{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.hernandulcin","code":"thing-q418686","url":"https://ver.cy/models/thing/q418686/","name":"hernandulcin","alternateNames":[],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Hernandulcin is an intensely sweet bisabolane-type sesquiterpenoid naturally occurring in Lippia dulcis, with sweetness arising from a nonglycosidic molecule containing alcohol and ketone functional groups.","purpose":"Enable an agent to identify hernandulcin, evaluate the condition and composition of a sample, and determine whether evidence supports its proposed analytical or sweetening use.","scope":{"in":["Molecular identity and distinction between hernandulcin stereoisomers","Identity, purity and provenance of isolated or synthesized samples","Solubility, phase behaviour and stability under recorded conditions","Sweetness measurements and their experimental context","Substance-specific hazard evidence and jurisdiction-dependent use status"],"out":["Taxonomy, cultivation and traditional uses of Lippia dulcis","Whole-plant extracts and essential oils as separately characterized mixtures","Manufacturing processes and biosynthetic pathways as operational systems","Finished foods, beverages and sweetener formulations","Separate models of epihernandulcin, lippidulcines and other chemical derivatives"],"boundaries":[]},"distinguishingFeatures":["Establish the bisabolane sesquiterpenoid structure through analytical evidence; botanical origin or a sweet taste alone cannot establish identity. [Structural research](https://www.beilstein-journals.org/bjoc/articles/11/228)","Resolve the assigned stereochemistry against an authenticated hernandulcin reference rather than accepting a molecular-mass match as sufficient.","Distinguish the parent compound from oxygenated relatives such as lippidulcines; closely related structures need not retain its sweetness. [Synthesis and taste evaluation](https://www.beilstein-journals.org/bjoc/articles/11/228)","Require a quantified hernandulcin component before treating a Lippia dulcis extract as a source sample, and distinguish that mixture from isolated substance."],"structure":{"bundles":[{"id":"hernandulcin-identity","name":"Hernandulcin identity","description":"Establish the molecular and stereochemical meaning of the registered name.","layers":[{"id":"molecular-reference","name":"Molecular reference","description":"Anchor identity in an authenticated chemical structure.","findings":[{"id":"structure-identifier-agreement","name":"Structure and identifier agreement","description":"Require names and external identifiers to resolve to a consistent structure rather than accepting catalogue labels alone.","questions":[{"text":"Which authenticated structure, molecular formula and structure identifier define hernandulcin for this entry?","id":"structure-identifier-agreement-q01","kind":"definition"},{"text":"Which CAS, PubChem and EC records correspond to that exact structure, and which describe less specific material?","id":"structure-identifier-agreement-q02","kind":"provenance"}]}]},{"id":"stereochemical-boundary","name":"Stereochemical boundary","description":"Distinguish the reference stereoisomer from epimers, enantiomers and unresolved mixtures.","findings":[{"id":"reference-stereoisomer","name":"Reference stereoisomer","description":"Record absolute configuration and the evidence establishing a sample's relationship to the reference.","questions":[{"text":"Does the registered name denote specifically natural (+)-hernandulcin, and how should racemic or stereochemically unspecified material be represented?","id":"reference-stereoisomer-q01","kind":"boundary"},{"text":"Which chiral analysis or configuration evidence distinguishes the sample from epihernandulcin and its opposite enantiomer?","id":"reference-stereoisomer-q02","kind":"measurement"}]}]}]},{"id":"sample-origin-and-composition","name":"Sample origin and composition","description":"Connect hernandulcin lots to provenance, assay and route-dependent impurities.","layers":[{"id":"origin-and-material-boundary","name":"Origin and material boundary","description":"Record how the material was obtained without absorbing the production process into this model.","findings":[{"id":"isolated-substance-or-mixture","name":"Isolated substance or mixture","description":"Identify whether the record represents isolated hernandulcin, an enriched fraction or a quantified component of a mixture.","questions":[{"text":"Is this lot botanically isolated, chemically synthesized or produced by another documented route?","id":"isolated-substance-or-mixture-q01","kind":"provenance"},{"text":"Does this record describe hernandulcin itself or a mixture requiring a separate extract or formulation model?","id":"isolated-substance-or-mixture-q02","kind":"boundary"}]}]},{"id":"assay-and-impurities","name":"Assay and impurities","description":"Determine actual parent content and distinguish chemical from stereochemical purity.","findings":[{"id":"qualified-lot-composition","name":"Qualified lot composition","description":"Use calibrated analysis to resolve hernandulcin from related terpenoids, co-extractives and synthesis residues.","questions":[{"text":"What mass fraction of hernandulcin is established by a calibrated assay rather than uncorrected chromatographic area?","id":"qualified-lot-composition-q01","kind":"measurement"},{"text":"Which