{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.loxoprofen","code":"thing-q2759348","url":"https://ver.cy/models/thing/q2759348/","name":"loxoprofen","alternateNames":["loxoprofen(1-)"],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.OBJ"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Loxoprofen is a propionic acid derivative nonsteroidal anti-inflammatory drug that acts mainly through an active trans-alcohol metabolite to inhibit cyclooxygenase-mediated prostaglandin synthesis, producing analgesic, anti-inflammatory and antipyretic effects.","purpose":"Enable an agent to identify loxoprofen, assess the identity and quality of material containing it, and determine which handling or use decisions require formulation-specific evidence.","scope":{"in":["Loxoprofen chemical identity and stereochemical specification","Relationships between the parent acid, sodium salt, and sodium hydrate","Material composition, assay basis, impurities, and degradation","Conversion of loxoprofen to its active trans-alcohol metabolite","Evidence needed to connect substance properties to handling and pharmaceutical use"],"out":["Finished tablets, patches, gels, their excipients, and release performance","Patient diagnosis, prescribing, and individualized dosing","Manufacturing facilities and detailed synthesis procedures","Independent models of metabolites and other NSAIDs","Brand ownership, distribution, and market authorization records"],"boundaries":[]},"distinguishingFeatures":["Match the molecular structure to loxoprofen; the parent formula C15H18O3 is an identity check but cannot distinguish structural isomers. [NCATS substance record](https://drugs.ncats.io/substance/3583H0GZAP)","Check explicitly for sodium and hydration state before treating a material as the parent acid; pharmaceutical records identify loxoprofen sodium hydrate as a named ingredient. [PMDA ingredient record](https://www.pmda.go.jp/PmdaSearch/rdDetail/iyaku/1149019F1714_1?user=1)","Distinguish the parent prodrug from its trans-alcohol metabolite, which is produced through carbonyl reduction. [Primary metabolism study](https://pmc.ncbi.nlm.nih.gov/articles/PMC6160907/)","Require an explicit stereochemical specification before identifying a stereoisomer-resolved sample with a record that leaves stereochemistry unspecified.","Distinguish substance quantity from finished-product strength: a sodium hydrate tablet record can express content on an anhydrous basis. [PMDA patient guide](https://www.info.pmda.go.jp/downfiles/guide/ph/450064_1149019F1498_1_00G.pdf)"],"structure":{"bundles":[{"id":"chemical-identity","name":"Chemical identity","description":"Recognize loxoprofen while preserving distinctions between structure, stereochemistry, and pharmaceutical form.","layers":[{"id":"parent-structure","name":"Parent structure","description":"Establish the molecular entity represented by the registry entry.","findings":[{"id":"structure-anchored-identity","name":"Structure-anchored identity","description":"Anchor the entry to a verified structure rather than identifying it solely through a name or formula.","questions":[{"text":"Which authoritative structure record defines loxoprofen for vr.tr.loxoprofen?","id":"structure-anchored-identity-q01","kind":"definition"},{"text":"Do the proposed identifiers resolve to the parent acid or to a salt or stereochemically restricted entity?","id":"structure-anchored-identity-q02","kind":"boundary"}]}]},{"id":"salt-and-stereochemistry","name":"Salt and stereochemistry","description":"Record chemical-form and stereochemical qualifications without creating duplicate registry concepts.","findings":[{"id":"qualified-material-identity","name":"Qualified material identity","description":"Treat counterion, hydration, and stereochemical composition as explicit identity qualifications for the material being assessed.","questions":[{"text":"Is this material loxoprofen acid, sodium salt, or sodium hydrate, and what evidence establishes that assignment?","id":"qualified-material-identity-q01","kind":"definition"},{"text":"Which stereoisomers and proportions are specified, measured, or left unresolved?","id":"qualified-material-identity-q02","kind":"measurement"},{"text":"Does an existing catalogue model already own any of these qualified forms?","id":"qualified-material-identity-q03","kind":"boundary"}]}]}]},{"id":"quantity-and-physical-form","name":"Quantity and physical form","description":"Make loxoprofen amounts and physical-property observations comparable.","layers":[{"id":"amount-basis","name":"Amount basis","description":"Separate measured material mass from the declared amount of a particular loxoprofen form.","findings":[{"id":"declared-equivalence","name":"Declared equivalence","description":"Every assay or strength value needs a stated chemical-form basis before conversion or comparison.","questions":[{"text":"Is the reported amount expressed as parent acid, anhydrous sodium salt, or hydrated material?","id":"declared-equivalence-q01","kind":"measurement"},{"text":"Which verified composition, water correction, and molecular masses justify a proposed conversion?","id":"declared-equivalence-q02","kind":"action"}]}]},{"id":"phase-and-solution-behavior","name":"Phase and solution behavior","description":"Connect physical observations to the particular loxoprofen form tested.","findings":[{"id":"conditioned-physical-properties","name":"Conditioned physical properties","description":"Record solid phase, water content, and solubility with their methods and conditions; leave unverified phase assignments unresolved.","questions":[{"text":"What measurements establish the sample's water content and solid-state form?","id":"conditioned-physical-properties-q01","kind":"measurement"},{"text":"For a reported solubility, what were the chemical form, solvent, pH, temperature, and equilibration