{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.cell-population-proliferation","code":"thing-q189101","url":"https://ver.cy/models/thing/q189101/","name":"cell population proliferation","alternateNames":["hemocyte proliferation","Leydig cell proliferation","fibroblast proliferation","mesenchymal cell proliferation","myoblast proliferation","inner cell mass cell proliferation","stem cell proliferation","neural precursor cell proliferation","trophectodermal cell proliferation","cell proliferation involved in heart valve development","chondrocyte proliferation","epithelial cell proliferation"],"kind":"thing","status":"published","version":"0.2.0-wave.2","language":"en","classifiers":{"family":"Thing Registry","category":"Activities and processes","entryKind":"thing","plane":"ACT","domain":["ACT.PRC"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"The multiplication of cells resulting in the expansion of a cell population, through cell division and survival, occurring in development, tissue growth and repair, immune responses and blood cell formation, in specific cell types such as fibroblasts, myoblasts, mesenchymal cells, Leydig cells, hemocytes and inner cell mass cells, and in cell culture; proliferation is regulated by growth factors and cell cycle controls, and its dysregulation underlies cancer.","purpose":"Let an agent explain cell proliferation and its regulation, describe its roles in development, repair and immunity, relate proliferation to cancer and therapy in general terms, and support learning in cell biology.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Cell division","Population increase","Regulation","Cancer link"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What proliferation is.","layers":[{"id":"concept","name":"Concept","description":"Concept and cell cycle.","findings":[{"id":"concept-finding","name":"Concept","description":"Concept.","questions":[{"text":"What is cell proliferation, and how do the cell cycle and its checkpoints control it?","kind":"definition"},{"text":"Which cell type or context is meant?","kind":"boundary"}]}]},{"id":"regulation","name":"Regulation","description":"Regulation.","findings":[{"id":"regulation-finding","name":"Regulation","description":"Regulation.","questions":[{"text":"How do growth factors, signalling pathways and contact inhibition regulate proliferation?","kind":"definition"},{"text":"Which entry fits cell signalling?","kind":"action"}]}]}]},{"id":"roles","name":"Roles","description":"Roles in organisms.","layers":[{"id":"development","name":"Development","description":"Development and repair.","findings":[{"id":"development-finding","name":"Development","description":"Development.","questions":[{"text":"How does proliferation drive embryonic development, tissue renewal and wound repair?","kind":"provenance"},{"text":"Which entry fits a specific tissue?","kind":"action"}]}]},{"id":"immune","name":"Immune","description":"Immune and blood cells.","findings":[{"id":"immune-finding","name":"Immune","description":"Immune.","questions":[{"text":"How do lymphocytes and blood cell precursors proliferate in immune responses and haematopoiesis?","kind":"provenance"},{"text":"Which entry fits immunology?","kind":"action"}]}]}]},{"id":"disease","name":"Disease","description":"Disease and research.","layers":[{"id":"cancer","name":"Cancer","description":"Proliferation and cancer.","findings":[{"id":"cancer-finding","name":"Cancer","description":"Cancer.","questions":[{"text":"How does dysregulated proliferation cause cancer, and how do therapies target it, in general terms?","kind":"provenance"},{"text":"Is the user asking about their own treatment, which needs a clinician?","kind":"boundary"}]}]},{"id":"assays","name":"Assays","description":"Measuring proliferation.","findings":[{"id":"assays-finding","name":"Assays","description":"Assays.","questions":[{"text":"How is proliferation measured in research and diagnostics?","kind":"provenance"},{"text":"Which entry fits a specific assay?","kind":"action"}]}]}]},{"id":"learn","name":"Learn","description":"History and teaching.","layers":[{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How were cell division and its regulation discovered?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"teach","name":"Teach","description":"Teaching.","findings":[{"id":"teach-finding","name":"Teach","description":"Teaching.","questions":[{"text":"How can proliferation be taught in cell biology?","kind":"action"},{"text":"Which misconceptions arise?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain cell proliferation in development, healing, immunity and disease.","Analyse proliferation data in research it is authorized to work on."],"mustNot":["Present laboratory proliferation findings as proof of a cure.","Interpret a person's test results as a cancer diagnosis.","Promote unproven products that claim to control cell growth.","Fabricate or selectively report experimental data."],"requiresHuman":["Using research findings in decisions about a patient's treatment."]},"ethics":{"considerations":["Uncontrolled proliferation is cancer; false hope from overstated results harms patients.","Cell lines and samples come from people whose consent must be respected."],"affectedParties":["Patients","Tissue donors","Researchers"]},"owners":{"steward":"Nobody owns the process; researchers answer for their data and samples.","roles":[],"masterSystems":[]},"relations":[{"target":"Q14873025","type":"parent","note":"registry parent class"},{"target":"Q9073584","type":"parent","note":"registry parent class"},{"target":"cellular process or phenomenon","type":"related","note":"category"},{"target":"epithelium","type":"related","note":"renewing tissues"},{"target":"adenoma","type":"related","note":"abnormal proliferation"},{"target":"gestation","type":"related","note":"embryonic proliferation"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.cell-population-proliferation","Wikidata: Q189101 (https://www.wikidata.org/wiki/Q189101)"]},"properties":{"applicability":"not-applicable","items":[]},"recognition":{"applicability":"optional","items":["Increase in cell number by division","Regulated by growth factors and cell cycle","Cell growth is increase in size; differentiation is change in type","Not visible; measured in culture and tissue."]},"capabilities":{"applicability":"required","items":["explain proliferation and regulation","describe roles","relate to cancer generally","support learning"]},"hazards":{"applicability":"required","items":["Agents giving medical advice on cancer","Confusing proliferation with growth or differentiation","Assay artefacts"]},"interfaces":{"applicability":"required","items":["Cell biology nomenclature and ontologies","Laboratory standards for proliferation assays","Research ethics for cell and tissue work"]},"context":{"applicability":"required","items":["Multiplication of cells expanding a population.","proliferation in development","proliferation in tissue repair","immune cell proliferation","proliferation of specific cell types such as fibroblasts and myoblasts","proliferation in cell culture"]}},"sources":[{"title":"Wikidata item Q189101: cell population proliferation","url":"https://www.wikidata.org/wiki/Q189101","note":"identity and sense of the item"},{"title":"Wikipedia: Cell proliferation","url":"https://en.wikipedia.org/wiki/Cell_proliferation","note":"general description of the item"}],"openQuestions":["Should the cell cycle be a separate entry?","How should ontologies be linked?","How should cancer resources be linked?"],"resources":{"spec":"/models/things/publications/thing-q189101/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q189101/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T03:00:56Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:51:56+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane ACT: no invented physical properties."},"score":1.0}}