{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.parthenolide","code":"thing-q2662393","url":"https://ver.cy/models/thing/q2662393/","name":"parthenolide","alternateNames":[],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Parthenolide is a naturally occurring germacranolide sesquiterpene lactone found in feverfew (Tanacetum parthenium), with an epoxide and an α-methylene-γ-lactone group that contribute to its biological reactivity.","purpose":"Enable an agent to identify parthenolide, assess a material lot or solution, and judge its suitability for a specified analytical or experimental use.","scope":{"in":["Parthenolide molecular identity, stereochemistry and identifier reconciliation","Isolated material, reference standards and solutions with quantified parthenolide content","Lot purity, impurities, provenance and analytical verification","Physical properties, solubility and stability under stated conditions","Handling constraints and interpretation of parthenolide-specific experimental evidence"],"out":["Feverfew taxonomy, cultivation and whole-plant biology","Complete compositions and therapeutic claims of feverfew extracts or supplements","Distinct parthenolide derivatives and their independent properties","Manufacturing processes beyond their effects on material provenance and quality","Disease models, clinical treatment protocols and patient-specific decisions"],"boundaries":[]},"distinguishingFeatures":["Require a stereochemically resolved structure match: molecular formula alone cannot distinguish parthenolide from isomers.","Identify the sesquiterpene lactone structure with its epoxide and exocyclic methylene group; use analytical evidence to distinguish structurally related compounds.","Distinguish isolated parthenolide from feverfew extract by separately recording compound identity, matrix composition and quantified content.","Treat covalently modified derivatives, including dimethylaminoparthenolide, as related substances rather than interchangeable names.","Distinguish material purity from parthenolide concentration in a solution; these answer different suitability questions."],"structure":{"bundles":[{"id":"parthenolide-identity","name":"Parthenolide identity","description":"Establish which chemical structure the registered name denotes.","layers":[{"id":"structure-resolution","name":"Structure resolution","description":"Resolve molecular connectivity and stereochemistry.","findings":[{"id":"stereochemical-identity","name":"Stereochemical identity","description":"Record the accepted structure and the evidence needed to recognize it in a sample.","questions":[{"text":"Which stereochemistry-resolved structure defines parthenolide for this registry entry?","id":"stereochemical-identity-q01","kind":"definition"},{"text":"Which NMR, mass-spectrometric and stereochemical evidence distinguishes the sample from related sesquiterpene lactones?","id":"stereochemical-identity-q02","kind":"measurement"}]}]},{"id":"identifier-and-derivative-boundaries","name":"Identifier and derivative boundaries","description":"Connect external identifiers without merging distinct substances.","findings":[{"id":"identifier-reconciliation","name":"Identifier reconciliation","description":"Check identifier scope against the resolved structure and maintain explicit derivative relationships.","questions":[{"text":"Which CAS, PubChem and EC records match the resolved structure, and do any cited records represent an obsolete or less specific identity?","id":"identifier-reconciliation-q01","kind":"provenance"},{"text":"Does the supplied name denote parthenolide itself, a derivative such as dimethylaminoparthenolide, or a mixture containing it?","id":"identifier-reconciliation-q02","kind":"boundary"}]}]}]},{"id":"lot-composition-and-origin","name":"Lot composition and origin","description":"Describe the actual parthenolide material supporting an observation or intended use.","layers":[{"id":"material-provenance","name":"Material provenance","description":"Trace isolated or synthesized material to a documented lot.","findings":[{"id":"origin-and-matrix","name":"Origin and matrix","description":"Separate provenance from composition and distinguish purified material from botanical matrices.","questions":[{"text":"Was this lot isolated from a documented botanical source or obtained through a synthetic route?","id":"origin-and-matrix-q01","kind":"provenance"},{"text":"Is the material purified parthenolide or an extract whose other constituents require a separate mixture model?","id":"origin-and-matrix-q02","kind":"boundary"}]}]},{"id":"assay-and-impurities","name":"Assay and impurities","description":"Establish the quantity and accompanying components of parthenolide.","findings":[{"id":"usable-parthenolide-content","name":"Usable parthenolide content","description":"Connect reported purity to its measurement basis and intended use.","questions":[{"text":"Is the reported purity chromatographic area percentage or a validated mass-fraction assay, and what uncertainty applies?","id":"usable-parthenolide-content-q01","kind":"measurement"},{"text":"Which residual solvents, water, related lactones or degradation products could invalidate the intended analysis or