related compounds and route-specific impurities were measured, with what detection limits?","id":"qualified-lot-composition-q02","kind":"measurement"}]}]}]},{"id":"physical-behaviour-and-integrity","name":"Physical behaviour and integrity","description":"Determine whether hernandulcin remains dissolved, chemically intact and analytically representative under intended conditions.","layers":[{"id":"phase-and-dissolution","name":"Phase and dissolution","description":"Establish physical state and achievable dissolved concentration.","findings":[{"id":"conditioned-physical-properties","name":"Conditioned physical properties","description":"Associate solubility and thermal observations with sample composition and measurement conditions.","questions":[{"text":"What equilibrium solubility is measured in water and the proposed solvent or matrix at the intended temperature?","id":"conditioned-physical-properties-q01","kind":"measurement"},{"text":"Which phase transitions are experimentally established, and does decomposition prevent assigning a melting or boiling point?","id":"conditioned-physical-properties-q02","kind":"measurement"}]}]},{"id":"exposure-and-degradation","name":"Exposure and degradation","description":"Track parent loss and new compounds during storage or processing.","findings":[{"id":"retained-parent-integrity","name":"Retained parent integrity","description":"Require measured stability before prescribing shelf life or treating heated or exposed material as unchanged hernandulcin.","questions":[{"text":"How do temperature, light, oxygen and aqueous conditions affect parent content and degradation products over time?","id":"retained-parent-integrity-q01","kind":"measurement"},{"text":"Which measured acceptance limits trigger retesting, restricted use or rejection of a stored lot?","id":"retained-parent-integrity-q02","kind":"action"}]}]}]},{"id":"sweetness-and-structure","name":"Sweetness and structure","description":"Represent sensory performance as evidence tied to a characterized sample and test conditions.","layers":[{"id":"relative-sweetness-evidence","name":"Relative sweetness evidence","description":"Make comparisons with sucrose reproducible and interpretable.","findings":[{"id":"contextual-sweetness-potency","name":"Contextual sweetness potency","description":"Attach each potency estimate to its concentration basis, reference solution and sensory design.","questions":[{"text":"What relative sweetness was measured for the identified sample, on a mass or molar basis and against which sucrose concentration?","id":"contextual-sweetness-potency-q01","kind":"measurement"},{"text":"Which matrix, temperature, panel method and uncertainty accompany that result?","id":"contextual-sweetness-potency-q02","kind":"provenance"}]}]},{"id":"sensory-specificity","name":"Sensory specificity","description":"Separate parent-compound sensory behaviour from impurities and structurally related compounds.","findings":[{"id":"attributable-sensory-profile","name":"Attributable sensory profile","description":"Record sweetness quality, onset, persistence and other sensations only for the material actually tested.","questions":[{"text":"Which aftertaste, bitterness or temporal effects are demonstrated for characterized hernandulcin rather than a botanical extract?","id":"attributable-sensory-profile-q01","kind":"measurement"},{"text":"Which sensory conclusions are specific to the tested stereoisomer and cannot be extended to epimers or oxygenated derivatives?","id":"attributable-sensory-profile-q02","kind":"boundary"}]}]}]},{"id":"evidence-for-permitted-use","name":"Evidence for permitted use","description":"Connect hernandulcin-specific safety evidence and legal status to the proposed application.","layers":[{"id":"hazards-and-exposure-evidence","name":"Hazards and exposure evidence","description":"Distinguish measured toxicological endpoints from missing data and mixture-level claims.","findings":[{"id":"sample-specific-safety-evidence","name":"Sample-specific safety evidence","description":"Assess relevance through tested identity, purity, dose, exposure route and duration.","questions":[{"text":"Which toxicological studies directly test characterized hernandulcin, and which endpoints or exposure durations remain unexamined?","id":"sample-specific-safety-evidence-q01","kind":"provenance"},{"text":"What documented hazard classification, handling controls or exposure limits apply to this material, and what remains undetermined?","id":"sample-specific-safety-evidence-q02","kind":"action"}]}]},{"id":"application-and-jurisdiction","name":"Application and jurisdiction","description":"Evaluate the proposed use against current authoritative requirements.","findings":[{"id":"use-specific-eligibility","name":"Use-specific eligibility","description":"Keep laboratory supply status, sensory-study eligibility and food authorization distinct.","questions":[{"text":"Which current authoritative record establishes the status of isolated hernandulcin for the intended use and jurisdiction?","id":"use-specific-eligibility-q01","kind":"provenance"},{"text":"What purity, exposure, study approval or application restrictions must be satisfied before the proposed use proceeds?","id":"use-specific-eligibility-q02","kind":"action"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of hernandulcin this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of