{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.l-methamphetamine","code":"thing-q402846","url":"https://ver.cy/models/thing/q402846/","name":"L-methamphetamine","alternateNames":[],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"L-methamphetamine, also called levomethamphetamine or levmetamfetamine, is the (R)-(−) enantiomer of methamphetamine, a sympathomimetic amine with substantially weaker central stimulant effects than the (S)-(+) enantiomer.","purpose":"Enable an agent to identify L-methamphetamine, assess the identity and condition of a material containing it, and determine which handling or use decisions require further evidence.","scope":{"in":["Stereochemical identity, synonyms and form-specific identifiers","Chemical purity, enantiomeric composition and impurity evidence","Physical form and properties under recorded conditions","Analytical identification and limits of interpretation","Substance-specific biological evidence, hazards and jurisdiction-dependent constraints"],"out":["Manufacturing routes, precursor conversion and extraction procedures","Finished inhaler design, excipients and delivered-dose performance","Patient diagnosis, prescribing and individual treatment decisions","Independent models of D-methamphetamine, racemic methamphetamine and amphetamine","Drug-testing programme administration and legal adjudication"],"boundaries":[]},"distinguishingFeatures":["Require the R stereochemical configuration associated with levmetamfetamine; a methamphetamine name or molecular formula alone does not resolve the enantiomer. Reference: [PubChem Levmetamfetamine](https://pubchem.ncbi.nlm.nih.gov/compound/Levmetamfetamine).","Require evidence of enantiomeric composition to distinguish an L-methamphetamine material from a racemic or D-enriched material; record the acceptance threshold rather than assuming absolute purity.","Distinguish the free base from hydrochloride by protonation and counterion identity; PubChem records them separately. Reference: [PubChem Levmetamfetamine hydrochloride](https://pubchem.ncbi.nlm.nih.gov/compound/12213639).","Confirm the N-methylated molecular connectivity to distinguish this substance from amphetamine, independently of determining chirality.","Distinguish the substance from a labelled inhalant containing it; a product label establishes a formulation relationship rather than bulk-material identity. Reference: [DailyMed levmetamfetamine inhalant](https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=d11e916f-90a6-4099-bf83-75f2dfbd6266&type=display)."],"structure":{"bundles":[{"id":"stereochemical-identity","name":"Stereochemical identity","description":"Establish what the L-methamphetamine entry denotes and how evidence resolves that identity.","layers":[{"id":"molecular-assignment","name":"Molecular assignment","description":"Separate molecular connectivity from absolute stereochemistry.","findings":[{"id":"connectivity-and-configuration","name":"Connectivity and configuration","description":"Require a structure that identifies both the methamphetamine connectivity and the intended stereocentre.","questions":[{"text":"Which explicit molecular structure defines this entry, including its stereocentre?","id":"connectivity-and-configuration-q01","kind":"definition"},{"text":"Which authoritative record supports the mapping between L-methamphetamine, levmetamfetamine and the R configuration?","id":"connectivity-and-configuration-q02","kind":"provenance"}]}]},{"id":"names-and-form-boundaries","name":"Names and form boundaries","description":"Control synonym resolution and relationships to salts and broader substance records.","findings":[{"id":"identifier-specificity","name":"Identifier specificity","description":"Accept an identifier only with evidence of its stereochemical and chemical-form scope.","questions":[{"text":"Which CAS, PubChem and EC identifiers explicitly denote this enantiomer in the stated form?","id":"identifier-specificity-q01","kind":"provenance"},{"text":"Does a candidate record describe the free base, a specified salt, a racemate or stereochemically unspecified methamphetamine?","id":"identifier-specificity-q02","kind":"boundary"},{"text":"Does an existing catalogue model already own this exact concept and therefore require a link rather than a duplicate?","id":"identifier-specificity-q03","kind":"boundary"}]}]}]},{"id":"composition-and-material-quality","name":"Composition and material quality","description":"Characterize a material's L-methamphetamine content without conflating chemical and stereochemical purity.","layers":[{"id":"enantiomeric-composition","name":"Enantiomeric composition","description":"Record the relative abundance of the two methamphetamine enantiomers.","findings":[{"id":"l-fraction-and-opposite-enantiomer","name":"L fraction and opposite enantiomer","description":"Treat the opposite enantiomer as a separately measured component