conditions?","id":"conditioned-physical-properties-q02","kind":"measurement"}]}]}]},{"id":"analytical-quality","name":"Analytical quality","description":"Assess whether a sample is the declared loxoprofen material and meets its intended specification.","layers":[{"id":"identity-and-assay-evidence","name":"Identity and assay evidence","description":"Bind analytical results to methods, reference materials, and acceptance criteria.","findings":[{"id":"form-appropriate-testing","name":"Form-appropriate testing","description":"Select tests and specifications that apply to the declared loxoprofen form and material grade.","questions":[{"text":"Which monograph or validated specification applies to this loxoprofen material and its intended use?","id":"form-appropriate-testing-q01","kind":"provenance"},{"text":"What identity and assay results were obtained, using which reference standard and reporting basis?","id":"form-appropriate-testing-q02","kind":"measurement"},{"text":"Do the results support acceptance, rejection, or continued quarantine?","id":"form-appropriate-testing-q03","kind":"action"}]}]},{"id":"impurities-and-stability","name":"Impurities and stability","description":"Distinguish impurities and storage-related changes from acceptable loxoprofen material.","findings":[{"id":"resolved-quality-changes","name":"Resolved quality changes","description":"Track identified and unidentified related substances alongside stability evidence for the actual form and container.","questions":[{"text":"Which impurity signals are identified, how were they assigned, and what concentrations or limits are reported?","id":"resolved-quality-changes-q01","kind":"measurement"},{"text":"What evidence supports the storage conditions and retest period for this form in this container?","id":"resolved-quality-changes-q02","kind":"provenance"},{"text":"After a storage excursion, which loxoprofen quality attributes require reassessment?","id":"resolved-quality-changes-q03","kind":"action"}]}]}]},{"id":"metabolic-activation-and-effect","name":"Metabolic activation and effect","description":"Represent loxoprofen's prodrug relationship and the evidence connecting chemical exposure to pharmacological effects.","layers":[{"id":"parent-metabolite-conversion","name":"Parent-metabolite conversion","description":"Identify the activation product and the biological context in which conversion is demonstrated.","findings":[{"id":"trans-alcohol-activation","name":"Trans-alcohol activation","description":"Loxoprofen undergoes carbonyl reduction to an active trans-alcohol metabolite; evidence must retain its experimental-system context. [Primary metabolism study](https://pmc.ncbi.nlm.nih.gov/articles/PMC6160907/)","questions":[{"text":"Which exact metabolite structure and stereochemical designation does the source mean by trans-OH?","id":"trans-alcohol-activation-q01","kind":"definition"},{"text":"Which enzyme, tissue, species, and experimental conditions support the reported conversion?","id":"trans-alcohol-activation-q02","kind":"provenance"},{"text":"Does the analytical method distinguish parent loxoprofen from its alcohol metabolites?","id":"trans-alcohol-activation-q03","kind":"measurement"}]}]},{"id":"pharmacological-evidence","name":"Pharmacological evidence","description":"Keep mechanistic and outcome claims attached to the compound and system actually studied.","findings":[{"id":"attributed-effect","name":"Attributed effect","description":"Separate effects measured for parent loxoprofen, isolated metabolites, and administration of a preparation capable of metabolic activation.","questions":[{"text":"Was the reported cyclooxygenase or prostaglandin effect measured for parent loxoprofen, an identified metabolite, or a metabolizing system?","id":"attributed-effect-q01","kind":"boundary"},{"text":"Which concentrations, endpoints, controls, and biological system support the effect claim?","id":"attributed-effect-q02","kind":"measurement"}]}]}]},{"id":"handling-and-use-boundaries","name":"Handling and use boundaries","description":"Connect substance assessment to material handling and route-specific pharmaceutical evidence.","layers":[{"id":"material-handling","name":"Material handling","description":"Determine handling requirements for the identified loxoprofen material and its intended operation.","findings":[{"id":"material-specific-controls","name":"Material-specific controls","description":"Use the applicable safety data and stability information for the actual form, concentration, and physical presentation.","questions":[{"text":"Which safety data sheet applies to this loxoprofen form and material grade?","id":"material-specific-controls-q01","kind":"provenance"},{"text":"What containment, protective equipment, storage, and disposal requirements apply to the planned weighing or preparation operation?","id":"material-specific-controls-q02","kind":"action"}]}]},{"id":"pharmaceutical-context","name":"Pharmaceutical context","description":"Link clinical-use constraints to the relevant product, route, jurisdiction, and dated evidence.","findings":[{"id":"route-specific-safety","name":"Route-specific safety","description":"Retain route scope for safety evidence: PMDA's 2016 oral loxoprofen sodium hydrate notice addresses intestinal stenosis and obstruction associated with ulcers. [PMDA safety revision](https://www.pmda.go.jp/files/000219738.pdf)","questions":[{"text":"Which current product information governs the proposed route and jurisdiction?","id":"route-specific-safety-q01","kind":"provenance"},{"text":"Which contraindications, interactions, and warnings in that information require evaluation in the linked patient or prescribing model?","id":"route-specific-safety-q02","kind":"boundary"},{"text":"What formulation and exposure evidence is needed before applying an oral-product finding to a topical product?","id":"route-specific-safety-q03","kind":"boundary"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of