{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.tissue-development","code":"thing-q2355306","url":"https://ver.cy/models/thing/q2355306/","name":"tissue development","alternateNames":["biomineral tissue development","decidualization","integument development","endosperm development","ganglion development","lymphoid tissue formation","ectoderm development","digestive tract mesoderm development","endoderm development","epidermis development","epithelium development","mesoderm development"],"kind":"thing","status":"published","version":"0.2.0-wave.3","language":"en","classifiers":{"family":"Thing Registry","category":"Activities and processes","entryKind":"thing","plane":"ACT","domain":["ACT.PRC"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"The biological process by which a tissue forms and matures from progenitor cells, through proliferation, differentiation, organisation and remodelling, in embryonic development, growth, regeneration and repair; examples include the development of the skin, lymphoid tissue, mineralised tissues, the endosperm in plants and specialised tissues such as the decidua in pregnancy.","purpose":"Let an agent explain tissue development as a category of developmental process, distinguish it from organ development and morphogenesis, relay Gene Ontology definitions and research findings with attribution, and route to specific tissue entries.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Tissue-level process","Stages from progenitors to mature tissue","Occurs in development, growth and repair","Defined in ontologies"],"structure":{"bundles":[{"id":"concept","name":"Concept","description":"What tissue development is.","layers":[{"id":"definition","name":"Definition","description":"Definition and levels.","findings":[{"id":"definition-finding","name":"Definition","description":"Definition.","questions":[{"text":"What is tissue development, and how does it relate to organ development and cell differentiation?","kind":"definition"},{"text":"Is the question about a tissue, an organ or a cell type?","kind":"boundary"}]}]},{"id":"stages","name":"Stages","description":"Stages.","findings":[{"id":"stages-finding","name":"Stages","description":"Stages.","questions":[{"text":"What stages does tissue development pass through?","kind":"definition"},{"text":"Which entry fits the specific tissue?","kind":"action"}]}]}]},{"id":"mechanisms","name":"Mechanisms","description":"How tissues form.","layers":[{"id":"cells","name":"Cells","description":"Cell behaviours.","findings":[{"id":"cells-finding","name":"Cells","description":"Cells.","questions":[{"text":"Which cell behaviours and signals drive tissue formation, with findings attributed?","kind":"provenance"},{"text":"Which entry fits morphogenesis?","kind":"action"}]}]},{"id":"regeneration","name":"Regeneration","description":"Repair and regeneration.","findings":[{"id":"regeneration-finding","name":"Regeneration","description":"Regeneration.","questions":[{"text":"How do tissues develop during repair and regeneration?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]}]},{"id":"kinds","name":"Kinds","description":"Across tissues and organisms.","layers":[{"id":"animal","name":"Animal","description":"Animal tissues.","findings":[{"id":"animal-finding","name":"Animal","description":"Animal.","questions":[{"text":"How do epithelial, connective, muscle and nervous tissues develop?","kind":"provenance"},{"text":"Which entry fits a specific tissue type?","kind":"action"}]}]},{"id":"plant","name":"Plant","description":"Plant tissues.","findings":[{"id":"plant-finding","name":"Plant","description":"Plant.","questions":[{"text":"How do plant tissues such as endosperm develop?","kind":"provenance"},{"text":"Which entry fits plant development?","kind":"action"}]}]}]},{"id":"study","name":"Study","description":"Research and teaching.","layers":[{"id":"research","name":"Research","description":"Research and medicine.","findings":[{"id":"research-finding","name":"Research","description":"Research.","questions":[{"text":"How is tissue development studied, and how does it inform tissue engineering, in general terms?","kind":"provenance"},{"text":"Which entry fits tissue engineering?","kind":"action"}]}]},{"id":"teach","name":"Teach","description":"Teaching.","findings":[{"id":"teach-finding","name":"Teach","description":"Teaching.","questions":[{"text":"How is tissue development taught in histology and developmental biology?","kind":"action"},{"text":"Which misconceptions arise?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain how tissues form, mature and repair, citing developmental biology sources.","Distinguish tissue development from organ and whole-organism development.","Mark hypotheses about developmental mechanisms as hypotheses."],"mustNot":["Present research hypotheses about tissue development as established fact.","Give clinical advice about a developmental disorder in a specific person.","Present experimental regenerative therapies as proven treatments.","Assist in work that manipulates human embryos outside lawful, ethically approved research."],"requiresHuman":["Using developmental findings in clinical or reproductive decisions."]},"ethics":{"considerations":["Research on embryos and regeneration raises real ethical questions that need oversight.","Overhyped regenerative claims are used to sell unproven treatments to vulnerable patients."],"affectedParties":["Patients and families","Researchers","The public"]},"owners":{"steward":"Nobody owns the process; the scientific community maintains the knowledge.","roles":[],"masterSystems":[]},"relations":[{"target":"Q14860201","type":"parent","note":"registry parent class"},{"target":"anatomical structure development","type":"related","note":"the ontology parent"},{"target":"organ development","type":"related","note":"the higher level"},{"target":"cell differentiation","type":"related","note":"a component process"},{"target":"developmental biology","type":"related","note":"the discipline"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.tissue-development","Wikidata: Q2355306 (https://www.wikidata.org/wiki/Q2355306)","Gene Ontology: GO:0009888 tissue development"]},"properties":{"applicability":"not-applicable","items":[]},"recognition":{"applicability":"optional","items":["Formation and maturation of a tissue","Proliferation, differentiation and organisation","Organ development is at a higher level; cell differentiation at a lower level","Not visible as a single thing; seen in the appearance and maturation of tissues over time."]},"capabilities":{"applicability":"required","items":["explain the process and its stages","distinguish tissue development from organ and cell development","relay ontology definitions","route to specific tissues"]},"hazards":{"applicability":"required","items":["Confusing levels of development","Developmental disorders when tissue development fails","Presenting hypotheses as established"]},"interfaces":{"applicability":"required","items":["Gene Ontology definitions","Research ethics rules for embryo and tissue research"]},"context":{"applicability":"required","items":["Not for anything; the process that forms tissues.","epithelial and integument development","connective and mineralised tissue development","muscle and nervous tissue development","lymphoid tissue formation","plant tissue development such as endosperm","specialised processes such as decidualisation"]}},"sources":[{"title":"Wikidata item Q2355306: tissue development","url":"https://www.wikidata.org/wiki/Q2355306","note":"identity and sense of the item"},{"title":"Wikipedia: Histogenesis","url":"https://en.wikipedia.org/wiki/Histogenesis","note":"general description of the item"}],"openQuestions":["Should each tissue development process be a separate entry?","How should ontology terms be linked?","The registry entry has merged aliases for specific tissues and plant processes; should they be split off?"],"resources":{"spec":"/models/things/publications/thing-q2355306/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q2355306/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T21:17:39Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:51:57+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane ACT: no invented physical properties."},"score":1.0}}