{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.zika-virus","code":"thing-q202864","url":"https://ver.cy/models/thing/q202864/","name":"Zika virus","alternateNames":[],"kind":"thing","status":"research-draft","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Activities and processes","entryKind":"thing","plane":"ACT","domain":["ACT.ACT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Zika virus (ZIKV) is a mosquito-borne orthoflavivirus (species Orthoflavivirus zikaense, family Flaviviridae) transmitted mainly by Aedes aegypti, capable of sexual and transplacental spread, that usually causes a mild self-limited infection in humans and is an established cause of congenital Zika syndrome and Guillain-Barré syndrome.","purpose":"Enable an AI agent to identify Zika virus, assess evidence of its presence and transmission relevance, and determine which handling, prevention or expert-review actions are justified.","scope":{"in":["Zika virus identity, aliases and relationships to reference sequences and named variants","Evidence distinguishing Zika from dengue, other flaviviruses and clinically similar infections","Specimen-specific observations of viral material and separately assessed infectiousness","Host, vector and transmission-route relationships with temporal and geographic limits","Links to congenital and neurological consequences that affect assessment priorities","Evidence and authority required for handling, prevention and escalation decisions"],"out":["Patient records, individual diagnoses and treatment plans","Congenital Zika syndrome and Guillain-Barré syndrome as independently modeled conditions","Mosquito taxonomy, life cycles and vector-control programme operations","Outbreak management, population surveillance systems and travel itineraries","Laboratory assay implementation, specimen inventory and experimental protocols","Independent models of dengue virus, chikungunya virus and other pathogens"],"boundaries":[]},"distinguishingFeatures":["Require Zika-specific laboratory attribution rather than identifying the virus from fever, rash or travel history, which overlap with other infections. [WHO Zika fact sheet](https://www.who.int/news-room/fact-sheets/detail/zika-virus)","Test whether a serological identification remains ambiguous because of other flavivirus exposures; even neutralization testing may not separate Zika from related viruses. [CDC diagnostic guidance](https://www.cdc.gov/zika/hcp/diagnosis-testing/)","Check that the referent is the virus itself rather than Zika virus disease, an infected person, a specimen or congenital Zika syndrome.","Use mosquito, sexual and maternal-fetal transmission relationships as contextual checks, never as stand-alone identity tests. [WHO Zika fact sheet](https://www.who.int/news-room/fact-sheets/detail/zika-virus)"],"structure":{"bundles":[{"id":"zika-identity-and-boundaries","name":"Zika identity and boundaries","description":"Establish what a Zika reference denotes and how its identity is supported.","layers":[{"id":"virus-referent","name":"Virus referent","description":"Keep the registered thing distinct from entities that contain it or result from infection.","findings":[{"id":"zika-reference-resolution","name":"Zika reference resolution","description":"Record whether a name denotes Zika virus, a particular viral variant or a neighbouring clinical or material entity.","questions":[{"text":"Does this use of 'Zika' denote the virus, an infection, a disease outcome or a specimen?","id":"zika-reference-resolution-q01","kind":"definition"},{"text":"Which existing registry or world-model reference owns any neighbouring concept mentioned here?","id":"zika-reference-resolution-q02","kind":"boundary"}]}]},{"id":"reference-and-variant-evidence","name":"Reference and variant evidence","description":"Anchor taxonomic and variant labels to inspectable references.","findings":[{"id":"traceable-zika-assignment","name":"Traceable Zika assignment","description":"Retain the reference version, assignment basis and limits of any lineage or isolate designation.","questions":[{"text":"Which authoritative reference or sequence accession supports this Zika assignment?","id":"traceable-zika-assignment-q01","kind":"provenance"},{"text":"What evidence supports the stated variant resolution, and what remains unresolved?","id":"traceable-zika-assignment-q02","kind":"boundary"}]}]}]},{"id":"zika-detection-and-differential","name":"Zika detection and differential","description":"Represent direct and indirect evidence without collapsing uncertainty into a positive or negative diagnosis.","layers":[{"id":"molecular-observations","name":"Molecular observations","description":"Qualify Zika RNA results by specimen, timing and assay interpretation.","findings":[{"id":"time-qualified-rna-result","name":"Time-qualified RNA result","description":"A negative NAAT does not exclude recent infection; record timing and test limitations alongside the result. [CDC diagnostic guidance](https://www.cdc.gov/zika/hcp/diagnosis-testing/)","questions":[{"text":"What specimen and collection interval does this Zika RNA result describe?","id":"time-qualified-rna-result-q01","kind":"measurement"},{"text":"Which assay limitations or conflicting observations constrain the result's