{"schema":"https://ver.cy/schemas/card/1.0.0","id":"vr.tr.estradiol-valerate","code":"thing-q5401768","url":"https://ver.cy/models/thing/q5401768/","name":"estradiol valerate","alternateNames":[],"kind":"thing","status":"published","version":"0.1.0-research.1","language":"en","classifiers":{"family":"Thing Registry","category":"Physical world and living systems","entryKind":"thing","plane":"PHY","domain":["PHY.MAT"],"industry":[],"navPath":"","tags":[],"facets":{}},"whatItIs":"Estradiol valerate is the 17β-valerate ester of estradiol, a synthetic steroidal estrogen prodrug that is hydrolysed in the body to estradiol and valeric acid.","purpose":"Enable an agent to identify estradiol valerate, assess a material lot's quality and condition, and determine whether evidence supports its intended handling or use.","scope":{"in":["Estradiol valerate molecular identity, stereochemistry and authoritative identifiers","Material grade, assay, related substances and lot provenance","Physical form and measured properties under specified conditions","Ester transformation, degradation and storage stability","Substance hazards, exposure controls and jurisdiction-specific identity","Relations to estradiol and products containing estradiol valerate"],"out":["Finished tablet or injectable formulation composition and product release","Patient-specific prescribing, dosing and monitoring","Estradiol, other estradiol esters and their independent substance models","Manufacturing equipment, synthesis procedures and facility qualification","Disease models and general estrogen physiology"],"boundaries":[]},"distinguishingFeatures":["Confirm the 17β-pentanoate ester of estradiol, distinguishing ester position and stereochemistry from similarly named steroids. [DailyMed description](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=66f40ab0-4432-4e85-b709-a0bc076868c6)","Check formula C23H32O3 and molecular mass 356.50 g/mol as supporting identity tests, without treating either as sufficient structural proof. [DailyMed description](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=66f40ab0-4432-4e85-b709-a0bc076868c6)","Require an analytical method that distinguishes intact estradiol valerate from unesterified estradiol and other estradiol esters.","Distinguish the substance from a medicine containing it: an oil injection includes vehicle and possibly preservatives beyond estradiol valerate. [DailyMed formulation description](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=66f40ab0-4432-4e85-b709-a0bc076868c6)"],"structure":{"bundles":[{"id":"ester-identity","name":"Ester identity","description":"Establishes exactly which estradiol derivative the registry entry denotes.","layers":[{"id":"molecular-boundary","name":"Molecular boundary","description":"Defines the ester attachment and stereochemical identity.","findings":[{"id":"reference-structure","name":"Reference structure","description":"Require a reference structure and analytical evidence that discriminate estradiol valerate from neighbouring steroid identities.","questions":[{"text":"Which reference structure establishes the pentanoate attachment position and complete stereochemistry?","id":"reference-structure-q01","kind":"definition"},{"text":"Which analytical results distinguish this sample from free estradiol, positional isomers and other estradiol esters?","id":"reference-structure-q02","kind":"measurement"}]}]},{"id":"identifier-resolution","name":"Identifier resolution","description":"Connects the registry entry to independently maintained substance records.","findings":[{"id":"substance-record-mapping","name":"Substance record mapping","description":"Map chemical identifiers to the defined molecule while keeping product identifiers separate.","questions":[{"text":"Which read sources verify the CAS number, PubChem CID, EC number and UNII for this exact structure?","id":"substance-record-mapping-q01","kind":"provenance"},{"text":"Does a supplied name or identifier denote estradiol valerate itself, a mixture, a reference solution or a finished medicine?","id":"substance-record-mapping-q02","kind":"boundary"}]}]}]},{"id":"lot-composition-and-grade","name":"Lot composition and grade","description":"Determines what a particular estradiol valerate lot contains and what its documentation supports.","layers":[{"id":"assay-and-related-substances","name":"Assay and related substances","description":"Separates intact ester content from impurities and measurement conventions.","findings":[{"id":"intact-ester-content","name":"Intact ester content","description":"Record a specific assay and impurity profile rather than treating a supplier purity claim as complete evidence.","questions":[{"text":"What is the estradiol valerate assay, on what correction basis, and does the method separate free estradiol?","id":"intact-ester-content-q01","kind":"measurement"},{"text":"Which steroid-related impurities, residual solvents and water levels were measured, with what reporting limits?","id":"intact-ester-content-q02","kind":"measurement"}]}]},{"id":"qualification-and-traceability","name":"Qualification