{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.cell-adhesion","code":"thing-q187640","url":"https://ver.cy/models/thing/q187640/","name":"cell adhesion","alternateNames":["cell adhesion involved in prostatic bud elongation","cell-substrate adhesion","cell adhesion mediated by integrin","cell adhesion involved in heart morphogenesis","cell-cell adhesion","cell adhesion involved in retrograde extension","cell adhesion involved in sprouting angiogenesis","bacterial adhesion"],"kind":"thing","status":"published","version":"0.2.0-wave.4","language":"en","classifiers":{"family":"Thing Registry","category":"Activities and processes","entryKind":"thing","plane":"ACT","domain":["ACT.PRC"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"The process by which cells attach to each other or to the extracellular matrix through adhesion molecules such as cadherins, integrins, selectins and immunoglobulin superfamily proteins, comprising cell-cell adhesion and cell-substrate adhesion, including integrin-mediated adhesion, and contributing to development in processes such as heart morphogenesis, prostatic bud elongation and retrograde extension of neurons, as annotated in the Gene Ontology; cell adhesion underlies tissue structure, immunity, wound healing and cancer metastasis.","purpose":"Let an agent explain cell adhesion and its molecular basis, relay adhesion molecule families, mechanisms and roles in development and disease from cell biology sources, describe the Gene Ontology sub-processes the registry aliases name, and distinguish cell adhesion from cell junctions as structures, from cell migration and from aggregation of non-living particles.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Adhesion molecules","Cell-cell and cell-matrix","Developmental roles","Disease relevance"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What cell adhesion is.","layers":[{"id":"definition","name":"Definition","description":"Definition.","findings":[{"id":"definition-finding","name":"Definition","description":"Definition.","questions":[{"text":"What is cell adhesion, and how does it differ from junctions, migration and particle aggregation?","kind":"definition"},{"text":"Is the question about molecules, mechanisms, development, disease or ontology terms?","kind":"boundary"}]}]},{"id":"kinds","name":"Kinds","description":"Kinds.","findings":[{"id":"kinds-finding","name":"Kinds","description":"Kinds.","questions":[{"text":"What are cell-cell, cell-substrate and integrin-mediated adhesion, and the developmental sub-processes named in the Gene Ontology?","kind":"definition"},{"text":"Which entry fits the specific kind?","kind":"action"}]}]}]},{"id":"molecules","name":"Molecules","description":"Molecules and mechanisms.","layers":[{"id":"families","name":"Families","description":"Molecule families.","findings":[{"id":"families-finding","name":"Families","description":"Families.","questions":[{"text":"How do cadherins, integrins, selectins and Ig superfamily molecules bind?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"signalling","name":"Signalling","description":"Signalling.","findings":[{"id":"signalling-finding","name":"Signalling","description":"Signalling.","questions":[{"text":"How does adhesion signal into the cell and connect to the cytoskeleton?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]}]},{"id":"biology","name":"Biology","description":"Development and disease.","layers":[{"id":"development","name":"Development","description":"Development.","findings":[{"id":"development-finding","name":"Development","description":"Development.","questions":[{"text":"How does adhesion drive morphogenesis, such as heart formation and prostatic bud elongation?","kind":"provenance"},{"text":"Which entry fits morphogenesis?","kind":"action"}]}]},{"id":"disease","name":"Disease","description":"Disease.","findings":[{"id":"disease-finding","name":"Disease","description":"Disease.","questions":[{"text":"How do adhesion changes contribute to metastasis, inflammation and genetic disorders?","kind":"provenance"},{"text":"Which entry fits metastasis?","kind":"action"}]}]}]},{"id":"context","name":"Context","description":"Methods and history.","layers":[{"id":"methods","name":"Methods","description":"Methods.","findings":[{"id":"methods-finding","name":"Methods","description":"Methods.","questions":[{"text":"How is cell adhesion measured in the laboratory?","kind":"provenance"},{"text":"Which entry fits cell adhesion assay?","kind":"action"}]}]},{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How did Holtfreter, Steinberg and later molecular work establish the field?","kind":"provenance"},{"text":"Which entry fits the history of cell biology?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Explain cell adhesion and its main molecule families in general terms, citing sources.","Summarise research on adhesion in disease, such as cancer spread, with references."],"mustNot":["Present laboratory findings as proven treatments for people.","Misstate or fabricate experimental data on adhesion molecules.","Promote unapproved therapies based on adhesion research."],"requiresHuman":["Using research results to make clinical decisions."]},"ethics":{"considerations":["Research on adhesion feeds cancer and immune treatments; overstated findings raise false hope.","Animal and human tissue research needs proper consent and oversight."],"affectedParties":["Patients","Researchers","Research animals"]},"owners":{"steward":"Nobody owns the process; the scientific community studies it.","roles":[],"masterSystems":[]},"relations":[{"target":"Q14873025","type":"parent","note":"registry parent class"},{"target":"cellular process or phenomenon","type":"related","note":"in registry terms"},{"target":"cell adhesion molecule","type":"related","note":"such as cadherins and integrins"},{"target":"cell junction","type":"related","note":"as structures"},{"target":"Gene Ontology","type":"related","note":"as GO:0007155"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.cell-adhesion","Wikidata: Q187640 (https://www.wikidata.org/wiki/Q187640)","GO: GO:0007155 cell adhesion","MeSH: D002448 Cell Adhesion"]},"properties":{"applicability":"not-applicable","items":["major molecule families: cadherins, integrins, selectins, Ig superfamily list","Gene Ontology term: GO:0007155 note - cell adhesion","integrin heterodimers, human: 24 count"]},"recognition":{"applicability":"optional","items":["Attachment of cells to cells or matrix","Cell-cell adhesion, cell-substrate adhesion, integrin-mediated adhesion, adhesion in heart morphogenesis and prostatic bud elongation","Junctions are the structures; migration is movement; particle aggregation is non-living","Not a visible object; cells attached to each other or to a matrix."]},"capabilities":{"applicability":"required","items":["explain the process","relay molecular mechanisms","describe developmental roles","distinguish related concepts"]},"hazards":{"applicability":"required","items":["Confusing adhesion with junction structures","Registry aliases naming narrow GO sub-terms","Overgeneralising from one molecule family"]},"interfaces":{"applicability":"required","items":["Gene Ontology annotation standards"]},"context":{"applicability":"required","items":["Not applicable; a cellular process.","cell-cell adhesion via cadherins and others","cell-substrate adhesion via integrins","selectin-mediated leukocyte adhesion","adhesion in morphogenesis such as heart and prostate development","adhesion in neuronal extension","adhesion in cancer and immunity"]}},"sources":[{"title":"Wikidata item Q187640: cell adhesion","url":"https://www.wikidata.org/wiki/Q187640","note":"identity and sense of the item"},{"title":"Wikipedia: Cell adhesion","url":"https://en.wikipedia.org/wiki/Cell_adhesion","note":"general description of the item"}],"openQuestions":["Should cell-cell and cell-substrate adhesion be separate primary entries?","How should cell biology sources be linked?","The registry entry has merged aliases naming specific GO sub-processes; should they be grouped?"],"resources":{"spec":"/models/things/publications/thing-q187640/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q187640/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-13T15:04:03Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:51:55+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane ACT: no invented physical properties."},"score":1.0}}