{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.leukemia","code":"thing-q29496","url":"https://ver.cy/models/thing/q29496/","name":"leukemia","alternateNames":["blast phase chronic myelogenous leukemia, BCR-ABL1 positive","blastic plasmacytoid dendritic cell neoplasm","radiation-induced leukemia","mast cell leukemia","childhood leukemia","classic mast cell leukemia","aleukemic mast cell leukemia","splenic manifestation of leukemia","neonatal leukemia","childhood precursor T-lymphoblastic lymphoma/leukemia","childhood acute myeloid leukemia","central nervous system leukemia"],"kind":"thing","status":"published","version":"0.2.0-wave.2","language":"en","classifiers":{"family":"Thing Registry","category":"Information and virtual systems","entryKind":"thing","plane":"INF","domain":["INF.KNW"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A group of cancers of the blood-forming tissues in which abnormal white blood cells proliferate in the bone marrow and blood, classified into acute and chronic forms and by cell lineage as lymphoid or myeloid, including childhood leukaemias, chronic myeloid leukaemia with its phases, rare forms such as mast cell leukaemia, and leukaemia induced by radiation; leukaemia is diagnosed by blood and marrow tests and treated with chemotherapy, targeted therapy, immunotherapy and transplantation, and this entry gives general information only.","purpose":"Let an agent explain leukaemia and its types in general terms, relay information on symptoms, diagnosis and treatment from medical bodies, point to support resources, and route personal questions to clinicians.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Blood cancer","Classified by speed and lineage","Marrow origin","Treatable forms"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What leukaemia is.","layers":[{"id":"types","name":"Types","description":"Types and classification.","findings":[{"id":"types-finding","name":"Types","description":"Types.","questions":[{"text":"How is leukaemia classified into acute and chronic, lymphoid and myeloid forms, and what characterises each, according to medical sources?","kind":"provenance"},{"text":"Is the user asking about their own health, which needs a clinician?","kind":"boundary"}]}]},{"id":"causes","name":"Causes","description":"Causes and risk factors.","findings":[{"id":"causes-finding","name":"Causes","description":"Causes.","questions":[{"text":"What risk factors such as radiation, genetics and prior treatment are documented?","kind":"provenance"},{"text":"Which entry fits a specific type?","kind":"action"}]}]}]},{"id":"care","name":"Care","description":"Diagnosis and treatment.","layers":[{"id":"diagnosis","name":"Diagnosis","description":"Symptoms and diagnosis.","findings":[{"id":"diagnosis-finding","name":"Diagnosis","description":"Diagnosis.","questions":[{"text":"What symptoms are associated with leukaemia, and how is it diagnosed by blood and marrow tests, according to guidelines?","kind":"provenance"},{"text":"Are urgent symptoms present now, requiring immediate care?","kind":"boundary"}]}]},{"id":"treatment","name":"Treatment","description":"Treatment.","findings":[{"id":"treatment-finding","name":"Treatment","description":"Treatment.","questions":[{"text":"What treatments are documented, including chemotherapy, targeted therapy, immunotherapy and stem cell transplantation, and how do they depend on type?","kind":"provenance"},{"text":"Which entry fits a specific treatment?","kind":"action"}]}]}]},{"id":"support","name":"Support","description":"Living with leukaemia.","layers":[{"id":"support","name":"Support","description":"Support resources.","findings":[{"id":"support-finding","name":"Support","description":"Support.","questions":[{"text":"What support resources exist for patients and families, including for childhood leukaemia?","kind":"provenance"},{"text":"Is someone in acute distress, needing crisis support?","kind":"boundary"}]}]},{"id":"survivorship","name":"Survivorship","description":"Survivorship.","findings":[{"id":"survivorship-finding","name":"Survivorship","description":"Survivorship.","questions":[{"text":"What is documented about long-term outcomes and survivorship care?","kind":"provenance"},{"text":"Which entry fits cancer survivorship?","kind":"action"}]}]}]},{"id":"learn","name":"Learn","description":"Research and statistics.","layers":[{"id":"statistics","name":"Statistics","description":"Epidemiology.","findings":[{"id":"statistics-finding","name":"Statistics","description":"Epidemiology.","questions":[{"text":"How common is leukaemia, and how have survival rates changed, according to cancer registries?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"research","name":"Research","description":"Research.","findings":[{"id":"research-finding","name":"Research","description":"Research.","questions":[{"text":"What are current research directions, such as cell therapies and targeted drugs?","kind":"provenance"},{"text":"Which misconceptions arise?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain kinds of leukaemia and their treatment in general terms.","Relay information from cancer authorities.","Urge people with symptoms to see a clinician."],"mustNot":["Give personal medical advice or diagnosis.","Promote unproven cures.","Advise stopping treatment.","Share patients' data without consent."],"requiresHuman":["Any treatment decision."]},"ethics":{"considerations":["Misinformation about cures can cost lives.","Patients and families face fear and financial strain."],"affectedParties":["Patients","Families","Donors"]},"owners":{"steward":"Nobody owns a disease; the treating clinicians answer for care.","roles":[],"masterSystems":["Cancer registries"]},"relations":[{"target":"Q1898104","type":"parent","note":"registry parent class"},{"target":"myeloproliferative disorders","type":"related","note":"category"},{"target":"carcinogen","type":"related","note":"radiation-induced leukaemia"},{"target":"histocompatibility","type":"related","note":"stem cell transplantation matching"},{"target":"stomach cancer","type":"related","note":"another cancer entry"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.leukemia","Wikidata: Q29496 (https://www.wikidata.org/wiki/Q29496)"]},"properties":{"applicability":"not-applicable","items":[]},"recognition":{"applicability":"optional","items":["Abnormal white cell proliferation","Acute or chronic, lymphoid or myeloid","Lymphoma arises in lymph tissue; anaemia is low red cells","Not visible externally; identified by blood and marrow tests."]},"capabilities":{"applicability":"required","items":["explain types generally","relay diagnosis and treatment information","point to support resources","route personal questions"]},"hazards":{"applicability":"required","items":["Agents giving personal medical advice","Misinformation about causes and cures","Delayed diagnosis from vague symptoms"]},"interfaces":{"applicability":"required","items":["Clinical guidelines from haematology and oncology bodies","WHO classification of haematological malignancies","Drug regulation"]},"context":{"applicability":"required","items":["Cancers of blood-forming tissue.","acute lymphoblastic leukaemia","acute myeloid leukaemia","chronic lymphocytic leukaemia","chronic myeloid leukaemia","rare leukaemias such as mast cell leukaemia"]}},"sources":[{"title":"Wikidata item Q29496: leukemia","url":"https://www.wikidata.org/wiki/Q29496","note":"identity and sense of the item"},{"title":"Wikipedia: Leukemia","url":"https://en.wikipedia.org/wiki/Leukemia","note":"general description of the item"}],"openQuestions":["Should each type be a separate entry?","How should guidelines be linked?","How should support organisations be linked?"],"resources":{"spec":"/models/things/publications/thing-q29496/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q29496/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T01:03:13Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:51:58+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane INF: no invented physical properties."},"score":1.0}}