bioassay?","id":"usable-parthenolide-content-q02","kind":"action"}]}]}]},{"id":"physical-state-and-solution-integrity","name":"Physical state and solution integrity","description":"Track thermal behavior, dissolution and changes during storage or exposure.","layers":[{"id":"solid-state-properties","name":"Solid-state properties","description":"Interpret physical measurements in their experimental context.","findings":[{"id":"thermal-and-form-evidence","name":"Thermal and form evidence","description":"Record measured transitions without assigning unsupported universal constants.","questions":[{"text":"What melting range and decomposition behavior were measured for characterized parthenolide, using which method?","id":"thermal-and-form-evidence-q01","kind":"measurement"},{"text":"Could solvent inclusion, water or impurities explain a difference between this lot and the reference thermal behavior?","id":"thermal-and-form-evidence-q02","kind":"measurement"}]}]},{"id":"dissolution-and-aging","name":"Dissolution and aging","description":"Follow parthenolide from stock preparation into its final use medium.","findings":[{"id":"effective-solution-content","name":"Effective solution content","description":"Distinguish preparation calculations from verified dissolved, intact compound.","questions":[{"text":"What parthenolide concentration remains dissolved in the specified solvent or assay medium at the stated temperature and time?","id":"effective-solution-content-q01","kind":"measurement"},{"text":"What evidence sets storage duration, light exposure and freeze-thaw limits before reanalysis is required?","id":"effective-solution-content-q02","kind":"action"}]}]}]},{"id":"reactivity-and-biological-interpretation","name":"Reactivity and biological interpretation","description":"Connect chemical integrity to experimental activity and its limits.","layers":[{"id":"reactive-structure","name":"Reactive structure","description":"Investigate reactions associated with parthenolide's functional groups.","findings":[{"id":"adducts-and-medium-interactions","name":"Adducts and medium interactions","description":"Assess whether reactions involving the methylene-lactone or epoxide alter the tested species.","questions":[{"text":"Which experimentally demonstrated reactions or adducts involve parthenolide under the intended medium conditions?","id":"adducts-and-medium-interactions-q01","kind":"provenance"},{"text":"Do thiol-containing additives, proteins or other medium components measurably change intact parthenolide during exposure?","id":"adducts-and-medium-interactions-q02","kind":"measurement"}]}]},{"id":"activity-evidence","name":"Activity evidence","description":"Keep biochemical, cellular, animal and human evidence distinct.","findings":[{"id":"endpoint-and-causality","name":"Endpoint and causality","description":"Represent activity as a result of a defined experiment with appropriate controls.","questions":[{"text":"Which endpoint, system, concentration, exposure duration and vehicle produced the reported response?","id":"endpoint-and-causality-q01","kind":"measurement"},{"text":"What controls distinguish direct target engagement from general cytotoxicity, assay interference or indirect pathway effects?","id":"endpoint-and-causality-q02","kind":"measurement"},{"text":"Does the evidence concern purified parthenolide, a derivative or a feverfew preparation, and what limits its transfer to human use?","id":"endpoint-and-causality-q03","kind":"boundary"}]}]}]},{"id":"handling-and-use-qualification","name":"Handling and use qualification","description":"Translate material-specific evidence into permitted handling and qualified uses.","layers":[{"id":"hazard-evidence","name":"Hazard evidence","description":"Resolve documented hazards for the supplied form and concentration.","findings":[{"id":"exposure-and-classification","name":"Exposure and classification","description":"Attach hazard statements to their source, material scope and jurisdiction.","questions":[{"text":"Which current SDS and authoritative records support hazard classifications, including any sensitization classification, for this material?","id":"exposure-and-classification-q01","kind":"provenance"},{"text":"Is a substance-specific exposure limit established, and which documented controls apply to powder weighing or stock handling?","id":"exposure-and-classification-q02","kind":"action"}]}]},{"id":"fitness-for-use","name":"Fitness for use","description":"Determine whether evidence and material quality support the proposed application.","findings":[{"id":"use-specific-acceptance","name":"Use-specific acceptance","description":"Set acceptance requirements for reference analysis or experiments without inferring clinical suitability.","questions":[{"text":"Which identity, assay, impurity and stability requirements must this lot meet for the proposed use?","id":"use-specific-acceptance-q01","kind":"action"},{"text":"What jurisdiction-specific evidence establishes any claimed authorization for the exact substance or formulation?","id":"use-specific-acceptance-q02","kind":"provenance"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of parthenolide this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of parthenolide this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of parthenolide this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of parthenolide this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of parthenolide this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of parthenolide this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Identify parthenolide as a sesquiterpene lactone of feverfew, citing sources.","Report source, purity and storage of a held sample."],"mustNot":["Recommend parthenolide or feverfew for a person's condition.","Present laboratory findings as proven effects in people.","Advise use in pregnancy or alongside blood-thinning medicines.","Label an extract as standardized without analysis."],"requiresHuman":["Using it in products for people.","Studies involving people or animals."]