{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.perimysium","code":"thing-q3543470","url":"https://ver.cy/models/thing/q3543470/","name":"perimysium","alternateNames":[],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.LIV"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Perimysium is the collagen-rich connective tissue of skeletal muscle that surrounds and separates muscle fascicles, supports larger intramuscular nerves and blood vessels, and contributes to force transmission.","purpose":"Enable an agent to identify perimysium, assess its organization and condition, and select justified observations or analyses of its role within skeletal muscle.","scope":{"in":["Perimysial boundaries and networks around muscle fascicles","Local collagen architecture and extracellular matrix composition","Connections with adjacent intramuscular connective tissue and attachment structures","Perimysial deformation and contributions to muscle mechanics","Regional remodeling, damage, and specimen-dependent observations"],"out":["Individual muscle fiber contractile machinery","Endomysium surrounding individual muscle fibers","Epimysium surrounding the whole muscle","Tendon, aponeurosis, and deep fascia as independently modeled structures","Blood vessels and nerves as independently modeled structures","Whole-muscle disease diagnosis and treatment planning"],"boundaries":[]},"distinguishingFeatures":["Identify connective tissue around groups of muscle fibers forming fascicles; tissue immediately surrounding individual fibers belongs to endomysium. See [muscle extracellular matrix architecture review](https://pmc.ncbi.nlm.nih.gov/articles/PMC10635663/).","Establish an internal fascicular boundary rather than the outer envelope of the entire muscle, which is epimysium.","Distinguish the connective tissue boundary from the fascicle's enclosed contractile fibers.","At an attachment interface, require anatomical tracing to distinguish perimysium from tendon or aponeurosis; collagen staining alone does not establish identity."],"structure":{"bundles":[{"id":"fascicular-identity","name":"Fascicular identity","description":"Establish which connective tissue region qualifies as perimysium.","layers":[{"id":"fascicle-enclosure","name":"Fascicle enclosure","description":"Recognize the tissue through its relationship to muscle fiber groups.","findings":[{"id":"boundary-around-fiber-groups","name":"Boundary around fiber groups","description":"Use the enclosed anatomical unit to distinguish a perimysial boundary from an individual fiber sheath.","questions":[{"text":"Does this connective tissue region surround or separate a recognizable group of muscle fibers?","id":"boundary-around-fiber-groups-q01","kind":"definition"},{"text":"What image or anatomical observation distinguishes it from endomysium?","id":"boundary-around-fiber-groups-q02","kind":"boundary"}]}]},{"id":"regional-localization","name":"Regional localization","description":"Place the identified perimysium within a particular muscle.","findings":[{"id":"host-and-position","name":"Host and position","description":"Attach the observation to its host muscle and sampled location.","questions":[{"text":"Which species, specimen, muscle, and intramuscular region supplied this observation?","id":"host-and-position-q01","kind":"provenance"},{"text":"Is the region internal to the muscle, near its surface, or near an attachment interface?","id":"host-and-position-q02","kind":"boundary"}]}]}]},{"id":"matrix-architecture","name":"Matrix architecture","description":"Describe the geometry and material organization of the perimysial network.","layers":[{"id":"network-geometry","name":"Network geometry","description":"Measure perimysial extent and spatial organization.","findings":[{"id":"thickness-and-connectivity","name":"Thickness and connectivity","description":"Record local thickness and observed continuity without inferring a complete network from a single section.","questions":[{"text":"What thickness distribution is measured across specified perimysial boundaries?","id":"thickness-and-connectivity-q01","kind":"measurement"},{"text":"Which apparent junctions or discontinuities are confirmed in serial sections or a three-dimensional volume?","id":"thickness-and-connectivity-q02","kind":"measurement"}]}]},{"id":"collagen-and-constituents","name":"Collagen and constituents","description":"Characterize matrix composition and collagen arrangement with localized evidence.","findings":[{"id":"localized-matrix-evidence","name":"Localized matrix evidence","description":"Keep constituent identification separate from architectural measurement and from bulk muscle composition.","questions":[{"text":"Which matrix constituents were demonstrated specifically within the perimysial region, using which assays?","id":"localized-matrix-evidence-q01","kind":"provenance"},{"text":"What collagen orientation and waviness are observed relative to the local fascicle axis?","id":"localized-matrix-evidence-q02","kind":"measurement"}]}]}]},{"id":"connective-tissue-interfaces","name":"Connective tissue interfaces","description":"Map perimysial relationships with neighboring tissues and structures.","layers":[{"id":"matrix-transitions","name":"Matrix transitions","description":"Trace transitions between perimysium and other connective