{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.furanocoumarin","code":"thing-q414774","url":"https://ver.cy/models/thing/q414774/","name":"furanocoumarin","alternateNames":["8-acetyl-5-hydroxy-6-(3-methylbutanoyl)-4-phenyl-2H-furo[2,3-h]chromen-2-one","5-hydroxy-6-(2-methylbutanoyl)-4-phenylfuro[2,3-h]chromen-2-one","Furanoracemosone","ochrocarpin A","ochrocarpin B","ochrocarpin C","ochrocarpin D","thonningine A","6-(2,4,5-trimethoxyphenyl)furo[3,2-g]chromen-7-one","thonningine B","2-(1-Methylethenyl)-3,4-dimethoxy-5-hydroxy-6-(3,4-dimethoxyphenyl)-7H-furo[3,2-g][1]benzopyran-7-one","6'-O-trans-feruloylnodakenin"],"kind":"thing","status":"published","version":"0.2.0-wave.2","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A class of organic compounds formed by a furan ring fused to a coumarin, produced by plants such as citrus, celery, parsnip and giant hogweed as defence chemicals, including psoralen, bergapten and xanthotoxin and many natural derivatives; furanocoumarins cause phytophotodermatitis when skin exposed to them meets sunlight, are responsible for grapefruit interactions with many drugs by inhibiting intestinal enzymes, and are used in controlled phototherapy for skin conditions.","purpose":"Let an agent explain furanocoumarins and their chemistry and plant sources, describe their effects on skin and drug metabolism in general terms, relay safety information from health bodies, and route personal medical questions to professionals.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Phototoxicity","Grapefruit drug interaction","Plant defence","Phototherapy use"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"What furanocoumarins are.","layers":[{"id":"chemistry","name":"Chemistry","description":"Chemistry.","findings":[{"id":"chemistry-finding","name":"Chemistry","description":"Chemistry.","questions":[{"text":"What are furanocoumarins, and how do linear and angular types and their derivatives differ?","kind":"definition"},{"text":"Which entry fits a specific compound?","kind":"action"}]}]},{"id":"sources","name":"Sources","description":"Plant sources.","findings":[{"id":"sources-finding","name":"Sources","description":"Sources.","questions":[{"text":"Which plants produce furanocoumarins, and why?","kind":"provenance"},{"text":"Which entry fits a specific plant?","kind":"action"}]}]}]},{"id":"effects","name":"Effects","description":"Effects on people.","layers":[{"id":"skin","name":"Skin","description":"Phototoxicity.","findings":[{"id":"skin-finding","name":"Skin","description":"Skin.","questions":[{"text":"How do furanocoumarins cause phytophotodermatitis, and what do health bodies advise after plant contact?","kind":"provenance"},{"text":"Is a skin reaction present now that needs medical attention?","kind":"boundary"}]}]},{"id":"drugs","name":"Drugs","description":"Drug interactions.","findings":[{"id":"drugs-finding","name":"Drugs","description":"Drugs.","questions":[{"text":"How does grapefruit interact with medicines through furanocoumarins, in general terms?","kind":"provenance"},{"text":"Is the user asking about their own medication, which needs a pharmacist or clinician?","kind":"boundary"}]}]}]},{"id":"use","name":"Use","description":"Uses and regulation.","layers":[{"id":"therapy","name":"Therapy","description":"Phototherapy.","findings":[{"id":"therapy-finding","name":"Therapy","description":"Therapy.","questions":[{"text":"How are psoralens used in controlled phototherapy, according to clinical guidelines?","kind":"provenance"},{"text":"Which entry fits phototherapy?","kind":"action"}]}]},{"id":"regulation","name":"Regulation","description":"Regulation.","findings":[{"id":"regulation-finding","name":"Regulation","description":"Regulation.","questions":[{"text":"How are furanocoumarins regulated in cosmetics and foods?","kind":"provenance"},{"text":"Which entry fits cosmetic regulation?","kind":"action"}]}]}]},{"id":"learn","name":"Learn","description":"Research and teaching.","layers":[{"id":"research","name":"Research","description":"Research.","findings":[{"id":"research-finding","name":"Research","description":"Research.","questions":[{"text":"What research exists on furanocoumarin biosynthesis and pharmacology?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"teach","name":"Teach","description":"Teaching.","findings":[{"id":"teach-finding","name":"Teach","description":"Teaching.","questions":[{"text":"How can plant chemistry and safety be taught with furanocoumarins?","kind":"action"},{"text":"Which misconceptions arise?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Explain furanocoumarins, their sources and effects, such as interactions with medicines.","Warn people handling plants such as giant hogweed about skin reactions in sunlight."],"mustNot":["Advise touching or cutting plants rich in furanocoumarins without protection.","Dismiss interactions between grapefruit and medicines.","Help use these compounds to harm people."],"requiresHuman":["Changing a patient's medication because of a dietary interaction."]},"ethics":{"considerations":["Contact with some plants causes severe burns, often in children.","Food-drug interactions can be dangerous and poorly known."],"affectedParties":["Children and gardeners","Patients on medication"]},"owners":{"steward":"Nobody: natural compounds held in common.","roles":[],"masterSystems":[]},"relations":[{"target":"Q107684571","type":"parent","note":"registry parent class"},{"target":"benzopyranoid","type":"related","note":"category"},{"target":"Citrus","type":"related","note":"a major source"},{"target":"herbicide","type":"related","note":"plant chemicals and agriculture"},{"target":"drug","type":"related","note":"interactions with medicines"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.furanocoumarin","Wikidata: Q414774 (https://www.wikidata.org/wiki/Q414774)"]},"properties":{"applicability":"required","items":["Molar mass:  g/mol - Calculate the value from the molecular formula of the identified furanocoumarin because substitutions vary across the class.","Melting temperature:  degrees Celsius - Measure the identified compound by thermal analysis or a melting point method while recording purity and any decomposition.","Solubility:  g/L - Measure the equilibrium dissolved concentration for the specified compound, solvent and temperature.","Ultraviolet absorption wavelength:  nm - Determine absorption maxima by ultraviolet-visible spectroscopy with the compound and solvent identified."]},"recognition":{"applicability":"required","items":["Furan ring fused to coumarin","Citrus, celery, parsnip, hogweed","Simple coumarins lack the furan ring; flavonoids are a different class","Not physical; molecules."]},"capabilities":{"applicability":"required","items":["explain chemistry and sources","describe effects generally","relay safety information","route personal questions"]},"hazards":{"applicability":"required","items":["Skin burns from plant contact and sun","Drug interactions from grapefruit","Agents giving personal medical advice"]},"interfaces":{"applicability":"required","items":["Drug labelling on grapefruit interactions","Cosmetic ingredient restrictions","Phototherapy clinical guidelines"]},"context":{"applicability":"required","items":["Furan-fused coumarin plant compounds.","linear furanocoumarins such as psoralen","angular furanocoumarins","citrus furanocoumarins","furanocoumarins in Apiaceae plants","derivatives from other plant families"]}},"sources":[{"title":"Wikidata item Q414774: furanocoumarin","url":"https://www.wikidata.org/wiki/Q414774","note":"identity and sense of the item"},{"title":"Wikipedia: Furanocoumarin","url":"https://en.wikipedia.org/wiki/Furanocoumarin","note":"general description of the item"}],"openQuestions":["Should psoralen be a separate entry?","How should drug interaction resources be linked?","How should plant safety information be linked?"],"resources":{"spec":"/models/things/publications/thing-q414774/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q414774/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T04:55:59Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:30+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}