{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.clofibric-acid","code":"thing-q3080279","url":"https://ver.cy/models/thing/q3080279/","name":"clofibric acid","alternateNames":[],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Clofibric acid is 2-(4-chlorophenoxy)-2-methylpropanoic acid, a chlorinated aromatic carboxylic acid that is the pharmacologically active metabolite of clofibrate and a studied pharmaceutical contaminant in water.","purpose":"Enable an agent to recognise clofibric acid, assess the condition and suitability of a sample, and choose evidence-supported analytical, handling, and disposal actions.","scope":{"in":["Molecular identity and distinctions from clofibrate, salts, and related chlorophenoxy acids","Sample purity, impurities, grade, and analytical traceability","Physical state, thermal properties, solubility, and acid-base behaviour under recorded conditions","Measurement in laboratory, environmental, and biological matrices","Transformation, biological-effect evidence, hazards, and applicable substance controls"],"out":["Clofibrate and other chemically distinct ester derivatives as standalone substances","Finished medicines, formulations, and patient treatment decisions","Manufacturing plants and complete synthesis processes","Wastewater treatment facilities and receiving ecosystems as whole systems","Analytical instruments and laboratory management systems"],"boundaries":[]},"distinguishingFeatures":["Match the structure to 2-(4-chlorophenoxy)-2-methylpropanoic acid, with a para-chlorophenoxy group and two methyl groups on the carbon adjacent to the carboxyl group. Identity reference: [PubChem CID 2797](https://pubchem.ncbi.nlm.nih.gov/compound/2797).","Cross-check CAS 882-09-7 and PubChem CID 2797 against the structure; a similar product name alone is insufficient.","Require the free carboxylic acid identity when distinguishing clofibric acid from clofibrate, its ethyl ester.","Distinguish the neutral acid, dissolved carboxylate, and isolated salts by protonation state and counterion records.","Check molecular formula C10H11ClO3 together with structural evidence; formula or nominal mass alone cannot exclude structural isomers."],"structure":{"bundles":[{"id":"clofibric-acid-identity","name":"Clofibric acid identity","description":"Establishes the molecular entity and prevents confusion with related fibrates and chemical forms.","layers":[{"id":"structure-and-identifiers","name":"Structure and identifiers","description":"Connects the registry entry to a verified molecular structure.","findings":[{"id":"identity-concordance","name":"Identity concordance","description":"Require agreement between the chlorophenoxy dimethyl carboxylic acid structure, identifiers, and sample documentation.","questions":[{"text":"Does the recorded structure match 2-(4-chlorophenoxy)-2-methylpropanoic acid?","id":"identity-concordance-q01","kind":"definition"},{"text":"Which authoritative record verifies the CAS, PubChem, and any EC identifier used for this sample?","id":"identity-concordance-q02","kind":"provenance"}]}]},{"id":"acid-ester-and-salt-boundaries","name":"Acid, ester, and salt boundaries","description":"Separates chemical identity from solution speciation and related substances.","findings":[{"id":"chemical-form-resolution","name":"Chemical form resolution","description":"Record whether evidence concerns free clofibric acid, its dissolved anion, an isolated salt, or an ester precursor.","questions":[{"text":"Is the material clofibric acid, clofibrate, or a salt with an explicitly identified counterion?","id":"chemical-form-resolution-q01","kind":"boundary"},{"text":"Does a reported amount represent the supplied chemical form or a clofibric-acid-equivalent amount?","id":"chemical-form-resolution-q02","kind":"measurement"}]}]}]},{"id":"lot-quality-and-physical-state","name":"Lot quality and physical state","description":"Defines whether a particular solid or solution is fit for its proposed use.","layers":[{"id":"assay-and-traceability","name":"Assay and traceability","description":"Captures lot-specific composition and evidence supporting assigned purity.","findings":[{"id":"usable-acid-content","name":"Usable acid content","description":"Separate assigned clofibric acid content from chromatographic area percentage, water, residual solvents, and impurities.","questions":[{"text":"What assay method and reporting basis establish the clofibric acid content of this lot?","id":"usable-acid-content-q01","kind":"measurement"},{"text":"Which certificate, lot identifier, and expiry or retest record support its use as a standard?","id":"usable-acid-content-q02","kind":"provenance"}]}]},{"id":"phase-and-storage-condition","name":"Phase and storage condition","description":"Describes the actual material and evidence for changes during storage or heating.","findings":[{"id":"physical-state-integrity","name":"Physical state integrity","description":"Record solid form or solution composition and distinguish observed thermal transitions from assumed constants.","questions":[{"text":"What solid form or solution composition is present, and has precipitation or another change occurred during storage?","id":"physical-state-integrity-q01","kind":"measurement"},{"text":"Which melting, boiling, or decomposition observations are supported, at what pressure and with what method?","id":"physical-state-integrity-q02","kind":"measurement"},{"text":"What evidence sets storage conditions and the point at which the sample must be requalified?","id":"physical-state-integrity-q03","kind":"action"}]}]}]},{"id":"aqueous-speciation-and-measurement","name":"Aqueous speciation and measurement","description":"Connects acid-base behaviour to dissolution, extraction, and