rather than an unspecified impurity.","questions":[{"text":"What are the measured L and D fractions, and what denominator defines those percentages?","id":"l-fraction-and-opposite-enantiomer-q01","kind":"measurement"},{"text":"What uncertainty and quantification limit apply to the minor enantiomer?","id":"l-fraction-and-opposite-enantiomer-q02","kind":"measurement"},{"text":"Which intended-use specification determines whether this composition is acceptable?","id":"l-fraction-and-opposite-enantiomer-q03","kind":"action"}]}]},{"id":"assay-and-other-components","name":"Assay and other components","description":"Account for the chemical form, water and non-enantiomeric impurities.","findings":[{"id":"mass-basis-and-impurity-accounting","name":"Mass basis and impurity accounting","description":"Make purity results traceable to a stated mass basis and a characterized sample.","questions":[{"text":"Is the assay expressed as free base, salt, dry material or material as received?","id":"mass-basis-and-impurity-accounting-q01","kind":"measurement"},{"text":"Which counterions, water, residual solvents and other impurities were measured, and which remain uncharacterized?","id":"mass-basis-and-impurity-accounting-q02","kind":"measurement"},{"text":"Which lot-specific analytical report supports the reported composition and claimed grade?","id":"mass-basis-and-impurity-accounting-q03","kind":"provenance"}]}]}]},{"id":"physical-form-and-condition","name":"Physical form and condition","description":"Connect observations and physical constants to the actual L-methamphetamine material.","layers":[{"id":"conditioned-physical-properties","name":"Conditioned physical properties","description":"Require chemical form and measurement conditions alongside physical-property values.","findings":[{"id":"phase-and-property-applicability","name":"Phase and property applicability","description":"Evaluate whether thermal, solubility and volatility evidence describes the material under assessment.","questions":[{"text":"What phase is observed at the recorded temperature and pressure for this chemical form?","id":"phase-and-property-applicability-q01","kind":"measurement"},{"text":"Which measured melting, boiling, solubility or vapour-pressure values are available with methods and conditions?","id":"phase-and-property-applicability-q02","kind":"provenance"},{"text":"Does a proposed property value refer to this enantiomer and form, or is its transfer from another record only an assumption?","id":"phase-and-property-applicability-q03","kind":"boundary"}]}]},{"id":"storage-and-change","name":"Storage and change","description":"Assess changes in composition or condition over a documented storage history.","findings":[{"id":"condition-and-retest-evidence","name":"Condition and retest evidence","description":"Base continued suitability on applicable stability evidence and lot observations.","questions":[{"text":"What container, temperature, light and moisture conditions are documented for this material?","id":"condition-and-retest-evidence-q01","kind":"provenance"},{"text":"What evidence establishes stability of assay and enantiomeric composition under those conditions?","id":"condition-and-retest-evidence-q02","kind":"provenance"},{"text":"Which observed deviation or elapsed interval requires retesting or withholding the lot from its intended use?","id":"condition-and-retest-evidence-q03","kind":"action"}]}]}]},{"id":"analytical-identification","name":"Analytical identification","description":"Define what analytical results can establish about L-methamphetamine.","layers":[{"id":"method-discrimination","name":"Method discrimination","description":"Match each identity claim to a method capable of resolving it.","findings":[{"id":"stereoselective-confirmation","name":"Stereoselective confirmation","description":"Require explicit evidence that the method distinguishes the relevant enantiomers and assigns them correctly.","questions":[{"text":"Does the method measure total methamphetamine or separately resolve its enantiomers?","id":"stereoselective-confirmation-q01","kind":"measurement"},{"text":"Which traceable reference materials support the assignment of the L signal?","id":"stereoselective-confirmation-q02","kind":"provenance"},{"text":"What validation demonstrates adequate specificity, resolution and sensitivity in this matrix?","id":"stereoselective-confirmation-q03","kind":"measurement"}]}]},{"id":"sample-and-interpretation","name":"Sample and interpretation","description":"Preserve the distinction between a result, the tested material and its possible source.","findings":[{"id":"limits-of-result-inference","name":"Limits of result inference","description":"Constrain identity and origin conclusions to what the sample history and assay establish.","questions":[{"text":"Was the sample bulk material, a formulation or a biological specimen, and how was its identity