loxoprofen this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-kinds","name":"Kinds and varieties","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these kinds and varieties hold for the sense of loxoprofen this model covers, and on what evidence?","id":"evidence-kinds-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of loxoprofen this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of loxoprofen this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of loxoprofen this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of loxoprofen this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-regional-variation","name":"Regional variation","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these regional variation hold for the sense of loxoprofen this model covers, and on what evidence?","id":"evidence-regional-variation-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of loxoprofen this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Describe loxoprofen, its uses and warnings from official drug information.","Remind users to follow the label and to ask a pharmacist about other medicines they take.","Track stock and expiry in a pharmacy the agent is authorized to manage."],"mustNot":["Recommend, dose or adjust loxoprofen for a particular person.","Advise taking it with other anti-inflammatory drugs.","Downplay its risks for people with stomach ulcers, kidney disease or late pregnancy.","Help anyone obtain it where a prescription is required."],"requiresHuman":["Use in children, pregnancy or people with serious illness."]},"ethics":{"considerations":["Common painkillers are widely used and their risks are often underestimated."],"affectedParties":["Patients","Older people","Pregnant people"]},"owners":{"steward":"The prescribing clinician or pharmacist for each use; medicines regulators authorize the product.","roles":[],"masterSystems":["National medicines registers"]},"relations":[{"target":"Q12140","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.loxoprofen","Wikidata: Q2759348 (https://www.wikidata.org/wiki/Q2759348)"]},"properties":{"applicability":"required","items":["Chemical identity: Verified molecular structure and identifiers; parent formula C15H18O3","Chemical form: Parent acid; sodium salt; sodium hydrate with specified hydration; unresolved","Stereochemical composition: Assigned stereoisomers and their fractions in %; method and uncertainty","Loxoprofen assay: % mass fraction or mg/g, with parent-acid, anhydrous-salt, or hydrated-form basis","Water content: % w/w and, when established, mol water/mol compound","Related substances: Individual impurity identities and concentrations; unidentified peaks; detection limits","Solid-state form: Experimentally assigned phase or mixture; amorphous; unresolved","Solubility under specified conditions: mg/mL or mol/L with solvent, pH, temperature, and chemical form","Metabolic activation: Parent loxoprofen to identified trans-alcohol metabolite, with biological system and evidence","Material disposition: Unassessed; quarantined; accepted against named specification; rejected; awaiting retest"]},"recognition":{"applicability":"required","items":["Tablets, tape patches or gels labelled with the drug name and strength."]},"capabilities":{"applicability":"required","items":["Reconcile a substance label or analytical record with loxoprofen identity while retaining salt and stereochemical distinctions.","Convert quantities between declared chemical-form bases when composition and hydration are established.","Select identity, assay, water, and impurity tests appropriate to the declared loxoprofen form.","Assess a material against a named specification and flag missing evidence before release.","Trace pharmacological claims to the parent compound, active metabolite, and experimental system.","Locate the applicable product information before supporting a route-specific pharmaceutical-use decision."]},"hazards":{"applicability":"required","items":["Can cause stomach bleeding and kidney problems.","Combining with other anti-inflammatory drugs raises the risk of harm."]},"interfaces":{"applicability":"required","items":["The Anatomical Therapeutic Chemical classification, maintained by the WHO Collaborating Centre for Drug Statistics Methodology, classifies loxoprofen as M01AE17 within propionic acid derivatives."]},"context":{"applicability":"required","items":["Loxoprofen is encountered in pharmaceutical materials and medicines used for pain, inflammation and fever where authorised.","Analytical and manufacturing work distinguishes the parent compound, its stereoisomers, salts and formulated products."]}},"sources":[{"title":"Wikidata item Q2759348: loxoprofen","url":"https://www.wikidata.org/wiki/Q2759348","note":"identity and sense of the item"},{"title":"Wikipedia: Loxoprofen","url":"https://en.wikipedia.org/wiki/Loxoprofen","note":"general description of the item"}],"openQuestions":["Does the existing Vercy catalogue already cover loxoprofen or its pharmaceutical forms, and which model should be the single source of truth?","Which authoritative identity record and stereochemical convention should define the registry entry's exact chemical scope?","Which current monographs govern relevant loxoprofen forms, including assay basis, hydration, stereochemical requirements, and impurity limits?","Which primary measurements establish form-specific solubility, solid phases, degradation pathways, and storage limits?","Which human evidence resolves stereoisomer-specific activation and parent-versus-metabolite exposure across oral and topical formulations?"],"resources":{"spec":"/models/things/publications/thing-q2759348/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q2759348/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T11:03:48Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:29+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}