{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.dauricine","code":"thing-q5228100","url":"https://ver.cy/models/thing/q5228100/","name":"dauricine","alternateNames":[],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Dauricine is a naturally occurring bisbenzylisoquinoline alkaloid found in Menispermum dauricum and investigated for its effects on ion channels and cellular signalling.","purpose":"Enable an agent to recognise dauricine, assess the identity and condition of a supplied sample, and determine whether its evidence and handling constraints support a proposed research use.","scope":{"in":["Molecular identity, stereochemistry and authoritative identifier mappings","Free-base identity and relationships to salts, solvates and protonated forms","Sample purity, related alkaloids, contaminants and analytical confirmation","Physical state, dissolution, concentration and stability under recorded conditions","Experimental biological activity, metabolic activation and hazard evidence with explicit applicability limits"],"out":["Botanical taxonomy, cultivation and whole-plant medicinal properties","The full composition and effects of extracts containing dauricine","Manufacturing and extraction process design","Independent models of dauricine metabolites and related alkaloids","Finished medicinal products, clinical treatment protocols and prescribing decisions"],"boundaries":[]},"distinguishingFeatures":["Match a structure-resolved record to the bisbenzylisoquinoline alkaloid dauricine, PubChem CID 73400, with formula C38H44N2O6; a name match alone is insufficient. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Dauricine)","Verify the reference structure's ether connectivity, methoxy and phenolic substitution pattern, and stereochemistry; formula or nominal mass alone cannot distinguish structural or stereochemical alternatives. [PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Dauricine)","Require reference-supported chromatographic and structural evidence to distinguish dauricine from related alkaloids such as daurisoline.","Establish whether the material is the free base, a salt or a mixture before applying identifiers, molecular-weight calculations or purity claims.","Distinguish unchanged dauricine from its metabolic products and adducts; quinone-methide-related metabolites have been investigated in human liver microsomes and rat bile. [Primary study](https://pubmed.ncbi.nlm.nih.gov/19358519/)"],"structure":{"bundles":[{"id":"dauricine-identity","name":"Dauricine identity","description":"Establish what molecular entity and supplied chemical form the dauricine name denotes.","layers":[{"id":"molecular-recognition","name":"Molecular recognition","description":"Resolve the registry name to a structure with explicit stereochemistry.","findings":[{"id":"reference-structure-match","name":"Reference structure match","description":"Record the reference structure and evidence that a candidate has the required connectivity and stereochemistry.","questions":[{"text":"Which authoritative structure record defines dauricine for this entry, including its stereocentres?","id":"reference-structure-match-q01","kind":"definition"},{"text":"Which analytical evidence distinguishes the candidate from daurisoline and other plausible related alkaloids?","id":"reference-structure-match-q02","kind":"measurement"}]}]},{"id":"chemical-form-boundary","name":"Chemical form boundary","description":"Separate the parent substance from counterions, solvent inclusion and mixtures.","findings":[{"id":"form-and-identifier-alignment","name":"Form and identifier alignment","description":"Associate identifiers and mass calculations with the actual material form.","questions":[{"text":"Does the supplied material contain dauricine free base, an identified salt or an unresolved mixture?","id":"form-and-identifier-alignment-q01","kind":"boundary"},{"text":"Which CAS, PubChem and EC mappings have been verified for that exact form, and which remain unresolved?","id":"form-and-identifier-alignment-q02","kind":"provenance"}]}]}]},{"id":"sample-composition","name":"Sample composition","description":"Determine whether a particular lot contains sufficiently characterised dauricine for its intended use.","layers":[{"id":"origin-and-authentication","name":"Origin and authentication","description":"Connect a lot to its origin, reference material and identity measurements.","findings":[{"id":"lot-identity-evidence","name":"Lot identity evidence","description":"Retain the evidence supporting identification without treating plant provenance as chemical proof.","questions":[{"text":"Was this lot isolated, synthesised or purchased, and what traceable record links it to the material being assessed?","id":"lot-identity-evidence-q01","kind":"provenance"},{"text":"Which combination of reference comparison, chromatography, mass spectrometry, NMR or stereochemical analysis supports its identity?","id":"lot-identity-evidence-q02","kind":"measurement"}]}]},{"id":"content-and-impurities","name":"Content and impurities","description":"Distinguish dauricine content from analytical purity and identify consequential accompanying material.","findings":[{"id":"usable-content","name":"Usable content","description":"Determine the amount of dauricine available and whether impurities compromise a proposed experiment.","questions":[{"text":"Is the stated purity a calibrated content assay or chromatographic area percentage, and what uncertainty and reporting basis