{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.small-nuclear-rna","code":"thing-q284578","url":"https://ver.cy/models/thing/q284578/","name":"small nuclear RNA","alternateNames":[],"kind":"thing","status":"research-draft","version":"0.2.0-wave.4","language":"en","classifiers":{"family":"Thing Registry","category":"","entryKind":"","plane":"","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A class of short non-coding RNA molecules found in the nucleus of eukaryotic cells, about 100 to 300 nucleotides long, that play key roles in processing other RNAs, especially the spliceosomal small nuclear RNAs U1, U2, U4, U5 and U6 that help remove introns from messenger RNA during splicing, with the registry aliases naming specific genes such as RNU4ATAC, RNU2-1 and RNU6-1; small nuclear RNAs combine with proteins to form small nuclear ribonucleoproteins or snRNPs, and mutations in some, such as RNU4ATAC, cause rare genetic disorders. They differ from small nucleolar RNAs and microRNAs.","purpose":"Let an agent explain small nuclear RNAs, relay their role in splicing, the snRNP complexes and links to disease from molecular biology sources, describe the named genes, and distinguish small nuclear RNA from small nucleolar RNA, microRNA, messenger RNA and transfer RNA.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Short nuclear RNA","Splicing role","Forms snRNPs","Distinct from other small RNAs"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What small nuclear RNA is.","layers":[{"id":"definition","name":"Definition","description":"Definition.","findings":[{"id":"definition-finding","name":"Definition","description":"Definition.","questions":[{"text":"What is small nuclear RNA, and how does it differ from small nucleolar RNA, microRNA, messenger RNA and transfer RNA?","kind":"definition"},{"text":"Is the question about molecular biology or a specific RNA gene?","kind":"boundary"}]}]},{"id":"genes","name":"Genes","description":"Named genes.","findings":[{"id":"genes-finding","name":"Genes","description":"Genes.","questions":[{"text":"What are RNU4ATAC, RNU2-1 and RNU6-1?","kind":"definition"},{"text":"Which entry fits the specific gene?","kind":"action"}]}]}]},{"id":"splicing","name":"Splicing","description":"Splicing role.","layers":[{"id":"spliceosome","name":"Spliceosome","description":"The spliceosome.","findings":[{"id":"spliceosome-finding","name":"Spliceosome","description":"Spliceosome.","questions":[{"text":"How do U1 to U6 snRNAs help splice messenger RNA?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"snrnp","name":"snRNP","description":"Small nuclear ribonucleoproteins.","findings":[{"id":"snrnp-finding","name":"snRNP","description":"snRNP.","questions":[{"text":"How do snRNAs combine with proteins to form snRNPs?","kind":"provenance"},{"text":"Which sources are cited?","kind":"provenance"}]}]}]},{"id":"classes","name":"Classes","description":"RNA classes.","layers":[{"id":"comparison","name":"Comparison","description":"Comparison.","findings":[{"id":"comparison-finding","name":"Comparison","description":"Comparison.","questions":[{"text":"How do snRNA, snoRNA and miRNA differ in function?","kind":"provenance"},{"text":"Which entry fits non-coding RNA?","kind":"action"}]}]},{"id":"minor","name":"Minor spliceosome","description":"Minor spliceosome.","findings":[{"id":"minor-finding","name":"Minor spliceosome","description":"Minor spliceosome.","questions":[{"text":"What is the minor spliceosome and its snRNAs?","kind":"provenance"},{"text":"Is the information accurate?","kind":"boundary"}]}]}]},{"id":"context","name":"Context","description":"Disease.","layers":[{"id":"disease","name":"Disease","description":"snRNA disease.","findings":[{"id":"disease-finding","name":"Disease","description":"Disease.","questions":[{"text":"How do mutations in genes such as RNU4ATAC cause disease, as research reports?","kind":"provenance"},{"text":"Is the presentation neutral and attributed?","kind":"boundary"}]}]},{"id":"research","name":"Research","description":"Research.","findings":[{"id":"research-finding","name":"Research","description":"Research.","questions":[{"text":"How are small nuclear RNAs studied?","kind":"provenance"},{"text":"Which entry fits RNA splicing?","kind":"action"}]}]}]}]},"agentConduct":{"may":["explain the role in splicing","relay snRNP complexes","describe named genes","relay disease links"],"mustNot":[],"requiresHuman":[]},"ethics":{"considerations":["minor spliceosome snRNAs"],"affectedParties":[]},"owners":{"steward":"","roles":[],"masterSystems":[]},"relations":[{"target":"non-coding RNA","type":"related","note":"in registry terms"},{"target":"small nuclear ribonucleoprotein","type":"related"},{"target":"small nucleolar RNA","type":"related"},{"target":"microRNA","type":"related"}],"interaction":{"identity":{"applicability":"required","items":[]},"properties":{"applicability":"required","items":["length: about 100-300 nucleotides note","spliceosomal snRNAs: U1, U2, U4, U5, U6 list","registry parents: small RNA, non-coding RNA note"]},"recognition":{"applicability":"required","items":["Short nuclear non-coding RNA in RNA processing","RNU4ATAC, RNU1-4, RNU2-1, RNU11, RNU6-1, RNU5F-1","Small nucleolar RNAs modify ribosomal RNA; microRNAs regulate gene expression; messenger RNA codes for protein; transfer RNA carries amino acids","Not visible; short RNA molecules studied in molecular biology."]},"capabilities":{"applicability":"required","items":["explain the role in splicing","relay snRNP complexes","describe named genes","relay disease links"]},"hazards":{"applicability":"required","items":["Confusing snRNA, snoRNA and miRNA","Confusing RNA classes","Oversimplified molecular biology"]},"interfaces":{"applicability":"required","items":["Gene nomenclature standards","RNA databases"]},"context":{"applicability":"required","items":["Processing RNA, especially splicing.","spliceosomal snRNAs","minor spliceosome snRNAs","other small nuclear RNAs"]}},"sources":[],"openQuestions":["Should spliceosomal snRNAs be separate entries?","How should RNA gene databases be linked?","How should snRNA-linked diseases be documented?","Which entry fits the specific gene?","Which entry fits non-coding RNA?","Which entry fits RNA splicing?"],"resources":{"spec":"/models/things/publications/thing-q284578/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q284578/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-14T02:52:00Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"derived","ethics":"derived","owners":"missing","relations":"filled","interaction.identity":"missing","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"missing"},"notes":{"agentConduct":"Affordances listed as what may be done; prohibitions collected from the text.","sources":"Written from model knowledge without web access; claims are unverified."},"score":0.765}}