{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.isoflavone","code":"thing-q412519","url":"https://ver.cy/models/thing/q412519/","name":"isoflavone","alternateNames":["6C-substituted isoflavone","2,8C-substituted isoflavone","6,8C-substituted isoflavone","8C-substituted isoflavone","2C-substituted isoflavone","3'C-substituted isoflavone","3',6,8C-substituted isoflavone","2'C-substituted isoflavone","4'-methoxyisoflavones","7-methoxyisoflavones","Lophirone L","8-Hydroxy-9-methoxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-[1]benzofuro[2,3-b]chromen-11-one"],"kind":"thing","status":"published","version":"0.2.0-wave.2","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A class of isoflavonoid compounds based on a three-phenylchromen-four-one skeleton, produced mainly by legumes such as soybeans, red clover and kudzu, including genistein, daidzein, formononetin and biochanin A and many substituted derivatives, acting in plants as defence and signalling compounds and studied in nutrition and medicine as phytoestrogens with weak oestrogenic activity; isoflavones are consumed in soy foods and supplements, with health effects that remain under research.","purpose":"Let an agent explain isoflavones and their chemistry and sources, describe biological activity and research on health effects with attribution, relay dietary guidance from health bodies, and support learning.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Isoflavonoid skeleton","Legume origin","Phytoestrogen activity","Dietary relevance"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What isoflavones are.","layers":[{"id":"structure","name":"Structure","description":"Structure and classes.","findings":[{"id":"structure-finding","name":"Structure","description":"Structure.","questions":[{"text":"What is the isoflavone skeleton, and how do the main compounds and substituted derivatives differ?","kind":"definition"},{"text":"Which entry fits a specific compound?","kind":"action"}]}]},{"id":"sources","name":"Sources","description":"Sources in plants.","findings":[{"id":"sources-finding","name":"Sources","description":"Sources.","questions":[{"text":"Which plants produce isoflavones, and what roles do they play in plant defence and signalling?","kind":"provenance"},{"text":"Which entry fits soybeans?","kind":"action"}]}]}]},{"id":"biology","name":"Biology","description":"Biological activity.","layers":[{"id":"activity","name":"Activity","description":"Phytoestrogen activity.","findings":[{"id":"activity-finding","name":"Activity","description":"Activity.","questions":[{"text":"How do isoflavones interact with oestrogen receptors and how are they metabolised?","kind":"definition"},{"text":"Which entry fits phytoestrogens?","kind":"action"}]}]},{"id":"research","name":"Research","description":"Health research.","findings":[{"id":"research-finding","name":"Research","description":"Research.","questions":[{"text":"What does research say about isoflavones and health outcomes, with findings and uncertainties attributed?","kind":"provenance"},{"text":"Which findings are contested?","kind":"boundary"}]}]}]},{"id":"diet","name":"Diet","description":"Diet and supplements.","layers":[{"id":"foods","name":"Foods","description":"Foods.","findings":[{"id":"foods-finding","name":"Foods","description":"Foods.","questions":[{"text":"Which foods contain isoflavones, and what do dietary guidelines say about soy consumption?","kind":"provenance"},{"text":"Is the user asking about a personal health condition, which needs a professional?","kind":"boundary"}]}]},{"id":"supplements","name":"Supplements","description":"Supplements.","findings":[{"id":"supplements-finding","name":"Supplements","description":"Supplements.","questions":[{"text":"How are isoflavone supplements regulated, and what do regulators say about health claims?","kind":"provenance"},{"text":"Which entry fits supplement regulation?","kind":"action"}]}]}]},{"id":"learn","name":"Learn","description":"History and teaching.","layers":[{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How were isoflavones discovered and their oestrogenic effects recognised?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"teach","name":"Teach","description":"Teaching.","findings":[{"id":"teach-finding","name":"Teach","description":"Teaching.","questions":[{"text":"How can isoflavones be taught in phytochemistry and nutrition?","kind":"action"},{"text":"Which misconceptions arise?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain isoflavones, their sources and the state of research on health effects.","Report published regulatory opinions on isoflavone supplements."],"mustNot":["Present isoflavones as proven to treat or prevent disease.","Recommend supplement doses to a specific person.","Hide reported uncertainties about effects in particular groups.","Market products with health claims authorities have not approved."],"requiresHuman":["Advising on supplements for someone with a hormone-sensitive condition."]},"ethics":{"considerations":["Supplement marketing exploits health worries with unproven claims.","Diet advice touches on culture and food traditions."],"affectedParties":["Consumers","Patients with hormone-related conditions","Producers"]},"owners":{"steward":"Nobody owns the compounds; producers answer for products under food law.","roles":[],"masterSystems":[]},"relations":[{"target":"Q3234924","type":"parent","note":"registry parent class"},{"target":"isoflavonoid","type":"related","note":"category"},{"target":"glycoside","type":"related","note":"isoflavone glycosides"},{"target":"lipid metabolism","type":"related","note":"hormone-related metabolism"},{"target":"alternative medicine","type":"related","note":"supplement use"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.isoflavone","Wikidata: Q412519 (https://www.wikidata.org/wiki/Q412519)"]},"properties":{"applicability":"required","items":["Molar mass:  grams per mole - Calculate from the molecular formula of the identified compound because substitutions and attached sugar groups change the value.","Melting temperature:  degrees Celsius - Measure for the identified compound and solid form using thermal analysis while recording any decomposition.","Solubility:  grams per litre - Measure the equilibrium dissolved concentration for a specified compound, solvent, temperature and pH."]},"recognition":{"applicability":"required","items":["Isoflavonoid with three-phenylchromenone skeleton","Soy and legume sources","Flavones have the phenyl at the two position; lignans are different phytoestrogens","Not visible; compounds in soy and other legumes."]},"capabilities":{"applicability":"required","items":["explain chemistry and sources","describe activity and research","relay dietary guidance","support learning"]},"hazards":{"applicability":"required","items":["Overstated health claims","Agents giving personal dietary or medical advice","Confusing isoflavones with hormones"]},"interfaces":{"applicability":"required","items":["Food and supplement regulation","Health claim regulations","Chemical nomenclature"]},"context":{"applicability":"required","items":["Phytoestrogen compounds from legumes.","genistein and daidzein","formononetin and biochanin A","substituted isoflavones","isoflavone glycosides","isoflavone metabolites such as equol"]}},"sources":[{"title":"Wikidata item Q412519: isoflavone","url":"https://www.wikidata.org/wiki/Q412519","note":"identity and sense of the item"},{"title":"Wikipedia: Isoflavone","url":"https://en.wikipedia.org/wiki/Isoflavone","note":"general description of the item"}],"openQuestions":["Should each compound be a separate entry?","How should research reviews be linked?","How should regulatory health claim decisions be linked?"],"resources":{"spec":"/models/things/publications/thing-q412519/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q412519/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T03:07:45Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:30+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}