tissue compartments.","findings":[{"id":"interface-attribution","name":"Interface attribution","description":"Record observed continuity and preserve uncertainty where compartment boundaries cannot be resolved.","questions":[{"text":"Where can this perimysial region be traced toward endomysium, epimysium, tendon, or aponeurosis?","id":"interface-attribution-q01","kind":"boundary"},{"text":"What tracing or imaging evidence supports each claimed connection?","id":"interface-attribution-q02","kind":"provenance"}]}]},{"id":"associated-structures","name":"Associated structures","description":"Locate vessels, nerves, or other structures relative to identified perimysial tissue.","findings":[{"id":"local-structure-relations","name":"Local structure relations","description":"Describe associated structures without treating their own connective tissue coverings as automatically perimysial.","questions":[{"text":"Which identified vessels or nerves lie within or alongside this perimysial region?","id":"local-structure-relations-q01","kind":"measurement"},{"text":"How were vascular walls or nerve sheaths excluded from perimysial segmentation?","id":"local-structure-relations-q02","kind":"boundary"}]}]}]},{"id":"fascicle-mechanics","name":"Fascicle mechanics","description":"Evaluate perimysial deformation and evidence for its mechanical contribution.","layers":[{"id":"interfascicular-deformation","name":"Interfascicular deformation","description":"Observe relative movement of fascicles and deformation of their separating tissue.","findings":[{"id":"shear-and-extension","name":"Shear and extension","description":"Perimysial mechanics should distinguish accommodation of interfascicular movement from evidence of force transmission; their relative contributions remain context dependent. See [intramuscular connective tissue function review](https://pmc.ncbi.nlm.nih.gov/articles/PMC7248366/).","questions":[{"text":"How much relative fascicle displacement and perimysial strain occur under the recorded loading condition?","id":"shear-and-extension-q01","kind":"measurement"},{"text":"Were observations made during passive stretch, active contraction, or another specified condition?","id":"shear-and-extension-q02","kind":"provenance"}]}]},{"id":"mechanical-attribution","name":"Mechanical attribution","description":"Determine which conclusions a test supports about perimysium itself.","findings":[{"id":"test-specific-load-evidence","name":"Test-specific load evidence","description":"Separate measured tissue response from a proposed perimysial contribution to whole-muscle behavior.","questions":[{"text":"Does the test measure isolated perimysial tissue, a fascicle bundle, or whole muscle?","id":"test-specific-load-evidence-q01","kind":"boundary"},{"text":"What controls or model assumptions support assigning the response to perimysium?","id":"test-specific-load-evidence-q02","kind":"provenance"},{"text":"Which additional measurement would distinguish competing explanations of the observed load transfer?","id":"test-specific-load-evidence-q03","kind":"action"}]}]}]},{"id":"condition-and-observation","name":"Condition and observation","description":"Assess perimysial alterations while accounting for sampling and preparation.","layers":[{"id":"remodeling-and-disruption","name":"Remodeling and disruption","description":"Describe changes relative to an appropriate anatomical comparison.","findings":[{"id":"supported-condition-assessment","name":"Supported condition assessment","description":"Record thickening, altered organization, cellular changes, or disruption as observations before assigning a pathological interpretation.","questions":[{"text":"Which perimysial features differ from anatomically and methodologically matched reference tissue?","id":"supported-condition-assessment-q01","kind":"measurement"},{"text":"What evidence separates remodeling or injury from regional variation and preparation damage?","id":"supported-condition-assessment-q02","kind":"boundary"},{"text":"What additional localized assay or expert assessment is needed before interpreting the alteration?","id":"supported-condition-assessment-q03","kind":"action"}]}]},{"id":"preparation-and-resolution","name":"Preparation and resolution","description":"Determine whether the specimen and method support the claimed perimysial observation.","findings":[{"id":"measurement-fitness","name":"Measurement fitness","description":"Retain preparation, orientation, resolution, and segmentation information alongside each tissue measurement.","questions":[{"text":"What fixation, sectioning, staining, and tissue length conditions were used?","id":"measurement-fitness-q01","kind":"provenance"},{"text":"Can the image resolution and section orientation distinguish the measured perimysium from adjacent tissue?","id":"measurement-fitness-q02","kind":"measurement"},{"text":"Should the region be reimaged, resampled, or marked unresolved before comparison?","id":"measurement-fitness-q03","kind":"action"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of perimysium this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-standards-and-regulation","name":"Standards and regulation","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these standards and regulation hold for the sense of perimysium this model covers, and