{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.pyridine-alkaloid","code":"thing-q30688752","url":"https://ver.cy/models/thing/q30688752/","name":"pyridine alkaloid","alternateNames":["2,5-Difluoropyridine","2,6-Difluoropyridine","2,4-Difluoropyridine","2,3-Difluoropyridine","3,5-Difluoropyridine","nikkomycin I","Nikkomycin Lz","[6-[5-[3-[4,5-Dihydroxy-6-(hydroxymethyl)-3-(3,4,5-trihydroxyoxan-2-yl)oxyoxan-2-yl]oxy-5,7-dihydroxy-4-oxochromen-2-yl]-2-hydroxyphenoxy]-3,4,5-trihydroxyoxan-2-yl]methyl pyridine-3-carboxylate","3-hydroxy-N-[24-hydroxy-7,11,13,17,20-pentamethyl-16-(3-methylbutan-2-yl)-3,10-bis(2-methylpropyl)-2,5,9,12,15,18,21-heptaoxo-8-oxa-1,4,11,14,17,20-hexazabicyclo[20.3.0]pentacosan-6-yl]pyridine-2-carboxamide","3-hydroxy-N-[24-hydroxy-13-(hydroxymethyl)-7,11,17,20-tetramethyl-16-(3-methylbutan-2-yl)-3-(2-methylpropyl)-2,5,9,12,15,18,21-heptaoxo-10-phenyl-8-oxa-1,4,11,14,17,20-hexazabicyclo[20.3.0]pentacosan-6-yl]pyridine-2-carboxamide","Etamycin","3-Phenyl-4,10,13,22-tetramethyl-9-(1,2-dimethylpropyl)-18-(2-methylpropyl)-21-[[(3-hydroxy-2-pyridyl)carbonyl]amino]-24-hydroxy-15,16-propano-1-oxa-4,7,10,13,16,19-hexaazacyclodocosane-2,5,8,11,14,17,20-heptone"],"kind":"thing","status":"published","version":"0.2.0-wave.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A naturally occurring organic compound containing a pyridine ring, such as nicotine, anabasine or trigonelline, often found in plants such as tobacco; many are biologically active and some are toxic.","purpose":"Let an agent handle pyridine alkaloids by compound, source, pharmacology in general terms, regulation and poisoning safety, without facilitating misuse.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Nitrogen heterocycle","Plant-derived","Often biologically active","Some highly toxic"],"structure":{"bundles":[{"id":"compound","name":"Compound","description":"Which alkaloid.","layers":[{"id":"identity","name":"Identity","description":"Name.","findings":[{"id":"identity-finding","name":"Identity","description":"Compound identity.","questions":[{"text":"Which pyridine alkaloid is meant, and what are its identifiers?","kind":"provenance"},{"text":"Which plants contain it?","kind":"provenance"}]}]},{"id":"chemistry","name":"Chemistry","description":"Structure.","findings":[{"id":"chemistry-finding","name":"Chemistry","description":"Chemistry.","questions":[{"text":"What is its structure and formula?","kind":"definition"},{"text":"How is it biosynthesised in plants, in general terms?","kind":"provenance"}]}]}]},{"id":"safety","name":"Safety","description":"Poisoning.","layers":[{"id":"poisoning","name":"Poisoning","description":"Exposure.","findings":[{"id":"poisoning-finding","name":"Poisoning","description":"Poisoning.","questions":[{"text":"Has someone swallowed nicotine liquid or tobacco, especially a child or pet?","kind":"boundary"},{"text":"Which poison centre or emergency number should be called now?","kind":"action"}]}]},{"id":"handling","name":"Handling","description":"Safe storage.","findings":[{"id":"handling-finding","name":"Handling","description":"Safe storage.","questions":[{"text":"How should nicotine products be stored away from children?","kind":"action"},{"text":"What does the safety data sheet say?","kind":"provenance"}]}]}]},{"id":"regulation","name":"Regulation","description":"Law.","layers":[{"id":"products","name":"Products","description":"Tobacco and vapes.","findings":[{"id":"products-finding","name":"Products","description":"Product rules.","questions":[{"text":"What rules apply to nicotine products here?","kind":"provenance"},{"text":"What are the age limits?","kind":"provenance"}]}]},{"id":"cessation","name":"Cessation","description":"Quitting support.","findings":[{"id":"cessation-finding","name":"Cessation","description":"Quitting support.","questions":[{"text":"Which official stop-smoking services exist here?","kind":"provenance"},{"text":"How can they be contacted?","kind":"action"}]}]}]},{"id":"limits","name":"Limits","description":"Agent conduct.","layers":[{"id":"misuse","name":"Misuse","description":"Extraction and dosing.","findings":[{"id":"misuse-finding","name":"Misuse","description":"Misuse limits.","questions":[{"text":"Does the request seek extraction, concentration or harmful dosing detail?","kind":"boundary"},{"text":"How should the agent decline?","kind":"action"}]}]},{"id":"advice","name":"Advice","description":"Clinicians.","findings":[{"id":"advice-finding","name":"Advice","description":"Advice limit.","questions":[{"text":"Is the user asking for personal medical advice?","kind":"boundary"},{"text":"How should they be referred to a clinician?