and traceability","description":"Links material grade to a specific lot and applicable acceptance criteria.","findings":[{"id":"supported-material-use","name":"Supported material use","description":"Assess intended-use suitability from traceable specifications and qualification evidence.","questions":[{"text":"Which manufacturer lot, certificate and specification edition support the claimed grade?","id":"supported-material-use-q01","kind":"provenance"},{"text":"Does the available evidence support reference testing, research or pharmaceutical processing, and which release decisions remain with another model?","id":"supported-material-use-q02","kind":"action"}]}]}]},{"id":"physical-form-and-compatibility","name":"Physical form and compatibility","description":"Captures the material properties needed to assess estradiol valerate under actual conditions.","layers":[{"id":"solid-state-and-thermal-behaviour","name":"Solid state and thermal behaviour","description":"Characterises the observed material without presuming unverified polymorphs or constants.","findings":[{"id":"conditioned-physical-identity","name":"Conditioned physical identity","description":"Record observed phase, any demonstrated solid form and qualified thermal measurements.","questions":[{"text":"What phase, solid-form evidence and particle-size distribution describe this lot under the recorded conditions?","id":"conditioned-physical-identity-q01","kind":"measurement"},{"text":"What measured melting interval and decomposition behaviour are supported, and is any reported boiling point experimental or estimated?","id":"conditioned-physical-identity-q02","kind":"provenance"}]}]},{"id":"solvent-and-matrix-behaviour","name":"Solvent and matrix behaviour","description":"Relates measured dissolution and compatibility to explicitly identified media.","findings":[{"id":"qualified-solubility","name":"Qualified solubility","description":"Keep equilibrium solubility and compatibility evidence distinct from a finished product's labelled concentration.","questions":[{"text":"What estradiol valerate solubility was measured in the relevant solvent or vehicle, at what temperature and equilibration conditions?","id":"qualified-solubility-q01","kind":"measurement"},{"text":"Which precipitation or compatibility conclusions apply to the substance, and which depend on a particular formulation?","id":"qualified-solubility-q02","kind":"boundary"}]}]}]},{"id":"ester-transformation-and-stability","name":"Ester transformation and stability","description":"Tracks intact ester, transformation products and the evidence needed to retain material acceptance.","layers":[{"id":"conversion-to-estradiol","name":"Conversion to estradiol","description":"Defines the relationship between ester transformation and the resulting estradiol species.","findings":[{"id":"conversion-evidence-and-quantity-basis","name":"Conversion evidence and quantity basis","description":"Require evidence for conversion conditions and distinguish chemical amount equivalence from therapeutic equivalence.","questions":[{"text":"Which studies establish estradiol valerate conversion products and rates in specified chemical or biological conditions?","id":"conversion-evidence-and-quantity-basis-q01","kind":"provenance"},{"text":"Is a reported quantity intact ester mass, molar amount or estradiol-equivalent mass, and how was it derived?","id":"conversion-evidence-and-quantity-basis-q02","kind":"measurement"},{"text":"Which conclusions about exposure or duration require a route-specific product model rather than molecular identity alone?","id":"conversion-evidence-and-quantity-basis-q03","kind":"boundary"}]}]},{"id":"degradation-and-retest","name":"Degradation and retest","description":"Connects storage history to evidence of continuing ester quality.","findings":[{"id":"stability-supported-disposition","name":"Stability-supported disposition","description":"Base retest or rejection on relevant stability data and a method capable of detecting degradation.","questions":[{"text":"Which studies establish changes in intact ester and degradants under relevant heat, light, moisture and container conditions?","id":"stability-supported-disposition-q01","kind":"provenance"},{"text":"Given this lot's storage history and retest date, what evidence supports continued acceptance, quarantine or retesting?","id":"stability-supported-disposition-q02","kind":"action"}]}]}]},{"id":"hazards-and-use-boundaries","name":"Hazards and use boundaries","description":"Establishes evidence-based handling constraints and links substance identity to regulated uses.","layers":[{"id":"substance-exposure-controls","name":"Substance exposure controls","description":"Resolves hazard evidence for the actual material and handling operation.","findings":[{"id":"applicable-hazard-assessment","name":"Applicable hazard assessment","description":"Record classifications and exposure-control bases with their source, material scope and jurisdiction.","questions":[{"text":"Which current safety data and authoritative assessments apply to this grade of estradiol valerate, and