{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.nucleus","code":"thing-q40260","url":"https://ver.cy/models/thing/q40260/","name":"nucleus","alternateNames":["fixed nucleus","alobate nucleus","micronucleus","macronucleus","germ cell nucleus","megasporocyte nucleus","primary endosperm nucleus","left nucleus","right nucleus","generative cell nucleus","microsporocyte nucleus","pronucleus"],"kind":"thing","status":"published","version":"0.2.0-wave.2","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.LIV"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"The membrane-bounded organelle in eukaryotic cells that contains most of the genetic material as chromosomes and controls gene expression, cell growth and division, with structures such as the nuclear envelope, nucleolus and nuclear pores, and variants such as the micronucleus and macronucleus of ciliates and the nuclei of germ cells; the cell nucleus is distinct from the atomic nucleus.","purpose":"Let an agent explain the cell nucleus and its structure and functions, describe variants across organisms, relate the nucleus to disease and research, and separate the atomic nucleus sense.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Genetic material container","Double membrane","Nucleolus and pores","Absent in prokaryotes"],"structure":{"bundles":[{"id":"structure","name":"Structure","description":"What the nucleus is.","layers":[{"id":"parts","name":"Parts","description":"Parts of the nucleus.","findings":[{"id":"parts-finding","name":"Parts","description":"Parts.","questions":[{"text":"What are the nuclear envelope, pores, nucleolus and chromatin, and how are they organised?","kind":"definition"},{"text":"Is the cell nucleus or the atomic nucleus meant?","kind":"boundary"}]}]},{"id":"function","name":"Function","description":"Functions.","findings":[{"id":"function-finding","name":"Function","description":"Functions.","questions":[{"text":"How does the nucleus control gene expression, replication and division?","kind":"definition"},{"text":"How do molecules move in and out?","kind":"definition"}]}]}]},{"id":"variants","name":"Variants","description":"Nuclei across life.","layers":[{"id":"types","name":"Types","description":"Kinds of nucleus.","findings":[{"id":"types-finding","name":"Types","description":"Kinds.","questions":[{"text":"What are micronuclei and macronuclei in ciliates, germ cell nuclei and multinucleate cells?","kind":"definition"},{"text":"How do plant reproductive nuclei such as megasporocyte nuclei differ?","kind":"provenance"}]}]},{"id":"evolution","name":"Evolution","description":"Origin of the nucleus.","findings":[{"id":"evolution-finding","name":"Evolution","description":"Evolution.","questions":[{"text":"How did the nucleus evolve, according to current research?","kind":"provenance"},{"text":"Which hypotheses are debated?","kind":"boundary"}]}]}]},{"id":"medicine","name":"Medicine","description":"Nucleus in disease and research.","layers":[{"id":"disease","name":"Disease","description":"Nuclear changes in disease.","findings":[{"id":"disease-finding","name":"Disease","description":"Disease.","questions":[{"text":"How are nuclear changes used in pathology, such as in cancer diagnosis, in general terms?","kind":"provenance"},{"text":"Is the user asking about their own results, which needs a clinician?","kind":"boundary"}]}]},{"id":"research","name":"Research","description":"Research methods.","findings":[{"id":"research-finding","name":"Research","description":"Research.","questions":[{"text":"How is the nucleus studied by microscopy, imaging and genomics?","kind":"provenance"},{"text":"Which entry fits a specific technique?","kind":"action"}]}]}]},{"id":"learn","name":"Learn","description":"Teaching and history.","layers":[{"id":"teach","name":"Teach","description":"Teaching the nucleus.","findings":[{"id":"teach-finding","name":"Teach","description":"Teaching.","questions":[{"text":"How can the cell nucleus be taught with models and microscopy?","kind":"action"},{"text":"Which misconceptions arise?","kind":"provenance"}]}]},{"id":"history","name":"History","description":"Discovery.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How was the nucleus discovered and its role established, from Brown onward?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain the structure and functions of the cell nucleus.","Distinguish the cell nucleus from the atomic nucleus."],"mustNot":["Confuse the cell nucleus with the atomic nucleus.","Give medical advice on nuclear pathology for a person.","Oversimplify nuclear organisation in teaching.","Present unconfirmed findings as established."],"requiresHuman":["Interpreting pathology reports for patients."]},"ethics":{"considerations":["Accurate biology education builds trust in science.","Pathology findings affect diagnoses."],"affectedParties":["Students","Patients","Researchers"]},"owners":{"steward":"Nobody: a biological structure.","roles":[],"masterSystems":[]},"relations":[{"target":"Q14349519","type":"parent","note":"registry parent class"},{"target":"intracellular membrane-bounded organelle","type":"related","note":"category"},{"target":"deoxyribonucleic acid","type":"contains","note":"genetic material"},{"target":"gene expression","type":"related","note":"controlled in the nucleus"},{"target":"atom","type":"related","note":"the atomic nucleus contrast"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.nucleus","Wikidata: Q40260 (https://www.wikidata.org/wiki/Q40260)"]},"properties":{"applicability":"required","items":["Diameter:  um - Diameter is measured by calibrated microscopy and depends on cell type, organism and cell cycle stage.","Volume:  um3 - Volume is estimated from three-dimensional microscopy with the nuclear boundary explicitly defined.","Nuclear envelope thickness:  nm - Envelope thickness is measured by electron microscopy with the two membranes and intervening space distinguished."]},"recognition":{"applicability":"required","items":["Membrane-bounded organelle with chromosomes","Eukaryotic cells only","The atomic nucleus is the core of an atom","A rounded organelle visible under the microscope after staining."]},"capabilities":{"applicability":"required","items":["explain structure and function","describe variants across organisms","relate to disease and research","separate the atomic sense"]},"hazards":{"applicability":"required","items":["Confusing cell and atomic nuclei","Oversimplifying nuclear organisation","Agents giving medical advice on nuclear pathology"]},"interfaces":{"applicability":"required","items":["Cell biology nomenclature","Research ethics for cell and genetic studies"]},"context":{"applicability":"required","items":["The control centre of eukaryotic cells.","typical eukaryotic nuclei","micronuclei and macronuclei of ciliates","germ cell nuclei","polyploid and multinucleate cells","nuclei in plant reproductive cells such as megasporocytes"]}},"sources":[{"title":"Wikidata item Q40260: nucleus","url":"https://www.wikidata.org/wiki/Q40260","note":"identity and sense of the item"},{"title":"Wikipedia: Cell nucleus","url":"https://en.wikipedia.org/wiki/Cell_nucleus","note":"general description of the item"}],"openQuestions":["Should nuclear organisation be a separate entry?","How should cell biology resources be linked?","How should disease information be linked?"],"resources":{"spec":"/models/things/publications/thing-q40260/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q40260/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-11T23:30:49Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:30+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}