{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.gestodene","code":"thing-q408289","url":"https://ver.cy/models/thing/q408289/","name":"gestodene","alternateNames":[],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Gestodene is a synthetic steroidal progestogen of the gonane group, with molecular formula C21H26O2, used principally as the progestogen component of combined hormonal contraceptives.","purpose":"Enable an agent to recognise gestodene, assess the identity and quality of a material containing it, and determine which handling or use decisions its evidence supports.","scope":{"in":["Molecular identity, stereochemistry and verified identifier mappings","Gestodene content, related substances and suitability of individual material lots","Solid form, solubility, thermal behaviour and storage stability","Gestodene-specific pharmacological activity and disposition evidence","Substance hazards, exposure controls and jurisdiction-specific identity records"],"out":["Finished contraceptive formulations, packaging and product authorisations","Patient-specific prescribing, dosing and contraceptive counselling","Manufacturing processes and production equipment","Independent models of metabolites, other progestogens and co-formulated estrogens","Clinical disease models and population-level contraceptive programmes"],"boundaries":[]},"distinguishingFeatures":["Require a stereochemical structure match to InChIKey SIGSPDASOTUPFS-XUDSTZEESA-N; a steroid name or molecular formula alone is insufficient. [ChEBI identity](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A135323)","Check formula C21H26O2 and CAS 60282-87-3 together with structure, rather than accepting either identifier alone. [ChEBI identity](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A135323)","Require analytical discrimination from related steroid impurities and stereoisomers through a qualified reference standard and a method with demonstrated specificity.","Distinguish isolated gestodene from a medicine containing gestodene and ethinylestradiol; the latter has additional ingredients and product-level properties. [Femodene composition](https://www.medicines.org.uk/emc/product/1123/smpc)"],"structure":{"bundles":[{"id":"gestodene-identity","name":"Gestodene identity","description":"Establish the exact molecule and its boundary against related steroids and containing products.","layers":[{"id":"molecular-reference","name":"Molecular reference","description":"Anchor recognition to a stereochemically explicit structure.","findings":[{"id":"structure-identifier-agreement","name":"Structure and identifier agreement","description":"ChEBI supplies a stereochemical structure, formula and CAS mapping for gestodene; the model should record agreement or conflict between these and the material documentation. [ChEBI](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A135323)","questions":[{"text":"Does the declared structure match the gestodene reference including every specified stereocentre and double bond?","id":"structure-identifier-agreement-q01","kind":"definition"},{"text":"Which read source establishes each CAS, PubChem or EC identifier mapping, and do any mappings conflict?","id":"structure-identifier-agreement-q02","kind":"provenance"}]}]},{"id":"substance-product-boundary","name":"Substance and product boundary","description":"Separate molecular identity from mixtures, standards and medicines.","findings":[{"id":"gestodene-bearing-material","name":"Gestodene-bearing material","description":"Classify the observed material as isolated substance, reference preparation or mixture, and link containing products separately.","questions":[{"text":"Is this material isolated gestodene, a reference solution or a formulation containing other active ingredients?","id":"gestodene-bearing-material-q01","kind":"boundary"},{"text":"Which reported properties belong to gestodene itself and which depend on the containing preparation?","id":"gestodene-bearing-material-q02","kind":"boundary"}]}]}]},{"id":"gestodene-quality","name":"Gestodene content and quality","description":"Determine whether an identified lot meets the requirements of its intended use.","layers":[{"id":"assay-specificity","name":"Assay and specificity","description":"Connect content measurements to methods capable of resolving relevant steroid species.","findings":[{"id":"qualified-content-result","name":"Qualified content result","description":"Record the gestodene assay basis, reference-standard qualification and demonstrated analytical selectivity.","questions":[{"text":"What gestodene content was measured, on what correction basis and with what uncertainty?","id":"qualified-content-result-q01","kind":"measurement"},{"text":"What evidence shows the method distinguishes gestodene from relevant related steroids and stereoisomers?","id":"qualified-content-result-q02","kind":"provenance"}]}]},{"id":"impurities-release","name":"Impurities and release","description":"Evaluate individual contaminants against a named specification.","findings":[{"id":"use-specific-acceptability","name":"Use-specific acceptability","description":"Tie impurity, solvent and water results to documented limits and a lot-level disposition.","questions":[{"text":"Which related substances, residual solvents and water levels were measured, and which remain unidentified or unmeasured?","id":"use-specific-acceptability-q01","kind":"measurement"},{"text":"Does this lot meet the applicable specification for its proposed use, or must it remain quarantined?","id":"use-specific-acceptability-q02","kind":"action"}]}]}]},{"id":"gestodene-physical-state","name":"Gestodene physical state and stability","description":"Capture the material conditions that govern preparation, storage and reliable