apply?","id":"usable-content-q01","kind":"measurement"},{"text":"Do related alkaloids, residual solvents, water or unidentified peaks require additional testing or rejection for the intended use?","id":"usable-content-q02","kind":"action"}]}]}]},{"id":"physical-state-and-preparation","name":"Physical state and preparation","description":"Characterise dauricine as received and as prepared for measurement or experimentation.","layers":[{"id":"solid-state-characterisation","name":"Solid-state characterisation","description":"Tie physical observations and thermal data to an identified lot and method.","findings":[{"id":"condition-dependent-properties","name":"Condition-dependent properties","description":"Record observed properties without inventing universal constants from unspecified supplier values.","questions":[{"text":"What phase, water or solvent content and thermal transitions are measured for the identified dauricine form?","id":"condition-dependent-properties-q01","kind":"measurement"},{"text":"Does a reported melting or boiling value describe a measured transition, decomposition or a prediction?","id":"condition-dependent-properties-q02","kind":"provenance"}]}]},{"id":"solution-integrity","name":"Solution integrity","description":"Assess whether prepared dauricine remains dissolved and chemically intact during use.","findings":[{"id":"verified-exposure-solution","name":"Verified exposure solution","description":"Connect nominal concentration to measured dissolved material and its stability window.","questions":[{"text":"At the intended solvent composition, pH and temperature, what dauricine concentration remains dissolved after dilution?","id":"verified-exposure-solution-q01","kind":"measurement"},{"text":"What evidence determines acceptable storage duration, light exposure and freeze-thaw history before reanalysis is needed?","id":"verified-exposure-solution-q02","kind":"action"}]}]}]},{"id":"biological-activity-and-transformation","name":"Biological activity and transformation","description":"Represent experimental effects and metabolic fate with their evidential boundaries.","layers":[{"id":"activity-attribution","name":"Activity attribution","description":"Link any proposed biological activity to measurements and appropriate controls.","findings":[{"id":"endpoint-specific-evidence","name":"Endpoint-specific evidence","description":"Require explicit evidence before assigning a molecular target, functional effect or therapeutic interpretation.","questions":[{"text":"Which endpoint was measured, in which biological system, at what verified concentration or dose and duration?","id":"endpoint-specific-evidence-q01","kind":"measurement"},{"text":"Do the controls distinguish the proposed activity from vehicle effects, precipitation, assay interference and general cytotoxicity?","id":"endpoint-specific-evidence-q02","kind":"boundary"}]}]},{"id":"metabolic-activation","name":"Metabolic activation","description":"Track evidence about transformation of dauricine into reactive products.","findings":[{"id":"parent-metabolite-separation","name":"Parent-metabolite separation","description":"Research in human liver microsomes and rat bile investigated quinone methide metabolites; record the experimental context and distinguish detected conjugates from inferred transient intermediates. [Primary study](https://pubmed.ncbi.nlm.nih.gov/19358519/)","questions":[{"text":"Which metabolites, trapping products or adducts were directly detected, and which intermediates were inferred?","id":"parent-metabolite-separation-q01","kind":"measurement"},{"text":"What evidence links the transformation pathway to the biological system and exposure conditions proposed for this sample?","id":"parent-metabolite-separation-q02","kind":"boundary"}]}]}]},{"id":"hazards-and-use-constraints","name":"Hazards and use constraints","description":"Translate applicable toxicological and documentary evidence into constraints on dauricine handling and research use.","layers":[{"id":"toxicological-evidence","name":"Toxicological evidence","description":"Retain the species, route and exposure limits of observed adverse effects.","findings":[{"id":"pulmonary-toxicity-signal","name":"Pulmonary toxicity signal","description":"A primary study examined pulmonary toxicity and metabolic activation in CD-1 mice; this is an experimental hazard signal, not a quantified human exposure limit. [Primary study](https://pubmed.ncbi.nlm.nih.gov/20008063/)","questions":[{"text":"What dose, route, duration and lung-injury endpoints underlie the reported toxicity?","id":"pulmonary-toxicity-signal-q01","kind":"measurement"},{"text":"Which conclusions apply to the proposed handling or experimental exposure, and which require unsupported extrapolation?","id":"pulmonary-toxicity-signal-q02","kind":"boundary"}]}]},{"id":"applicable-handling-record","name":"Applicable handling record","description":"Resolve the documents governing the exact material and proposed activity.","findings":[{"id":"documented-use-decision","name":"Documented use decision","description":"Base handling and use decisions on current, attributable documents and explicitly record missing limits or classifications.","questions":[{"text":"Which current SDS, GHS classification and jurisdiction-specific restrictions apply to this dauricine form and concentration?","id":"documented-use-decision-q01","kind":"provenance"},{"text":"What containment, storage and disposal requirements follow from those records, and does