{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.morphinan-alkaloid","code":"thing-q4303473","url":"https://ver.cy/models/thing/q4303473/","name":"morphinan alkaloid","alternateNames":["o-Methylflavinantine","Salutadimerine","Thebaine N-oxide","Amurinine","(4R,7R,12bS)-9-methoxy-3-methyl-2,4,6,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol","(1S,9S)-4,5,13-trimethoxy-17-methyl-17-azatetracyclo[7.5.3.0¹,¹⁰.0²,⁷]heptadeca-2,4,6,10,13-pentaen-12-one","(4R,7S,7aR,12bS)-11-[(4R,7S,7aR,12bS)-7,9-dihydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-11-yl]-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol","16-Methoxy-5,7-dioxa-20-azapentacyclo[10.5.3.01,13.02,10.04,8]icosa-2,4(8),9,13,16-pentaen-15-one","BU08028","5-Hydroxy-3-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,13-tetraen-12-one","3-Hydroxy-4,12-dimethoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,11-tetraen-13-one","Morphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoxy-17-methyl-"],"kind":"thing","status":"published","version":"0.2.0-wave.2","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A class of alkaloids sharing the morphinan ring skeleton, produced by opium poppies and some other plants and also made synthetically, including morphine, codeine, thebaine and their derivatives and natural relatives such as amurinine and salutaridine intermediates; morphinan alkaloids include important analgesics and antitussives as well as controlled substances, and are studied in natural products chemistry, pharmacology and drug regulation, described here without synthesis or misuse detail.","purpose":"Let an agent explain morphinan alkaloids as a chemical class and their biosynthesis, describe their pharmacology and medical uses at a general level with attribution, describe regulation, and decline synthesis or misuse detail.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Shared skeleton","Analgesic activity in many members","Controlled status","Plant biosynthesis"],"structure":{"bundles":[{"id":"understand","name":"Understand","description":"The chemical class.","layers":[{"id":"structure","name":"Structure","description":"Skeleton and members.","findings":[{"id":"structure-finding","name":"Structure","description":"Structure.","questions":[{"text":"What is the morphinan skeleton, and which natural and synthetic compounds belong to the class?","kind":"definition"},{"text":"Is the request seeking synthesis, extraction or misuse information, which must be declined?","kind":"boundary"}]}]},{"id":"biosynthesis","name":"Biosynthesis","description":"Biosynthesis in plants.","findings":[{"id":"biosynthesis-finding","name":"Biosynthesis","description":"Biosynthesis.","questions":[{"text":"How do plants produce morphinan alkaloids from tyrosine through intermediates, according to biochemistry?","kind":"provenance"},{"text":"Which entry fits the opium poppy?","kind":"action"}]}]}]},{"id":"medicine","name":"Medicine","description":"Pharmacology and use.","layers":[{"id":"pharmacology","name":"Pharmacology","description":"Pharmacology.","findings":[{"id":"pharmacology-finding","name":"Pharmacology","description":"Pharmacology.","questions":[{"text":"How do morphinan alkaloids act on opioid receptors, and what medical uses and risks are documented?","kind":"provenance"},{"text":"Is the user asking about their own medication, which needs a clinician or pharmacist?","kind":"boundary"}]}]},{"id":"safety","name":"Safety","description":"Safety and dependence.","findings":[{"id":"safety-finding","name":"Safety","description":"Safety.","questions":[{"text":"What do health bodies say about overdose, dependence and safe use of opioid medicines?","kind":"provenance"},{"text":"Is an overdose emergency present now, requiring emergency services?","kind":"boundary"}]}]}]},{"id":"regulation","name":"Regulation","description":"Regulation.","layers":[{"id":"control","name":"Control","description":"Drug control.","findings":[{"id":"control-finding","name":"Control","description":"Control.","questions":[{"text":"How are morphinan alkaloids scheduled under international and national drug control, and how is legitimate supply regulated?","kind":"provenance"},{"text":"Which entry fits drug policy?","kind":"action"}]}]},{"id":"debates","name":"Debates","description":"Policy debates.","findings":[{"id":"debates-finding","name":"Debates","description":"Debates.","questions":[{"text":"What are the attributed positions in debates on opioid access and the opioid crisis?","kind":"provenance"},{"text":"Is the presentation neutral?","kind":"boundary"}]}]}]},{"id":"learn","name":"Learn","description":"History and research.","layers":[{"id":"history","name":"History","description":"History.","findings":[{"id":"history-finding","name":"History","description":"History.","questions":[{"text":"How