measurement.","layers":[{"id":"solid-thermal-properties","name":"Solid and thermal properties","description":"Describe the observed solid and distinguish phase changes from decomposition.","findings":[{"id":"conditioned-solid-description","name":"Conditioned solid description","description":"Record solid-form evidence, particle characteristics and measured thermal events without assuming a universal polymorph or boiling point.","questions":[{"text":"What diffraction, thermal or other evidence identifies the solid form of this gestodene lot?","id":"conditioned-solid-description-q01","kind":"measurement"},{"text":"Do reported melting or boiling values specify conditions and distinguish intact phase change from decomposition?","id":"conditioned-solid-description-q02","kind":"provenance"}]}]},{"id":"solution-storage-behaviour","name":"Solution and storage behaviour","description":"Assess solution preparation and retention of quality over time.","findings":[{"id":"supported-preparation-lifetime","name":"Supported preparation lifetime","description":"Connect solvent choice, concentration, packaging and environmental exposure to measured solubility and stability.","questions":[{"text":"At the intended concentration and temperature, what evidence supports complete dissolution and absence of precipitation?","id":"supported-preparation-lifetime-q01","kind":"measurement"},{"text":"Which stability results justify the storage conditions and retest or expiry interval for this solid or solution?","id":"supported-preparation-lifetime-q02","kind":"action"}]}]}]},{"id":"gestodene-biological-behaviour","name":"Gestodene biological behaviour","description":"Represent activity and disposition with enough context to prevent unsupported extrapolation.","layers":[{"id":"activity-attribution","name":"Activity attribution","description":"Distinguish gestodene-specific pharmacology from combination-product outcomes.","findings":[{"id":"activity-evidence-boundary","name":"Activity evidence boundary","description":"Record receptor-level and functional evidence separately from outcomes observed with gestodene-containing contraceptives.","questions":[{"text":"Which experiments establish gestodene's progestogenic activity, and what receptor system and comparator did they use?","id":"activity-evidence-boundary-q01","kind":"provenance"},{"text":"Was the reported effect measured for gestodene alone or for an estrogen-progestogen combination?","id":"activity-evidence-boundary-q02","kind":"boundary"}]}]},{"id":"binding-exposure","name":"Binding and exposure","description":"Preserve the biological conditions behind disposition measurements.","findings":[{"id":"shbg-dependent-context","name":"SHBG-dependent context","description":"The Femodene label describes gestodene binding to albumin and SHBG and SHBG-dependent pharmacokinetics; retain these conditions when reusing measurements. [Femodene SmPC](https://www.medicines.org.uk/emc/product/1123/smpc)","questions":[{"text":"Do reported concentrations represent total or unbound gestodene, and what binding conditions were measured?","id":"shbg-dependent-context-q01","kind":"measurement"},{"text":"What route, dosing history, co-administered estrogen and population qualify each exposure or elimination estimate?","id":"shbg-dependent-context-q02","kind":"boundary"}]}]}]},{"id":"gestodene-handling-constraints","name":"Gestodene hazards and permitted uses","description":"Connect bulk-substance handling and use decisions to applicable evidence.","layers":[{"id":"occupational-environmental-evidence","name":"Occupational and environmental evidence","description":"Assess the evidence relevant to exposure during weighing, transfer and disposal.","findings":[{"id":"substance-hazard-basis","name":"Substance hazard basis","description":"Record verified bulk-substance classifications and exposure-control evidence, marking missing limits explicitly.","questions":[{"text":"Which current safety data sheet or authoritative classification applies to this gestodene material and jurisdiction?","id":"substance-hazard-basis-q01","kind":"provenance"},{"text":"What evidence supports containment, protective measures and waste handling for the proposed quantity and physical form?","id":"substance-hazard-basis-q02","kind":"action"}]}]},{"id":"regulatory-use-boundaries","name":"Regulatory use boundaries","description":"Separate substance records, material qualification and finished-product permissions.","findings":[{"id":"qualified-use-link","name":"Qualified use link","description":"Associate intended use with dated jurisdictional records and quality requirements without treating ingredient identity as permission to manufacture or administer a medicine.","questions":[{"text":"Which jurisdictional record and quality standard govern the proposed research or pharmaceutical use of this gestodene lot?","id":"qualified-use-link-q01","kind":"provenance"},{"text":"Which remaining decision belongs to the containing medicine's authorisation or a clinical model?","id":"qualified-use-link-q02","kind":"boundary"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of gestodene this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of gestodene this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-standards-and-regulation","name":"Standards and regulation","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these standards and regulation hold for the sense of gestodene this model covers, and on what evidence?","id":"evidence-standards-and-regulation-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of gestodene this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of gestodene this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of gestodene this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-regional-variation","name":"Regional