on what evidence?","id":"evidence-standards-and-regulation-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of perimysium this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of perimysium this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of perimysium this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of perimysium this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Describe perimysium and its role in muscle structure from anatomy sources.","Annotate tissue images for teaching or research when the samples were lawfully obtained."],"mustNot":["Interpret a person's muscle biopsy or scan as a diagnosis.","Use human tissue samples outside the consent under which they were taken.","Give advice on treating a muscle injury or disease as if it were medical care."],"requiresHuman":["Discussing findings in a person's own biopsy or imaging report."]},"ethics":{"considerations":["Human tissue comes from people who have rights over how it is used.","Health information drawn from tissue is private."],"affectedParties":["Patients and tissue donors","People with muscle diseases","Researchers"]},"owners":{"steward":"Nobody owns it as a structure; the clinic or biobank answers for a stored sample.","roles":[],"masterSystems":["Biobank sample registers"]},"relations":[{"target":"Q6036578","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.perimysium","Wikidata: Q3543470 (https://www.wikidata.org/wiki/Q3543470)"]},"properties":{"applicability":"required","items":["Host muscle and sampled region: Species, individual or specimen identifier, named muscle, side, depth, and longitudinal position","Fascicular boundary assignment: Confirmed perimysium; probable perimysium; mixed interface; unresolved","Perimysial thickness: Micrometers, with sampling locations, section orientation, and summary distribution","Perimysial area fraction: Percent of an explicitly defined muscle section or region","Collagen orientation: Angular distribution in degrees relative to the local fascicle axis, with acquisition method","Matrix constituent evidence: Identified constituent, assay, localization, and detected, not detected, or unresolved status","Mechanical response: Stress in kPa or MPa, dimensionless strain, and modulus in kPa or MPa, with loading mode and protocol","Observed tissue condition: Record continuity, thickening, disruption, cellular changes, and indeterminate features separately"]},"recognition":{"applicability":"required","items":["Thin sheets of connective tissue that wrap bundles of muscle fibres in a cross-section.","Visible in meat as the fine white lines separating muscle bundles."]},"capabilities":{"applicability":"required","items":["Annotate perimysial boundaries in muscle sections or three-dimensional image volumes.","Select anatomically matched regions for thickness, area fraction, and collagen orientation measurements.","Trace interfaces with endomysium, epimysium, and attachment structures.","Compare perimysial organization across specimens using compatible preparation and measurement methods.","Design or interpret mechanical measurements with explicit tissue attribution limits.","Flag unresolved remodeling or damage for additional imaging, assays, or expert review."]},"hazards":{"applicability":"required","items":["Fibrosis or inflammation of the perimysium occurs in some muscle diseases.","Misinterpreted tissue findings can delay correct diagnosis."]},"interfaces":{"applicability":"required","items":["Terminologia Histologica, issued by the Federative International Committee on Anatomical Terminology, provides standardized histological nomenclature for perimysium."]},"context":{"applicability":"required","items":["Perimysium is encountered in skeletal muscle anatomy, histology, pathology and studies of muscle mechanics.","Its organization is examined to understand fascicle boundaries, connective tissue changes and the pathways of larger intramuscular vessels and nerves."]}},"sources":[{"title":"Wikidata item Q3543470: perimysium","url":"https://www.wikidata.org/wiki/Q3543470","note":"identity and sense of the item"},{"title":"Wikipedia: Perimysium","url":"https://en.wikipedia.org/wiki/Perimysium","note":"general description of the item"}],"openQuestions":["Which species and muscle-specific conventions reliably distinguish fascicles and perimysial subdivisions in this registry's intended coverage?","What reference distributions for perimysial thickness and area fraction are defensible across muscle regions, ages, and preparation methods?","Under which loading conditions does perimysium primarily accommodate interfascicular shear, and when can its contribution to force transmission be isolated experimentally?","Which localized composition and architecture measurements best explain mechanical differences without relying on bulk muscle collagen measurements?","What evidence is sufficient to distinguish pathological perimysial fibrosis from adaptive remodeling, normal regional variation, and preparation artifacts?"],"resources":{"spec":"/models/things/publications/thing-q3543470/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q3543470/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T12:00:46Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-09T07:30:01+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}