{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.rhabdomyosarcoma","code":"thing-q1898141","url":"https://ver.cy/models/thing/q1898141/","name":"rhabdomyosarcoma","alternateNames":["childhood pleomorphic rhabdomyosarcoma","Childhood Rhabdomyosarcoma","pleomorphic rhabdomyosarcoma","bile duct rhabdomyosarcoma","central nervous system rhabdomyosarcoma","mediastinum rhabdomyosarcoma","gallbladder rhabdomyosarcoma","ovary rhabdomyosarcoma","mixed type rhabdomyosarcoma","anus rhabdomyosarcoma","rhabdomyosarcoma recurrent","adult rhabdomyosarcoma"],"kind":"thing","status":"published","version":"0.2.0-wave.4","language":"en","classifiers":{"family":"Thing Registry","category":"Cross-cutting context","entryKind":"thing","plane":"XCT","domain":["XCT.STA"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A malignant soft tissue sarcoma arising from cells destined to form skeletal muscle, the most common soft tissue sarcoma of childhood, occurring in sites such as the head and neck, genitourinary tract, extremities and rarely the bile ducts, mediastinum or central nervous system, with subtypes including embryonal, alveolar, spindle cell and pleomorphic rhabdomyosarcoma, the last mainly in adults but also in children; treatment combines chemotherapy, surgery and radiotherapy under specialist teams. The model gives general information and routes people to clinicians.","purpose":"Let an agent explain rhabdomyosarcoma, relay biology, subtypes, diagnosis, treatment and prognosis from paediatric oncology sources in general terms, describe the subtypes and sites the registry aliases name, and distinguish it from other soft tissue sarcomas, rhabdomyoma and Ewing sarcoma, supporting families compassionately and routing to specialists.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Muscle lineage","Childhood predominance","Many sites","Fusion status matters"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What rhabdomyosarcoma is.","layers":[{"id":"definition","name":"Definition","description":"Definition.","findings":[{"id":"definition-finding","name":"Definition","description":"Definition.","questions":[{"text":"What is rhabdomyosarcoma, and how does it differ from other sarcomas, rhabdomyoma and Ewing sarcoma?","kind":"definition"},{"text":"Is a family facing a diagnosis, needing their specialist team and support services?","kind":"boundary"}]}]},{"id":"subtypes","name":"Subtypes","description":"Subtypes and sites.","findings":[{"id":"subtypes-finding","name":"Subtypes","description":"Subtypes.","questions":[{"text":"What are embryonal, alveolar and pleomorphic subtypes, and rare sites such as bile duct and CNS?","kind":"definition"},{"text":"Which entry fits the specific subtype?","kind":"action"}]}]}]},{"id":"biology","name":"Biology","description":"Biology and diagnosis.","layers":[{"id":"genetics","name":"Genetics","description":"Genetics.","findings":[{"id":"genetics-finding","name":"Genetics","description":"Genetics.","questions":[{"text":"How do fusion-positive and fusion-negative tumours differ?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"diagnosis","name":"Diagnosis","description":"Diagnosis and staging.","findings":[{"id":"diagnosis-finding","name":"Diagnosis","description":"Diagnosis.","questions":[{"text":"How is rhabdomyosarcoma diagnosed and risk-grouped, in general terms?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]}]},{"id":"care","name":"Care","description":"Treatment.","layers":[{"id":"treatment","name":"Treatment","description":"Treatment.","findings":[{"id":"treatment-finding","name":"Treatment","description":"Treatment.","questions":[{"text":"What general treatment approaches do protocols describe?","kind":"provenance"},{"text":"Which entry fits childhood cancer treatment?","kind":"action"}]}]},{"id":"late","name":"Late effects","description":"Survivorship.","findings":[{"id":"late-finding","name":"Late effects","description":"Late effects.","questions":[{"text":"What late effects and follow-up care do survivors need, in general terms?","kind":"provenance"},{"text":"Which entry fits cancer survivorship?","kind":"action"}]}]}]},{"id":"context","name":"Context","description":"Support and research.","layers":[{"id":"support","name":"Support","description":"Support.","findings":[{"id":"support-finding","name":"Support","description":"Support.","questions":[{"text":"What support exists for children and families?","kind":"provenance"},{"text":"Which entry fits childhood cancer support organisations?","kind":"action"}]}]},{"id":"research","name":"Research","description":"Research.","findings":[{"id":"research-finding","name":"Research","description":"Research.","questions":[{"text":"What research and trials are underway, as reported?","kind":"provenance"},{"text":"Which entry fits paediatric oncology research?