{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.matairesinol","code":"thing-q4284467","url":"https://ver.cy/models/thing/q4284467/","name":"matairesinol","alternateNames":[],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Matairesinol is a plant-derived dibenzylbutyrolactone lignan with molecular formula C20H22O6 that can serve as a precursor of enterolactone through intestinal microbial metabolism.","purpose":"Enable an agent to identify matairesinol, assess the identity and condition of a sample, and determine its suitability for a specified analytical or research use.","scope":{"in":["Matairesinol molecular structure, stereochemistry and corresponding chemical identifiers","Free matairesinol content, chemical purity, stereochemical purity and related lignan impurities","Solid and dissolved sample states, measured properties and storage stability","Occurrence and preparation provenance supporting sample identification","Documented transformation relationships and evidence governing research use and handling"],"out":["Whole plant, food and botanical extract composition beyond their relationship to matairesinol","Matairesinol glycosides and other covalently modified derivatives as independent substances","Secoisolariciresinol, enterolactone and other related lignans as independent substances","Manufacturing equipment, extraction workflows and analytical instruments","Supplement formulations, clinical treatment decisions and organism-level health outcomes"],"boundaries":[]},"distinguishingFeatures":["Confirm the dibenzylbutyrolactone skeleton bearing two 4-hydroxy-3-methoxybenzyl groups; the reference structure has formula C20H22O6. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Matairesinol)","Resolve stereochemistry explicitly: PubChem CID 119205 describes the (3R,4R), (-) form; a matching formula alone cannot distinguish its stereoisomers. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Matairesinol)","Establish whether the analyte is free matairesinol or a glycoside: matairesinoside carries a glucose substituent on a phenolic oxygen. [PubChem: Matairesinoside](https://pubchem.ncbi.nlm.nih.gov/compound/Matairesinoside)","Require structural or validated analytical discrimination from secoisolariciresinol and enterolactone; a precursor or metabolite relationship does not establish chemical identity."],"structure":{"bundles":[{"id":"matairesinol-identity","name":"Matairesinol identity","description":"Define the molecular and naming boundary of this registered lignan.","layers":[{"id":"molecular-boundary","name":"Molecular boundary","description":"Recognize the matairesinol aglycone and distinguish neighboring substances.","findings":[{"id":"aglycone-structure","name":"Aglycone structure","description":"Use the dibenzylbutyrolactone structure as the identity anchor; separately record any glycosylation or other covalent modification. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Matairesinol)","questions":[{"text":"What structure evidence establishes matairesinol rather than a related lignan?","id":"aglycone-structure-q01","kind":"definition"},{"text":"Does the reported material contain free matairesinol, a glycoside or a mixture?","id":"aglycone-structure-q02","kind":"boundary"}]}]},{"id":"stereochemistry-and-names","name":"Stereochemistry and names","description":"Align the registry name with structure-specific identifiers.","findings":[{"id":"identifier-stereochemical-scope","name":"Identifier stereochemical scope","description":"CID 119205 provides a reference for (-)-matairesinol, but the registry's intended stereochemical breadth requires explicit resolution. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Matairesinol)","questions":[{"text":"Does vr.tr.matairesinol denote the (3R,4R) form specifically or a stereochemically broader concept?","id":"identifier-stereochemical-scope-q01","kind":"boundary"},{"text":"Which verified CAS, PubChem and EC records refer to exactly that scope?","id":"identifier-stereochemical-scope-q02","kind":"provenance"}]}]}]},{"id":"analytical-identity-and-content","name":"Analytical identity and content","description":"Establish what a sample contains and whether its measurements are comparable.","layers":[{"id":"identity-confirmation","name":"Identity confirmation","description":"Assess structural identification and stereochemical evidence.","findings":[{"id":"orthogonal-identity-evidence","name":"Orthogonal identity evidence","description":"Record reference-standard comparisons and complementary structural evidence; a mass match alone does not settle stereochemistry or exclude isomers.","questions":[{"text":"Which NMR, mass-spectral and chromatographic observations support the assignment?","id":"orthogonal-identity-evidence-q01","kind":"measurement"},{"text":"What chiral analysis or appropriately conditioned optical-rotation measurement supports the stereochemical assignment?","id":"orthogonal-identity-evidence-q02","kind":"measurement"}]}]},{"id":"assay-and-impurities","name":"Assay and impurities","description":"Separate analyte amount from apparent chromatographic purity.","findings":[{"id":"quantitative-basis","name":"Quantitative basis","description":"Express content with calibration, sample basis, recovery and uncertainty, including whether hydrolysis preceded measurement.","questions":[{"text":"Is