{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.immune-disorder","code":"thing-q3843811","url":"https://ver.cy/models/thing/q3843811/","name":"immune disorder","alternateNames":["immune system organ benign neoplasm","hemangioma of spleen","natural killer cell leukemia","small intestinal enteropathy-associated T-cell lymphoma","immune deficiency with skin involvement","spleen symptom","eosinophil peroxidase deficiency","autoimmune pulmonary alveolar proteinosis","Autoinflammatory diseases","immune amnesia","mast cell activation disorders","immune system cancer"],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Cross-cutting context","entryKind":"thing","plane":"XCT","domain":["XCT.STA"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"An immune disorder is a pathological condition involving deficient, excessive, misdirected or otherwise dysregulated immune function, encompassing multiple diseases rather than a single diagnosis.","purpose":"Enable an AI agent to recognise an immune disorder, represent evidence about its immune dysfunction and current state, and identify which assessments or actions require condition-specific clinical authority.","scope":{"in":["The defining immune dysfunction and boundaries of the immune disorder category","Subtype, affected immune components and supported mechanisms","Aetiology, predisposition and acquired contributors, with uncertainty recorded","Evidence requirements, diagnostic criteria and versioned classification mappings","Immune manifestations, disease activity, functional impairment and longitudinal course","Condition-specific assessment, monitoring and intervention constraints"],"out":["The patient's complete identity, history and overall health record","Visits, admissions, referrals and other episodes of care","Laboratory assays as technical procedures and specimens as physical objects","Medicines, vaccines and therapeutic products as independently modelled things","Infections, malignancies and organ diseases except for their documented relationship to immune dysfunction","Normal immune responses without evidence of a disorder"],"boundaries":[]},"distinguishingFeatures":["Require evidence or an explicit hypothesis of pathological immune function; an immune response to an ordinary challenge alone does not establish an immune disorder.","Distinguish the underlying disorder from an isolated abnormal immune test by recording clinical relevance, persistence and alternative explanations.","Distinguish immune deficiency, immune-mediated tissue injury, hypersensitivity and dysregulated inflammation without assuming these categories are mutually exclusive.","Distinguish an immune disorder from an infection or organ manifestation by recording whether each is a cause, consequence, associated condition or unresolved alternative.","Treat 'immune disorder' as a broad category unless evidence supports a named subtype; do not equate the entire category with autoimmune disease."],"structure":{"bundles":[{"id":"immune-disorder-boundaries","name":"Immune disorder boundaries","description":"Establish what constitutes the disorder and how specifically it can be named.","layers":[{"id":"pathological-immune-function","name":"Pathological immune function","description":"Separate immune dysfunction from normal responses and incidental abnormalities.","findings":[{"id":"immune-dysfunction-boundary","name":"Immune dysfunction boundary","description":"Record the basis for treating an immune phenomenon as a disorder rather than a physiological response or isolated result.","questions":[{"text":"What pathological change in immune function defines the proposed disorder?","id":"immune-dysfunction-boundary-q01","kind":"definition"},{"text":"What evidence distinguishes it from a normal response, transient variation or incidental laboratory abnormality?","id":"immune-dysfunction-boundary-q02","kind":"boundary"}]}]},{"id":"subtype-and-overlap","name":"Subtype and overlap","description":"Locate the disorder within researched immune disease categories while allowing overlap.","findings":[{"id":"supported-subtype","name":"Supported subtype","description":"Record the narrowest justified classification and its relationship to neighbouring immune disorders.","questions":[{"text":"Which named disorder or family is supported, and which defining features justify that specificity?","id":"supported-subtype-q01","kind":"definition"},{"text":"Does the presentation combine deficiency, autoimmunity, hypersensitivity or other dysregulation, and how does the chosen classification represent that overlap?","id":"supported-subtype-q02","kind":"boundary"}]}]}]},{"id":"immune-mechanism-and-origin","name":"Immune mechanism and origin","description":"Represent the affected immune functions and the evidence for why they are abnormal.","layers":[{"id":"affected-immune-functions","name":"Affected immune functions","description":"Identify implicated components and distinguish functional evidence from proposed mechanisms.","findings":[{"id":"component-function-evidence","name":"Component and function evidence","description":"Connect implicated immune components to demonstrable functional changes.","questions":[{"text":"Which immune cells, molecules or pathways are implicated, and what function is deficient, excessive or misdirected?","id":"component-function-evidence-q01","kind":"definition"},{"text":"Which functional tests or other observations support that mechanism, and which parts remain hypothetical?","id":"component-function-evidence-q02","kind":"provenance"}]}]},{"id":"causes-and-contributors","name":"Causes and contributors","description":"Distinguish underlying causes, susceptibility factors, triggers and secondary effects.","findings":[{"id":"aetiological-evidence","name":"Aetiological evidence","description":"Represent inherited and acquired explanations without inferring origin from age at presentation alone.","questions":[{"text":"What evidence supports an inherited, acquired or multifactorial origin, and who made that attribution?","id":"aetiological-evidence-q01","kind":"provenance"},{"text":"Are linked exposures, medicines, infections or genetic findings established causes, predispositions, triggers