{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.cell-death","code":"thing-q2383867","url":"https://ver.cy/models/thing/q2383867/","name":"cell death","alternateNames":["neuron death","necrotic cell death","Activation-induced cell death","immunogenic cell death","cell death in response to oxidative stress"],"kind":"thing","status":"published","version":"0.2.0-wave.3","language":"en","classifiers":{"family":"Thing Registry","category":"Activities and processes","entryKind":"thing","plane":"ACT","domain":["ACT.PRC"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"The irreversible end of the life of a cell, occurring by regulated programmes such as apoptosis, necroptosis, pyroptosis and ferroptosis or by uncontrolled necrosis after injury, and serving development, tissue homeostasis and defence against infection and cancer; forms include immunogenic cell death that alerts the immune system, activation-induced death of lymphocytes and neuron death in neurodegeneration, and failures of cell death control underlie cancer and degenerative diseases.","purpose":"Let an agent explain cell death and its forms, relay mechanisms and classification from cell biology sources, describe its roles in development, disease and therapy, and distinguish regulated from accidental death.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Regulated and accidental forms","Molecular programmes","Developmental and defensive roles","Disease relevance"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What cell death is.","layers":[{"id":"forms","name":"Forms","description":"Forms.","findings":[{"id":"forms-finding","name":"Forms","description":"Forms.","questions":[{"text":"What forms of cell death exist, and how are they classified?","kind":"definition"},{"text":"Is the process cell death, senescence or autophagy?","kind":"boundary"}]}]},{"id":"mechanisms","name":"Mechanisms","description":"Mechanisms.","findings":[{"id":"mechanisms-finding","name":"Mechanisms","description":"Mechanisms.","questions":[{"text":"What molecular pathways drive apoptosis, necroptosis, pyroptosis and ferroptosis?","kind":"definition"},{"text":"Which entry fits the specific form?","kind":"action"}]}]}]},{"id":"roles","name":"Roles","description":"Roles in the body.","layers":[{"id":"development","name":"Development","description":"Development and homeostasis.","findings":[{"id":"development-finding","name":"Development","description":"Development.","questions":[{"text":"How does cell death shape development and maintain tissues?","kind":"provenance"},{"text":"Which entry fits developmental biology?","kind":"action"}]}]},{"id":"immunity","name":"Immunity","description":"Immunity.","findings":[{"id":"immunity-finding","name":"Immunity","description":"Immunity.","questions":[{"text":"How do immunogenic and activation-induced cell death function in immunity?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]}]},{"id":"disease","name":"Disease","description":"Disease and therapy.","layers":[{"id":"disease","name":"Disease","description":"Disease.","findings":[{"id":"disease-finding","name":"Disease","description":"Disease.","questions":[{"text":"How do failures of cell death control contribute to cancer and neurodegeneration, with findings attributed?","kind":"provenance"},{"text":"Is the user asking about a personal condition, which needs a clinician?","kind":"boundary"}]}]},{"id":"therapy","name":"Therapy","description":"Therapies.","findings":[{"id":"therapy-finding","name":"Therapy","description":"Therapy.","questions":[{"text":"How do therapies target cell death pathways?","kind":"provenance"},{"text":"Which entry fits a specific drug class?","kind":"action"}]}]}]},{"id":"study","name":"Study","description":"Methods and history.","layers":[{"id":"methods","name":"Methods","description":"Methods.","findings":[{"id":"methods-finding","name":"Methods","description":"Methods.","questions":[{"text":"How is cell death detected and measured in the laboratory?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]},{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How was programmed cell death discovered and recognised, including the 2002 Nobel Prize?","kind":"provenance"},{"text":"Which entry fits the history of cell biology?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Explain the forms of cell death and their roles, citing sources.","Distinguish apoptosis, necrosis and other regulated forms.","Summarise research without overstating its clinical meaning."],"mustNot":["Give a person medical advice about cancer or neurodegeneration based on cell death research.","Confuse forms of cell death in research records.","Present early findings as proven treatments.","Use research data from patient samples without consent."],"requiresHuman":["Any treatment decision based on cell death research."]},"ethics":{"considerations":["Patients with cancer and neurodegenerative disease look to this research with hope; accuracy matters.","Research with human tissue depends on consent."],"affectedParties":["Patients","Tissue donors","Researchers"]},"owners":{"steward":"Nobody: a biological process studied in common.","roles":[],"masterSystems":[]},"relations":[{"target":"Q14873025","type":"parent","note":"registry parent class"},{"target":"Q4086887","type":"parent","note":"registry parent class"},{"target":"cellular process","type":"related","note":"in registry terms"},{"target":"biological destruction","type":"related","note":"in registry terms"},{"target":"apoptosis","type":"related","note":"the best-known programme"},{"target":"caspase","type":"related","note":"in apoptosis and pyroptosis"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.cell-death","Wikidata: Q2383867 (https://www.wikidata.org/wiki/Q2383867)","Gene Ontology: GO:0008219 cell death"]},"properties":{"applicability":"not-applicable","items":["cells dying daily in an adult human: tens of billions count - estimates"]},"recognition":{"applicability":"optional","items":["Irreversible end of a cell","Regulated programmes and accidental necrosis","Senescence is arrest without death; autophagy is usually survival","Not visible to the eye; seen by microscopy as shrinkage and fragmentation in apoptosis or swelling and rupture in necrosis."]},"capabilities":{"applicability":"required","items":["explain forms and mechanisms","relay classification standards","describe roles in disease and therapy","distinguish regulated from accidental death"]},"hazards":{"applicability":"required","items":["Cancer from evasion of cell death","Degeneration from excess death","Confusing forms in research"]},"interfaces":{"applicability":"required","items":["Nomenclature Committee on Cell Death recommendations","Research ethics for animal and human studies"]},"context":{"applicability":"required","items":["Removing cells for development, homeostasis and defence.","apoptosis","necroptosis, pyroptosis and ferroptosis","accidental necrosis","immunogenic cell death","activation-induced cell death of lymphocytes","neuron death in development and neurodegeneration","cell death from oxidative stress"]}},"sources":[{"title":"Wikidata item Q2383867: cell death","url":"https://www.wikidata.org/wiki/Q2383867","note":"identity and sense of the item"},{"title":"Wikipedia: Cell death","url":"https://en.wikipedia.org/wiki/Cell_death","note":"general description of the item"}],"openQuestions":["Should each form be a separate entry?","How should nomenclature recommendations be linked?","The registry entry has merged aliases naming forms and contexts; should they be split off?"],"resources":{"spec":"/models/things/publications/thing-q2383867/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q2383867/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T22:45:36Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:51:57+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane ACT: no invented physical properties."},"score":1.0}}