{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.chromosome","code":"thing-q37748","url":"https://ver.cy/models/thing/q37748/","name":"chromosome","alternateNames":["artificial chromosome","homologous chromosome","autosome","heterosome","mouse chromosome 2","mouse chromosome 4","mouse chromosome 7","mouse chromosome 8","mouse chromosome 9","mouse chromosome 10","mouse chromosome 13","mouse chromosome 14"],"kind":"thing","status":"published","version":"0.2.0-wave.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.LIV"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A thread-like structure of DNA and proteins that carries genetic information in cells; humans typically have 23 pairs (22 autosome pairs and the sex chromosomes), and chromosome number and structure vary across species.","purpose":"Let an agent explain chromosomes in general biological terms and point to genetic services for testing and counselling, without interpreting personal results.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["DNA and proteins","Carries genes","Species-specific number","Visible during cell division"],"structure":{"bundles":[{"id":"structure","name":"Structure","description":"What it is.","layers":[{"id":"parts","name":"Parts","description":"Centromere and arms.","findings":[{"id":"parts-finding","name":"Parts","description":"Structure.","questions":[{"text":"What are the parts of a chromosome?","kind":"definition"},{"text":"How is DNA packaged?","kind":"definition"}]}]},{"id":"number","name":"Number","description":"Karyotype.","findings":[{"id":"number-finding","name":"Number","description":"Chromosome number.","questions":[{"text":"How many chromosomes does this species have, according to sources?","kind":"provenance"},{"text":"How is a karyotype written?","kind":"definition"}]}]}]},{"id":"genetics","name":"Genetics","description":"Inheritance.","layers":[{"id":"inheritance","name":"Inheritance","description":"Meiosis.","findings":[{"id":"inheritance-finding","name":"Inheritance","description":"Inheritance.","questions":[{"text":"How are chromosomes passed to offspring?","kind":"definition"},{"text":"What happens in meiosis?","kind":"definition"}]}]},{"id":"variation","name":"Variation","description":"Differences.","findings":[{"id":"variation-finding","name":"Variation","description":"Chromosomal variation.","questions":[{"text":"What chromosomal variations do sources describe, in general terms?","kind":"provenance"},{"text":"Is the language respectful and non-stigmatising?","kind":"boundary"}]}]}]},{"id":"testing","name":"Testing","description":"Genetic services.","layers":[{"id":"results","name":"Results","description":"Personal results.","findings":[{"id":"results-finding","name":"Results","description":"Personal results.","questions":[{"text":"Is the user asking the agent to interpret their own test result?","kind":"boundary"},{"text":"How can they access genetic counselling?","kind":"action"}]}]},{"id":"prenatal","name":"Prenatal","description":"Screening.","findings":[{"id":"prenatal-finding","name":"Prenatal","description":"Prenatal screening.","questions":[{"text":"What prenatal screening is offered, according to health services?","kind":"provenance"},{"text":"Who can explain results and options?","kind":"provenance"}]}]}]},{"id":"research","name":"Research","description":"Science.","layers":[{"id":"species","name":"Species","description":"Comparisons.","findings":[{"id":"species-finding","name":"Species","description":"Comparative genomics.","questions":[{"text":"How do chromosome numbers compare across species?","kind":"provenance"},{"text":"Why does number not reflect complexity?","kind":"definition"}]}]},{"id":"artificial","name":"Artificial","description":"Engineered chromosomes.","findings":[{"id":"artificial-finding","name":"Artificial","description":"Artificial chromosomes.","questions":[{"text":"What are artificial chromosomes used for in research?","kind":"definition"},{"text":"Which regulations apply?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain chromosome structure and number from standard biology sources.","Describe karyotypes and chromosomal conditions in general terms."],"mustNot":["Interpret a person's chromosome test as a diagnosis in place of a qualified clinician.","Disclose a person's genetic or chromosomal information without consent.","Use chromosomal differences to stigmatise people or deny them rights.","Claim sex or ability can be read from chromosomes alone in ways that misrepresent the science."],"requiresHuman":["Communicating a chromosomal finding to a patient or family.","Decisions about prenatal testing or its outcomes."]},"ethics":{"considerations":["Genetic information is highly personal and can affect a family.","Chromosomal variation has been used to justify discrimination."],"affectedParties":["People with chromosomal conditions","Families and relatives","Patients undergoing testing"]},"owners":{"steward":"Nobody owns chromosomes; a person's genetic data is theirs, held by the laboratory or clinic that tests it.","roles":[],"masterSystems":[]},"relations":[{"target":"Q22326185","type":"parent","note":"registry parent class"},{"target":"cellular structure","type":"related","note":"category"},{"target":"gene","type":"related","note":"content"},{"target":"DNA and histones","type":"related","note":"composition"},{"target":"cytogenetics","type":"related","note":"field"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.chromosome","Wikidata: Q37748 (https://www.wikidata.org/wiki/Q37748)"]},"properties":{"applicability":"required","items":["human chromosome number: 46 chromosomes - typical diploid"]},"recognition":{"applicability":"required","items":["Karyotype images","Autosomes and sex chromosomes","Chromatin is the less condensed form","Seen under the microscope during cell division as condensed X-shaped or rod structures."]},"capabilities":{"applicability":"required","items":["explain chromosome structure and number","describe karyotypes in general terms","find genetic counselling services","compare chromosome numbers across species"]},"hazards":{"applicability":"required","items":["Agents interpreting personal genetic results","Oversimplifying sex and chromosomes","Genetic determinism"]},"interfaces":{"applicability":"required","items":["ISCN cytogenetic nomenclature","Genetic testing regulation"]},"context":{"applicability":"required","items":["Carrying and transmitting genetic information.","autosomes","sex chromosomes","homologous chromosomes","artificial chromosomes","chromosomes of model organisms"]}},"sources":[{"title":"Wikidata item Q37748: chromosome","url":"https://www.wikidata.org/wiki/Q37748","note":"identity and sense of the item"},{"title":"Wikipedia: Chromosome","url":"https://en.wikipedia.org/wiki/Chromosome","note":"general description of the item"}],"openQuestions":["Should chromosome types be separate entries?","How should karyotype nomenclature be linked?","How should variation be described respectfully?"],"resources":{"spec":"/models/things/publications/thing-q37748/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q37748/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-11T11:08:18Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:51:59+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}