or unresolved associations?","id":"aetiological-evidence-q02","kind":"boundary"}]}]}]},{"id":"immune-diagnostic-evidence","name":"Immune diagnostic evidence","description":"Define how diagnostic assertions and immune investigations should be interpreted.","layers":[{"id":"criteria-and-terminology","name":"Criteria and terminology","description":"Anchor diagnostic and coding claims to identifiable authorities and releases.","findings":[{"id":"versioned-diagnostic-basis","name":"Versioned diagnostic basis","description":"Record the applicable criteria, their intended use and the precision of terminology mappings.","questions":[{"text":"Which issuing body's criteria and version support the assertion, and are they diagnostic criteria or classification criteria for another purpose?","id":"versioned-diagnostic-basis-q01","kind":"provenance"},{"text":"Which verified ICD and SNOMED CT concepts map to this category or subtype, in which releases, and with what degree of equivalence?","id":"versioned-diagnostic-basis-q02","kind":"boundary"}]}]},{"id":"immune-test-interpretation","name":"Immune test interpretation","description":"Capture the context and limitations of evidence used to assess immune function.","findings":[{"id":"interpretable-immune-results","name":"Interpretable immune results","description":"Require sufficient measurement context to judge immune abnormalities and discordant results.","questions":[{"text":"What assay, units, reference interval, specimen and collection date accompany each result, and are age or treatment relevant to interpretation?","id":"interpretable-immune-results-q01","kind":"measurement"},{"text":"What condition-specific evidence is needed to resolve transient, conflicting or clinically unexplained results?","id":"interpretable-immune-results-q02","kind":"action"}]}]}]},{"id":"immune-course-and-impact","name":"Immune course and impact","description":"Describe how the disorder develops and how it affects health over time.","layers":[{"id":"activity-and-persistence","name":"Activity and persistence","description":"Represent onset, persistence and changes in immune disease activity.","findings":[{"id":"longitudinal-immune-state","name":"Longitudinal immune state","description":"Use condition-appropriate definitions for active disease, stable dysfunction, relapse and remission.","questions":[{"text":"What evidence establishes onset and a persistent, episodic or resolving course?","id":"longitudinal-immune-state-q01","kind":"measurement"},{"text":"Which activity or remission definitions apply to this subtype, and how do they distinguish improvement from lasting immune impairment?","id":"longitudinal-immune-state-q02","kind":"definition"}]}]},{"id":"manifestations-and-populations","name":"Manifestations and populations","description":"Connect clinical consequences and population patterns to the correct disorder definition.","findings":[{"id":"attributable-burden","name":"Attributable burden","description":"Record manifestation burden and epidemiological evidence without conflating association with causation.","questions":[{"text":"Which infections, inflammatory manifestations or organ impairments are attributed to the disorder, and what supports each attribution?","id":"attributable-burden-q01","kind":"provenance"},{"text":"For each frequency estimate, what subtype, case definition, population, geography and observation year were studied?","id":"attributable-burden-q02","kind":"measurement"}]}]}]},{"id":"immune-management-constraints","name":"Immune management constraints","description":"Represent the clinical authority and evidence needed to assess management options.","layers":[{"id":"assessment-and-monitoring","name":"Assessment and monitoring","description":"Identify condition-specific follow-up needs and escalation criteria.","findings":[{"id":"monitoring-and-escalation-basis","name":"Monitoring and escalation basis","description":"Connect monitoring and escalation decisions to documented guidance and the relevant immune phenotype.","questions":[{"text":"Which changes in infection pattern, immune measurements or organ manifestations require reassessment under the applicable guidance?","id":"monitoring-and-escalation-basis-q01","kind":"action"},{"text":"Which authority specifies monitoring intervals and escalation criteria, and for which subtype and population?","id":"monitoring-and-escalation-basis-q02","kind":"provenance"}]}]},{"id":"intervention-eligibility","name":"Intervention eligibility","description":"Capture prerequisites and constraints for clinician-directed interventions.","findings":[{"id":"immune-specific-action-constraints","name":"Immune-specific action constraints","description":"Record how the established immune phenotype affects consideration of treatment, vaccination or preventive measures.","questions":[{"text":"What subtype-specific evidence and clinical review are required before considering immune-directed treatment, vaccination or infection prevention?","id":"immune-specific-action-constraints-q01","kind":"action"},{"text":"Which documented immune deficits, current infections or treatment effects alter eligibility or require specialist review?","id":"immune-specific-action-constraints-q02","kind":"boundary"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of immune disorder this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-kinds","name":"Kinds and varieties","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these kinds and varieties hold for the sense of immune disorder this model covers, and on what evidence?","id":"evidence-kinds-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of immune disorder this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-standards-and-regulation","name":"Standards and regulation","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these standards and regulation hold for the sense of immune disorder this model covers, and on what evidence?","id":"evidence-standards-and-regulation-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of immune disorder this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of immune disorder this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of immune disorder