interpretation?","id":"time-qualified-rna-result-q02","kind":"boundary"}]}]},{"id":"serological-attribution","name":"Serological attribution","description":"Separate evidence of a flavivirus immune response from attribution specifically to Zika.","findings":[{"id":"cross-reactivity-resolution","name":"Cross-reactivity resolution","description":"Record relevant prior exposures, vaccination history and differential-test interpretations rather than treating a reactive antibody result as self-explanatory.","questions":[{"text":"Which prior flavivirus infections or vaccinations could affect this Zika antibody interpretation?","id":"cross-reactivity-resolution-q01","kind":"provenance"},{"text":"Does the reviewed evidence resolve Zika specifically, or must attribution remain an unspecified flavivirus response?","id":"cross-reactivity-resolution-q02","kind":"boundary"}]}]}]},{"id":"zika-material-and-transmission","name":"Zika material and transmission","description":"Connect observed viral material to carefully bounded assessments of infectiousness and transmission.","layers":[{"id":"compartment-specific-state","name":"Compartment-specific state","description":"Assess observations within their host, specimen and anatomical context.","findings":[{"id":"presence-versus-infectiousness","name":"Presence versus infectiousness","description":"Require explicit evidence before translating a molecular observation into a claim that material can transmit Zika.","questions":[{"text":"Is this observation of Zika RNA, indirect exposure evidence or material with separately supported infectiousness?","id":"presence-versus-infectiousness-q01","kind":"definition"},{"text":"What evidence supports the infectiousness assessment for this compartment and observation time?","id":"presence-versus-infectiousness-q02","kind":"provenance"}]}]},{"id":"route-and-exposure-context","name":"Route and exposure context","description":"Represent candidate transmission routes and the evidence for each.","findings":[{"id":"supported-transmission-attribution","name":"Supported transmission attribution","description":"Record source and recipient links, route, place and exposure interval without treating vector presence or travel alone as proof of transmission.","questions":[{"text":"What evidence supports mosquito-borne, sexual, maternal-fetal or another proposed route in this event?","id":"supported-transmission-attribution-q01","kind":"provenance"},{"text":"Which alternative routes or uncertain exposure dates prevent a definite transmission attribution?","id":"supported-transmission-attribution-q02","kind":"boundary"}]}]}]},{"id":"zika-consequence-relevance","name":"Zika consequence relevance","description":"Capture consequence relationships that change review priorities while leaving clinical management to neighbouring models.","layers":[{"id":"pregnancy-and-fetal-links","name":"Pregnancy and fetal links","description":"Keep maternal exposure, maternal infection, fetal infection and observed outcomes distinct.","findings":[{"id":"maternal-fetal-evidence-separation","name":"Maternal-fetal evidence separation","description":"Represent each supported relationship separately and preserve uncertainty in exposure timing and outcome attribution.","questions":[{"text":"Which evidence supports maternal exposure, maternal infection, fetal infection or a congenital outcome, respectively?","id":"maternal-fetal-evidence-separation-q01","kind":"provenance"},{"text":"What pregnancy timing information and uncertainty must accompany referral to the pregnancy or congenital-condition model?","id":"maternal-fetal-evidence-separation-q02","kind":"action"}]}]},{"id":"neurological-outcome-links","name":"Neurological outcome links","description":"Qualify links between Zika evidence and separately assessed neurological conditions.","findings":[{"id":"neurological-attribution-limit","name":"Neurological attribution limit","description":"Distinguish a general consequence relationship from evidence attributing a particular person's neurological condition to Zika.","questions":[{"text":"What supports the proposed relationship between this Zika observation and the linked neurological condition?","id":"neurological-attribution-limit-q01","kind":"provenance"},{"text":"Which conclusions require clinical assessment rather than inference from the virus model?","id":"neurological-attribution-limit-q02","kind":"boundary"}]}]}]},{"id":"zika-action-eligibility","name":"Zika action eligibility","description":"Determine which evidence, guidance and responsible authority govern a proposed action involving Zika.","layers":[{"id":"material-handling-authority","name":"Material handling authority","description":"Link Zika-containing or suspected material to institutionally applicable handling requirements.","findings":[{"id":"authorized-material-disposition","name":"Authorized material disposition","description":"Record material state, requested operation, applicable requirements and responsible approval without embedding experimental procedures.","questions":[{"text":"Which current institutional requirements apply to the proposed storage, transfer, analysis or disposal of this material?","id":"authorized-material-disposition-q01","kind":"provenance"},{"text":"Does the responsible role have sufficient evidence and authorization to