpose?","id":"product-linked-permission-q01","kind":"provenance"},{"text":"Which concentration, animal-class and use restrictions must be passed to the treatment or feed-product model?","id":"product-linked-permission-q02","kind":"action"}]}]},{"id":"residue-rule-status","name":"Residue rule status","description":"Separate residue thresholds, withdrawal conditions and accepted testing methods.","findings":[{"id":"dated-regulatory-determination","name":"Dated regulatory determination","description":"Record each operative rule, its effective date and its scope; distinguish proposals from final decisions and method actions from product-authorization actions.","questions":[{"text":"Which current legal instruments govern carbadox-related residues in the destination market?","id":"dated-regulatory-determination-q01","kind":"provenance"},{"text":"What analyte, tissue, threshold and accepted method does each instrument specify?","id":"dated-regulatory-determination-q02","kind":"definition"},{"text":"What unresolved regulatory evidence prevents a use or residue-compliance determination?","id":"dated-regulatory-determination-q03","kind":"action"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of carbadox this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of carbadox this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of carbadox this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of carbadox this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of carbadox this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-regional-variation","name":"Regional variation","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these regional variation hold for the sense of carbadox this model covers, and on what evidence?","id":"evidence-regional-variation-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of carbadox this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain carbadox as a veterinary antibacterial for pigs and summarize regulatory decisions on it from official sources.","Report whether its use is permitted in a given jurisdiction."],"mustNot":["Recommend adding carbadox to feed where it is banned or without veterinary authorization.","Help hide carbadox use or residues in meat from inspectors or buyers.","Handle medicated feed without the protection its label requires.","Ignore withdrawal periods before slaughter."],"requiresHuman":["Any decision to use medicated feed in a herd."]},"ethics":{"considerations":["Residues of some veterinary drugs in meat raise cancer concerns for consumers.","Antibiotic use in livestock contributes to antimicrobial resistance."],"affectedParties":["Consumers of pork","Pigs","Farm workers"]},"owners":{"steward":"The prescribing veterinarian and the farmer; veterinary medicines regulators authorize its use.","roles":[],"masterSystems":["National veterinary medicines registers"]},"relations":[{"target":"Q11173","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.carbadox","Wikidata: Q1810456 (https://www.wikidata.org/wiki/Q1810456)"]},"properties":{"applicability":"required","items":["Chemical identity: Verified structural identifier, molecular formula, CAS number, PubChem CID and EC identifier where established","Carbadox assay: % mass fraction with as-received or dry basis, method and uncertainty","Related substances: Individual impurity identities and concentrations in mg/kg or % mass fraction","Physical and thermal condition: Observed phase and solid form; thermal events in °C with method and decomposition annotation","Solubility under analytical conditions: mg/L or g/L with solvent, pH, temperature and equilibration method","Storage and stability status: Within validated conditions, excursion, degraded or unassessed","Residue-analyte relationship: Parent carbadox, desoxycarbadox, QCA or another explicitly identified residue; matrix and supporting evidence","Analytical result: mg/kg or µg/kg with analyte, matrix, recovery, uncertainty, LOD and LOQ","Hazard and exposure-control basis: Endpoint-specific evidence, applicable GHS classification, SDS revision and exposure limit with jurisdiction, or explicitly unestablished","Applicable authorization: Jurisdiction, product, species, purpose, conditions, legal instrument, effective date and verification date"]},"recognition":{"applicability":"required","items":["Identified by feed or premix label and veterinary prescription rather than appearance."]},"capabilities":{"applicability":"required","items":["Verify a candidate material against a carbadox reference identity and suitable analytical evidence.","Assess a lot against documented assay, impurity and stability requirements.","Select a validated analytical method for a specified carbadox-related analyte and matrix.","Flag residue conclusions that exceed what the measured marker and method establish.","Retrieve applicable handling controls and identify missing hazard evidence.","Check a proposed use against dated, jurisdiction-specific authorization records."]},"hazards":{"applicability":"required","items":["Drug residues in meat.","Contribution to antimicrobial resistance.","Worker exposure during feed mixing."]},"interfaces":{"applicability":"required","items":["The Federal Food, Drug, and Cosmetic Act, enacted by the United States Congress and administered by the Food and Drug Administration, governs animal drug approval and medicated feed uses involving carbadox in the United States.","The Globally Harmonized System of Classification and Labelling of Chemicals, published by the United Nations Economic Commission for Europe, provides the framework for chemical hazard communication where implemented."]},"context":{"applicability":"required","items":["Carbadox is encountered in veterinary pharmaceutical research, medicated pig feed contexts, and testing for veterinary drug residues.","Its presence in a material does not establish that the material is authorised or suitable for a particular veterinary use."]}},"sources":[{"title":"Wikidata item Q1810456: carbadox","url":"https://www.wikidata.org/wiki/Q1810456","note":"identity and sense of the item"},{"title":"Wikipedia: Carbadox","url":"https://en.wikipedia.org/wiki/Carbadox","note":"general description of the item"}],"openQuestions":["Which CAS, EC and PubChem identifiers resolve to the intended carbadox structure, and do differing database records reflect stereochemical specificity or historical mappings?","Which authoritative measurements establish carbadox solid form, thermal decomposition, solubility and storage stability under explicitly stated conditions?","Which impurity specifications, certified reference materials and analytical methods are suitable for the intended material grade and sample matrices?","What current evidence establishes relationships among QCA, desoxycarbadox and the complete residue fraction of carcinogenic concern?","As of the intended decision date, which jurisdictions authorize the proposed carbadox use, and which hazard classifications, exposure limits, residue rules and regulatory methods apply?"],"resources":{"spec":"/models/things/publications/thing-q1810456/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q1810456/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T08:22:49Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:27+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}