analytical results.","layers":[{"id":"dissociation-and-dissolution","name":"Dissociation and dissolution","description":"Records conditions governing the neutral acid and carboxylate fractions.","findings":[{"id":"conditioned-solubility","name":"Conditioned solubility","description":"Keep intrinsic solubility, apparent solubility, and dissociation evidence distinct.","questions":[{"text":"What measured pKa is applicable to the solvent, temperature, and ionic strength under consideration?","id":"conditioned-solubility-q01","kind":"measurement"},{"text":"Does the solubility value refer to neutral acid or total dissolved species, and at what pH?","id":"conditioned-solubility-q02","kind":"boundary"},{"text":"What dissolution or dilution conditions maintain the intended dissolved concentration?","id":"conditioned-solubility-q03","kind":"action"}]}]},{"id":"analytical-confirmation","name":"Analytical confirmation","description":"Establishes selective detection and reliable concentration assignment in the actual matrix.","findings":[{"id":"matrix-specific-quantification","name":"Matrix-specific quantification","description":"Require reference-standard agreement and validation of recovery, interference, and sensitivity.","questions":[{"text":"Which retention and spectral criteria confirm clofibric acid against an authenticated standard?","id":"matrix-specific-quantification-q01","kind":"measurement"},{"text":"What recovery, matrix effect, uncertainty, and quantification limit apply to this sample type?","id":"matrix-specific-quantification-q02","kind":"measurement"},{"text":"Could preparation hydrolyse an ester precursor or release bound material, changing what the reported clofibric acid result includes?","id":"matrix-specific-quantification-q03","kind":"boundary"}]}]}]},{"id":"environmental-fate-and-transformation","name":"Environmental fate and transformation","description":"Organises evidence for occurrence, transport, and chemical or biological transformation.","layers":[{"id":"occurrence-and-partitioning","name":"Occurrence and partitioning","description":"Links measured occurrence to sampling context and phase distribution.","findings":[{"id":"interpretable-environmental-detection","name":"Interpretable environmental detection","description":"Record environmental detections with matrix, fraction, pH, and evidence supporting any proposed origin.","questions":[{"text":"Was clofibric acid measured in water, solids, or biota, and was the result dissolved, extractable, or total?","id":"interpretable-environmental-detection-q01","kind":"measurement"},{"text":"What evidence links this occurrence to a precursor or release source?","id":"interpretable-environmental-detection-q02","kind":"provenance"},{"text":"Which measured partition coefficient applies at the site's pH and matrix conditions?","id":"interpretable-environmental-detection-q03","kind":"measurement"}]}]},{"id":"transformation-and-treatment","name":"Transformation and treatment","description":"Assesses removal mechanisms, products, and the extent of destruction.","findings":[{"id":"parent-loss-versus-destruction","name":"Parent loss versus destruction","description":"Distinguish transfer to another phase from transformation and mineralisation of clofibric acid.","questions":[{"text":"Under which light, oxidant, biological, temperature, and pH conditions was a transformation rate measured?","id":"parent-loss-versus-destruction-q01","kind":"measurement"},{"text":"Do products and carbon or chlorine balances support destruction, or only loss of the parent analytical signal?","id":"parent-loss-versus-destruction-q02","kind":"boundary"},{"text":"What further measurements are needed before the tested treatment can be judged effective?","id":"parent-loss-versus-destruction-q03","kind":"action"}]}]}]},{"id":"biological-effects-and-permitted-handling","name":"Biological effects and permitted handling","description":"Connects substance-specific effect evidence to justified handling and use decisions.","layers":[{"id":"biological-evidence-boundaries","name":"Biological evidence boundaries","description":"Keeps direct clofibric acid observations separate from precursor, formulation, and class-level evidence.","findings":[{"id":"effect-attribution","name":"Effect attribution","description":"Record biological endpoints with the tested substance, exposure conditions, and experimental system.","questions":[{"text":"Was clofibric acid directly tested, measured after clofibrate exposure, or inferred from a broader fibrate class?","id":"effect-attribution-q01","kind":"provenance"},{"text":"What endpoint, species or cell system, concentration basis, and exposure duration support the reported effect?","id":"effect-attribution-q02","kind":"measurement"},{"text":"Which conclusions remain unsupported when transferring this result to another organism or exposure route?","id":"effect-attribution-q03","kind":"boundary"}]}]},{"id":"classification-and-disposition","name":"Classification and disposition","description":"Determines applicable controls for the identified material and proposed activity.","findings":[{"id":"supported-handling-decision","name":"Supported handling decision","description":"Ground handling and disposal in dated classifications and sample composition rather than assumptions from medicinal use.","questions":[{"text":"Which current jurisdictional record and supplier safety data sheet apply to this acid, grade, or solution?","id":"supported-handling-decision-q01","kind":"provenance"},{"text":"Is a substance-specific exposure limit established, absent from the consulted source, or still unverified?","id":"supported-handling-decision-q02","kind":"boundary"},{"text":"What containment, storage