variation","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these regional variation hold for the sense of gestodene this model covers, and on what evidence?","id":"evidence-regional-variation-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of gestodene this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Identify gestodene by name, identifiers and documented properties, citing sources.","Report approved contraceptive products and their warnings from official product information.","Check a material lot's certificate of analysis against its specification."],"mustNot":["Recommend a contraceptive or dose for a particular person.","Downplay blood clot risks when describing products containing it.","Disclose or infer a person's contraceptive use without consent.","Supply it outside lawful pharmaceutical channels."],"requiresHuman":["Any decision to start, stop or switch a person's contraception.","Releasing or destroying a material lot."]},"ethics":{"considerations":["Contraception is a private choice tied to bodily autonomy.","Women deserve honest information about clot risks that differ between progestogens."],"affectedParties":["People using hormonal contraception","Prescribers and pharmacists","Manufacturing staff"]},"owners":{"steward":"The marketing authorization holder for each medicine; the national medicines regulator oversees it.","roles":[],"masterSystems":["National medicines registers"]},"relations":[{"target":"Q126615154","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.gestodene","Wikidata: Q408289 (https://www.wikidata.org/wiki/Q408289)"]},"properties":{"applicability":"required","items":["Stereochemical identity: Verified stereochemical structure and InChIKey; matched, conflicting or unresolved","Gestodene assay: % mass fraction, with as-is or corrected basis, method and uncertainty","Related-substance profile: Individual and total impurities in % or mg/kg; distinguish calibrated concentration from chromatographic area %","Material grade and release state: Declared grade; quarantined, released, rejected or awaiting retest; governing specification","Physical form: Observed phase, crystalline or amorphous character, identified solid form and particle-size distribution","Thermal behaviour: Melting range and decomposition onset in °C; boiling point only with pressure and evidence of intact vaporisation","Solubility: mg/mL or mol/L, specifying solvent, temperature, pH where relevant and measurement method","Biological activity: Assay-specific EC50, IC50 or binding affinity in nM, with receptor, system and comparator","Protein binding and disposition context: Links to albumin and SHBG binding evidence, exposure studies and co-administered substances","Hazard and exposure status: Verified classification, jurisdiction, source date and applicable exposure limit or documented absence of an established limit"]},"recognition":{"applicability":"required","items":["Identity rests on the label, batch record and certificate of analysis, not appearance.","Usually found in combined products with an estrogen, named on the pack."]},"capabilities":{"applicability":"required","items":["Reconcile a supplier's gestodene identity against a verified stereochemical reference.","Compare a gestodene lot with an explicitly selected analytical or pharmaceutical specification.","Select a supported sampling and analytical approach that distinguishes gestodene from related substances.","Assess whether recorded storage conditions and stability evidence support continued use or require retesting.","Link gestodene to containing products and biological studies while preserving their formulation and exposure context.","Identify missing hazard or quality evidence that prevents a proposed handling or use decision."]},"hazards":{"applicability":"required","items":["Raised risk of venous blood clots with combined products.","Missed pills reducing contraceptive protection.","Hormonal exposure of manufacturing staff."]},"interfaces":{"applicability":"required","items":["ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients, International Council for Harmonisation."]},"context":{"applicability":"required","items":["Gestodene is used principally with an estrogen in combined hormonal contraceptive medicines.","It is encountered in pharmaceutical manufacturing, finished contraceptive products and laboratories assessing ingredient identity, purity and content."]}},"sources":[{"title":"Wikidata item Q408289: gestodene","url":"https://www.wikidata.org/wiki/Q408289","note":"identity and sense of the item"},{"title":"Wikipedia: Gestodene","url":"https://en.wikipedia.org/wiki/Gestodene","note":"general description of the item"}],"openQuestions":["Which authoritative source verifies gestodene's EC identifier and the bulk-substance hazard classifications applicable in the target jurisdictions?","Which current pharmacopoeial or validated specifications define gestodene assay, stereochemical identity and acceptable related-substance limits?","What experimentally supported solid forms, melting behaviour, decomposition behaviour and condition-specific solubilities should be recognised?","What substance-specific occupational exposure limits, environmental evidence and stability studies support handling and storage decisions?","How should ChEBI's estrogen role annotation be reconciled with gestodene's progestogenic role using primary pharmacology evidence? [ChEBI role annotation](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A135323)"],"resources":{"spec":"/models/things/publications/thing-q408289/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q408289/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T09:59:59Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:30+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}