where do classifications disagree?","id":"applicable-hazard-assessment-q01","kind":"provenance"},{"text":"Is there an authoritative occupational exposure limit or a documented internal limit, and what averaging period and units apply?","id":"applicable-hazard-assessment-q02","kind":"measurement"},{"text":"Which containment, protective equipment and waste controls follow from the assessed powder, solution or spill exposure?","id":"applicable-hazard-assessment-q03","kind":"action"}]}]},{"id":"ingredient-product-and-jurisdiction","name":"Ingredient, product and jurisdiction","description":"Separates the substance's regulatory records from permissions attached to particular medicines.","findings":[{"id":"bounded-use-authorization","name":"Bounded use authorization","description":"Link relevant ingredient requirements and product authorizations without treating either as unrestricted permission to use a lot.","questions":[{"text":"Which ingredient standards or restrictions apply in the intended jurisdiction as of the recorded date?","id":"bounded-use-authorization-q01","kind":"provenance"},{"text":"Which containing product owns the route, concentration, sterility requirements and authorization being relied upon?","id":"bounded-use-authorization-q02","kind":"boundary"},{"text":"What additional product qualification is required before this material can enter the intended regulated use?","id":"bounded-use-authorization-q03","kind":"action"}]}]}]},{"id":"evidence-and-external-alignment","name":"Evidence and external alignment","description":"What the world already says about this thing, gathered so the model can be checked against it.","layers":[{"id":"reported-evidence","name":"Reported evidence","description":"Findings from the breadth pass, kept separate from the structural claims.","findings":[{"id":"evidence-confidence-notes","name":"Check these first","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these check these first hold for the sense of estradiol valerate this model covers, and on what evidence?","id":"evidence-confidence-notes-q01","kind":"provenance"}]},{"id":"evidence-identifiers","name":"Identifiers and schemes","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these identifiers and schemes hold for the sense of estradiol valerate this model covers, and on what evidence?","id":"evidence-identifiers-q01","kind":"provenance"}]},{"id":"evidence-standards-and-regulation","name":"Standards and regulation","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these standards and regulation hold for the sense of estradiol valerate this model covers, and on what evidence?","id":"evidence-standards-and-regulation-q01","kind":"provenance"}]},{"id":"evidence-real-world-use","name":"Real-world use","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these real-world use hold for the sense of estradiol valerate this model covers, and on what evidence?","id":"evidence-real-world-use-q01","kind":"provenance"}]},{"id":"evidence-measurements","name":"Typical measurements","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these typical measurements hold for the sense of estradiol valerate this model covers, and on what evidence?","id":"evidence-measurements-q01","kind":"provenance"}]},{"id":"evidence-failure-modes-and-hazards","name":"Failure modes and hazards","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these failure modes and hazards hold for the sense of estradiol valerate this model covers, and on what evidence?","id":"evidence-failure-modes-and-hazards-q01","kind":"provenance"}]},{"id":"evidence-regional-variation","name":"Regional variation","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these regional variation hold for the sense of estradiol valerate this model covers, and on what evidence?","id":"evidence-regional-variation-q01","kind":"provenance"}]},{"id":"evidence-neighbours","name":"Neighbouring kinds and how to tell them apart","description":"Recalled without web access and unsourced; every item is a lead to verify.","questions":[{"text":"Which of these neighbouring kinds and how to tell them apart hold for the sense of estradiol valerate this model covers, and on what evidence?","id":"evidence-neighbours-q01","kind":"provenance"}]}]}]}]},"agentConduct":{"may":["Describe estradiol valerate and its approved uses from medicines information.","Report authorization status and labelled warnings for a stated country."],"mustNot":["Recommend it, a dose or a regimen for a person.","Supply it outside the regulated prescription chain.","Advise self-administration of injections without a prescriber.","Disclose a person's hormone treatment, gender identity or reproductive history without consent."],"requiresHuman":["Starting, stopping or changing hormone treatment for any person."]