{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.cell-migration","code":"thing-q189092","url":"https://ver.cy/models/thing/q189092/","name":"cell migration","alternateNames":["leukocyte migration","germ cell migration","migracytosis","neuron migration","glial cell migration","ameboidal-type cell migration","muscle cell migration","wound healing, spreading of cells","skeletal muscle satellite cell migration","cell migration involved in heart development","forebrain cell migration","hypothalamus cell migration"],"kind":"thing","status":"published","version":"0.2.0-wave.3","language":"en","classifiers":{"family":"Thing Registry","category":"Activities and processes","entryKind":"thing","plane":"ACT","domain":["ACT.PRC"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"The directed movement of cells from one place to another, essential to embryonic development, immune responses, wound healing and tissue maintenance, and involved in cancer spread; cells migrate by crawling on surfaces or through tissues using the cytoskeleton, adhesion and signalling cues, in modes such as amoeboid, mesenchymal and collective migration.","purpose":"Let an agent explain cell migration and its modes, relay mechanisms and roles in development, immunity, healing and disease from cell biology sources, and route clinical questions about cancer spread to clinicians.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Active, directed cell movement","Driven by cytoskeleton and adhesion","Guided by chemical and physical cues","Central to development, immunity and metastasis"],"structure":{"bundles":[{"id":"mechanism","name":"Mechanism","description":"How cells move.","layers":[{"id":"machinery","name":"Machinery","description":"Cytoskeleton and adhesion.","findings":[{"id":"machinery-finding","name":"Machinery","description":"Machinery.","questions":[{"text":"How do the cytoskeleton, adhesions and membrane protrusions move a cell?","kind":"definition"},{"text":"Is the question about active migration or passive transport?","kind":"boundary"}]}]},{"id":"guidance","name":"Guidance","description":"Guidance cues.","findings":[{"id":"guidance-finding","name":"Guidance","description":"Guidance.","questions":[{"text":"How do chemical gradients, stiffness and other cues direct migration?","kind":"provenance"},{"text":"Which entry fits chemotaxis?","kind":"action"}]}]}]},{"id":"modes","name":"Modes","description":"Kinds of migration.","layers":[{"id":"single","name":"Single","description":"Single-cell modes.","findings":[{"id":"single-finding","name":"Single","description":"Single.","questions":[{"text":"How do amoeboid and mesenchymal migration differ?","kind":"definition"},{"text":"Which entry fits a specific cell type?","kind":"action"}]}]},{"id":"collective","name":"Collective","description":"Collective migration.","findings":[{"id":"collective-finding","name":"Collective","description":"Collective.","questions":[{"text":"How do groups of cells migrate together in development and healing?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]}]},{"id":"roles","name":"Roles","description":"Roles in biology and disease.","layers":[{"id":"normal","name":"Normal","description":"Development, immunity, healing.","findings":[{"id":"normal-finding","name":"Normal","description":"Normal.","questions":[{"text":"What roles does migration play in development, immune responses and wound healing?","kind":"provenance"},{"text":"Which entry fits wound healing?","kind":"action"}]}]},{"id":"disease","name":"Disease","description":"Disease.","findings":[{"id":"disease-finding","name":"Disease","description":"Disease.","questions":[{"text":"How does migration contribute to metastasis and developmental disorders, in general terms?","kind":"provenance"},{"text":"Is the user asking about their own diagnosis, which needs a clinician?","kind":"boundary"}]}]}]},{"id":"study","name":"Study","description":"Methods and teaching.","layers":[{"id":"methods","name":"Methods","description":"Methods.","findings":[{"id":"methods-finding","name":"Methods","description":"Methods.","questions":[{"text":"How is migration studied, from live imaging to migration assays and modelling?","kind":"provenance"},{"text":"How is migration measured?","kind":"measurement"}]}]},{"id":"teach","name":"Teach","description":"Teaching.","findings":[{"id":"teach-finding","name":"Teach","description":"Teaching.","questions":[{"text":"How is cell migration taught in cell biology?","kind":"action"},{"text":"Which misconceptions arise?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain cell migration in development, immunity, wound healing and cancer spread.","Report research findings with their limits."],"mustNot":["Present laboratory findings as treatments for cancer.","Promote unproven therapies claimed to stop cancer spread.","Give a person a prognosis based on cell migration research."],"requiresHuman":["Use of human cells or tissue in research."]},"ethics":{"considerations":["Cancer patients are vulnerable to overstated claims.","Human cells come from donors who must consent."],"affectedParties":["Cancer patients","Tissue donors","Researchers"]},"owners":{"steward":"Nobody owns the process; it belongs to biology.","roles":[],"masterSystems":[]},"relations":[{"target":"Q14873676","type":"parent","note":"registry parent class"},{"target":"cell motility","type":"related","note":"the general category"},{"target":"morphogenesis","type":"related","note":"a developmental role"},{"target":"immune system","type":"related","note":"leukocyte trafficking"},{"target":"metastasis","type":"related","note":"cancer cell spread"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.cell-migration","Wikidata: Q189092 (https://www.wikidata.org/wiki/Q189092)","Gene Ontology: GO:0016477 cell migration"]},"properties":{"applicability":"not-applicable","items":["speed: about 0.1-20 micrometres per minute - immune cells fastest"]},"recognition":{"applicability":"optional","items":["Cells moving directionally","Modes: amoeboid, mesenchymal, collective","Passive transport in blood and cell division are different processes","Not visible to the eye; under the microscope cells extending protrusions and crawling."]},"capabilities":{"applicability":"required","items":["explain mechanisms and modes","describe roles in development, immunity and healing","explain involvement in cancer metastasis in general terms","relay methods used to study migration"]},"hazards":{"applicability":"required","items":["Metastasis when cancer cells migrate","Developmental disorders from failed migration","Agents giving clinical advice"]},"interfaces":{"applicability":"required","items":["Gene Ontology definitions","Research ethics rules for animal and human tissue studies"]},"context":{"applicability":"required","items":["Moving cells to where they are needed in development, defence and repair.","leukocyte migration","neuronal and glial migration in the developing brain","germ cell migration","collective migration of cell sheets","amoeboid and mesenchymal single-cell migration","cancer cell invasion"]}},"sources":[{"title":"Wikidata item Q189092: cell migration","url":"https://www.wikidata.org/wiki/Q189092","note":"identity and sense of the item"},{"title":"Wikipedia: Cell migration","url":"https://en.wikipedia.org/wiki/Cell_migration","note":"general description of the item"}],"openQuestions":["Should each migration mode be a separate entry?","How should Gene Ontology terms be linked?","The registry entry has merged aliases for specific cell types; should they be split off?"],"resources":{"spec":"/models/things/publications/thing-q189092/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q189092/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T20:28:17Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:51:56+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane ACT: no invented physical properties."},"score":1.0}}