an unresolved requirement prevent the proposed use?","id":"documented-use-decision-q02","kind":"action"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of dauricine this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of dauricine this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of dauricine this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of dauricine this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of dauricine this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of dauricine this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Identify dauricine as an alkaloid of Menispermum dauricum and describe research on it, citing sources.","Report the source, purity and storage of a held sample."],"mustNot":["Recommend dauricine or plant extracts containing it as a treatment for a person.","Present laboratory or animal findings as proven effects in people.","Label a plant extract as pure dauricine without analysis.","Dispose of it in drains or general waste."],"requiresHuman":["Using it in any study involving people or animals.","Adding it to products intended for people."]},"ethics":{"considerations":["Alkaloids active on heart ion channels can cause harm if used without evidence.","Herbal claims can mislead patients away from effective care."],"affectedParties":["Patients and consumers","Research animals","Laboratory workers"]},"owners":{"steward":"The laboratory that holds the sample.","roles":[],"masterSystems":[]},"relations":[{"target":"Q104402407","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.dauricine","Wikidata: Q5228100 (https://www.wikidata.org/wiki/Q5228100)"]},"properties":{"applicability":"required","items":["Structure-resolved identity: Stereochemical structure, canonical identifier and verified database mapping","Material form: Free base; identified salt; identified solvate or hydrate; unresolved form","Dauricine content: % mass fraction or mg/g, with assay method and dry or as-received basis","Related alkaloid and contaminant profile: Identified components in mg/g or %, with detection and quantification limits","Solution concentration: mol/L or mg/mL, with material form, solvent, pH, temperature and verification method","Physical and thermal behaviour: Observed phase; thermal events in °C; pressure and method; decomposition where observed","Storage and solution integrity: Within verified stability conditions; changed; expired; unassessed","Biological evidence context: Study linked to sample identity, endpoint, test system, concentration or dose, duration and controls","Applicable hazard and regulatory record: Dated SDS, jurisdiction, material form, classification source and applicable restrictions"]},"recognition":{"applicability":"required","items":["A solid that cannot be identified by appearance.","Identity is settled by chromatography and spectroscopy against a reference."]},"capabilities":{"applicability":"required","items":["Resolve a supplied dauricine label to a verified molecular identity and material form.","Accept, quarantine or reject a research sample against documented identity and composition criteria.","Calculate preparation amounts using measured content and the correct chemical form.","Select compatible preparation and storage conditions from evidence applicable to the sample.","Compare biological studies while retaining exposure, vehicle and test-system differences.","Flag unresolved hazard, metabolic-activation or regulatory evidence before a proposed use."]},"hazards":{"applicability":"required","items":["Toxic effects on the heart in uncontrolled use.","Misidentified or adulterated extracts."]},"interfaces":{"applicability":"required","items":["Globally Harmonized System of Classification and Labelling of Chemicals (GHS), United Nations."]},"context":{"applicability":"required","items":["Dauricine is encountered in natural product research as an alkaloid isolated from plant material or supplied as a research chemical.","It is used in laboratory studies of ion channels and cellular signalling, where sample identity and purity are important for interpreting results."]}},"sources":[{"title":"Wikidata item Q5228100: dauricine","url":"https://www.wikidata.org/wiki/Q5228100","note":"identity and sense of the item"},{"title":"Wikipedia: Dauricine","url":"https://en.wikipedia.org/wiki/Dauricine","note":"general description of the item"}],"openQuestions":["Which CAS and EC identifiers are authoritative for the registry's intended stereochemical structure and free-base identity, and how should distinct salts be linked?","Which experimentally supported solubility, thermal and storage-stability values are available with sufficiently specified chemical form and conditions?","Which related alkaloids and degradation products require explicit analytical discrimination, and what acceptance limits suit each intended research use?","How far do the metabolic-activation and animal-toxicity findings extend to human-relevant exposure, and where does evidence remain insufficient?","What current jurisdiction-specific classifications, exposure limits and authorised-use records exist for dauricine, as distinct from supplier statements or products containing it?"],"resources":{"spec":"/models/things/publications/thing-q5228100/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q5228100/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T09:01:47Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:31+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}