},"ethics":{"considerations":["Herbal products can cause allergies and interactions that users do not expect.","Overstated anticancer claims exploit vulnerable patients."],"affectedParties":["Consumers and patients","People allergic to daisy-family plants","Laboratory workers"]},"owners":{"steward":"The laboratory or producer that holds the material.","roles":[],"masterSystems":[]},"relations":[{"target":"Q108243163","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.parthenolide","Wikidata: Q2662393 (https://www.wikidata.org/wiki/Q2662393)"]},"properties":{"applicability":"required","items":["Chemical identity anchor: C15H20O3; molecular weight 248.32 g/mol; stereochemistry-resolved structure","Registry identifier mapping: vr.tr.parthenolide linked to verified CAS, PubChem and applicable EC records","Identity verification: Unverified, supplier asserted, analytically supported or discrepant","Purity and impurity profile: Mass fraction %, chromatographic area % and identified impurities, each with method","Material form and matrix: Solid, solvent stock or matrix-containing sample; solvent and additives specified","Dissolved concentration: mol/L or mg/mL, with solvent, temperature, preparation time and verification method","Thermal behavior: Melting range and decomposition onset in °C, with method; boiling data only when experimentally meaningful","Storage and solution stability: Verified within limits, untested, precipitated or chemically changed; conditions and elapsed time recorded","Biological response: Endpoint-specific response or potency, with concentration, exposure duration and experimental system","Handling and regulatory evidence: Applicable SDS, jurisdiction, revision date, classification and exposure-limit evidence"]},"recognition":{"applicability":"required","items":["A solid that cannot be identified by sight; its source plant has small daisy-like flowers.","Identity is settled by chromatography against a reference."]},"capabilities":{"applicability":"required","items":["Match a named sample to a verified parthenolide structure and flag identity conflicts.","Compare lots against purpose-specific identity, purity and impurity requirements.","Calculate a stock or dilution using verified assay content and check whether the intended concentration remains dissolved.","Determine whether a stored solid or solution needs reanalysis before use.","Compare biological results only after accounting for material quality, vehicle, exposure and experimental system.","Select handling and disposal requirements from evidence applicable to the actual material and jurisdiction."]},"hazards":{"applicability":"required","items":["Allergic skin reactions in sensitive people.","Variable content in herbal products."]},"interfaces":{"applicability":"required","items":["Globally Harmonized System of Classification and Labelling of Chemicals (GHS), United Nations."]},"context":{"applicability":"required","items":["Parthenolide is encountered in natural product chemistry, plant extract analysis and experimental studies of biological activity.","Laboratories use authenticated material as an analytical reference or research substance, with suitability depending on documented identity, purity and stability."]}},"sources":[{"title":"Wikidata item Q2662393: parthenolide","url":"https://www.wikidata.org/wiki/Q2662393","note":"identity and sense of the item"},{"title":"Wikipedia: Parthenolide","url":"https://en.wikipedia.org/wiki/Parthenolide","note":"general description of the item"}],"openQuestions":["Which CAS, EC and current or historical PubChem records resolve to the exact stereochemical identity intended by vr.tr.parthenolide?","Which measured thermal constants and solvent-specific solubilities are supported by characterized material and reproducible methods?","What storage and assay-medium conditions preserve quantified, intact parthenolide, and which degradation products require monitoring?","Which biological effects have direct mechanistic support, and which remain dependent on a particular assay, formulation or exposure?","Which hazard classifications, exposure limits and use authorizations are substantiated for the relevant material form and jurisdiction?"],"resources":{"spec":"/models/things/publications/thing-q2662393/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q2662393/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T11:55:42Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:29+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}