{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.fluspirilene","code":"thing-q408300","url":"https://ver.cy/models/thing/q408300/","name":"fluspirilene","alternateNames":[],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Fluspirilene is a synthetic diphenylbutylpiperidine antipsychotic substance whose dopamine D2 receptor antagonism supports its use in long-acting intramuscular preparations for treating schizophrenia.","purpose":"Enable an agent to identify fluspirilene, assess the quality and state of a material containing it, and determine whether evidence supports a proposed handling, research or pharmaceutical use.","scope":{"in":["Molecular structure and identifiers distinguishing fluspirilene from related antipsychotics","Composition, assay, impurities and grade of fluspirilene material","Solid form, particle properties, solubility and stability under recorded conditions","Experiment-specific pharmacological activity and its evidential limits","Substance-level hazards, storage requirements and jurisdiction-specific identity"],"out":["Finished injectable medicines, their excipients, packaging and administration devices","Patient diagnosis, prescribing, dosing and treatment monitoring","Manufacturing routes and production equipment","Independent models of metabolites, degradation products and related antipsychotics","Clinical trials and regulatory applications as managed activities"],"boundaries":[]},"distinguishingFeatures":["Match the molecular structure to PubChem CID 3396 and InChIKey QOYHHIBFXOOADH-UHFFFAOYSA-N; a similar drug name or therapeutic class is insufficient.","Require the combination of a bis(4-fluorophenyl)butyl substituent and a phenyl-substituted triazaspirodecanone framework, rather than identifying any diphenylbutylpiperidine antipsychotic as fluspirilene.","Check consistency with molecular formula C29H31F2N3O and CAS 1841-19-6, while using analytical evidence to establish the identity of an actual sample.","Distinguish fluspirilene substance from products called Imap or Redeptin, which require their own composition and authorization records.","Distinguish the parent substance from salts, solvates, metabolites and degradation products through explicit composition and structure records."],"structure":{"bundles":[{"id":"fluspirilene-identity","name":"Fluspirilene identity and boundaries","description":"Establishes the exact chemical entity and separates it from named medicines and neighboring substances.","layers":[{"id":"molecular-recognition","name":"Molecular recognition","description":"Connects structure and identifiers to sample-level identity evidence.","findings":[{"id":"parent-structure","name":"Parent structure match","description":"The identity anchor is the structure recorded for fluspirilene in [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Fluspirilene); sample recognition additionally requires suitable analytical evidence.","questions":[{"text":"Does the supplied structure match fluspirilene's fluorinated aromatic substituents and triazaspirodecanone framework?","id":"parent-structure-q01","kind":"definition"},{"text":"Which reference material and analytical results establish that this sample contains fluspirilene?","id":"parent-structure-q02","kind":"provenance"}]}]},{"id":"substance-product-boundary","name":"Substance and product boundary","description":"Prevents product names or modified chemical forms from silently replacing the parent substance.","findings":[{"id":"form-and-name-resolution","name":"Form and name resolution","description":"A product label, salt designation or solvate claim must be resolved explicitly before assigning parent-substance properties.","questions":[{"text":"Does the record describe fluspirilene itself, a specified chemical form or a formulated medicine containing it?","id":"form-and-name-resolution-q01","kind":"boundary"},{"text":"What evidence connects a supplier synonym or product name to the registered substance?","id":"form-and-name-resolution-q02","kind":"provenance"}]}]}]},{"id":"fluspirilene-material-quality","name":"Fluspirilene material quality","description":"Establishes the composition and fitness of an identifiable lot.","layers":[{"id":"content-and-contaminants","name":"Content and contaminants","description":"Records fluspirilene content separately from impurities, water and residual solvents.","findings":[{"id":"assay-basis","name":"Interpretable assay","description":"Assay values need a measurement method and reporting basis before they can support quantity calculations.","questions":[{"text":"What is the measured fluspirilene mass fraction, and is it reported as-is or after correction for water and solvents?","id":"assay-basis-q01","kind":"measurement"},{"text":"Which related substances, residual solvents and other contaminants were measured, and at what limits?","id":"assay-basis-q02","kind":"measurement"}]}]},{"id":"grade-and-disposition","name":"Grade and disposition","description":"Connects lot documentation to a specific intended use.","findings":[{"id":"use-specific-acceptance","name":"Use-specific acceptance","description":"Research grade, reference-standard status and pharmaceutical suitability require separate supporting evidence.","questions":[{"text":"Which specification, certificate and lot history substantiate the claimed fluspirilene grade?","id":"use-specific-acceptance-q01","kind":"provenance"},{"text":"Should this lot be accepted for the proposed use, tested further or quarantined?","id":"use-specific-acceptance-q02","kind":"action"}]}]}]},{"id":"fluspirilene-physical-behavior","name":"Fluspirilene