{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.oleandrin","code":"thing-q411532","url":"https://ver.cy/models/thing/q411532/","name":"oleandrin","alternateNames":[],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Oleandrin is a naturally occurring cardenolide cardiac glycoside found in oleander (Nerium oleander) that inhibits sodium-potassium ATPase and contributes to the plant's toxicity.","purpose":"Enable an agent to recognise oleandrin, assess the identity and condition of a particular sample, and determine which handling, analytical or research actions its evidence supports.","scope":{"in":["Molecular identity, stereochemistry and verified chemical identifiers","Oleandrin content, purity, related compounds and sample matrix","Physical form, measured properties and stability under stated conditions","Analytical identification, quantification and reference-material traceability","Substance-specific hazard evidence and handling constraints","Evidence boundaries for biological activity and proposed research uses"],"out":["Oleander plants, their cultivation and ecological relationships","Whole botanical extracts and formulated products containing oleandrin","Oleandrigenin and other related compounds as independently registered substances","Manufacturing and extraction processes as operational systems","Diagnosis and treatment of poisoning or other clinical conditions","Clinical interventions, commercial products and their approval histories"],"boundaries":[]},"distinguishingFeatures":["Require agreement with a verified oleandrin structure, including stereochemistry; a shared molecular formula alone does not establish identity.","Distinguish oleandrin from oleandrigenin by evidence resolving the glycoside from its corresponding aglycone.","Require an analytical method capable of separating oleandrin from related glycosides rather than accepting an undifferentiated total-glycoside result.","Distinguish an isolated oleandrin sample from an oleander extract by recording the matrix and the measured oleandrin fraction.","Treat botanical origin, a supplier label or reported biological activity as supporting context rather than sufficient chemical identification."],"structure":{"bundles":[{"id":"oleandrin-identity-and-boundaries","name":"Oleandrin identity and boundaries","description":"Establishes which chemical entity the registry entry denotes and distinguishes it from neighbouring substances and materials.","layers":[{"id":"molecular-identity","name":"Molecular identity","description":"Connects the registered name to a verified structure and identifier set.","findings":[{"id":"structure-and-identifier-agreement","name":"Structure and identifier agreement","description":"Require identifiers and names to resolve to the same oleandrin structure, including stereochemistry.","questions":[{"text":"Which authoritative records establish oleandrin's structure, stereochemistry, molecular formula and preferred name?","id":"structure-and-identifier-agreement-q01","kind":"definition"},{"text":"Which CAS number, PubChem CID and applicable EC identifier resolve to that same structure, and are any mappings inconsistent?","id":"structure-and-identifier-agreement-q02","kind":"provenance"}]}]},{"id":"neighbouring-chemical-entities","name":"Neighbouring chemical entities","description":"Separates oleandrin from its aglycone, related glycosides and botanical mixtures.","findings":[{"id":"glycoside-and-mixture-boundaries","name":"Glycoside and mixture boundaries","description":"Keep the identity of oleandrin distinct from related compounds and from materials in which it is detected.","questions":[{"text":"What structural and analytical evidence distinguishes oleandrin from oleandrigenin and the related glycosides present in the sample?","id":"glycoside-and-mixture-boundaries-q01","kind":"boundary"},{"text":"Does the record describe isolated oleandrin, a reference solution or a multicomponent extract containing oleandrin?","id":"glycoside-and-mixture-boundaries-q02","kind":"boundary"}]}]}]},{"id":"sample-composition-and-analytical-confidence","name":"Sample composition and analytical confidence","description":"Records how much oleandrin is present and how convincingly the sample has been identified.","layers":[{"id":"content-and-related-compounds","name":"Content and related compounds","description":"Describes oleandrin quantity alongside constituents that affect interpretation.","findings":[{"id":"content-on-a-defined-basis","name":"Content on a defined basis","description":"Separate absolute oleandrin content from chromatographic purity and account for the sample matrix.","questions":[{"text":"What is the measured oleandrin content, with units, uncertainty and an as-received or dry-mass basis where relevant?","id":"content-on-a-defined-basis-q01","kind":"measurement"},{"text":"Which related glycosides, degradation products, residual solvents or unidentified constituents accompany oleandrin?","id":"content-on-a-defined-basis-q02","kind":"measurement"}]}]},{"id":"selectivity-and-traceability","name":"Selectivity and traceability","description":"Evaluates whether analytical evidence resolves oleandrin and supports its reported quantity.","findings":[{"id":"reference-supported-identification","name":"Reference-supported