proceed, or is specialist review required?","id":"authorized-material-disposition-q02","kind":"action"}]}]},{"id":"exposure-prevention-guidance","name":"Exposure prevention guidance","description":"Bind prevention and public-health referrals to the relevant route, location, date and affected context.","findings":[{"id":"contextual-zika-guidance","name":"Contextual Zika guidance","description":"Record the guidance version and its applicability instead of hard-coding changing travel classifications, prevention intervals or testing eligibility.","questions":[{"text":"Which dated authority covers this exposure route, jurisdiction and pregnancy or reproductive context?","id":"contextual-zika-guidance-q01","kind":"provenance"},{"text":"What evidence or contextual change would require updating the guidance link or escalating to a qualified professional?","id":"contextual-zika-guidance-q02","kind":"action"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-kinds","name":"Kinds and varieties","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these kinds and varieties hold for the sense of Zika virus this model covers, and on what evidence?","id":"evidence-kinds-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of Zika virus this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-standards-and-regulation","name":"Standards and regulation","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these standards and regulation hold for the sense of Zika virus this model covers, and on what evidence?","id":"evidence-standards-and-regulation-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these real-world use hold for the sense of Zika virus this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these typical measurements hold for the sense of Zika virus this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of Zika virus this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-regional-variation","name":"Regional variation","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these regional variation hold for the sense of Zika virus this model covers, and on what evidence?","id":"evidence-regional-variation-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Reported by the breadth pass; each item needs checking against its source before it becomes normative.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of Zika virus this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Resolve a Zika-labelled observation against reference identity and differential evidence.","Attach and compare specimen-qualified observations while preserving conflicting interpretations.","Assess whether available evidence supports presence, exposure or infectiousness as separate conclusions.","Link suspected transmission to host, route, place and time without asserting an unproven chain.","Flag pregnancy-related or neurological contexts for appropriate expert review.","Determine whether a proposed handling or prevention action has applicable guidance and sufficient authorization."],"mustNot":["Test whether a serological identification remains ambiguous because of other flavivirus exposures; even neutralization testing may not separate Zika from related viruses. [CDC diagnostic guidance](https://www.cdc.gov/zika/hcp/diagnosis-testing/)","Use mosquito, sexual and maternal-fetal transmission relationships as contextual checks, never as stand-alone identity tests. [WHO Zika fact sheet](https://www.who.int/news-room/fact-sheets/detail/zika-virus)"],"requiresHuman":["Check that the referent is the virus itself rather than Zika virus disease, an infected person, a specimen or congenital Zika syndrome.","Neither particle appearance nor the appearance of an infected person or mosquito reliably distinguishes Zika virus, so identification requires validated laboratory evidence."]},"ethics":{"considerations":["Outbreak management, population surveillance systems and travel itineraries","Zika virus is encountered in infectious disease surveillance, mosquito monitoring and laboratory research on mosquito-borne infections."],"affectedParties":[]},"owners":{"steward":"","roles":[],"masterSystems":[]},"relations":[{"target":"Q131345497","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.zika-virus","Wikidata: Q202864 (https://www.wikidata.org/wiki/Q202864)"]},"properties":{"applicability":"not-applicable","items":["Identity resolution: Zika-supported; unresolved flavivirus; conflicting evidence; unassessed","Reference and variant assignment: Named reference or sequence accession with version, assignment method and uncertainty","Observed material: Viral RNA; virus-containing material; host antibody response; unspecified","Zika detection result: Detected; not detected; equivocal; invalid; not tested, qualified by method and specimen","Measured RNA abundance: Assay-reported copies/mL or other validated unit; include detection limit and specimen matrix","Infectiousness evidence: Demonstrated; suspected; not demonstrated under stated conditions; unknown","Observation timing: Collection date and days relative to exposure, symptom onset or birth, with uncertainty","Host and specimen context: Linked host or vector, specimen type and anatomical compartment","Transmission attribution: Mosquito-borne; sexual; maternal-fetal; blood-associated; laboratory-associated; other proposed; unknown, each evidence-qualified","Action authority: Applicable guidance or institutional decision with jurisdiction, version, effective date and responsible role"]},"recognition":{"applicability":"optional","items":["Electron microscopy can reveal small, roughly spherical enveloped particles, but this appearance is shared with other flaviviruses.","Neither particle appearance nor the appearance of an infected person or mosquito reliably distinguishes Zika virus, so identification requires validated laboratory evidence."]