{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.mafenide","code":"thing-q3843044","url":"https://ver.cy/models/thing/q3843044/","name":"mafenide","alternateNames":[],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Mafenide is a synthetic antibacterial sulfonamide, chemically 4-(aminomethyl)benzenesulfonamide, used principally as its acetate salt in topical preparations for burn wounds.","purpose":"Enable an agent to recognise mafenide, assess the identity and quality of a material containing it, and determine which handling or use decisions require further evidence.","scope":{"in":["Mafenide identity and mappings between chemical identifiers and verified structures","Distinction between mafenide base, its acetate salt and quantities expressed as base equivalents","Purity, impurities, grade and analytical evidence for mafenide material","Form-dependent physical properties, stability and storage condition assessments","Antibacterial properties and biological hazards supported by attributable evidence","Links to applicable substance standards and product-specific restrictions"],"out":["Commercial cream or solution composition, packaging and product authorisation","Patient-specific prescribing, dosing and burn-treatment decisions","Burn wounds, skin grafts and their clinical state","Manufacturing processes and production equipment","Separate substance models for metabolites, excipients or counterions","Facility-wide pharmaceutical quality and waste-management systems"],"boundaries":[]},"distinguishingFeatures":["Require a verified structure-to-identifier match for mafenide; membership in the sulfonamide class alone does not establish identity.","Distinguish mafenide base from mafenide acetate by counterion evidence and form-specific identifiers before comparing masses or properties.","Distinguish the active substance from Sulfamylon cream: the cited label describes mafenide acetate in a vehicle and expresses strength as mafenide base equivalents. [DailyMed cream label](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=008eaa23-8f19-4e39-85ff-540c1c834a9e)","Distinguish mafenide from its metabolite p-carboxybenzenesulfonamide when attributing analytical signals or biological effects. [DailyMed solution label](https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e48cc935-2058-48c0-9281-b8b919629493&version=16)"],"structure":{"bundles":[{"id":"mafenide-identity-and-form","name":"Mafenide identity and form","description":"Establish what chemical entity a mafenide record or material actually represents.","layers":[{"id":"structure-and-identifiers","name":"Structure and identifiers","description":"Anchor mafenide recognition in verified chemical identity.","findings":[{"id":"verified-mafenide-reference","name":"Verified mafenide reference","description":"Record a sourced structure and reconcile identifiers against that structure before accepting synonyms.","questions":[{"text":"Which authoritative record establishes the structure associated with mafenide?","id":"verified-mafenide-reference-q01","kind":"definition"},{"text":"Which CAS, PubChem and applicable EC identifiers resolve to that same chemical form?","id":"verified-mafenide-reference-q02","kind":"provenance"}]}]},{"id":"base-salt-product-boundaries","name":"Base, salt and product boundaries","description":"Keep chemical-form identity distinct from formulation identity.","findings":[{"id":"acetate-and-base-equivalence","name":"Acetate and base equivalence","description":"Record the actual material form separately from the basis used to express mafenide content; the cream label explicitly uses base-equivalent strength. [DailyMed cream label](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=008eaa23-8f19-4e39-85ff-540c1c834a9e)","questions":[{"text":"Does this record describe mafenide base, mafenide acetate or a formulation containing the salt?","id":"acetate-and-base-equivalence-q01","kind":"boundary"},{"text":"What verified composition and assay basis justify any salt-to-base mass conversion?","id":"acetate-and-base-equivalence-q02","kind":"measurement"}]}]}]},{"id":"mafenide-material-quality","name":"Mafenide material quality","description":"Assess the content and quality of an identified mafenide material lot.","layers":[{"id":"identity-and-content-testing","name":"Identity and content testing","description":"Connect lot-level analytical results to an appropriate mafenide reference.","findings":[{"id":"assay-basis-and-selectivity","name":"Assay basis and selectivity","description":"Require methods and reference standards that establish identity and quantify mafenide on an explicit basis.","questions":[{"text":"Which identity tests distinguish the claimed mafenide form from related compounds and mixtures?","id":"assay-basis-and-selectivity-q01","kind":"measurement"},{"text":"Is the assay reported as base or acetate, and on an as-is, dried or other specified basis?","id":"assay-basis-and-selectivity-q02","kind":"measurement"}]}]},{"id":"impurities-and-grade","name":"Impurities and grade","description":"Evaluate non-mafenide components and the specification governing acceptance.","findings":[{"id":"lot-suitability-evidence","name":"Lot suitability evidence","description":"Record related substances, water, residual solvents and any intended-use-specific quality requirements without inventing universal limits.","questions":[{"text":"Which impurities and residual components were measured, with what limits and analytical coverage?","id":"lot-suitability-evidence-q01","kind":"measurement"},{"text":"Which named specification and version support accepting this lot for its intended use?","id":"lot-suitability-evidence-q02","kind":"action"}]}]}]},{"id":"mafenide-physical-state-and-stability","name":"Mafenide physical state and