identification","description":"Link identification and quantification to suitable reference material and demonstrated method performance.","questions":[{"text":"Which reference material, lot and certificate support the oleandrin assignment and calibration?","id":"reference-supported-identification-q01","kind":"provenance"},{"text":"How does the method demonstrate selectivity against related compounds and control recovery or matrix effects in this sample?","id":"reference-supported-identification-q02","kind":"measurement"},{"text":"What additional evidence is required when retention time, mass-spectral evidence or another identity check disagrees?","id":"reference-supported-identification-q03","kind":"action"}]}]}]},{"id":"physical-condition-and-stability","name":"Physical condition and stability","description":"Connects oleandrin's observed form and measured properties to storage and experimental conditions.","layers":[{"id":"form-and-condition-dependent-properties","name":"Form and condition-dependent properties","description":"Records the physical state and the conditions under which property measurements apply.","findings":[{"id":"usable-physical-property-evidence","name":"Usable physical property evidence","description":"Accept physical constants only with enough context to distinguish measured behaviour from assumptions.","questions":[{"text":"What solid form or solution composition was used for the reported oleandrin solubility and thermal measurements?","id":"usable-physical-property-evidence-q01","kind":"measurement"},{"text":"Do thermal data establish melting, decomposition or boiling, and under what pressure and measurement conditions?","id":"usable-physical-property-evidence-q02","kind":"measurement"}]}]},{"id":"storage-and-transformation","name":"Storage and transformation","description":"Tracks whether stored solids and prepared solutions retain their established composition.","findings":[{"id":"continued-sample-suitability","name":"Continued sample suitability","description":"Base continued use on evidence appropriate to the particular oleandrin material and storage history.","questions":[{"text":"What evidence establishes stability for this oleandrin solid or solution under its temperature, light, solvent and pH conditions?","id":"continued-sample-suitability-q01","kind":"provenance"},{"text":"What changes in oleandrin content, related-compound profile or precipitation require reassessment before use?","id":"continued-sample-suitability-q02","kind":"action"}]}]}]},{"id":"hazards-and-evidence-bounded-use","name":"Hazards and evidence-bounded use","description":"Connects verified hazard information and biological evidence to decisions about oleandrin samples.","layers":[{"id":"hazard-records-and-controls","name":"Hazard records and controls","description":"Identifies applicable classifications and the controls they support.","findings":[{"id":"material-specific-hazard-basis","name":"Material-specific hazard basis","description":"Distinguish classifications for oleandrin from those for its solutions, extracts and formulations.","questions":[{"text":"Which current, jurisdiction-specific sources establish hazard classifications and any occupational exposure limits for oleandrin, and where are limits unestablished?","id":"material-specific-hazard-basis-q01","kind":"provenance"},{"text":"Which containment, handling and waste requirements apply to this sample's concentration, solvent and intended operation?","id":"material-specific-hazard-basis-q02","kind":"action"}]}]},{"id":"biological-attribution-and-use-boundaries","name":"Biological attribution and use boundaries","description":"Preserves the distinction between evidence about oleandrin, evidence about extracts and claims about practical use.","findings":[{"id":"activity-with-an-explicit-evidence-context","name":"Activity with an explicit evidence context","description":"Record biological observations with the tested material and experimental limits needed to interpret them.","questions":[{"text":"Was the reported biological effect measured using analytically characterised oleandrin or a mixture containing it?","id":"activity-with-an-explicit-evidence-context-q01","kind":"provenance"},{"text":"Which assay system, endpoint, concentration and exposure duration support the observation?","id":"activity-with-an-explicit-evidence-context-q02","kind":"measurement"},{"text":"What additional evidence or authorization would the proposed use require beyond the reported experimental observation?","id":"activity-with-an-explicit-evidence-context-q03","kind":"action"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of oleandrin this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of oleandrin this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of oleandrin this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of oleandrin this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of oleandrin this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of oleandrin this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain that oleander and its oleandrin are poisonous to people and animals.","Warn keepers of children and pets about oleander plants nearby.","Point to poison control services when exposure is suspected."],"mustNot":["Assist in extracting, concentrating or using oleandrin to harm a person or animal.","Promote oleander preparations as a cure for cancer or other disease.","Advise home treatment instead of emergency care after exposure.","Recommend burning oleander cuttings near people."],"requiresHuman":["Any medical use or trial involving oleandrin.","Removing oleander plants from a garden or public space."]