},"ethics":{"considerations":["Hormone treatment touches on gender identity and reproductive health, which are deeply private.","It carries risks such as blood clots that require medical oversight."],"affectedParties":["Patients, including transgender people and women in menopause","Prescribers"]},"owners":{"steward":"The marketing authorization holder; medicines regulators and prescribers control its use.","roles":[],"masterSystems":["Medicines regulators' product registers"]},"relations":[{"target":"Q177911","type":"parent","note":"registry parent class"}],"interaction":{"identity":{"applicability":"required","items":["Vercy registry: vr.tr.estradiol-valerate","Wikidata: Q5401768 (https://www.wikidata.org/wiki/Q5401768)"]},"properties":{"applicability":"required","items":["Registry and chemical identity: vr.tr.estradiol-valerate; PubChem CID 13791; verified CAS, EC and UNII mappings with source dates","Ester position and stereochemistry: Reference molecular structure with explicit stereochemistry and 17-pentanoate attachment","Grade and specification: Research material, analytical reference material or pharmaceutical material; named specification and edition","Estradiol valerate assay: % mass fraction, with as-is or corrected basis, method and uncertainty","Related substances and residuals: Individual and total impurities in % or mg/kg; residual solvents in mg/kg; water in %","Physical form and particle attributes: Observed phase, identified solid form and particle-size distribution in µm, with conditions","Thermal and solubility properties: Melting interval and decomposition onset in °C; solubility in mg/mL with solvent and temperature; boiling data only with pressure and evidence","Storage and retest condition: Container, temperature history, light and moisture exposure, retest date and excursion assessment","Hazard and exposure classification: Source-specific GHS classes, jurisdiction, revision date and exposure limits in the source's stated units"]},"recognition":{"applicability":"required","items":["Supplied as tablets or an oily solution for injection; identified by label."]},"capabilities":{"applicability":"required","items":["Match a labelled sample to the estradiol valerate reference identity and flag analytical inconsistencies.","Compare a lot's assay and impurity results with a named specification.","Select applicable storage and handling controls from verified material evidence.","Flag a lot for quarantine or retesting after an excursion or unresolved identity result.","Link ingredient quantities to containing products while preserving the distinction between ester mass and estradiol-equivalent reporting.","Route formulation suitability and clinical-use questions to the relevant product and treatment models."]},"hazards":{"applicability":"required","items":["Raises the risk of blood clots, stroke and some cancers.","Unsupervised use can lead to dangerous hormone levels."]},"interfaces":{"applicability":"required","items":["European Pharmacopoeia monograph on estradiol valerate, European Directorate for the Quality of Medicines and HealthCare."]},"context":{"applicability":"required","items":["Estradiol valerate is encountered in estrogen-containing medicines, including oral and injectable formulations.","Pharmaceutical manufacturing, quality control and research use its chemical identity to distinguish the ester from estradiol and other estrogen esters."]}},"sources":[{"title":"Wikidata item Q5401768: estradiol valerate","url":"https://www.wikidata.org/wiki/Q5401768","note":"identity and sense of the item"},{"title":"Wikipedia: Estradiol valerate","url":"https://en.wikipedia.org/wiki/Estradiol_valerate","note":"general description of the item"}],"openQuestions":["Which authoritative records confirm the CAS, EC and UNII mappings against the complete stereochemical structure?","Which current pharmacopoeial monographs apply, and what assay, related-substance and residual limits do they require?","Which experimentally supported solid forms, melting intervals, solubilities and decomposition data exist, and which reported constants are estimates?","What bulk-material stability evidence supports storage conditions and retest periods independently of finished injection or tablet labels?","Which jurisdiction-specific GHS classifications, occupational exposure limits and environmental disposal requirements are established for estradiol valerate?"],"resources":{"spec":"/models/things/publications/thing-q5401768/spec.json"},"provenance":{"origin":"thing registry research (pass 2)","builtFrom":["models/things/publications/thing-q5401768/spec.json"],"providers":["Codex"],"researchStatus":"unreviewed","generatedAt":"2026-09-12T09:32:34Z","builder":"tools/build_cards.py@1.0.0"},"completeness":{"sections":{"classifiers":"filled","whatItIs":"filled","purpose":"filled","distinguishingFeatures":"filled","structure":"filled","agentConduct":"filled","ethics":"filled","owners":"filled","relations":"filled","interaction.identity":"filled","interaction.properties":"filled","interaction.recognition":"filled","interaction.capabilities":"filled","interaction.hazards":"filled","interaction.interfaces":"filled","interaction.context":"filled","sources":"filled"},"notes":{"_gate":"Published through the thing publication gate 1.0 on 2026-10-07T10:10:31+00:00: completeness 1.00; sense: Wikidata description; 2 live sources; review by codex: pass"},"score":1.0}}