preserved?","id":"limits-of-result-inference-q01","kind":"provenance"},{"text":"Which conclusions about L-methamphetamine identity or quantity are supported by this specific result?","id":"limits-of-result-inference-q02","kind":"boundary"},{"text":"What additional evidence is required before attributing the result to a particular product or exposure?","id":"limits-of-result-inference-q03","kind":"action"}]}]}]},{"id":"biological-evidence-and-use-constraints","name":"Biological evidence and use constraints","description":"Connect substance-specific evidence to handling and permitted-use assessments.","layers":[{"id":"biological-and-exposure-context","name":"Biological and exposure context","description":"Keep biological claims tied to the tested enantiomer, formulation and exposure conditions.","findings":[{"id":"effect-evidence-specificity","name":"Effect evidence specificity","description":"Record the applicability and limits of evidence for L-methamphetamine effects.","questions":[{"text":"Which primary studies specifically characterize L-methamphetamine rather than the opposite enantiomer or a racemate?","id":"effect-evidence-specificity-q01","kind":"provenance"},{"text":"What route, exposure, formulation and study population bound each reported effect?","id":"effect-evidence-specificity-q02","kind":"measurement"},{"text":"Which claimed effects or safety conclusions remain unsupported for the intended context?","id":"effect-evidence-specificity-q03","kind":"boundary"}]}]},{"id":"hazard-and-permission-applicability","name":"Hazard and permission applicability","description":"Resolve handling evidence and legal constraints for the actual form and activity.","findings":[{"id":"form-specific-hazard-evidence","name":"Form-specific hazard evidence","description":"Ground handling decisions in applicable classifications and exposure information.","questions":[{"text":"Which current SDS and GHS classifications explicitly apply to this chemical form and concentration?","id":"form-specific-hazard-evidence-q01","kind":"provenance"},{"text":"Are authoritative exposure limits available for this substance, and what route, units and averaging period do they cover?","id":"form-specific-hazard-evidence-q02","kind":"measurement"},{"text":"What handling controls follow from the documented material hazards and proposed activity?","id":"form-specific-hazard-evidence-q03","kind":"action"}]},{"id":"jurisdiction-and-preparation-status","name":"Jurisdiction and preparation status","description":"Keep substance controls and preparation-specific permissions separately evidenced.","questions":[{"text":"Which current rules govern the stated activity involving L-methamphetamine in the relevant jurisdiction?","id":"jurisdiction-and-preparation-status-q01","kind":"provenance"},{"text":"Does a cited permission or exemption cover bulk substance, a specified salt or only a particular medicinal preparation?","id":"jurisdiction-and-preparation-status-q02","kind":"boundary"},{"text":"What authorization or product-specific evidence must be established before the proposed activity proceeds?","id":"jurisdiction-and-preparation-status-q03","kind":"action"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of L-methamphetamine this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-kinds","name":"Kinds and varieties","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these kinds and varieties hold for the sense of L-methamphetamine this model covers, and on what evidence?","id":"evidence-kinds-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of L-methamphetamine this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of L-methamphetamine this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of L-methamphetamine this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of L-methamphetamine this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-regional-variation","name":"Regional variation","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these regional variation hold for the sense of L-methamphetamine this model covers, and on what evidence?","id":"evidence-regional-variation-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of L-methamphetamine this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["State what L-methamphetamine is and how it differs from its stronger stimulant enantiomer.","Explain its legal status in general terms with the jurisdiction and source.","Check labelled products against lawful authorizations in an inventory it is permitted to manage."],"mustNot":["Assist in making, extracting, converting or concentrating it or any related stimulant.","Help obtain, divert or sell it outside lawful medical or retail channels.","Give dosing advice for non-medical use.","Present it as harmless because it is weaker than the other enantiomer."],"requiresHuman":["Releasing controlled or regulated stock to anyone.","Advising a person who may be harmed by misuse or interactions."]