{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.axon-guidance","code":"thing-q2034716","url":"https://ver.cy/models/thing/q2034716/","name":"axon guidance","alternateNames":["motor neuron axon guidance","commissural neuron axon guidance","retinal ganglion cell axon guidance","dorsal/ventral axon guidance","anterior/posterior axon guidance","olfactory bulb axon guidance","sensory neuron axon guidance","corticospinal neuron axon guidance","corticospinal neuron axon guidance through spinal cord","dopaminergic neuron axon guidance","serotonergic neuron axon guidance","photoreceptor cell axon guidance"],"kind":"thing","status":"published","version":"0.2.0-wave.4","language":"en","classifiers":{"family":"Thing Registry","category":"Activities and processes","entryKind":"thing","plane":"ACT","domain":["ACT.PRC"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"The process by which developing nerve cell axons navigate to their correct targets, steered by a growth cone at the axon tip that responds to attractive and repulsive guidance cues such as netrins, slits, semaphorins and ephrins, acting at short and long range, as studied in systems the registry aliases name, including commissural neuron axons crossing the midline of the spinal cord, retinal ganglion cell axons forming the optic chiasm and mapping to the brain, motor neuron axons reaching muscles, olfactory axons converging in the olfactory bulb, and dorsal-ventral and anterior-posterior guidance along body axes; errors in axon guidance are linked to some developmental disorders, and guidance molecules are studied for nerve regeneration.","purpose":"Let an agent explain axon guidance, relay growth cone biology, guidance cues, model systems and medical relevance from developmental neuroscience sources, describe the named systems, and distinguish axon guidance from neuronal migration, synaptogenesis, axon regeneration and dendrite development.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Growth cone steering","Attractive and repulsive cues","Midline crossing decisions","Topographic maps"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What axon guidance is.","layers":[{"id":"definition","name":"Definition","description":"Definition.","findings":[{"id":"definition-finding","name":"Definition","description":"Definition.","questions":[{"text":"What is axon guidance, and how does it differ from neuronal migration, synaptogenesis, regeneration and dendrite development?","kind":"definition"},{"text":"Is the question about basic neuroscience, a disorder or regeneration research?","kind":"boundary"}]}]},{"id":"systems","name":"Systems","description":"Named systems.","findings":[{"id":"systems-finding","name":"Systems","description":"Systems.","questions":[{"text":"What are commissural, retinal ganglion, motor neuron and olfactory axon guidance and axial guidance?","kind":"definition"},{"text":"Which entry fits the specific system?","kind":"action"}]}]}]},{"id":"biology","name":"Biology","description":"Mechanisms.","layers":[{"id":"growthcone","name":"Growth cone","description":"Growth cones.","findings":[{"id":"growthcone-finding","name":"Growth cone","description":"Growth cone.","questions":[{"text":"How does the growth cone sense cues and steer?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"cues","name":"Cues","description":"Guidance cues.","findings":[{"id":"cues-finding","name":"Cues","description":"Cues.","questions":[{"text":"How do netrins, slits, semaphorins and ephrins attract or repel axons?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]}]},{"id":"models","name":"Models","description":"Model systems.","layers":[{"id":"midline","name":"Midline","description":"Midline crossing.","findings":[{"id":"midline-finding","name":"Midline","description":"Midline.","questions":[{"text":"How do commissural axons decide to cross the midline once?","kind":"provenance"},{"text":"Which entry fits Robo receptor?","kind":"action"}]}]},{"id":"visual","name":"Visual system","description":"Retinotectal map.","findings":[{"id":"visual-finding","name":"Visual system","description":"Visual system.","questions":[{"text":"How do retinal axons form topographic maps?","kind":"provenance"},{"text":"Which entry fits chemoaffinity hypothesis?","kind":"action"}]}]}]},{"id":"context","name":"Context","description":"Medicine.","layers":[{"id":"disorders","name":"Disorders","description":"Guidance disorders.","findings":[{"id":"disorders-finding","name":"Disorders","description":"Disorders.","questions":[{"text":"Which developmental conditions have been linked to guidance genes, with evidence attributed?","kind":"provenance"},{"text":"Is the presentation neutral and attributed?","kind":"boundary"}]}]},{"id":"regeneration","name":"Regeneration","description":"Regeneration research.","findings":[{"id":"regeneration-finding","name":"Regeneration","description":"Regeneration.","questions":[{"text":"How is guidance research applied to spinal cord repair, with limits noted?","kind":"provenance"},{"text":"Which entry fits spinal cord injury research?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Explain axon guidance, growth cones and guidance cues such as netrins and semaphorins.","Summarise research findings with their model organism and limits."],"mustNot":["Present findings in animal models as proven treatments for people.","Promote unproven therapies for nerve injury or developmental disorders.","Share research data on human tissue without the donors' consent and ethics approval."],"requiresHuman":["Moving laboratory findings into clinical trials."]},"ethics":{"considerations":["Hope for nerve repair makes patients vulnerable to overstated claims.","Research on embryos and animals raises welfare and consent questions."],"affectedParties":["Patients with nerve injury","Research animals","Tissue donors"]},"owners":{"steward":"Nobody owns the process; research institutions answer for the studies they run.","roles":[],"masterSystems":[]},"relations":[{"target":"Q21433477","type":"parent","note":"registry parent class"},{"target":"neuron projection guidance","type":"related","note":"in registry terms"},{"target":"growth cone","type":"related"},{"target":"netrin","type":"related"},{"target":"neuronal migration","type":"related"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.axon-guidance","Wikidata: Q2034716 (https://www.wikidata.org/wiki/Q2034716)"]},"properties":{"applicability":"not-applicable","items":["growth cone described: Santiago Ramon y Cajal, 1890 note","netrin identified: 1994 year","main cue families: netrins, slits, semaphorins, ephrins list"]},"recognition":{"applicability":"optional","items":["Navigation of growing axons","Motor neuron axon guidance, commissural neuron axon guidance, retinal ganglion cell axon guidance, dorsal-ventral axon guidance, anterior-posterior axon guidance, olfactory bulb axon guidance","Neuronal migration moves cell bodies; synaptogenesis forms synapses; regeneration regrows injured axons; dendrite development shapes inputs","Not visible without microscopy; seen as growth cones and labelled axon paths."]},"capabilities":{"applicability":"required","items":["explain growth cones and cues","relay model systems","describe named systems","relay medical relevance with attribution"]},"hazards":{"applicability":"required","items":["Overstating links to disorders","Oversimplifying cue functions","Confusing development and regeneration"]},"interfaces":{"applicability":"required","items":["Animal research ethics rules for developmental studies"]},"context":{"applicability":"required","items":["Wiring the developing nervous system.","midline guidance","topographic mapping","motor axon pathfinding","olfactory convergence","axial guidance"]}},"sources":[{"title":"Wikidata item Q2034716: axon guidance","url":"https://www.wikidata.org/wiki/Q2034716","note":"identity and sense of the item"},{"title":"Wikipedia: Axon guidance","url":"https://en.wikipedia.org/wiki/Axon_guidance","note":"general description of the item"}],"openQuestions":["Should each model system be a separate entry?","How should Gene Ontology terms be linked?","How should disease associations be presented?"],"resources":{"spec":"/models/things/publications/thing-q2034716/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q2034716/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-14T00:01:21Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:51:56+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane ACT: no invented physical properties."},"score":1.0}}