{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.mitochondrion","code":"thing-q39572","url":"https://ver.cy/models/thing/q39572/","name":"mitochondrion","alternateNames":["extracellular mitochondrion","mitoplast","mouse mitochondrion","ragged-red fiber","mitochondrion of muscle cell","mitochondrion of adipocyte","Mitochondrion of cardiac myocyte","muscle mitochondria","heart mitochondria","liver mitochondria","Sarkosom"],"kind":"thing","status":"published","version":"0.2.0-wave.2","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.LIV"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A membrane-bound organelle found in most eukaryotic cells that generates most of the cell chemical energy through oxidative phosphorylation, contains its own DNA and ribosomes assembled within cells, and participates in metabolism, signalling, calcium regulation and programmed cell death, with numbers and forms varying by cell type from muscle to fat cells; mitochondrial DNA is typically inherited maternally in humans, but inheritance patterns vary among organisms; mitochondria arose from an ancient bacterial endosymbiont and their dysfunction underlies mitochondrial diseases and contributes to ageing.","purpose":"Let an agent explain mitochondria and their structure, function and origin, describe their roles in health and disease in general terms, support learning in cell biology, and route personal medical questions to clinicians.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Double membrane and cristae","Own genome","ATP production","Endosymbiotic origin"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What mitochondria are.","layers":[{"id":"structure","name":"Structure","description":"Structure.","findings":[{"id":"structure-finding","name":"Structure","description":"Structure.","questions":[{"text":"What is the structure of a mitochondrion, including membranes, cristae, matrix and genome?","kind":"definition"},{"text":"Which cell type or aspect is meant?","kind":"boundary"}]}]},{"id":"function","name":"Function","description":"Functions.","findings":[{"id":"function-finding","name":"Function","description":"Function.","questions":[{"text":"How do mitochondria produce ATP, and what other roles in metabolism, signalling and cell death do they play?","kind":"definition"},{"text":"Which entry fits cellular respiration?","kind":"action"}]}]}]},{"id":"origin","name":"Origin","description":"Origin and genetics.","layers":[{"id":"endosymbiosis","name":"Endosymbiosis","description":"Endosymbiotic origin.","findings":[{"id":"endosymbiosis-finding","name":"Endosymbiosis","description":"Endosymbiosis.","questions":[{"text":"How did mitochondria arise from bacteria, and what evidence supports this?","kind":"provenance"},{"text":"Which entry fits endosymbiotic theory?","kind":"action"}]}]},{"id":"genetics","name":"Genetics","description":"Mitochondrial DNA.","findings":[{"id":"genetics-finding","name":"Genetics","description":"Genetics.","questions":[{"text":"What is mitochondrial DNA, how is it inherited, and how is it used in ancestry and forensics?","kind":"provenance"},{"text":"Which entry fits mitochondrial DNA?","kind":"action"}]}]}]},{"id":"health","name":"Health","description":"Health and disease.","layers":[{"id":"disease","name":"Disease","description":"Disease and ageing.","findings":[{"id":"disease-finding","name":"Disease","description":"Disease.","questions":[{"text":"How does mitochondrial dysfunction relate to disease and ageing, in general terms?","kind":"provenance"},{"text":"Is the user asking about their own condition, which needs a clinician?","kind":"boundary"}]}]},{"id":"claims","name":"Claims","description":"Claims and evidence.","findings":[{"id":"claims-finding","name":"Claims","description":"Claims.","questions":[{"text":"What does evidence say about supplements and lifestyle claims for mitochondrial health, with findings attributed?","kind":"provenance"},{"text":"Is the presentation free of unfounded claims?","kind":"boundary"}]}]}]},{"id":"learn","name":"Learn","description":"History and teaching.","layers":[{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How were mitochondria discovered and their functions worked out?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"teach","name":"Teach","description":"Teaching.","findings":[{"id":"teach-finding","name":"Teach","description":"Teaching.","questions":[{"text":"How can mitochondria be taught beyond the powerhouse metaphor?","kind":"action"},{"text":"Which misconceptions arise?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain mitochondria, their structure, function and origin.","Describe mitochondrial diseases in general terms from health sources.","Support learning about cellular respiration."],"mustNot":["Diagnose mitochondrial disease in a specific person.","Promote supplements as mitochondrial boosters without evidence.","Reduce mitochondria to only powerhouses when their roles are wider.","Speculate about a named person's maternal ancestry from mitochondrial DNA."],"requiresHuman":["Using mitochondrial DNA testing to decide ancestry, identity or treatment."]},"ethics":{"considerations":["Mitochondrial DNA reveals maternal ancestry; genetic privacy matters.","Families with mitochondrial disease are targeted by false cures."],"affectedParties":["People with mitochondrial disease","People whose DNA is tested","Students"]},"owners":{"steward":"Nobody: a biological structure held in common.","roles":[],"masterSystems":[]},"relations":[{"target":"Q12051365","type":"parent","note":"registry parent class"},{"target":"Q14349519","type":"parent","note":"registry parent class"},{"target":"Q66562904","type":"parent","note":"registry parent class"},{"target":"semiautonomous organelle","type":"related","note":"category"},{"target":"intracellular membrane-bounded organelle","type":"related","note":"category"},{"target":"mitochondrial disease","type":"related","note":"disorders of mitochondria"},{"target":"symbiosis","type":"related","note":"the endosymbiotic origin"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.mitochondrion","Wikidata: Q39572 (https://www.wikidata.org/wiki/Q39572)"]},"properties":{"applicability":"required","items":["Organelle length:  um - Measured by calibrated microscopy, with length varying as mitochondria elongate, divide and fuse.","Organelle width:  um - Measured across the organelle using calibrated microscopy with the imaging and preparation methods recorded.","Organelle volume:  um3 - Estimated from three-dimensional microscopy after defining the boundary of an individual mitochondrion or connected network."]},"recognition":{"applicability":"required","items":["A mitochondrion is an organelle producing ATP by oxidative phosphorylation.","Mitochondria have their own DNA and an endosymbiotic origin, with mitochondrial DNA inheritance typically maternal in humans but variable among organisms.","Chloroplasts are plant organelles for photosynthesis; the nucleus holds the main genome.","Not visible without a microscope; double-membraned organelles."]},"capabilities":{"applicability":"required","items":["explain structure and function","describe origin","describe roles in disease generally","support learning"]},"hazards":{"applicability":"required","items":["Oversimplifying mitochondria as only powerhouses","Agents giving personal medical advice","Unfounded supplement claims"]},"interfaces":{"applicability":"required","items":["Cell biology nomenclature","Regulation of mitochondrial donation","Laboratory standards"]},"context":{"applicability":"required","items":["Energy-producing organelles.","mitochondria of muscle cells","mitochondria of fat cells","mitochondria in neurons","mitoplasts and isolated preparations","mitochondria in other eukaryotes"]}},"sources":[{"title":"Wikidata item Q39572: mitochondrion","url":"https://www.wikidata.org/wiki/Q39572","note":"identity and sense of the item"},{"title":"Wikipedia: Mitochondria","url":"https://en.wikipedia.org/wiki/Mitochondria","note":"general description of the item"}],"openQuestions":["Should mitochondrial DNA be a separate entry?","How should cell biology resources be linked?","How should research literature be linked?"],"resources":{"spec":"/models/things/publications/thing-q39572/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q39572/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T05:54:32Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T12:16:32+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}