this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-regional-variation","name":"Regional variation","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these regional variation hold for the sense of immune disorder this model covers, and on what evidence?","id":"evidence-regional-variation-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of immune disorder this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain what immune disorders are and how the main groups differ, citing medical sources.","Direct people with symptoms or concerns to qualified clinicians."],"mustNot":["Diagnose an immune disorder or rule one out for a specific person.","Advise starting, stopping or changing immunosuppressive or immune treatments.","Disclose a person's immune status or diagnosis without consent.","Promote unproven remedies that claim to boost or cure the immune system."],"requiresHuman":["Any treatment or vaccination decision for a person with an immune disorder.","Sharing health data about a person's immune condition."]},"ethics":{"considerations":["People with immune disorders face infection risks and stigma that misinformation makes worse.","Health data about immunity is sensitive and can lead to discrimination."],"affectedParties":["Patients","Families and carers","Close contacts of immunocompromised people"]},"owners":{"steward":"The patient, with the treating clinician; health authorities set clinical guidance.","roles":[],"masterSystems":["Patient health records"]},"relations":[{"target":"Q18557436","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.immune-disorder","Wikidata: Q3843811 (https://www.wikidata.org/wiki/Q3843811)"]},"properties":{"applicability":"not-applicable","items":["Diagnostic specificity: Broad immune disorder category; named disorder family; named subtype; unresolved","Immune dysfunction pattern: Deficiency; autoimmunity; hypersensitivity; autoinflammatory dysfunction; other dysregulation; mixed; undetermined; terminology subject to research","Affected immune component: Links to implicated immune cells, antibodies, complement components, tissues or pathways, with evidence status","Aetiological attribution: Inherited; acquired; multifactorial; unexplained; disputed, with supporting evidence","Diagnostic assertion status: Suspected; supported; confirmed under named criteria; disputed; excluded; historical","Diagnostic framework: Issuing body, criteria title, version, intended population and assessment date","Classification mapping: Verified ICD or SNOMED CT concept, system release, jurisdiction or edition, and mapping relationship","Immune assessment result: Assay-specific result and unit, method, reference interval, specimen, date and relevant clinical context","Disease activity: Condition-specific activity state or validated score; unknown when not established","Clinical consequence: Linked manifestations, infections, organ injury or functional limitations, each with attribution confidence","Population frequency: Prevalence or incidence with denominator, population, geography, observation period, case definition and uncertainty"]},"recognition":{"applicability":"optional","items":["Diagnosis rests on laboratory tests of immune function rather than appearance.","Recurrent, severe or unusual infections can be a sign that prompts testing.","Some autoimmune and allergic disorders show visible rashes or swelling."]},"capabilities":{"applicability":"required","items":["Determine whether a record supports only the broad immune disorder category or a more specific subtype.","Identify missing immune evidence and the condition-specific criteria needed to interpret it.","Compare diagnostic assertions across criteria versions and terminology releases.","Track immune activity, manifestations and lasting impairment as separate aspects of course.","Surface documented monitoring needs and intervention constraints for qualified clinical review.","Flag unsupported causal attributions, incompatible classifications and unresolved alternatives."]},"hazards":{"applicability":"required","items":["Serious or opportunistic infections in people with weakened immunity.","Immune attack on the body's own tissues and organs.","Severe allergic reactions such as anaphylaxis.","Delayed diagnosis because symptoms resemble common illnesses."]},"interfaces":{"applicability":"required","items":["International Classification of Diseases (ICD-11), World Health Organization."]},"context":{"applicability":"required","items":["Immune disorders are encountered in clinical care when immune dysfunction contributes to recurrent infections, inflammation, allergic reactions or damage to the body's own tissues.","The term groups diverse conditions for assessment and communication, while diagnosis and management depend on the specific disorder and clinical evidence."]}},"sources":[{"title":"Wikidata item Q3843811: immune disorder","url":"https://www.wikidata.org/wiki/Q3843811","note":"identity and sense of the item"},{"title":"Wikipedia: Immune disorder","url":"https://en.wikipedia.org/wiki/Immune_disorder","note":"general description of the item"}],"openQuestions":["Which authoritative definition should anchor this undefined registry entry, and exactly which immune disorder families does that definition include?","Does an existing Vercy world model already own this concept or any proposed subtype boundary, requiring a link instead of another publication?","Which current ICD and SNOMED CT concepts represent the broad category, and where are mappings broader, narrower or absent?","Which diagnostic frameworks and validated activity measures apply to specific subtypes, and where is there no accepted common framework?","Which population-specific epidemiological sources and management authorities are suitable for this category without generalising evidence from individual disorders?"],"resources":{"spec":"/models/things/publications/thing-q3843811/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q3843811/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T10:25:41Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:30+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane XCT: no invented physical properties."},"score":1.0}}