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Explain rhabdomyosarcoma, its subtypes and general treatment approach from oncology sources.","Point families to specialist children's cancer and sarcoma services."],"mustNot":["Give a person or family individual treatment or prognosis advice in place of their care team.","Frame prognosis insensitively or give survival figures for a named child.","Promote unproven alternative treatments in place of specialist care.","Mix subtypes and sites in the registry aliases as one disease."],"requiresHuman":["Any decision about a named patient's care or trial participation."]},"ethics":{"considerations":["It is the most common soft tissue sarcoma of childhood, so families need careful information.","Delayed diagnosis worsens outcomes."],"affectedParties":["Children and families","Adult patients","Care teams"]},"owners":{"steward":"Nobody owns the condition; oncology bodies and specialist centres set guidance.","roles":[],"masterSystems":["National cancer registries"]},"relations":[{"target":"Q18556167","type":"parent","note":"registry parent class"},{"target":"Q5097977","type":"parent","note":"registry parent class"},{"target":"skeletal muscle cancer","type":"related","note":"in registry terms"},{"target":"paediatric oncology","type":"related","note":"in registry terms"},{"target":"rhabdomyoma","type":"related","note":"benign"},{"target":"Ewing sarcoma","type":"related"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.rhabdomyosarcoma","Wikidata: Q1898141 (https://www.wikidata.org/wiki/Q1898141)","ICD-O: 8900/3 rhabdomyosarcoma","MeSH: D012208 Rhabdomyosarcoma"]},"properties":{"applicability":"not-applicable","items":["share of childhood cancers: about 3 percent","alveolar fusion: PAX3 or PAX7 with FOXO1 note","described: 1854 year - Weber"]},"recognition":{"applicability":"optional","items":["Sarcoma of skeletal muscle lineage","Childhood and pleomorphic rhabdomyosarcoma, bile duct, CNS and mediastinal sites","Other sarcomas have other lineages; rhabdomyoma is benign; Ewing sarcoma has different genetics","Not a visible object; a soft tissue tumour."]},"capabilities":{"applicability":"required","items":["explain the disease","relay treatment in general terms","route to specialists and support","distinguish related tumours"]},"hazards":{"applicability":"required","items":["Agents giving personal medical advice","Insensitive framing of prognosis","Registry aliases mixing subtypes and sites"]},"interfaces":{"applicability":"required","items":["Paediatric oncology protocols such as COG and EpSSG","Clinical trial regulations"]},"context":{"applicability":"required","items":["Not applicable; a cancer.","embryonal rhabdomyosarcoma","alveolar rhabdomyosarcoma","spindle cell and sclerosing rhabdomyosarcoma","pleomorphic rhabdomyosarcoma","rhabdomyosarcoma by site such as bile duct, CNS and mediastinum"]}},"sources":[{"title":"Wikidata item Q1898141: rhabdomyosarcoma","url":"https://www.wikidata.org/wiki/Q1898141","note":"identity and sense of the item"},{"title":"Wikipedia: Rhabdomyosarcoma","url":"https://en.wikipedia.org/wiki/Rhabdomyosarcoma","note":"general description of the item"}],"openQuestions":["Should embryonal and alveolar rhabdomyosarcoma be separate primary entries?","How should oncology sources be linked?","The registry entry has merged aliases naming sites; should they be grouped?"],"resources":{"spec":"/models/things/publications/thing-q1898141/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q1898141/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-13T19:07:11Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:51:56+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane XCT: no invented physical properties."},"score":1.0}}