{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.syphilis","code":"thing-q41083","url":"https://ver.cy/models/thing/q41083/","name":"syphilis","alternateNames":["syphilitic aortic aneurysm","neurosyphilis","secondary syphilitic hepatitis","bursa syphilis","syphilitic retrobulbar neuritis","syphilitic meningitis","asymptomatic neurosyphilis","syphilitic peritonitis","syphilitic pericarditis","congenital syphilitic encephalitis","meningovascular neurosyphilis","tertiary syphilitic meningitis"],"kind":"thing","status":"published","version":"0.2.0-wave.3","language":"en","classifiers":{"family":"Thing Registry","category":"Activities and processes","entryKind":"thing","plane":"ACT","domain":["ACT.ACT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A sexually transmitted infection caused by the bacterium Treponema pallidum, progressing if untreated through primary, secondary, latent and tertiary stages that can affect the skin, mucous membranes, heart, nervous system and other organs, and transmissible from mother to child in pregnancy; it is diagnosed by blood tests and cured by antibiotics, usually penicillin.","purpose":"Let an agent explain syphilis in general terms, relay testing, treatment and prevention guidance from health authorities, describe its public health and historical significance including ethical failures in research, and route personal symptoms or results to clinicians and sexual health services.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Caused by Treponema pallidum","Staged course with latency","Curable with penicillin","Congenital transmission preventable by antenatal screening"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What syphilis is.","layers":[{"id":"course","name":"Course","description":"Stages and transmission.","findings":[{"id":"course-finding","name":"Course","description":"Course.","questions":[{"text":"How is syphilis transmitted, and what happens in each stage if untreated?","kind":"definition"},{"text":"Is the user describing their own symptoms, which need a clinician?","kind":"boundary"}]}]},{"id":"recognise","name":"Recognise","description":"Signs.","findings":[{"id":"recognise-finding","name":"Recognise","description":"Recognise.","questions":[{"text":"What signs characterise each stage, and how is it distinguished from other conditions?","kind":"definition"},{"text":"Which entry fits another sexually transmitted infection?","kind":"action"}]}]}]},{"id":"care","name":"Care","description":"Testing and treatment.","layers":[{"id":"testing","name":"Testing","description":"Testing.","findings":[{"id":"testing-finding","name":"Testing","description":"Testing.","questions":[{"text":"Who should be tested according to guidelines, and how is testing accessed?","kind":"provenance"},{"text":"Which services provide testing locally?","kind":"action"}]}]},{"id":"treatment","name":"Treatment","description":"Treatment.","findings":[{"id":"treatment-finding","name":"Treatment","description":"Treatment.","questions":[{"text":"What treatment do guidelines describe, and why is follow-up needed?","kind":"provenance"},{"text":"Is the presentation free of personal treatment advice?","kind":"boundary"}]}]}]},{"id":"prevent","name":"Prevent","description":"Prevention and public health.","layers":[{"id":"prevention","name":"Prevention","description":"Prevention.","findings":[{"id":"prevention-finding","name":"Prevention","description":"Prevention.","questions":[{"text":"What prevention and partner notification measures do authorities recommend?","kind":"provenance"},{"text":"Which entry fits sexual health services?","kind":"action"}]}]},{"id":"congenital","name":"Congenital","description":"Pregnancy and screening.","findings":[{"id":"congenital-finding","name":"Congenital","description":"Congenital.","questions":[{"text":"How is congenital syphilis prevented through antenatal screening?","kind":"provenance"},{"text":"Which entry fits antenatal care?","kind":"action"}]}]}]},{"id":"history","name":"History","description":"History and ethics.","layers":[{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How did syphilis spread and how was it treated before antibiotics, with debates about origin attributed?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"ethics","name":"Ethics","description":"Research ethics.","findings":[{"id":"ethics-finding","name":"Ethics","description":"Ethics.","questions":[{"text":"What happened in the Tuskegee and Guatemala studies, and how did they change research ethics?","kind":"provenance"},{"text":"Is the presentation accurate and attributed?","kind":"boundary"}]}]}]}]},"agentConduct":{"may":["Explain syphilis, its stages, testing and treatment in general terms from health authorities.","Direct people to sexual health services for testing."],"mustNot":["Diagnose syphilis in a person or advise on their treatment.","Disclose a person's diagnosis or status to anyone without their consent or a legal duty.","Shame or stigmatise people with the infection.","Suggest that untreated syphilis will resolve on its own."],"requiresHuman":["Notifying partners or public health authorities about a case."]},"ethics":{"considerations":["Stigma delays testing and treatment and lets the infection spread.","Congenital syphilis harms babies when antenatal screening is missed."],"affectedParties":["People with the infection","Their partners","Unborn children"]},"owners":{"steward":"The patient for their own health; public health authorities run surveillance of notifiable cases.","roles":[],"masterSystems":["Notifiable disease surveillance systems"]},"relations":[{"target":"Q1243869","type":"parent","note":"registry parent class"},{"target":"Q56369564","type":"parent","note":"registry parent class"},{"target":"sexually transmitted infection","type":"related","note":"the category"},{"target":"Treponema pallidum","type":"related","note":"the bacterium"},{"target":"penicillin","type":"related","note":"first-line antibiotic"},{"target":"yaws","type":"related","note":"a related treponemal disease"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.syphilis","Wikidata: Q41083 (https://www.wikidata.org/wiki/Q41083)","ICD-10: A50-A53","ICD-11: 1A60-1A62"]},"properties":{"applicability":"not-applicable","items":["incubation to primary stage: about 10-90 days - typically about three weeks","new infections: millions per year worldwide - WHO estimates"]},"recognition":{"applicability":"optional","items":["Painless chancre at the site of infection","Secondary rash often on palms and soles","Other treponematoses such as yaws are related but distinct infections","Not visible as an object; a painless sore in the primary stage, a rash in the secondary stage, and no signs in latency."]},"capabilities":{"applicability":"required","items":["explain stages and transmission in general terms","relay testing and treatment guidance from authorities","relay prevention and partner notification information","route personal questions to clinical services"]},"hazards":{"applicability":"required","items":["Untreated progression to neurological and cardiovascular disease","Congenital syphilis from missed antenatal screening","Stigma delaying testing","Agents giving personal medical advice"]},"interfaces":{"applicability":"required","items":["WHO guidelines on treatment and antenatal screening","National sexually transmitted infection guidelines","Notifiable disease reporting","Research ethics rules adopted after historical abuses"]},"context":{"applicability":"required","items":["Not applicable; a disease.","primary, secondary, latent and tertiary syphilis","neurosyphilis and ocular syphilis","cardiovascular syphilis","congenital syphilis","syphilis in pregnancy"]}},"sources":[{"title":"Wikidata item Q41083: syphilis","url":"https://www.wikidata.org/wiki/Q41083","note":"identity and sense of the item"},{"title":"Wikipedia: Syphilis","url":"https://en.wikipedia.org/wiki/Syphilis","note":"general description of the item"}],"openQuestions":["Should congenital syphilis be a separate entry?","How should national guidelines be linked?","The registry entry has merged aliases for specific complications; should they be split off?"],"resources":{"spec":"/models/things/publications/thing-q41083/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q41083/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T19:59:28Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"not-applicable","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-06T19:51:59+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass","interaction.properties":"Plane ACT: no invented physical properties."},"score":1.0}}