stability","description":"Qualify physical-property and stability evidence by material form and conditions.","layers":[{"id":"form-dependent-properties","name":"Form-dependent properties","description":"Record measured properties with enough context to apply them correctly.","findings":[{"id":"solubility-and-thermal-evidence","name":"Solubility and thermal evidence","description":"Attach solvent, pH, temperature, phase and method to property values, and distinguish melting from decomposition.","questions":[{"text":"What solubility is measured for the specified mafenide form at the stated solvent composition, pH and temperature?","id":"solubility-and-thermal-evidence-q01","kind":"measurement"},{"text":"Which thermal transitions are documented, and does decomposition prevent assigning a meaningful melting or boiling value?","id":"solubility-and-thermal-evidence-q02","kind":"measurement"}]}]},{"id":"storage-and-condition-history","name":"Storage and condition history","description":"Assess whether handling and storage history remain compatible with material quality.","findings":[{"id":"stability-supported-disposition","name":"Stability-supported disposition","description":"Use evidence applicable to the material and container to assess excursions and retest needs; prepared-product holding times belong to product records.","questions":[{"text":"What stability evidence supports storage conditions and retest intervals for this mafenide material and container?","id":"stability-supported-disposition-q01","kind":"provenance"},{"text":"Do recorded exposure conditions or analytical changes require quarantine, retesting or rejection?","id":"stability-supported-disposition-q02","kind":"action"}]}]}]},{"id":"mafenide-biological-properties","name":"Mafenide biological properties","description":"Represent antibacterial evidence and relevant biological liabilities without prescribing treatment.","layers":[{"id":"antibacterial-evidence","name":"Antibacterial evidence","description":"Connect activity claims to organisms, methods and exposure conditions.","findings":[{"id":"activity-with-context","name":"Activity with context","description":"Mafenide is described as a topical antibacterial sulfonamide; more specific activity claims require organism-level evidence. [NCBI MeSH](https://www.ncbi.nlm.nih.gov/mesh/D008272)","questions":[{"text":"Which organisms or strains have measured susceptibility to mafenide, using which assays and endpoints?","id":"activity-with-context-q01","kind":"measurement"},{"text":"What evidence supports transferring those results to a proposed formulation or wound environment?","id":"activity-with-context-q02","kind":"boundary"}]}]},{"id":"metabolites-and-systemic-effects","name":"Metabolites and systemic effects","description":"Keep parent substance, metabolite and clinical consequence linked but distinct.","findings":[{"id":"carbonic-anhydrase-liability","name":"Carbonic anhydrase liability","description":"The solution label associates mafenide acetate and p-carboxybenzenesulfonamide with carbonic anhydrase inhibition and possible metabolic acidosis. [DailyMed solution label](https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e48cc935-2058-48c0-9281-b8b919629493&version=16)","questions":[{"text":"Which evidence attributes carbonic anhydrase inhibition to the parent material, the metabolite or both?","id":"carbonic-anhydrase-liability-q01","kind":"provenance"},{"text":"Which exposure-related constraints must accompany a handoff to a product or patient-care model?","id":"carbonic-anhydrase-liability-q02","kind":"action"}]}]}]},{"id":"mafenide-handling-and-use-constraints","name":"Mafenide handling and use constraints","description":"Determine which material-specific handling rules and regulatory references apply.","layers":[{"id":"substance-handling-evidence","name":"Substance handling evidence","description":"Identify supported controls for the actual form and grade being handled.","findings":[{"id":"form-specific-hazard-record","name":"Form-specific hazard record","description":"Record current safety documentation for the actual mafenide material and distinguish absent exposure limits from established safe exposure.","questions":[{"text":"Which SDS and jurisdiction-specific classification apply to this base or acetate material?","id":"form-specific-hazard-record-q01","kind":"provenance"},{"text":"What documented controls govern dust exposure, contact, spills and disposal, and are occupational exposure limits established?","id":"form-specific-hazard-record-q02","kind":"action"}]}]},{"id":"standards-and-product-handoff","name":"Standards and product handoff","description":"Link substance evidence to applicable standards without assigning product permissions to the substance.","findings":[{"id":"qualified-use-boundary","name":"Qualified use boundary","description":"Record the relevant jurisdiction and standard; require a linked product record for formulation-specific authorisation and instructions.","questions":[{"text":"Which current pharmacopoeial or other recognised standards cover the claimed mafenide form and grade?","id":"qualified-use-boundary-q01","kind":"provenance"},{"text":"Does the proposed action concern raw-material suitability or require a separate authorised-product and clinical assessment?","id":"qualified-use-boundary-q02","kind":"boundary"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of mafenide this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-kinds","name":"Kinds and varieties","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these kinds and varieties hold for the sense of mafenide this model covers, and on what evidence?","id":"evidence-kinds-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of mafenide