},"ethics":{"considerations":["Oleander is common in gardens, so accidental poisoning of children and pets is a real risk.","False cure claims exploit seriously ill people."],"affectedParties":["Children","Pets and livestock","People seeking cancer treatment"]},"owners":{"steward":"Nobody owns the compound; gardeners and landowners answer for oleander plants they keep.","roles":[],"masterSystems":[]},"relations":[{"target":"Q105130969","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.oleandrin","Wikidata: Q411532 (https://www.wikidata.org/wiki/Q411532)"]},"properties":{"applicability":"required","items":["Verified molecular identity: Source-verified structure, stereochemical representation and chemical identifiers","Sample matrix: Isolated substance, reference solution, botanical extract, formulated material or biological matrix","Oleandrin content: Mass fraction, mg/g, mg/mL or mol/L, with measurement basis and uncertainty","Related-compound profile: Identified constituents and their concentrations or explicitly qualified chromatographic area percentages","Physical form and solvent state: Solid or solution; crystallinity if established; solvent, water content and visible precipitation","Condition-dependent physical properties: Solubility in mg/mL or mol/L; thermal transitions in °C; temperature, medium and method recorded","Storage and stability status: Within validated conditions, excursion recorded, degradation detected or stability unestablished","Analytical reference linkage: Reference material, lot, certificate, method and supporting analytical records","Hazard and regulatory evidence: Dated classification or restriction linked to source, jurisdiction and applicable material","Biological evidence context: Tested material, assay system, endpoint, concentration, exposure duration and study source"]},"recognition":{"applicability":"required","items":["Occurs in oleander, an evergreen shrub with narrow leathery leaves and pink, red or white flowers.","The pure compound cannot be identified by eye and needs laboratory analysis."]},"capabilities":{"applicability":"required","items":["Compare a candidate sample with verified oleandrin identity evidence and flag unresolved mismatches.","Quantify oleandrin in a specified matrix using a suitably selective, documented method.","Assess whether storage history and analytical results support continued use of a sample.","Select applicable handling, containment and disposal requirements from verified substance and mixture records.","Compare research observations while preserving differences in purity, matrix and exposure conditions.","Route unsupported identity, safety or biological claims for further investigation before relying on them."]},"hazards":{"applicability":"required","items":["Poisoning disturbs heart rhythm and can be fatal.","Smoke from burning the plant can also cause poisoning."]},"interfaces":{"applicability":"required","items":["The Globally Harmonized System of Classification and Labelling of Chemicals, issued by the United Nations, provides the framework for communicating the hazards of oleandrin supplied as a chemical."]},"context":{"applicability":"required","items":["Oleandrin is encountered in oleander plant material and in analytical or research preparations derived from it.","It is studied for its interaction with sodium-potassium ATPase and measured in investigations involving exposure to oleander constituents."]}},"sources":[{"title":"Wikidata item Q411532: oleandrin","url":"https://www.wikidata.org/wiki/Q411532","note":"identity and sense of the item"},{"title":"Wikipedia: Oleandrin","url":"https://en.wikipedia.org/wiki/Oleandrin","note":"general description of the item"}],"openQuestions":["Which authoritative identity records agree on oleandrin's complete stereochemistry and registry identifiers, and do any synonyms introduce ambiguity?","Which primary measurements establish solubility and thermal behaviour, and is a meaningful boiling point available before decomposition?","Which related compounds and degradation products must be resolved to identify and quantify oleandrin reliably in each relevant matrix?","What validated storage conditions and stability periods apply separately to isolated oleandrin and its commonly used reference solutions?","Which hazard classifications, exposure limits and use restrictions are established in the relevant jurisdictions, and which biological claims remain limited to particular experimental systems?"],"resources":{"spec":"/models/things/publications/thing-q411532/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q411532/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T11:44:13Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:30+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}