physical behavior","description":"Characterizes the material properties relevant to dissolution, suspension and storage.","layers":[{"id":"solid-and-thermal-state","name":"Solid and thermal state","description":"Records observed phase, particle properties and thermal transitions.","findings":[{"id":"characterized-solid","name":"Characterized solid material","description":"Solid form and thermal properties are measurements to establish for the material, not constants to infer from its drug name.","questions":[{"text":"What diffraction, thermal or other evidence identifies the fluspirilene solid form and any solvation?","id":"characterized-solid-q01","kind":"measurement"},{"text":"What particle-size distribution and melting or decomposition behavior were measured under stated conditions?","id":"characterized-solid-q02","kind":"measurement"}]}]},{"id":"solution-and-storage-behavior","name":"Solution and storage behavior","description":"Connects solvent conditions and storage history to usable material state.","findings":[{"id":"preparation-stability","name":"Preparation and stability evidence","description":"Preparation decisions require measured solubility and stability for the actual solvent system and intended duration.","questions":[{"text":"What fluspirilene concentration remains dissolved at the specified solvent composition, pH and temperature?","id":"preparation-stability-q01","kind":"measurement"},{"text":"Which storage or preparation conditions have evidence for maintaining assay and limiting degradation or precipitation?","id":"preparation-stability-q02","kind":"action"}]}]}]},{"id":"fluspirilene-biological-activity","name":"Fluspirilene biological activity","description":"Organizes evidence for antipsychotic pharmacology and experimentally observed target interactions.","layers":[{"id":"pharmacological-context","name":"Pharmacological context","description":"Connects the substance to its documented drug class without assigning patient-level instructions.","findings":[{"id":"antipsychotic-role","name":"Documented antipsychotic role","description":"The [IUPHAR/BPS Guide to Pharmacology](https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=85) describes fluspirilene as a long-acting typical antipsychotic.","questions":[{"text":"Which primary experiments support the recorded dopamine-receptor interactions, with what species and assay conditions?","id":"antipsychotic-role-q01","kind":"provenance"},{"text":"Which duration-of-action claims depend on an injectable formulation rather than the isolated substance?","id":"antipsychotic-role-q02","kind":"boundary"}]}]},{"id":"experimental-target-effects","name":"Experimental target effects","description":"Preserves the context and limitations of additional biological findings.","findings":[{"id":"calcium-channel-evidence","name":"Calcium-channel interaction evidence","description":"A [primary study](https://pubmed.ncbi.nlm.nih.gov/2538426/) reports high-affinity binding in porcine cardiac sarcolemmal membranes and evidence of L-type calcium-channel inhibition; this does not establish a separate clinical indication.","questions":[{"text":"Was the recorded result binding, functional inhibition or a downstream cellular response, and at what concentration?","id":"calcium-channel-evidence-q01","kind":"measurement"},{"text":"What evidence supports extrapolation beyond the tested preparation, species and exposure conditions?","id":"calcium-channel-evidence-q02","kind":"boundary"}]}]}]},{"id":"fluspirilene-handling-constraints","name":"Fluspirilene handling and regulatory constraints","description":"Connects the identified material to documented hazards and permitted uses.","layers":[{"id":"hazards-and-exposure","name":"Hazards and exposure","description":"Captures applicable safety classifications and evidence for exposure controls.","findings":[{"id":"documented-hazard-basis","name":"Documented hazard basis","description":"Hazard classification and exposure controls must be tied to a current source covering the actual material.","questions":[{"text":"Which current safety data sheet or authoritative classification covers this fluspirilene material and jurisdiction?","id":"documented-hazard-basis-q01","kind":"provenance"},{"text":"What exposure limits or containment criteria are documented, and what controls follow for powder or solution handling?","id":"documented-hazard-basis-q02","kind":"action"}]}]},{"id":"regulatory-use-boundary","name":"Regulatory use boundary","description":"Separates chemical identification from authorization of a product or activity.","findings":[{"id":"jurisdiction-specific-use","name":"Jurisdiction-specific use evidence","description":"Substance identifiers support record matching; pharmaceutical authorization requires separate dated, jurisdiction-specific evidence.","questions":[{"text":"Which jurisdiction, date and authoritative record govern the proposed procurement, research or pharmaceutical use?","id":"jurisdiction-specific-use-q01","kind":"provenance"},{"text":"Does the cited permission apply to fluspirilene material, a particular medicinal product or a licensed activity?","id":"jurisdiction-specific-use-q02","kind":"boundary"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of fluspirilene this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of fluspirilene this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of fluspirilene this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of fluspirilene this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of