the reported value a calibrated mass fraction, concentration or detector-area percentage?","id":"quantitative-basis-q01","kind":"measurement"},{"text":"How are related lignans, glycosides, residual solvent and water accounted for in the assay?","id":"quantitative-basis-q02","kind":"measurement"}]}]}]},{"id":"physical-form-and-preservation","name":"Physical form and preservation","description":"Describe the conditions under which matairesinol is stored, measured and prepared.","layers":[{"id":"solid-and-solution-properties","name":"Solid and solution properties","description":"Attach physical measurements to the actual material and conditions.","findings":[{"id":"conditioned-property-records","name":"Conditioned property records","description":"Record measured thermal behavior and solvent-dependent solubility without supplying unsupported reference values.","questions":[{"text":"What melting or decomposition behavior was measured, and for which purity and solid form?","id":"conditioned-property-records-q01","kind":"measurement"},{"text":"At the proposed solvent composition, temperature and concentration, is matairesinol fully dissolved?","id":"conditioned-property-records-q02","kind":"measurement"}]}]},{"id":"storage-and-change","name":"Storage and change","description":"Assess whether stored material still represents its original assay.","findings":[{"id":"stability-qualified-use","name":"Stability-qualified use","description":"Base storage and reuse decisions on supplier instructions or measured change in matairesinol content and impurity profile.","questions":[{"text":"What evidence supports the storage temperature, light protection and solution holding time?","id":"stability-qualified-use-q01","kind":"provenance"},{"text":"What assay loss, new peaks or precipitation would require reanalysis or replacement?","id":"stability-qualified-use-q02","kind":"action"}]}]}]},{"id":"origin-and-lignan-transformations","name":"Origin and lignan transformations","description":"Connect matairesinol to its source and experimentally supported chemical or biological conversions.","layers":[{"id":"sample-origin","name":"Sample origin","description":"Trace the tested material to an authenticated preparation.","findings":[{"id":"origin-versus-preparation","name":"Origin versus preparation","description":"Distinguish matairesinol detected before sample treatment from matairesinol obtained after extraction, hydrolysis or another conversion.","questions":[{"text":"Which lot, synthesis record or authenticated biological specimen supplied this material?","id":"origin-versus-preparation-q01","kind":"provenance"},{"text":"Was matairesinol present as the free compound before processing, or measured only after a conversion step?","id":"origin-versus-preparation-q02","kind":"boundary"}]}]},{"id":"microbial-conversion","name":"Microbial conversion","description":"Represent enterolignan formation as a conditional transformation relationship.","findings":[{"id":"enterolactone-relationship","name":"Enterolactone relationship","description":"Primary research investigates matairesinol metabolism by human fecal microflora as an enterolignan precursor; conversion observations belong to their experimental conditions. [Primary study](https://pubs.acs.org/doi/10.1021/jf010038a)","questions":[{"text":"Which microbial preparation, incubation conditions and analytical evidence establish the observed products?","id":"enterolactone-relationship-q01","kind":"provenance"},{"text":"What conversion fraction and time course were measured, and do they apply to the proposed use context?","id":"enterolactone-relationship-q02","kind":"measurement"}]}]}]},{"id":"research-use-and-handling","name":"Research use and handling","description":"Connect material quality and evidence to a particular use decision.","layers":[{"id":"use-fitness","name":"Use fitness","description":"Determine whether the characterized material can support the intended measurement or experiment.","findings":[{"id":"application-specific-acceptance","name":"Application-specific acceptance","description":"Define acceptance criteria for matairesinol content, stereochemical composition, solvent and contaminants according to the experiment.","questions":[{"text":"What assay traceability and uncertainty are required before this lot can serve as a quantitative reference?","id":"application-specific-acceptance-q01","kind":"action"},{"text":"Could related lignans, solvent effects or conversion products account for the biological signal attributed to matairesinol?","id":"application-specific-acceptance-q02","kind":"boundary"}]}]},{"id":"hazard-and-regulatory-evidence","name":"Hazard and regulatory evidence","description":"Record applicable handling information without inferring safety from botanical origin.","findings":[{"id":"material-specific-handling","name":"Material-specific handling","description":"Associate hazard classifications and handling requirements with the identified substance or supplied preparation, jurisdiction and document date.","questions":[{"text":"Which current supplier SDS and jurisdictional records apply to this exact material, and what remains unclassified or unknown?","id":"material-specific-handling-q01","kind":"provenance"},{"text":"What containment, protective equipment and disposal route do those records specify