},"capabilities":{"applicability":"required","items":["Resolve a Zika-labelled observation against reference identity and differential evidence.","Attach and compare specimen-qualified observations while preserving conflicting interpretations.","Assess whether available evidence supports presence, exposure or infectiousness as separate conclusions.","Link suspected transmission to host, route, place and time without asserting an unproven chain.","Flag pregnancy-related or neurological contexts for appropriate expert review.","Determine whether a proposed handling or prevention action has applicable guidance and sufficient authorization."]},"hazards":{"applicability":"required","items":["Infection during pregnancy can cause congenital Zika syndrome and serious developmental impairment.","Infection can be associated with Guillain-Barre syndrome and other neurological complications.","Unrecognised infection can contribute to mosquito-borne, sexual or transplacental transmission.","Misidentification or false reassurance from incomplete testing can delay appropriate clinical and public health assessment."]},"interfaces":{"applicability":"required","items":["The International Committee on Taxonomy of Viruses classifies Zika virus within the species Orthoflavivirus zikaense in the family Flaviviridae."]},"context":{"applicability":"required","items":["Zika virus is encountered in infectious disease surveillance, mosquito monitoring and laboratory research on mosquito-borne infections.","Its identification supports assessment of transmission, pregnancy-related risks and the need for specialist public health review."]}},"sources":[{"title":"Zika virus (fact sheet) - World Health Organization","url":"https://www.who.int/news-room/fact-sheets/detail/zika-virus","note":"Clinical picture, incubation (3-14 days), Aedes transmission, sexual and congenital transmission, Guillain-Barré syndrome, and the 2016 PHEIC."},{"title":"Zika virus - U.S. Centers for Disease Control and Prevention","url":"","note":"U.S. case definitions, diagnostic algorithm versus dengue, pregnancy outcomes, notifiable-disease practice, and biosafety/clinical guidance."},{"title":"Virus Taxonomy: Orthoflavivirus zikaense - International Committee on Taxonomy of Viruses","url":"","note":"Current species name Orthoflavivirus zikaense and placement in genus Orthoflavivirus, family Flaviviridae (virus name remains Zika virus)."},{"title":"Zika virus. I. Isolations and serological specificity - Transactions of the Royal Society of Tropical Medicine and Hygiene (Dick, Kitchen & Haddow, 1952)","url":"","note":"Original isolation from a rhesus macaque in the Zika Forest, Uganda (1947), and early serological identity of the agent."},{"title":"Zika virus outbreak on Yap Island, Federated States of Micronesia - New England Journal of Medicine (Duffy et al., 2009)","url":"","note":"First well-documented large human outbreak and the widely cited estimate that most infections are asymptomatic."},{"title":"Zika Virus - Clinical Microbiology Reviews (Musso & Gubler, 2016)","url":"","note":"Virology, African versus Asian lineages, diagnostics, and distinction from related flaviviruses and chikungunya."},{"title":"Wikidata item Q202864: Zika virus","url":"https://www.wikidata.org/wiki/Q202864","note":"identity and sense of the item"},{"title":"Wikipedia: Zika virus","url":"https://en.wikipedia.org/wiki/Zika_virus","note":"general description of the item"}],"openQuestions":["Which current taxonomic authority, reference accessions and variant vocabulary should anchor Zika identity, and does an existing world model already own this concept?","Which assay- and specimen-specific evidence rules should govern Zika attribution across differing prior flavivirus exposures?","What evidence supports the duration of infectiousness in each relevant compartment, and where are only RNA-persistence observations available?","How precisely can congenital and neurological risks be qualified by infection timing, population and study uncertainty?","Which maintained jurisdictional and institutional sources should govern transmission classifications, prevention guidance and material-handling decisions?"],"resources":{"spec":"/models/things/publications/thing-q202864/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q202864/spec.json"],"providers":["Codex","Grok"],"researchStatus":"unreviewed","generatedAt":"2026-09-07T11:57:52Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"derived","ethics":"derived","owners":"missing","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"agentConduct":"Affordances listed as what may be done; prohibitions collected from the text.","interaction.properties":"Plane ACT: no invented physical properties."},"score":0.875}}