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Describe pyridine alkaloids, their sources and effects from scientific sources, citing them.","Explain the health risks of nicotine and related compounds."],"mustNot":["Assist in extracting, concentrating or using these alkaloids to poison people or animals.","Promote nicotine products to minors or non-users.","Give dosing advice for alkaloids outside approved medical products.","Present tobacco or betel products as safe."],"requiresHuman":["Use of nicotine replacement or related medicines for a specific person."]},"ethics":{"considerations":["Nicotine is addictive and toxic; tobacco causes millions of deaths each year.","Plants rich in these alkaloids are part of the cultures of many communities."],"affectedParties":["Young people","Smokers and users","Farm workers handling tobacco"]},"owners":{"steward":"Nobody: a class of natural compounds; medicines and tobacco regulators control products containing them.","roles":[],"masterSystems":[]},"relations":[{"target":"Q47317020","type":"parent","note":"registry parent class"},{"target":"Q70702","type":"parent","note":"registry parent class"},{"target":"alkaloid and pyridine","type":"related","note":"category"},{"target":"nicotine","type":"related","note":"member"},{"target":"tobacco plant","type":"related","note":"source"},{"target":"tobacco and nicotine law","type":"related","note":"regulation"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.pyridine-alkaloid","Wikidata: Q30688752 (https://www.wikidata.org/wiki/Q30688752)"]},"properties":{"applicability":"required","items":["Molar mass:  grams per mole - Molar mass is calculated from the molecular formula of the identified compound, including its specified salt or hydrate form.","Melting temperature:  degrees Celsius - Melting behavior is measured for an identified sample by thermal analysis, with decomposition and chemical form recorded.","Water solubility:  grams per litre - Equilibrium solubility is measured for the individual compound at a stated temperature and pH because the class has no common numerical range.","Vapor pressure:  pascals - Vapor pressure is measured for the specified compound and chemical form at a stated temperature."]},"recognition":{"applicability":"required","items":["Pyridine ring in structure","Plant sources such as Nicotiana","Simple pyridine derivatives are not alkaloids","Usually oily liquids or crystalline solids; found in plant tissues."]},"capabilities":{"applicability":"required","items":["identify pyridine alkaloids and sources","describe effects in general terms from reliable sources","find regulation such as tobacco and nicotine rules","route poisoning to poison centres"]},"hazards":{"applicability":"required","items":["Nicotine poisoning, especially in children and pets","Providing extraction or dosing detail","Agents giving personal medical advice"]},"interfaces":{"applicability":"required","items":["EU Tobacco Products Directive","WHO Framework Convention on Tobacco Control","CLP hazard classification"]},"context":{"applicability":"required","items":["Chemistry, pharmacology, toxicology and plant biology.","nicotine and related tobacco alkaloids","anabasine","trigonelline","other pyridine and piperidine alkaloids"]}},"sources":[{"title":"Wikidata item Q30688752: pyridine alkaloid","url":"https://www.wikidata.org/wiki/Q30688752","note":"identity and sense of the item"},{"title":"Wikipedia: Pyridine alkaloids","url":"https://en.wikipedia.org/wiki/Pyridine_alkaloids","note":"general description of the item"}],"openQuestions":["Should each alkaloid be a separate entry?","How should chemical databases be linked?","How should cessation resources be localised?"],"resources":{"spec":"/models/things/publications/thing-q30688752/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q30688752/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-11T10:25:10Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T12:16:32+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}