hernandulcin this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of hernandulcin this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of hernandulcin this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of hernandulcin this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of hernandulcin this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Identify hernandulcin as an intensely sweet compound of Lippia dulcis, citing sources.","Report source, purity and storage of a held sample."],"mustNot":["Present it as an approved sweetener where it is not authorized for food.","Recommend it or plant extracts as safe sugar substitutes without evidence.","Label a plant extract as hernandulcin without analysis.","Make health claims for it in marketing."],"requiresHuman":["Adding it to food or drink for people.","Sensory testing with human participants."]},"ethics":{"considerations":["New sweeteners need safety evaluation before people consume them.","Traditional use of the plant should be credited to the communities who know it."],"affectedParties":["Consumers","Study participants","Communities with traditional knowledge"]},"owners":{"steward":"The laboratory or producer that holds the material; food authorities decide on approval.","roles":[],"masterSystems":[]},"relations":[{"target":"Q108219536","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.hernandulcin","Wikidata: Q418686 (https://www.wikidata.org/wiki/Q418686)"]},"properties":{"applicability":"required","items":["Structure and stereochemical assignment: Verified structure identifier with explicit stereochemistry; unresolved assignment","Chemical identifier correspondence: CAS, PubChem CID and EC identifiers linked to verified structures and dated sources","Hernandulcin content: % mass fraction or mg/g, with method, uncertainty and reporting basis","Stereoisomer composition: Enantiomer and diastereomer fractions; % ee or % de with method","Route-linked impurity profile: mg/kg or % for identified co-extractives, residual solvents, reagents and related compounds","Solubility: g/L or mol/L at specified temperature, solvent composition and pH where applicable","Phase and thermal behaviour: Observed phase at temperature and pressure; melting, boiling or decomposition observations in °C","Stability: % parent remaining and degradation-product amounts after stated time and exposure conditions","Relative sweetness: Ratio to sucrose with mass or molar basis, reference concentration, matrix and sensory method","Use eligibility: Supported, restricted, unsupported or undetermined for a specified use, jurisdiction and date"]},"recognition":{"applicability":"required","items":["A compound that cannot be identified by sight; its source plant is a low herb with small white flowers.","Identity is settled by chromatography and spectroscopy."]},"capabilities":{"applicability":"required","items":["Match a sample to authenticated hernandulcin using complementary structural and stereochemical evidence.","Compare isolated, synthetic and extract-derived lots against a declared composition specification.","Calculate hernandulcin concentrations from measured content and preparation records.","Assess whether storage or processing has altered parent content or impurity composition.","Compare published sweetness measurements after aligning concentration basis and experimental conditions.","Gate proposed sensory or food applications on applicable safety evidence and use authorization."]},"hazards":{"applicability":"required","items":["Unassessed safety in food use.","Misidentified or adulterated extracts."]},"interfaces":{"applicability":"required","items":["Globally Harmonized System of Classification and Labelling of Chemicals (GHS), United Nations."]},"context":{"applicability":"required","items":["Hernandulcin is encountered in natural product research on sweet constituents of Lippia dulcis.","It is studied in analytical chemistry and investigations of molecular sweetness, where identity and sample purity require supporting evidence.","Its occurrence in a sweet plant does not by itself establish suitability for a proposed food application."]}},"sources":[{"title":"Wikidata item Q418686: hernandulcin","url":"https://www.wikidata.org/wiki/Q418686","note":"identity and sense of the item"},{"title":"Wikipedia: Hernandulcin","url":"https://en.wikipedia.org/wiki/Hernandulcin","note":"general description of the item"}],"openQuestions":["Does vr.tr.hernandulcin specifically denote natural (+)-hernandulcin, and which external identifiers match that stereochemical scope?","Which experimentally measured solubility, phase-transition and stability values are reliable for well-characterized hernandulcin?","How reproducible are sucrose-relative sweetness and aftertaste findings across concentrations, matrices and stereochemical purity?","Which impurity limits and assay methods are justified for isolated botanical versus synthetic hernandulcin?","What current jurisdiction-specific food-use status, hazard classification and longer-term toxicological evidence exist for the isolated compound?"],"resources":{"spec":"/models/things/publications/thing-q418686/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q418686/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T10:14:49Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:30+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}