for the intended amount and physical form?","id":"material-specific-handling-q02","kind":"action"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of matairesinol this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of matairesinol this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of matairesinol this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of matairesinol this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of matairesinol this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of matairesinol this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Identify matairesinol by name, identifiers and plant sources, citing sources.","Describe its conversion by gut microbes to enterolactone, citing studies."],"mustNot":["Present research associations with health as proven benefits.","Recommend supplements to a particular person on the basis of it.","Mislabel supplement content."],"requiresHuman":["Making health claims in products sold to the public."]},"ethics":{"considerations":["Nutrition claims based on early research can mislead people about their health."],"affectedParties":["Consumers","Researchers"]},"owners":{"steward":"Nobody owns the substance; producers answer for products that contain it.","roles":[],"masterSystems":[]},"relations":[{"target":"Q105160505","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.matairesinol","Wikidata: Q4284467 (https://www.wikidata.org/wiki/Q4284467)"]},"properties":{"applicability":"required","items":["Molecular identity: Structure representation with explicit stereochemistry; reference formula C20H22O6","Identifier correspondence: Registry id vr.tr.matairesinol; verified PubChem, CAS and EC mappings with stereochemical scope","Stereochemical composition: Enantiomeric excess (%) and diastereomer fractions (%), with method; unknown permitted","Matairesinol assay: Mass fraction (%), mg/g or mol/L, with free versus hydrolysis-derived basis and uncertainty","Related substance profile: Individual impurity fractions or concentrations, detection limits and unresolved peaks","Sample physical form: Solid, dissolved, suspended or unknown; solvent, water content and temperature recorded","Solubility and thermal behavior: Solubility in mg/mL or mol/L; melting or decomposition range in °C; conditions and method required","Source and lot provenance: Supplier and lot, synthesis record, or authenticated organism and tissue linked to isolation evidence","Handling evidence status: Current applicable SDS and classification verified, incomplete or unavailable"]},"recognition":{"applicability":"required","items":["Identity rests on labels and analysis, not appearance."]},"capabilities":{"applicability":"required","items":["Reconcile a matairesinol label with a structure-specific identifier and supporting certificate.","Select orthogonal analytical checks for identity, stereochemistry and related lignan contamination.","Calculate preparation amounts from the measured assay and specified solution conditions.","Determine whether a sample is suitable as a quantitative reference or research reagent.","Compare free matairesinol measurements with hydrolysis-derived measurements while preserving their different meanings.","Link observed conversion or assay results to the tested material, exposure conditions and evidence limits."]},"hazards":{"applicability":"required","items":["Unproven health claims in supplement marketing.","Mislabelled extracts."]},"interfaces":{"applicability":"required","items":["The Globally Harmonized System of Classification and Labelling of Chemicals, issued by the United Nations, provides the framework for assessing and communicating chemical hazards where implemented, without establishing a specific hazard classification for matairesinol."]},"context":{"applicability":"required","items":["Matairesinol is encountered in plant extracts and research on dietary lignans and intestinal microbial metabolism.","Analytical laboratories use identified reference material to investigate its occurrence, quantify it in samples, and distinguish it from related compounds."]}},"sources":[{"title":"Wikidata item Q4284467: matairesinol","url":"https://www.wikidata.org/wiki/Q4284467","note":"identity and sense of the item"},{"title":"Wikipedia: Matairesinol","url":"https://en.wikipedia.org/wiki/Matairesinol","note":"general description of the item"}],"openQuestions":["Does the registry intend specifically (-)-(3R,4R)-matairesinol, and which CAS and EC identifiers match that boundary?","Which experimentally supported melting, decomposition and solvent-specific solubility values are reliable enough to adopt as reference ranges?","What stability data support storage periods for purified solids and commonly used analytical stock solutions?","Which validated methods best distinguish and quantify free matairesinol, its stereoisomers and glycosides in the intended matrices?","What current hazard classifications, exposure limits if any, and use restrictions are documented for the relevant material and jurisdictions?"],"resources":{"spec":"/models/things/publications/thing-q4284467/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q4284467/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T11:11:24Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:30+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}