were morphine and related alkaloids discovered and developed, according to historians of pharmacy?","kind":"provenance"},{"text":"Which references are standard?","kind":"provenance"}]}]},{"id":"research","name":"Research","description":"Research.","findings":[{"id":"research-finding","name":"Research","description":"Research.","questions":[{"text":"What research seeks safer analgesics within and beyond the morphinan class?","kind":"provenance"},{"text":"Which entry fits analgesic research?","kind":"action"}]}]}]}]},"agentConduct":{"may":["Explain the morphinan class in general terms and its place in medicine and history.","Point people with pain or dependence to clinicians and support services."],"mustNot":["Provide synthesis, extraction or diversion information for any morphinan.","Advise a person on dosing, combining or obtaining these drugs.","Help anyone obtain controlled substances without a lawful prescription.","Downplay the risks of overdose and dependence."],"requiresHuman":["Any decision on prescribing or stopping these medicines for a patient."]},"ethics":{"considerations":["Opioid overdose kills many people each year; misinformation adds to that toll.","Patients in pain need access to relief without stigma."],"affectedParties":["People who use opioids","Patients in pain","Families"]},"owners":{"steward":"Nobody owns the class; drug control authorities regulate the controlled members.","roles":[],"masterSystems":["National controlled substance schedules"]},"relations":[{"target":"Q70702","type":"parent","note":"registry parent class"},{"target":"Q75011544","type":"parent","note":"registry parent class"},{"target":"alkaloid","type":"related","note":"category"},{"target":"morphinan","type":"related","note":"category"},{"target":"aporphine alkaloids","type":"related","note":"another isoquinoline-derived class"},{"target":"drug","type":"related","note":"medicines and controlled substances"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.morphinan-alkaloid","Wikidata: Q4303473 (https://www.wikidata.org/wiki/Q4303473)"]},"properties":{"applicability":"required","items":["Molar mass:  g/mol - Molar mass is calculated from the formula of the identified compound, including any salt components or water of crystallization.","Melting temperature:  degrees Celsius - Melting behavior is measured for an identified solid form using thermal analysis or a melting-point apparatus, with decomposition recorded separately.","Solubility:  g/L - Equilibrium solubility is measured in a specified solvent at a stated temperature and pH because compound identity and salt form strongly affect it."]},"recognition":{"applicability":"required","items":["Morphinan ring skeleton","Opium poppy origin or synthetic","Aporphine alkaloids have a different skeleton","Not physical as a class; crystalline compounds in the laboratory."]},"capabilities":{"applicability":"required","items":["explain the chemical class","describe pharmacology generally","describe regulation","decline synthesis or misuse detail"]},"hazards":{"applicability":"required","items":["Providing synthesis or diversion information","Overdose and dependence","Agents giving personal medical advice"]},"interfaces":{"applicability":"required","items":["International drug control conventions","National controlled substance schedules","Pharmacopoeial standards for medicines"]},"context":{"applicability":"required","items":["Alkaloids with the morphinan skeleton.","natural opiates such as morphine, codeine and thebaine","semi-synthetic derivatives","synthetic morphinans","biosynthetic intermediates","non-analgesic morphinans such as antitussives"]}},"sources":[{"title":"Wikidata item Q4303473: morphinan alkaloid","url":"https://www.wikidata.org/wiki/Q4303473","note":"identity and sense of the item"},{"title":"Morphinan","url":"https://en.wikipedia.org/wiki/Morphinan","note":"The parent chemical skeleton of morphinan alkaloids and its naturally occurring derivatives."},{"title":"PubChem: Morphinan","url":"https://pubchem.ncbi.nlm.nih.gov/compound/Morphinan","note":"Chemical identity and structure of the parent compound defining the morphinan family."}],"openQuestions":["Should each compound be a separate entry?","How should regulatory schedules be linked?","How should safety boundaries be documented?"],"resources":{"spec":"/models/things/publications/thing-q4303473/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q4303473/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T00:23:59Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T12:51:18+00:00: completeness 1.00; sense: Wikidata description; 3 live sources; review by codex: pass"},"score":1.0}}