{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.hematopoietic-system-disease","code":"thing-q1963588","url":"https://ver.cy/models/thing/q1963588/","name":"hematopoietic system disease","alternateNames":["EBV-positive T-cell lymphoproliferative disorder of childhood","hemic system symptom","hematopoietic system symptom","microcytosis","chromosome 7 abnormalities in blood disorders","hemodilution","hemoconcentration","hyperviscosity syndrome","elevated alkaline phosphatase","blood group incompatibility","bone marrow disease","blood protein disease"],"kind":"thing","status":"published","version":"0.2.0-wave.3","language":"en","classifiers":{"family":"Thing Registry","category":"Information and virtual systems","entryKind":"thing","plane":"INF","domain":["INF.KNW"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Any disease or disorder of the blood-forming and blood tissues, including the bone marrow, blood cells and related organs, such as anaemias, leukaemias, lymphomas and lymphoproliferative disorders, clotting and platelet disorders and bone marrow failure; signs such as microcytosis and chromosomal abnormalities found in blood disorders are findings rather than diseases themselves. These conditions are diagnosed by blood tests, marrow examination and genetics and treated in haematology.","purpose":"Let an agent explain haematopoietic system diseases as a category, relay classification, common signs and diagnostic principles from clinical sources, distinguish diseases from laboratory signs and from artefacts such as haemodilution, and route personal questions to clinicians.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Blood and marrow origin","Diagnosis by blood and marrow tests","Benign and malignant forms","Genetic markers"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What the category covers.","layers":[{"id":"definition","name":"Definition","description":"Definition and kinds.","findings":[{"id":"definition-finding","name":"Definition","description":"Definition.","questions":[{"text":"What are haematopoietic system diseases, and what kinds exist?","kind":"definition"},{"text":"Is the user asking about their own results or symptoms, which need a clinician?","kind":"boundary"}]}]},{"id":"signs","name":"Signs","description":"Signs and findings.","findings":[{"id":"signs-finding","name":"Signs","description":"Signs.","questions":[{"text":"What signs and laboratory findings point to blood disorders, and how do findings differ from diseases?","kind":"definition"},{"text":"Which entry fits the specific disorder?","kind":"action"}]}]}]},{"id":"clinical","name":"Clinical","description":"Diagnosis and care.","layers":[{"id":"diagnosis","name":"Diagnosis","description":"Diagnosis.","findings":[{"id":"diagnosis-finding","name":"Diagnosis","description":"Diagnosis.","questions":[{"text":"How are blood disorders diagnosed with blood counts, marrow examination and genetics?","kind":"provenance"},{"text":"Is the presentation free of personal medical advice?","kind":"boundary"}]}]},{"id":"care","name":"Care","description":"Treatment principles.","findings":[{"id":"care-finding","name":"Care","description":"Care.","questions":[{"text":"What treatment principles apply across the category, in general terms?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]}]},{"id":"classify","name":"Classify","description":"Classification.","layers":[{"id":"classification","name":"Classification","description":"Classifications.","findings":[{"id":"classification-finding","name":"Classification","description":"Classification.","questions":[{"text":"How do ICD and WHO classifications organise blood diseases?","kind":"provenance"},{"text":"Which entry fits the classification system?","kind":"action"}]}]},{"id":"genetics","name":"Genetics","description":"Genetic markers.","findings":[{"id":"genetics-finding","name":"Genetics","description":"Genetics.","questions":[{"text":"What role do chromosomal and molecular abnormalities play in diagnosis and prognosis?","kind":"provenance"},{"text":"Which entry fits cancer genetics?","kind":"action"}]}]}]},{"id":"context","name":"Context","description":"Burden and research.","layers":[{"id":"burden","name":"Burden","description":"Burden.","findings":[{"id":"burden-finding","name":"Burden","description":"Burden.","questions":[{"text":"What do studies report about the burden of blood disorders, with sources?","kind":"measurement"},{"text":"Which sources are cited?","kind":"provenance"}]}]},{"id":"research","name":"Research","description":"Research.","findings":[{"id":"research-finding","name":"Research","description":"Research.","questions":[{"text":"What are current research directions, such as cell and gene therapies?","kind":"provenance"},{"text":"Which entry fits haematology?