},"ethics":{"considerations":["Confusion between enantiomers can cause legal and health harm to ordinary users of decongestants.","Stimulant misuse harms users, families and communities."],"affectedParties":["People using it as a decongestant","People at risk of stimulant misuse","Pharmacists and regulators"]},"owners":{"steward":"The licensed maker, pharmacy or holder of the product; drug control authorities regulate it.","roles":[],"masterSystems":["National controlled substance and medicines registers"]},"relations":[{"target":"Q44909815","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.l-methamphetamine","Wikidata: Q402846 (https://www.wikidata.org/wiki/Q402846)"]},"properties":{"applicability":"required","items":["Stereochemical identity: R assignment supported; conflicting assignment; unresolved","Chemical form: Free base; specified salt; solvated form; unresolved","Identity references: Verified structure record, PubChem CID, CAS number and EC number where applicable, each with source and chemical form","L-enantiomer fraction: mol% of total methamphetamine enantiomers, with method and uncertainty","Chemical assay: Mass %, with as-received, dry, salt or free-base-equivalent basis explicitly stated","Impurity profile: Named impurity concentrations in mass %, mg/kg or another justified unit, with reporting limits","Phase and thermal properties: Observed phase; melting or boiling temperature in °C with pressure in kPa, chemical form and method","Optical rotation: Observed rotation in degrees or specific rotation with its convention, wavelength, temperature, solvent and concentration","Material condition: Within documented specification; deviating; unassessed; with storage and inspection evidence","Hazard and exposure evidence: Form-specific SDS, applicable GHS classification, exposure-limit authority and revision date; unresolved where unavailable","Regulatory applicability: Jurisdiction, effective date, substance or preparation covered, activity and governing source"]},"recognition":{"applicability":"required","items":["Identity cannot be settled by appearance; it needs the label and laboratory analysis.","Lawful products carry regulated labelling and batch numbers."]},"capabilities":{"applicability":"required","items":["Resolve a supplier name or registry identifier against a stereochemically explicit substance record.","Compare a lot's chemical assay and enantiomeric composition against a documented intended-use specification.","Select evidence needed to distinguish L-methamphetamine from other methamphetamine compositions.","Determine whether a physical-property or hazard record applies to the material's actual chemical form.","Link containing products and analytical observations while preserving their distinct identities.","Flag handling or use decisions that lack current jurisdictional, material-quality or safety evidence."]},"hazards":{"applicability":"required","items":["Misuse can raise heart rate and blood pressure.","Mislabelled or diverted material can expose people to the more potent enantiomer."]},"interfaces":{"applicability":"required","items":["United States Controlled Substances Act, enforced by the Drug Enforcement Administration."]},"context":{"applicability":"required","items":["L-methamphetamine is encountered as an ingredient in certain nasal decongestant products and as a reference material in analytical laboratories.","Toxicology and forensic analysis distinguish it from the opposite enantiomer because their pharmacological effects and possible sources differ."]}},"sources":[{"title":"Wikidata item Q402846: L-methamphetamine","url":"https://www.wikidata.org/wiki/Q402846","note":"identity and sense of the item"},{"title":"Wikipedia: Levomethamphetamine","url":"https://en.wikipedia.org/wiki/Levomethamphetamine","note":"general description of the item"}],"openQuestions":["Which authoritative CAS and EC identifiers apply specifically to the free base, and how should related salt records link to this registry entry?","Which primary measurements establish physical constants and storage stability for explicitly characterized L-methamphetamine forms?","Which validated analytical methods and intended-use specifications establish acceptable chemical purity and opposite-enantiomer limits?","Which primary studies support substance-specific biological and toxicological conclusions across relevant exposure contexts?","Which current jurisdiction-specific controls, preparation exemptions, GHS classifications and occupational exposure limits apply to the intended material and activity?"],"resources":{"spec":"/models/things/publications/thing-q402846/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q402846/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T10:50:33Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:30+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}