this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-standards-and-regulation","name":"Standards and regulation","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these standards and regulation hold for the sense of mafenide this model covers, and on what evidence?","id":"evidence-standards-and-regulation-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of mafenide this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of mafenide this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of mafenide this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of mafenide this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Identify mafenide as a topical sulfonamide used on burn wounds, citing sources.","Report stock, expiry and storage of a held supply to the responsible pharmacy."],"mustNot":["Recommend applying mafenide to a person's wound without a clinician's decision.","Advise its use for someone with a known sulfonamide allergy.","Present it as suitable for general cuts or minor burns at home.","Use expired or unlabelled products."],"requiresHuman":["Any treatment decision for a burn patient.","Disposing of stock."]},"ethics":{"considerations":["Burn patients are vulnerable and treatment errors cause pain and harm.","Antibacterial misuse drives resistance."],"affectedParties":["Burn patients","Clinicians and nurses","Pharmacists"]},"owners":{"steward":"The hospital pharmacy or manufacturer holding it; the medicines regulator authorizes its use.","roles":[],"masterSystems":["National medicines registers"]},"relations":[{"target":"Q124338655","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.mafenide","Wikidata: Q3843044 (https://www.wikidata.org/wiki/Q3843044)"]},"properties":{"applicability":"required","items":["Verified chemical identity: Structure linked to source-verified CAS, PubChem and applicable EC identifiers","Material form: Base; acetate salt; other verified form; unresolved","Assay and reporting basis: % w/w with base-equivalent or salt basis, as-is or dried basis, method and uncertainty","Related substances: Individual and total impurity concentrations in % or mg/kg, with detection limits","Water and residual solvents: Water in % w/w; identified solvents in mg/kg; method and sample conditioning","Physical state and thermal behaviour: Observed phase and solid form; transition temperature in °C with decomposition status and method","Solubility under stated conditions: mg/mL or mol/L with solvent, temperature, pH and material form","Antibacterial activity evidence: Organism or strain, assay endpoint, concentration, conditions and source","Quality disposition: Unassessed; conforms to named specification; nonconforming; quarantined; retest required","Applicable hazard and regulatory record: Material-specific SDS, jurisdiction, revision date, classification and applicable standard"]},"recognition":{"applicability":"required","items":["As a medicine, a cream or solution in labelled packs for topical use.","Cannot be identified by appearance; the label and analysis settle identity."]},"capabilities":{"applicability":"required","items":["Resolve a mafenide-labelled material to a verified chemical identity and material form.","Normalise mafenide quantities to a common reporting basis when salt composition and assay are established.","Compare a material lot with a named specification and flag missing or failed evidence.","Assess whether storage history and analytical results support continued use or require retesting.","Retrieve organism-specific activity evidence and identify unsupported extrapolations.","Route proposed pharmaceutical use to the relevant product and clinical models with substance-specific constraints attached."]},"hazards":{"applicability":"required","items":["Pain on application and allergic reactions.","Systemic effects when used on large areas without monitoring."]},"interfaces":{"applicability":"required","items":["Globally Harmonized System of Classification and Labelling of Chemicals (GHS), United Nations."]},"context":{"applicability":"required","items":["Mafenide is encountered in pharmaceutical chemistry, quality control and specialist burn care, principally in preparations containing its acetate salt.","It is used as a topical antibacterial agent in selected burn wound treatments under clinical supervision.","Chemical and pharmaceutical records distinguish the parent compound from its salt and from finished formulations when assessing identity, quality and intended use."]}},"sources":[{"title":"Wikidata item Q3843044: mafenide","url":"https://www.wikidata.org/wiki/Q3843044","note":"identity and sense of the item"},{"title":"Wikipedia: Mafenide","url":"https://en.wikipedia.org/wiki/Mafenide","note":"general description of the item"}],"openQuestions":["Which authoritative chemical records settle the structures, formulae and CAS, PubChem and applicable EC identifiers for mafenide base and acetate?","Which measured solubility, ionisation and thermal data are reliable for each form, and which commonly reported constants refer to a different form or to decomposition?","Which current quality standards define assay methods, impurity limits, grades and retest requirements for mafenide materials?","What form-specific stability, GHS classification and occupational exposure evidence supports raw-material handling and storage?","What evidence establishes organism-specific antibacterial activity, resistance limitations and the separate contributions of mafenide and its metabolite to carbonic anhydrase inhibition?"],"resources":{"spec":"/models/things/publications/thing-q3843044/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q3843044/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T11:06:25Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:30+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}