{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.alcohol-oxidoreductase","code":"thing-q4713306","url":"https://ver.cy/models/thing/q4713306/","name":"alcohol oxidoreductase","alternateNames":["Sulfopropanediol 3-dehydrogenase","Sulfoacetaldehyde reductase","Uracil dehydrogenase","2-Deoxy-scyllo-inosamine dehydrogenase (SAM-dependent)","PQQ-dependent membrane bound dehydrogenase","glucose-6-phosphate dehydrogenase","Bile-acid 7alpha-dehydroxylase","Testosterone 17-beta-dehydrogenase 3","oxidoreductase, acting on the CH-OH group of donors, NAD or NADP as acceptor","oxidoreductase, acting on the CH-OH group of donors, oxygen as acceptor","oxidoreductase, acting on the CH-OH group of donors, cytochrome as acceptor","oxidoreductase, acting on the CH-OH group of donors, quinone or similar compound as acceptor"],"kind":"thing","status":"published","version":"0.2.0-wave.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"A group of oxidoreductase enzymes that act on the CH-OH group of donors, classified under EC 1.1, including alcohol dehydrogenase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase, usually using NAD+ or NADP+ as acceptor.","purpose":"Let an agent handle alcohol oxidoreductases by EC class, reaction, cofactor, biological role and data sources.","scope":{"in":[],"out":[],"boundaries":[]},"distinguishingFeatures":["Oxidise alcohol groups","Mostly use NAD(P)+","Very large class","Central to metabolism"],"structure":{"bundles":[{"id":"classification","name":"Classification","description":"EC numbers.","layers":[{"id":"ec","name":"EC","description":"Number.","findings":[{"id":"ec-finding","name":"EC","description":"EC number.","questions":[{"text":"What is the full EC number of this enzyme?","kind":"provenance"},{"text":"Which acceptor subclass is it in?","kind":"definition"}]}]},{"id":"names","name":"Names","description":"Systematic names.","findings":[{"id":"names-finding","name":"Names","description":"Names.","questions":[{"text":"What are its systematic and accepted names?","kind":"provenance"},{"text":"Has it been reclassified?","kind":"provenance"}]}]}]},{"id":"reaction","name":"Reaction","description":"Chemistry.","layers":[{"id":"substrate","name":"Substrate","description":"Donor.","findings":[{"id":"substrate-finding","name":"Substrate","description":"Substrates.","questions":[{"text":"Which alcohol substrate does it oxidise, and what is the product?","kind":"definition"},{"text":"What is its substrate specificity?","kind":"measurement"}]}]},{"id":"cofactor","name":"Cofactor","description":"Acceptor.","findings":[{"id":"cofactor-finding","name":"Cofactor","description":"Cofactor.","questions":[{"text":"Which cofactor or acceptor does it use?","kind":"definition"},{"text":"What are its kinetic parameters?","kind":"measurement"}]}]}]},{"id":"biology","name":"Biology","description":"Role.","layers":[{"id":"pathway","name":"Pathway","description":"Metabolism.","findings":[{"id":"pathway-finding","name":"Pathway","description":"Pathways.","questions":[{"text":"Which metabolic pathway does it participate in?","kind":"provenance"},{"text":"In which organisms?","kind":"provenance"}]}]},{"id":"health","name":"Health","description":"Deficiency.","findings":[{"id":"health-finding","name":"Health","description":"Health links.","questions":[{"text":"Is a deficiency of this enzyme linked to a condition, according to medical sources?","kind":"provenance"},{"text":"Is the user asking about their own health?","kind":"boundary"}]}]}]},{"id":"data","name":"Data","description":"Databases.","layers":[{"id":"databases","name":"Databases","description":"BRENDA and UniProt.","findings":[{"id":"databases-finding","name":"Databases","description":"Databases.","questions":[{"text":"Which database entries describe this enzyme?","kind":"provenance"},{"text":"Is a structure available in the PDB?","kind":"provenance"}]}]},{"id":"applications","name":"Applications","description":"Biotech.","findings":[{"id":"applications-finding","name":"Applications","description":"Applications.","questions":[{"text":"How is the enzyme used in diagnostics or biocatalysis?","kind":"provenance"},{"text":"Which products use it?","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Report enzymes in this group with their EC numbers from enzyme nomenclature databases.","Explain their reactions and roles in metabolism."],"mustNot":["Confuse EC subclasses or assign wrong EC numbers.","Interpret a person's enzyme test results as a diagnosis."],"requiresHuman":["Medical decisions based on enzyme tests."]},"ethics":{"considerations":["Accurate classification underpins research and diagnostics."],"affectedParties":["Researchers and students","Patients undergoing tests"]},"owners":{"steward":"Nobody owns the group; enzyme nomenclature is kept by the scientific community.","roles":[],"masterSystems":["Enzyme nomenclature lists"]},"relations":[{"target":"Q407479","type":"parent","note":"registry parent class"},{"target":"oxidoreductase","type":"related","note":"category"},{"target":"alcohol dehydrogenase","type":"related","note":"example"},{"target":"NAD+","type":"related","note":"cofactor"},{"target":"EC number","type":"related","note":"scheme"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.alcohol-oxidoreductase","Wikidata: Q4713306 (https://www.wikidata.org/wiki/Q4713306)","EC number: 1.1 enzyme subclass"]},"properties":{"applicability":"required","items":["Molecular mass:  kDa - Determine mass from the specific enzyme sequence or mass spectrometry, distinguishing individual subunits from assembled complexes.","Isoelectric point:  pH units - Measure the pH at which the specified enzyme has zero net charge using isoelectric focusing.","Hydrodynamic radius:  nm - Measure the effective solution radius using a suitable diffusion-based method while recording buffer conditions and aggregation state."]},"recognition":{"applicability":"required","items":["EC numbers beginning 1.1","Dehydrogenases using NAD+ or NADP+","Oxidases acting on other groups belong elsewhere","Proteins, not visible; described by structures and reactions."]},"capabilities":{"applicability":"required","items":["classify an enzyme by EC number","describe the reaction and cofactor","find enzyme data in databases","relate enzymes to metabolism and disease in general terms"]},"hazards":{"applicability":"required","items":["Confusing EC subclasses","Over-interpreting diagnostic enzyme tests"]},"interfaces":{"applicability":"required","items":["IUBMB enzyme nomenclature"]},"context":{"applicability":"required","items":["Metabolism, biochemistry, diagnostics and biotechnology.","EC 1.1.1 with NAD+ or NADP+ as acceptor","EC 1.1.2 with a cytochrome as acceptor","EC 1.1.3 with oxygen as acceptor","EC 1.1.5 with a quinone as acceptor","other acceptors"]}},"sources":[{"title":"Wikidata item Q4713306: alcohol oxidoreductase","url":"https://www.wikidata.org/wiki/Q4713306","note":"identity and sense of the item"},{"title":"Wikipedia: Alcohol oxidoreductase","url":"https://en.wikipedia.org/wiki/Alcohol_oxidoreductase","note":"general description of the item"}],"openQuestions":["Should each enzyme be a separate entry?","How should BRENDA and UniProt be linked?","How should EC reclassification be tracked?"],"resources":{"spec":"/models/things/publications/thing-q4713306/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q4713306/spec.json"],"providers":["Claude"],"researchStatus":"unreviewed","generatedAt":"2026-09-11T12:04:03Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:31+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}