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Explain blood disorders in general terms from medical sources.","Help people understand test reports and prepare questions for their clinician."],"mustNot":["Diagnose a blood disorder or interpret a person's results as a diagnosis.","Recommend stopping, starting or changing treatment such as transfusion or chemotherapy.","Promote unproven cures for leukaemia, lymphoma or other blood cancers.","Share a patient's diagnosis or genetic findings without consent."],"requiresHuman":["Any decision about treatment, transfusion or bone marrow transplant."]},"ethics":{"considerations":["Blood cancers and serious anaemias are life-threatening; false hope and bad advice cost lives.","Some blood disorders are inherited, so information about one person touches their family."],"affectedParties":["Patients","Families and carers","Blood and marrow donors"]},"owners":{"steward":"Nobody owns a disease; clinicians and health services keep patient records, and disease registries record cases.","roles":[],"masterSystems":["Cancer and disease registries","Bone marrow donor registries"]},"relations":[{"target":"Q169872","type":"parent","note":"registry parent class"},{"target":"Q18557436","type":"parent","note":"registry parent class"},{"target":"disease of anatomical entity","type":"related","note":"in registry terms"},{"target":"symptom","type":"related","note":"in registry terms, for the sign aliases"},{"target":"bone marrow","type":"related","note":"and blood"},{"target":"hematology","type":"related","note":"the specialty"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.hematopoietic-system-disease","Wikidata: Q1963588 (https://www.wikidata.org/wiki/Q1963588)","ICD-10: D50-D89 diseases of blood and blood-forming organs, with cancers in C81-C96","ICD-11: chapter 3 diseases of the blood or blood-forming organs"]},"properties":{"applicability":"not-applicable","items":[]},"recognition":{"applicability":"optional","items":["Disease of blood-forming tissue and blood","Anaemias, blood cancers, clotting and marrow disorders","Microcytosis and haemodilution are findings, not diseases; immune diseases are a related category","Not a visible object; presentations include fatigue, pallor, bleeding, infections and enlarged nodes or spleen."]},"capabilities":{"applicability":"required","items":["explain the category and its kinds","relay classification and diagnostic principles","distinguish diseases from signs and artefacts","route personal questions to clinicians"]},"hazards":{"applicability":"required","items":["Delayed diagnosis","Confusing findings with diseases","Agents giving personal medical advice"]},"interfaces":{"applicability":"required","items":["WHO classification of haematolymphoid tumours","Clinical guidelines from haematology societies","Laboratory standards for blood testing"]},"context":{"applicability":"required","items":["Not applicable; a category of disease.","anaemias and red cell disorders","leukaemias, lymphomas and lymphoproliferative disorders including EBV-positive childhood disorders","platelet and clotting disorders","bone marrow failure syndromes","chromosomal abnormalities in blood disorders such as those of chromosome 7","laboratory findings such as microcytosis and haemodilution, listed as aliases"]}},"sources":[{"title":"Wikidata item Q1963588: hematopoietic system disease","url":"https://www.wikidata.org/wiki/Q1963588","note":"identity and sense of the item"},{"title":"Wikipedia: Hematologic disease","url":"https://en.wikipedia.org/wiki/Hematologic_disease","note":"general description of the item"}],"openQuestions":["Should anaemia and blood cancers be the primary linked entries?","How should classifications be linked?","The registry entry has merged aliases naming findings and specific disorders; should they be split off?"],"resources":{"spec":"/models/things/publications/thing-q1963588/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q1963588/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T22:59:37Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:28+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane INF: no invented physical properties."},"score":1.0}}