fluspirilene this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-regional-variation","name":"Regional variation","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these regional variation hold for the sense of fluspirilene this model covers, and on what evidence?","id":"evidence-regional-variation-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of fluspirilene this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain fluspirilene's class and use as a long-acting antipsychotic from authoritative sources.","Help a care team keep records of scheduled injections that they have authorised."],"mustNot":["Recommend, dose or administer it without a prescriber's decision.","Assist in giving it to a person covertly or without lawful authority.","Disclose a person's psychiatric diagnosis or treatment without consent or legal basis.","Dismiss movement disorders or other side effects a patient reports."],"requiresHuman":["Any decision on treatment of a person, especially under mental health law."]},"ethics":{"considerations":["Long-acting antipsychotics are sometimes given under compulsion; consent and rights must be respected.","Mental illness carries stigma, so treatment information is sensitive."],"affectedParties":["Patients with schizophrenia","Families and carers","Clinicians"]},"owners":{"steward":"The marketing authorisation holder where it is licensed; the prescriber answers for each patient's use.","roles":[],"masterSystems":["National medicines registers"]},"relations":[{"target":"Q11173","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.fluspirilene","Wikidata: Q408300 (https://www.wikidata.org/wiki/Q408300)"]},"properties":{"applicability":"required","items":["Chemical identity: CAS 1841-19-6; PubChem CID 3396; EC 217-418-6; UNII C5QA4GLR9M","Molecular composition: C29H31F2N3O; molecular weight approximately 475.6 g/mol","Assay and reporting basis: % w/w or validated equivalent; as-is, dried or solvent-free basis","Impurity profile: Individual and total impurities in % or mg/kg, with method and detection limits","Solid form and particle distribution: Observed crystalline or amorphous state; identified phase; D10, D50 and D90 in µm","Solubility under specified conditions: mg/mL or mol/L, with solvent, pH, temperature and equilibration method","Thermal behavior: Melting or decomposition interval in °C; method, pressure and sample form","Target activity evidence: Target, species, assay, effect type and Ki, Kd, IC50 or EC50 with units","Material disposition: Unassessed, quarantined, accepted for specified use, rejected or expired"]},"recognition":{"applicability":"required","items":["Supplied as an injectable suspension for intramuscular use; identity must be confirmed by label and pharmacy records."]},"capabilities":{"applicability":"required","items":["Resolve a named or coded material to fluspirilene using structural identifiers and analytical records.","Assess whether a lot meets an explicitly selected research or pharmaceutical material specification.","Calculate fluspirilene content and preparation concentrations using assay and molecular-form corrections.","Evaluate whether measured solubility, solid form and particle properties support a proposed preparation.","Compare biological activity reports while preserving target, species and assay differences.","Assign evidence-supported handling and storage requirements or hold the material pending missing evidence."]},"hazards":{"applicability":"required","items":["Can cause movement disorders, including late-onset involuntary movements.","Rare but serious reactions such as neuroleptic malignant syndrome are possible.","Long action means side effects persist after the injection."]},"interfaces":{"applicability":"required","items":["The Anatomical Therapeutic Chemical classification maintained by the WHO Collaborating Centre for Drug Statistics Methodology assigns fluspirilene code N05AG01."]},"context":{"applicability":"required","items":["Fluspirilene is used as an antipsychotic substance in long-acting intramuscular pharmaceutical preparations.","It is also encountered in pharmaceutical analysis and receptor pharmacology research, where substance identity and formulation must be distinguished."]}},"sources":[{"title":"Wikidata item Q408300: fluspirilene","url":"https://www.wikidata.org/wiki/Q408300","note":"identity and sense of the item"},{"title":"Wikipedia: Fluspirilene","url":"https://en.wikipedia.org/wiki/Fluspirilene","note":"general description of the item"}],"openQuestions":["Which authoritative fluspirilene specification establishes assay, related-substance limits and reference-standard requirements for each intended grade?","Which solid forms are experimentally established, and what reliable melting, decomposition, solubility and stability measurements apply to each?","What current GHS classifications and occupational exposure limits, if any, apply to fluspirilene in the relevant jurisdiction?","Which fluspirilene medicinal products are currently authorized in the intended jurisdiction, and which claims about prolonged action depend on their formulation?","Which primary receptor and functional studies best establish fluspirilene's activity profile, and which additional target effects remain experimental?"],"resources":{"spec":"/models/things/publications/thing-q408300/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q408300/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T09:47:03Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:30+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}