compatibility, and waste route follow from the verified hazards and solvent composition?","id":"supported-handling-decision-q03","kind":"action"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of clofibric acid this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of clofibric acid this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of clofibric acid this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of clofibric acid this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of clofibric acid this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of clofibric acid this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain clofibric acid as the active metabolite of clofibrate and a studied pharmaceutical pollutant.","Report environmental monitoring data with sources and detection limits."],"mustNot":["Present trace environmental concentrations as an immediate health threat without evidence.","Dismiss findings of pharmaceuticals in water without evidence.","Recommend clofibrate-type drugs for a specific person.","Dispose of pharmaceutical waste into drains."],"requiresHuman":["Using monitoring results in a public advisory about drinking water."]},"ethics":{"considerations":["Pharmaceutical residues in water raise long-term environmental concerns.","Public communication about water safety must be accurate and not alarming."],"affectedParties":["Water users","Aquatic ecosystems","Water utilities"]},"owners":{"steward":"The laboratory or business that holds it; chemical safety authorities regulate supply and use.","roles":[],"masterSystems":[]},"relations":[{"target":"Q11173","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.clofibric-acid","Wikidata: Q3080279 (https://www.wikidata.org/wiki/Q3080279)"]},"properties":{"applicability":"required","items":["Chemical identity: CAS 882-09-7; PubChem CID 2797; C10H11ClO3","Molar mass: 214.64 g/mol for the neutral acid","Acid-base and counterion state: Neutral acid, carboxylate, or mixture; pH, solvent, and counterion where applicable","Assay and impurity profile: Mass fraction or molar fraction; method, uncertainty, water content, and identified impurities","Physical and thermal state: Solid or solution; solid form where established; melting and boiling behaviour in °C with pressure and decomposition observations","Solubility and dissociation: Solubility in mg/L or mol/L; pKa dimensionless; solvent, pH, temperature, and ionic strength","Matrix concentration: ng/L, µg/L, mg/kg, or mol/L; matrix, fraction, recovery, and quantification limit","Partitioning and transformation: log Kow, log D at specified pH, Kd in L/kg, and transformation half-life with experimental conditions","Relationship to clofibrate: Clofibric acid is a metabolite of clofibrate","Hazard and regulatory status: Verified EC identifier, jurisdiction, dated classification, exposure limits where established, and use-specific restrictions"]},"recognition":{"applicability":"required","items":["Identified by container label, chemical name and identifier, and certificate of analysis rather than by appearance alone."]},"capabilities":{"applicability":"required","items":["Resolve an incoming sample or literature record to clofibric acid, flagging ester, salt, or identity mismatches.","Judge whether a lot or standard meets the purity and traceability requirements of a specified analysis.","Interpret concentration and phase behaviour using pH, matrix, and acid-equivalent reporting basis.","Select a validated identification or quantification method suited to the matrix and required sensitivity.","Evaluate transformation results using product evidence and mass balance alongside parent-compound loss.","Determine handling, storage, and waste-routing requirements from verified substance and sample records."]},"hazards":{"applicability":"required","items":["Persistence in water and treatment systems.","Misinterpretation of trace monitoring data."]},"interfaces":{"applicability":"required","items":["Globally Harmonized System of Classification and Labelling of Chemicals (GHS), United Nations."]},"context":{"applicability":"required","items":["Clofibric acid is encountered in pharmaceutical research as the active metabolite of clofibrate.","Environmental laboratories study it as a pharmaceutical contaminant in water and use authenticated reference material to support chemical identification and measurement."]}},"sources":[{"title":"Wikidata item Q3080279: clofibric acid","url":"https://www.wikidata.org/wiki/Q3080279","note":"identity and sense of the item"},{"title":"Wikipedia: Clofibric acid","url":"https://en.wikipedia.org/wiki/Clofibric_acid","note":"general description of the item"}],"openQuestions":["Which authoritative EC identifier, jurisdiction-specific GHS classifications, and occupational exposure limits can be verified for clofibric acid itself?","Which measured pKa, intrinsic solubility, melting range, and boiling or decomposition data are sufficiently documented for adoption, and under which conditions?","Which impurities, solid forms, and storage changes materially affect lot qualification and reference-standard validity?","Which matrix-specific analytical methods distinguish directly present clofibric acid from amounts generated or released during sample preparation?","What primary evidence establishes environmental transformation rates, product identities, mineralisation, and biological effects under relevant exposure conditions?"],"resources":{"spec":"/models/things/publications/thing-q3080279/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q3080279/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T08:45:27Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:29+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}