{"schema":"https://ver.cy/schemas/card/1.0.0","id":"","code":"thing-q18252680","url":"https://ver.cy/models/thing/q18252680/","name":"NOG","alternateNames":[],"kind":"thing","status":"published","version":"0.2.0-wave.None","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.LIV"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"NOG is the human protein-coding gene for noggin, a secreted protein that binds bone morphogenetic proteins and blocks their signalling, which is important in embryonic development of the nervous system, bones and joints; variants in NOG are associated with inherited conditions involving joint fusion.","purpose":"Let an agent explain the NOG gene and its product noggin, relay function and curated disease associations from genomic sources, and keep the gene apart from the protein, from other BMP antagonists and from the everyday word noggin.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["The gene is not the protein: NOG names the gene, noggin the protein","Distinct from other BMP antagonists such as chordin and follistatin","Human gene, distinct from orthologues studied in frogs and mice","Not the informal English word noggin for the head"],"structure":{"bundles":[{"id":"gene-identity","name":"Gene identity","description":"Symbol, name and location.","layers":[{"id":"nomenclature","name":"Nomenclature","description":"Symbol and aliases.","findings":[{"id":"nomenclature-finding","name":"Nomenclature","description":"Symbol and aliases.","questions":[{"text":"What is the official symbol and name, and which aliases are in use?","kind":"definition"},{"text":"Which database holds the authoritative record?","kind":"provenance"}]}]},{"id":"locus","name":"Locus","description":"Chromosomal location.","findings":[{"id":"locus-finding","name":"Locus","description":"Chromosomal location.","questions":[{"text":"On which chromosome and band does NOG lie?","kind":"provenance"},{"text":"Which genome assembly is the location given against?","kind":"measurement"}]}]}]},{"id":"signalling","name":"Signalling","description":"Noggin and BMP.","layers":[{"id":"mechanism","name":"Mechanism","description":"Binding BMPs.","findings":[{"id":"mechanism-finding","name":"Mechanism","description":"Binding BMPs.","questions":[{"text":"How does noggin block bone morphogenetic protein signalling?","kind":"definition"},{"text":"Which BMPs does it bind most strongly?","kind":"provenance"}]}]},{"id":"antagonists","name":"Antagonists","description":"Related inhibitors.","findings":[{"id":"antagonists-finding","name":"Antagonists","description":"Related inhibitors.","questions":[{"text":"How does noggin differ from chordin and follistatin?","kind":"boundary"},{"text":"Which reference compares them?","kind":"provenance"}]}]}]},{"id":"development","name":"Development","description":"Role in the embryo.","layers":[{"id":"nervous-system","name":"Nervous system","description":"Neural induction.","findings":[{"id":"nervous-system-finding","name":"Nervous system","description":"Neural induction.","questions":[{"text":"What role does noggin play in forming the nervous system in embryos?","kind":"provenance"},{"text":"Which findings come from model organisms rather than humans?","kind":"boundary"}]}]},{"id":"skeleton","name":"Skeleton","description":"Bones and joints.","findings":[{"id":"skeleton-finding","name":"Skeleton","description":"Bones and joints.","questions":[{"text":"How does noggin shape joint and bone formation?","kind":"provenance"},{"text":"Which experiments support this?","kind":"provenance"}]}]}]},{"id":"clinical","name":"Clinical","description":"Associated conditions.","layers":[{"id":"conditions","name":"Conditions","description":"NOG-related disorders.","findings":[{"id":"conditions-finding","name":"Conditions","description":"NOG-related disorders.","questions":[{"text":"Which inherited conditions are associated with NOG variants in curated databases?","kind":"provenance"},{"text":"How are they inherited?","kind":"definition"}]}]},{"id":"variants","name":"Variants","description":"Interpretation.","findings":[{"id":"variants-finding","name":"Variants","description":"Interpretation.","questions":[{"text":"How is a NOG variant classified, and by whom?","kind":"provenance"},{"text":"Who may interpret a variant found in a patient?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Relay the gene's function and associations from curated databases and cite them.","Explain the difference between the gene, its protein and a variant."],"mustNot":["Interpret a person's genetic test result as a diagnosis.","Disclose or infer a named person's genetic data without consent.","State a variant is disease-causing without a curated classification."],"requiresHuman":["Clinical interpretation of a variant found in a patient.","Any genetic counselling decision."]},"ethics":{"considerations":["Inherited conditions affect relatives, so genetic findings carry family privacy stakes.","Families need accurate, non-alarming information about rare conditions."],"affectedParties":["People with NOG-related conditions","Their relatives","Researchers"]},"owners":{"steward":"Nobody owns the gene; the gene nomenclature authority maintains its official name and symbol.","roles":[],"masterSystems":["HGNC","NCBI Gene","Ensembl","UniProt","OMIM"]},"relations":[{"target":"Q20747295","type":"parent","note":"registry parent class"},{"target":"protein-coding gene","type":"related"},{"target":"chordin","type":"related","note":"another BMP antagonist with a similar developmental role"},{"target":"noggin (protein)","type":"related","note":"the product, not the gene"},{"target":"bone morphogenetic protein","type":"related","note":"the signals it binds and blocks"}],"interaction":{"identity":{"applicability":"required","items":["Wikidata: Q18252680 (https://www.wikidata.org/wiki/Q18252680)","Wikidata: Q18252680 registry item","HGNC symbol: NOG official human gene symbol","HGNC ID: HGNC: followed by digits look up in the HGNC database","NCBI Gene ID: digits only look up in NCBI Gene"]},"properties":{"applicability":"required","items":["kind: protein-coding gene note","organism: Homo sapiens note","product: noggin, a secreted BMP antagonist note"]},"recognition":{"applicability":"required","items":["Official HGNC symbol NOG in human gene records","Protein named noggin","Described as an antagonist of bone morphogenetic proteins"]},"capabilities":{"applicability":"required","items":["identify the gene and its official symbol","relay the function of noggin","relay curated disease associations","distinguish it from other BMP antagonists","point to authoritative gene records"]},"hazards":{"applicability":"required","items":["Confusing the gene with the protein or with other BMP antagonists","Treating a variant of uncertain significance as causal","Misusing personal genetic data"]},"interfaces":{"applicability":"required","items":["HGNC gene nomenclature rules","Genetic data protection under health and privacy law","Clinical variant classification guidance from professional genetics bodies"]},"context":{"applicability":"required","items":["Encoding noggin, which regulates bone morphogenetic protein signalling during development.","BMP antagonists","orthologues in vertebrates"]}},"sources":[{"title":"Wikidata item Q18252680: NOG","url":"https://www.wikidata.org/wiki/Q18252680","note":"identity and sense of the item"},{"title":"Wikipedia: Noggin (protein)","url":"https://en.wikipedia.org/wiki/Noggin_%28protein%29","note":"general description of the item"}],"openQuestions":["Should NOG-related conditions be grouped as one spectrum entry?","Should the protein have its own linked entry?","How should orthologues in model organisms be linked?"],"resources":{"spec":"/models/things/publications/thing-q18252680/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q18252680/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-10-06T10:46:19Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-09T07:29:59+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}